@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_NR1I3_MOUSE: (2016-03-19 )
MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQAQRRAEKASLQLNQQQKELVQILLGAHTRHVGPMFDQFVQFKPPAYLFMHHRPFQPRGPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTENFFCGPLCYKMEDAVHAGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATALFSPDRPGVTQREEIDQLQEEMALILNNHIMEQQSRLQSRFLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS
Atome Classification :
(20 SA)
.........10........20........30........40........50--........60........70........80........90........100.......110.------------------------------------......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220...-....230..-..--....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340..---..---.-..350......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
A
M
L
T
L
ETMASEEEYGPRN
C
V
V
CGDRAT
G
Y
H
F
H
A
L
T
C
E
G
C
K
G
F
F
R
R
T
V
S
K
--TIGPICPFAGRCEV
S
K
A
QRRHC
P
A
C
R
L
Q
K
C
L
N
VGMRKDM
I
L
S
A
E
A
L
A
L
R
R
A
R
Q
A
Q
R
R
A
E
K
A
S
------------------------------------LQ
L
N
Q
Q
Q
K
E
L
V
Q
I
L
L
G
AHTRH
V
G
P
M
F
D
Q
F
VQFKP
P
A
Y
L
F
M
HHRPFQPRG
P
V
L
P
L
L
T
H
F
A
D
I
N
T
F
M
V
Q
Q
I
I
K
F
TKDL
P
L
F
R
SL
T
M
E
D
Q
I
S
L
L
KGA
A
V
E
I
L
H
I
SLN
T
T
F
C
L
QTE-NFFC
G
-
P
L
C
-
Y
K
--
M
E
D
A
V
HAG
F
Q
Y
E
F
L
E
S
I
L
H
F
H
KNLKGLHLQEP
E
Y
V
L
M
A
A
T
A
LFSPDRPGV
T
Q
R
E
E
I
D
Q
L
Q
E
E
M
A
L
I
L
N
N
H
I
M
E
Q
Q
S
R
L
Q
S
R
F
L
Y
A
K
L
M
G
L
L
A
D
L
R
S
IN
N
A
Y
S
Y
E
L
Q
R
L
E
---
E
L
---
S
-
A
M
T
P
L
L
G
E
ICS
23
PsiBlast_CBE
96.62
99%
-148
- C2 -
1XLS
1
NR1I3_MOUSE
F:
[1-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
Q
Q
K
E
L
V
Q
I
L
L
G
A
H
T
R
H
V
G
P
L
F
D
Q
F
V
Q
F
R
P
P
A
Y
L
F
M
H
H
R
P
F
Q
P
R
G
P
V
L
P
L
L
T
H
F
A
D
I
N
T
F
M
V
Q
Q
I
I
K
F
T
K
D
L
P
L
F
R
S
L
T
M
E
D
Q
I
S
L
L
K
G
A
A
V
E
I
L
H
I
S
L
N
T
T
F
C
L
Q
T
E
-
N
F
F
C
G
-
P
L
C
-
Y
K
--
M
E
D
A
V
H
A
G
F
Q
Y
E
F
L
E
S
I
L
H
F
H
K
N
L
K
G
L
H
L
Q
E
P
E
Y
V
L
M
A
A
T
A
L
F
S
P
D
R
P
G
V
T
Q
R
E
E
I
D
Q
L
Q
E
E
M
A
L
I
L
N
N
H
I
M
E
Q
Q
S
R
L
Q
S
R
F
L
Y
A
K
L
M
G
L
L
A
D
L
R
S
I
N
N
A
Y
S
Y
E
L
Q
R
L
E
---
E
L
---
S
-
A
M
T
P
L
L
G
E
I
C
S
21
PsiBlast_CBE
96.47
99%
-149
- C2 -
1XLS
1
NR1I3_MOUSE
H:
[1-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
Q
Q
K
E
L
V
Q
I
L
L
G
A
H
T
R
H
V
G
P
L
F
D
Q
F
V
Q
F
R
P
P
A
Y
L
F
M
H
H
R
P
F
Q
P
R
G
P
V
L
P
L
L
T
H
F
A
D
I
N
T
F
M
V
Q
Q
I
I
K
F
T
K
D
L
P
L
F
R
S
L
T
M
E
D
Q
I
S
L
L
K
G
A
A
V
E
I
L
H
I
S
L
N
T
T
F
C
L
Q
T
E
-
N
F
F
C
G
-
P
L
C
-
Y
K
--
M
E
D
A
V
H
A
G
F
Q
Y
E
F
L
E
S
I
L
H
F
H
K
N
L
K
G
L
H
L
Q
E
P
E
Y
V
L
M
A
A
T
A
L
F
S
P
D
R
P
G
V
T
Q
R
E
E
I
D
Q
L
Q
E
E
M
A
L
I
L
N
N
H
I
M
E
Q
Q
S
R
L
Q
S
R
F
L
Y
A
K
L
M
G
L
L
A
D
L
R
S
I
N
N
A
Y
S
Y
E
L
Q
R
L
E
---
E
L
---
S
-
A
M
T
P
L
L
G
E
I
C
S
22
PsiBlast_CBE
96.39
99%
-148
- C2 -
1XLS
1
NR1I3_MOUSE
G:
[1-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
Q
Q
K
E
L
V
Q
I
L
L
G
A
H
T
R
H
V
G
P
L
F
D
Q
F
V
Q
F
R
P
P
A
Y
L
F
M
H
H
R
P
F
Q
P
R
G
P
V
L
P
L
L
T
H
F
A
D
I
N
T
F
M
V
Q
Q
I
I
K
F
T
K
D
L
P
L
F
R
S
L
T
M
E
D
Q
I
S
L
L
K
G
A
A
V
E
I
L
H
I
S
L
N
T
T
F
C
L
Q
T
E
-
N
F
F
C
G
-
P
L
C
-
Y
K
--
M
E
D
A
V
H
A
G
F
Q
Y
E
F
L
E
S
I
L
H
F
H
K
N
L
K
G
L
H
L
Q
E
P
E
Y
V
L
M
A
A
T
A
L
F
S
P
D
R
P
G
V
T
Q
R
E
E
I
D
Q
L
Q
E
E
M
A
L
I
L
N
N
H
I
M
E
Q
Q
S
R
L
Q
S
R
F
L
Y
A
K
L
M
G
L
L
A
D
L
R
S
I
N
N
A
Y
S
Y
E
L
Q
R
L
E
---
E
L
---
S
-
A
M
T
P
L
L
G
E
I
C
S
2
PsiBlast_PDB
96.17
99%
-148
- C2 -
1XLS
1
NR1I3_MOUSE
E:
[1-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
Q
Q
K
E
L
V
Q
I
L
L
G
A
H
T
R
H
V
G
P
L
F
D
Q
F
V
Q
F
R
P
P
A
Y
L
F
M
H
H
R
P
F
Q
P
R
G
P
V
L
P
L
L
T
H
F
A
D
I
N
T
F
M
V
Q
Q
I
I
K
F
T
K
D
L
P
L
F
R
S
L
T
M
E
D
Q
I
S
L
L
K
G
A
A
V
E
I
L
H
I
S
L
N
T
T
F
C
L
Q
T
E
-
N
F
F
C
G
-
P
L
C
-
Y
K
--
M
E
D
A
V
H
A
G
F
Q
Y
E
F
L
E
S
I
L
H
F
H
K
N
L
K
G
L
H
L
Q
E
P
E
Y
V
L
M
A
A
T
A
L
F
S
P
D
R
P
G
V
T
Q
R
E
E
I
D
Q
L
Q
E
E
M
A
L
I
L
N
N
H
I
M
E
Q
Q
S
R
L
Q
S
R
F
L
Y
A
K
L
M
G
L
L
A
D
L
R
S
I
N
N
A
Y
S
Y
E
L
Q
R
L
E
---
E
L
---
S
-
A
M
T
P
L
L
G
E
I
C
S
1
PsiBlast_PDB
94.61
98%
-140
- C2 -
1XNX
1
NR1I3_MOUSE
A:
[12-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
N
Q
Q
Q
K
E
L
V
Q
I
L
L
G
A
H
T
R
H
V
G
P
L
F
D
Q
F
V
Q
F
K
P
P
A
Y
L
F
M
H
H
R
P
F
Q
P
R
G
P
V
L
P
L
L
T
H
F
A
D
I
N
T
F
M
V
Q
Q
I
I
K
F
T
K
D
L
P
L
F
R
S
L
T
M
E
D
Q
I
S
L
L
K
G
A
A
V
E
I
L
H
I
S
L
N
T
T
F
C
L
Q
T
E
-
N
F
F
C
G
-
P
L
C
-
Y
K
--
M
E
D
A
V
H
A
G
F
Q
Y
E
F
L
E
S
I
L
H
F
H
K
N
L
K
G
L
H
L
Q
E
P
E
Y
V
L
M
A
A
T
A
L
F
S
P
D
R
P
G
V
T
Q
R
E
E
I
D
Q
L
Q
E
E
M
A
L
I
L
N
N
H
I
M
E
Q
Q
S
R
L
Q
S
R
F
L
Y
A
K
L
M
G
L
L
A
D
L
R
S
I
N
N
A
Y
S
Y
E
L
Q
R
L
E
---
E
-----------------
3
PsiBlast_PDB
88.27
71%
-139
- C2 -
1XV9
-
NR1I3_HUMAN
B:
[2-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
S
K
E
Q
E
E
L
I
R
T
L
L
G
A
H
T
R
H
M
G
T
M
F
E
Q
F
V
Q
F
R
P
P
A
H
L
F
I
H
H
Q
P
L
P
T
L
A
P
V
L
P
L
V
T
H
F
A
D
I
N
T
F
M
V
L
Q
V
I
K
F
T
K
D
L
P
V
F
R
S
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
V
E
I
C
H
I
V
L
N
T
T
F
C
L
Q
T
Q
-
N
F
L
C
G
-
P
L
R
-
Y
T
--
I
E
D
G
A
R
V
G
F
Q
V
E
F
L
E
L
L
F
H
F
H
G
T
L
R
K
L
Q
L
Q
E
P
E
Y
V
L
L
A
A
M
A
L
F
S
P
D
R
P
G
V
T
Q
R
D
E
I
D
Q
L
Q
E
E
M
A
L
T
L
Q
S
Y
I
K
G
Q
Q
R
R
P
R
D
R
F
L
Y
A
K
L
L
G
L
L
A
E
L
R
S
I
N
E
A
Y
G
Y
Q
I
Q
H
I
Q
---
G
L
---
S
-
A
M
M
P
L
L
Q
E
I
C
S
31
HHSearch
87.48
71%
-137
- C2 -
1XVP
-
NR1I3_HUMAN
B:
[3-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
K
E
Q
E
E
L
I
R
T
L
L
G
A
H
T
R
H
M
G
T
M
F
E
Q
F
V
Q
F
R
P
P
A
H
L
F
I
H
H
Q
P
L
P
T
L
A
P
V
L
P
L
V
T
H
F
A
D
I
N
T
F
M
V
L
Q
V
I
K
F
T
K
D
L
P
V
F
R
S
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
V
E
I
C
H
I
V
L
N
T
T
F
C
L
Q
T
Q
-
N
F
L
C
G
-
P
L
R
-
Y
T
--
I
E
D
G
A
R
V
G
F
Q
V
E
F
L
E
L
L
F
H
F
H
G
T
L
R
K
L
Q
L
Q
E
P
E
Y
V
L
L
A
A
M
A
L
F
S
P
D
R
P
G
V
T
Q
R
D
E
I
D
Q
L
Q
E
E
M
A
L
T
L
Q
S
Y
I
K
G
Q
Q
R
R
P
R
D
R
F
L
Y
A
K
L
L
G
L
L
A
E
L
R
S
I
N
E
A
Y
G
Y
Q
I
Q
H
I
Q
---
G
L
---
S
-
A
M
M
P
L
L
Q
E
I
C
S
4
PsiBlast_PDB
87.27
71%
-137
- C2 -
1XVP
-
NR1I3_HUMAN
B:
[2-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
S
K
E
Q
E
E
L
I
R
T
L
L
G
A
H
T
R
H
M
G
T
M
F
E
Q
F
V
Q
F
R
P
P
A
H
L
F
I
H
H
Q
P
L
P
T
L
A
P
V
L
P
L
V
T
H
F
A
D
I
N
T
F
M
V
L
Q
V
I
K
F
T
K
D
L
P
V
F
R
S
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
V
E
I
C
H
I
V
L
N
T
T
F
C
L
Q
T
Q
-
N
F
L
C
G
-
P
L
R
-
Y
T
--
I
E
D
G
A
R
V
G
F
Q
V
E
F
L
E
L
L
F
H
F
H
G
T
L
R
K
L
Q
L
Q
E
P
E
Y
V
L
L
A
A
M
A
L
F
S
P
D
R
P
G
V
T
Q
R
D
E
I
D
Q
L
Q
E
E
M
A
L
T
L
Q
S
Y
I
K
G
Q
Q
R
R
P
R
D
R
F
L
Y
A
K
L
L
G
L
L
A
E
L
R
S
I
N
E
A
Y
G
Y
Q
I
Q
H
I
Q
---
G
L
---
S
-
A
M
M
P
L
L
Q
E
I
C
S
24
PsiBlast_CBE
86.50
71%
-136
- C2 -
1XVP
1
NR1I3_HUMAN
D:
[2-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
S
K
E
Q
E
E
L
I
R
T
L
L
G
A
H
T
R
H
M
G
T
M
F
E
Q
F
V
Q
F
R
P
P
A
H
L
F
I
H
H
Q
P
L
P
T
L
A
P
V
L
P
L
V
T
H
F
A
D
I
N
T
F
M
V
L
Q
V
I
K
F
T
K
D
L
P
V
F
R
S
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
V
E
I
C
H
I
V
L
N
T
T
F
C
L
Q
T
Q
-
N
F
L
C
G
-
P
L
R
-
Y
T
--
I
E
D
G
A
R
V
G
F
Q
V
E
F
L
E
L
L
F
H
F
H
G
T
L
R
K
L
Q
L
Q
E
P
E
Y
V
L
L
A
A
M
A
L
F
S
P
D
R
P
G
V
T
Q
R
D
E
I
D
Q
L
Q
E
E
M
A
L
T
L
Q
S
Y
I
K
G
Q
Q
R
R
P
R
D
R
F
L
Y
A
K
L
L
G
L
L
A
E
L
R
S
I
N
E
A
Y
G
Y
Q
I
Q
H
I
Q
---
G
L
---
S
-
A
M
M
P
L
L
Q
E
I
C
S
51
Fugue
77.38
31%
-104
- C2 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
--------
K
G
P
A
P
K
M
L
G
H
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
GG
A
R
R
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEG
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
----
Q
P
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
-
D
F
T
-
Y
S
--
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
--
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
---
L
Q
D--
K
-
K
L
P
P
L
L
S
E
I
W
D
9
PsiBlast_PDB
76.15
35%
-113
- C2 -
1IE9
1
VDR_HUMAN
A:
[6-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
-
N
Q
D
-
Y
K
YR
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
FQP
E
C
---
S
M
K
L
T
P
L
V
L
E
V
--
12
PsiBlast_PDB
75.59
35%
-110
- C2 -
3TKC
1
?
A:
[6-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
-
N
Q
D
-
Y
K
YR
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
FQP
E
C
---
S
M
K
L
T
P
L
V
L
E
V
--
10
PsiBlast_PDB
75.53
35%
-111
- C2 -
3OGT
1
VDR_HUMAN
A:
[6-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
-
N
Q
D
-
Y
K
YR
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
FQP
E
C
---
S
M
K
L
T
P
L
V
L
E
V
--
15
PsiBlast_PDB
75.52
35%
-114
- C2 -
3B0T
1
VDR_HUMAN
A:
[5-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
-
N
Q
D
-
Y
K
YR
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
FQP
E
C
---
S
M
K
L
T
P
L
V
L
E
V
--
33
HHSearch
75.38
35%
-118
- C2 -
3B0T
1
VDR_HUMAN
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
N
Q
D
Y
K
Y
R
--
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
---
F
Q
PEC
S
M
K
L
T
P
L
V
L
E
V
F
G
11
PsiBlast_PDB
75.36
35%
-113
- C2 -
3KPZ
1
VDR_HUMAN
A:
[6-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
-
N
Q
D
-
Y
K
YR
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
FQP
E
C
---
S
M
K
L
T
P
L
V
L
E
V
--
5
PsiBlast_PDB
75.30
35%
-116
- C2 -
3A2J
1
VDR_HUMAN
A:
[10-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
--
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
-
N
Q
D
-
Y
K
YR
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
F
S
K
Q
Y
R
C
L
S
FQP
E
C
---
S
M
K
L
T
P
L
V
L
E
V
--
18
PsiBlast_PDB
75.08
35%
-119
- C2 -
3AZ3
1
VDR_HUMAN
A:
[4-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
-
N
Q
D
-
Y
K
YR
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
FQP
E
C
---
S
M
K
L
T
P
L
V
L
E
V
--
17
PsiBlast_PDB
75.02
35%
-118
- C2 -
3AZ2
1
VDR_HUMAN
A:
[4-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
-
N
Q
D
-
Y
K
YR
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
FQP
E
C
---
S
M
K
L
T
P
L
V
L
E
V
--
6
PsiBlast_PDB
74.94
35%
-116
- C2 -
3A2I
1
VDR_HUMAN
A:
[10-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
--
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
-
S
W
T
C
G
-
N
Q
D
-
Y
K
YR
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
FQP
E
C
---
S
M
K
L
T
P
L
V
L
E
V
--