@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_NR2C2_HUMAN: (2016-03-19 )
MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110..--.....120.......130.......140.......150.........160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440...-....450......---------.460..--.--.....-.470........480.......490.......500--...--..---.-------.510.......520.......530.---.---.--....--540.......550.......560...-....570.......580.......590....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTSPS
P
R
I
Q
I
I
STDSAVAS
P
Q
R
I
Q
I
V
TDQQTG
Q
K
I
Q
I
V
T
A
VDASGSP
K
Q
Q
F
I
L
TSPDGAGT
G
K
V
I
L
ASPETSSA
K
Q
L
I
F
TTSDNLVPG
R
I
Q
I
V
TD
S
A
S
V
E
R
L
LGKTDVQR
P
Q
V
V
--
E
Y
C
V
VCGDKASGRHY
G
A
V
S
C
E
G
C
K
G
F
F
K
R
S
V
R
KN
L
T
--
Y
SCRSNQ
D
C
I
INKHHR
N
R
C
Q
F
C
R
L
K
K
C
L
E
MGM
K
M
E
S
V
Q
SERKPFDVQREKPSNCAAST
E
K
I
Y
I
R
K
DLRSPLIATP
T
F
V
ADKDGARQTGLLDPG
M
L
V
NIQ
Q
P
L
IRED
G
T
V
L
L
ATDSKAETSQG
A
L
G
T
L
A
N
V
V
T
S
L
A
N
L
S
E
SLNNGDTSEIQPEDQ
S
A
S
E
I
T
R
A
F
D
T
L
A
K
A
LNTTDSSSSPSLADGIDTSGG
G
S
I
H
V
I
SRDQST
P
I
I
E
VEGPLLSD
T
H
V
T
F
K
LTMPSP
M
P
E
Y
L
N
V
H
Y
I
CESAS
R
L
L
F
L
S
M
H
W
A
RS
I
P
A
F
Q
A
LGQDC
N
T
S
L
V
R
A
C
W
N
E
L
F
T
L
G
L
A
Q
C
A
Q
V
M
S
L
S
T
I
L
A
-
A
I
V
N
H
L
Q
N
S
I
Q
ED---------KL--
S
G
--
D
--
R
I
K
Q
V
-
M
E
-
H
I
W
K
L
Q
E
F
C
N
S
M
A
KLDIDG
Y
E
Y
A
Y
L
K
A
I
V
L
FS--PDH--PG---L-------T
S
T
S
Q
I
E
K
F
Q
E
K
A
Q
M
E
L
Q
D
Y
V
Q
K
TY---S---E--
D
T
Y
R
--
L
A
R
I
L
V
R
L
P
A
L
R
L
M
S
SN
I
T
E
E
L
F
F
T
G-LIGNV
S
I
D
S
I
I
P
Y
I
L
K
M
ETAEYN
G
Q
ITGASL
51
Fugue
90.04
28%
-75
- C3 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
----------------------------------------------------------------------------------------------------------
K
G
P
A
P
K
M
L
GH
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
RR
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
---------------
R
K
K
K
I
R
K
Q
Q
Q
Q
E
------------------------------------------
S
Q
S
Q
S
Q
S
P
V
G
P
Q
G
S
S
S
S
A
S
G
P
G
A
S
P
G
G
S
E
A
G
S
Q
G
S
G
E
G
E
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
-----------------
Q
P
K
V
T
P
-----
W
P
L
G
A
D
P
Q
--------
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
-
K
D
F
T
Y
S
K
D
D
F
H
R
A
---------
G
L
--
Q
------------
V
E
-
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
--
A
D
R
--
P
N
---
V
-------
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
---
P
---
Q
--
D
Q
L
R
--
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
-
L
Q
D
K
-
K
L
P
P
L
L
S
E
I
W
D
V
--------------
19
PsiBlast_PDB
75.08
34%
-118
- C3 -
1Z5X
-
?
U:
[69-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
A
A
D
R
Q
L
Y
Q
L
I
E
W
A
K
H
I
P
H
F
T
E
L
P
V
E
D
Q
V
I
L
L
K
S
G
W
N
E
L
L
I
A
G
F
S
H
R
S
M
S
V
K
D
G
I
M
L
A
T
G
L
V
V
H
-
R
N
C
A
H
Q
A
---------
G
V
--
G
A
IF
D
--
R
V
-----------
L
T
E
L
V
A
K
M
R
E
M
K
M
D
K
T
E
L
G
C
L
R
S
I
V
L
F
N
--
P
E
A
--
K
G
---
L
-------
K
S
T
Q
Q
V
E
N
L
R
E
K
V
Y
A
I
L
E
E
Y
C
R
Q
T
Y
---
P
---
D
--
Q
S
G
R
--
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
-
L
V
G
N
T
S
I
D
S
F
L
L
S
M
L
E
---------------
17
PsiBlast_PDB
73.89
35%
-109
- C3 -
4XAJ
-
MALE_ECO57 (first)
A:
[378-569]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
C
E
S
A
A
R
L
L
F
M
S
I
K
W
A
K
S
V
P
A
F
S
T
L
S
L
Q
D
Q
L
M
L
L
E
D
A
W
R
E
L
F
V
L
G
I
A
Q
W
A
I
P
V
D
A
N
T
L
L
A
-
V
------
S
G
M
N
G
D
---------
N
T
--
D
S
--
Q
--
R
L
T
L
I
-
I
S
-
E
I
Q
A
L
Q
E
V
V
A
R
F
R
Q
L
R
L
D
A
T
E
F
A
C
L
K
C
I
V
T
F
K
AV
P
------LRS
F
-------
R
N
A
A
A
I
A
A
L
Q
D
E
A
Q
L
T
L
N
S
Y
I
H
T
R
Y
---
P
---
T
--
Q
P
V
R
--
F
G
K
L
L
L
L
L
P
A
L
R
S
I
S
P
S
T
I
E
E
V
F
F
K
K
-
T
I
G
N
V
P
I
T
R
L
L
--------------------
1
PsiBlast_PDB
73.78
38%
-122
- C3 -
3CJW
-
COT2_HUMAN
A:
[207-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
I
E
N
I
C
E
L
A
A
R
M
L
F
S
A
V
E
W
A
R
N
I
P
F
F
P
D
L
Q
I
T
D
Q
V
A
L
L
R
L
T
W
S
E
L
F
V
L
N
A
A
Q
C
S
M
P
L
H
V
A
P
---------------------------------------
V
A
F
-
M
D
-
H
I
R
I
F
Q
E
Q
V
E
K
L
K
A
L
H
V
D
S
A
E
Y
S
C
L
K
A
I
V
L
F
T
--
S
D
A
--
C
G
---
L
-------
S
D
V
A
H
V
E
S
L
Q
E
K
S
Q
C
A
L
E
E
Y
V
R
S
Q
Y
---
P
---
N
--
Q
P
T
R
--
F
G
K
L
L
L
R
L
P
S
L
R
T
V
S
S
S
V
I
E
Q
L
F
F
V
R
-
L
V
G
K
T
P
I
E
T
L
I
--------------------
18
PsiBlast_PDB
71.21
34%
-105
- C3 -
1XIU
1
RXR_BIOGL
A:
[36-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
T
E
L
P
L
E
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
G
F
S
H
R
S
-
I
M
A
K
D
G
I
L
L
-
A
T
G
L
H
V
H
R
S
S
A
H
Q
---------
A
G
--
V
G
--
T
--
I
F
D
R
V
--------
L
T
E
L
V
A
K
M
R
D
M
K
M
D
K
T
E
L
G
C
L
R
A
V
V
L
F
N
--
P
D
A
--
K
G
---
L
-------
T
A
V
Q
E
V
E
Q
L
R
E
K
V
Y
A
S
L
E
E
Y
T
K
S
R
Y
---
P
---
E
--
E
P
G
R
--
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
-
L
I
G
D
Q
P
I
D
T
F
L
M
E
M
L
E
---------------
20
PsiBlast_PDB
70.68
33%
-98
- C3 -
1LBD
-
RXRA_HUMAN
A:
[268-462]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
-
T
G
L
H
V
H
R
N
S
A
H
S
A
---------
G
V
--
G
A
IF
D
--
R
V
-----------
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
--
P
D
S
--
K
G
---
L
-------
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
---
P
---
E
--
Q
P
G
R
--
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
-
L
I
G
D
T
P
I
D
T
F
L
-----
M
E
M
L
E
A
P
H
Q
M
T
----
49
HHSearch
69.83
30%
-107
- C3 -
2NXX
-
?
A:
[35-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
T
V
N
N
I
C
Q
A
T
H
K
Q
L
F
Q
L
V
Q
W
A
K
L
V
P
H
F
T
S
L
P
L
T
D
Q
V
Q
L
L
R
A
G
W
N
E
L
L
I
A
A
F
S
H
R
S
M
Q
A
-
Q
D
A
I
V
L
-
A
T
G
L
T
V
N
--
K
S
T
A
---------
H
----------
A
V
G
-
V
-
G
N
I
Y
D
R
V
L
S
E
L
V
N
K
M
K
E
M
K
M
D
K
T
E
L
G
C
L
R
A
I
I
L
Y
N
--
P
D
V
--
R
G
---
I
-------
K
S
V
Q
E
V
E
M
L
R
E
K
I
Y
G
V
L
E
E
Y
T
R
T
T
H
---
P
---
N
--
E
P
G
R
--
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
-
L
I
G
D
V
P
I
D
T
F
---
L
M
E
M
L
E
G
-----------
46
HHSearch
68.12
32%
-118
- C3 -
3F5C
-
NR0B1_MOUSE
B:
[251-470]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
P
Q
V
V
C
E
A
A
S
A
G
L
L
K
T
L
R
F
V
K
Y
L
P
C
F
Q
I
L
P
L
D
Q
Q
L
V
L
V
R
S
C
W
A
P
L
L
M
L
E
L
A
Q
D
H
L
H
F
E
M
M
E
I
--------------------------------------
H
L
L
P
A
A
-
A
V
Q
A
I
K
S
F
F
F
K
C
W
S
L
N
I
D
T
K
E
Y
A
Y
L
K
G
T
V
L
F
N
--
P
D
L
--
P
G
---
L
-------
Q
C
V
K
Y
I
E
G
L
Q
W
R
T
Q
Q
I
L
T
E
H
I
R
M
M
Q
---
R
---
E
--
Y
Q
I
R
--
S
A
E
L
N
S
A
L
F
L
L
R
F
I
N
S
D
V
V
T
E
L
F
F
R
P
-
I
I
G
A
V
S
M
D
D
M
---
M
L
E
M
L
C
A
-----------
24
HHSearch
65.33
34%
-84
- C3 -
1LBD
-
RXRA_HUMAN
A:
[262-458]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
-
K
D
G
I
L
L
-
A
T
G
L
H
V
H
--
R
N
S
A
---------
H
----------
S
A
G
V
G
-
A
I
-
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
--
P
D
S
--
K
G
---
L
-------
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
---
P
---
E
--
Q
P
G
R
--
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
-
L
I
G
D
T
P
I
D
T
F
---
L
M
E
M
L
E
A
P
----------
45
HHSearch
64.97
24%
-111
- C3 -
1PDU
-
HR38_DROME
A:
[350-547]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
E
A
D
K
V
Q
Q
F
Y
Q
L
L
T
S
S
V
D
V
I
K
Q
F
A
E
K
I
P
G
Y
F
D
L
L
P
E
D
Q
E
L
L
F
Q
S
A
S
L
E
L
F
V
L
R
L
A
Y
R
A
R
I
D
-
D
T
K
L
I
F
-
C
N
G
T
V
L
H
--
R
T
Q
---------------------
C
L
R
S
F
-
G
E
-
W
L
N
D
I
M
E
F
S
R
S
L
H
N
L
E
I
D
I
S
A
F
A
C
L
C
A
L
T
L
I
T
--
E
-
R
--
H
G
---
L
-------
R
E
P
K
K
V
E
Q
L
Q
M
K
I
I
G
S
L
R
D
H
V
T
Y
N
A
---
E
AQ-
K
--
K
Q
H
Y
--
F
S
R
L
L
G
K
L
P
E
L
R
S
L
S
V
Q
G
L
Q
R
I
F
Y
L
K
-
L
E
D
L
V
P
A
P
A
L
---
I
E
N
M
F
V
T
-----------
28
HHSearch
63.88
23%
-99
- C3 -
2E2R
4
ERR3_HUMAN
A:
[41-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
-
E
D
E
L
V
Y
-
A
D
D
Y
I
M
D
--
E
D
Q
S
--------------------
K
L
A
G
L
-
L
D
-
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
--
S
D
S
--
M
H
---
I
-------
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
A
G
Q
H
---
M
---
E
--
D
P
R
R
--
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
-
L
E
G
K
V
P
M
H
K
L
---
F
L
E
M
L
E
A
-----------
55
Fugue
63.75
15%
-81
- C3 -
1BSX
1
THB_HUMAN
A:
[10-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
K
V
D
L
E
A
F
S
H
F
T
-
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
-----
R
Y
D
P
E
S
E
-
T
L
T
L
N
G
E
M
A
V
T
R
G
---------
Q
L
--
K
N
--
G
--
G
L
G
V
V
-
S
D
-
A
I
F
---
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
--
S
D
R
--
P
G
---
L
-------
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
---
H
---
H
--
V
T
H
F
--
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
-
V
E
--
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------
47
HHSearch
63.30
19%
-103
* C3 *
3B0T
1
VDR_HUMAN
A:
[54-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
-
S
F
T
M
D
D
M
S
W
T
C
-
G
N
Q
D
Y
K
Y
R
-
V
S
D
-----------
V
------
T
--
K
A
G
H
S
-
L
E
-
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
--
P
D
R
--
P
G
---
V
-------
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
---
P
---
P
PG
S
H
L
L
--
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
-
F
Q
P
E
C
S
M
-
K
L
T
P
L
V
L
E
V
F
G
------------
36
HHSearch
63.28
26%
-96
- C3 -
1HG4
1
USP_DROME
A:
[45-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
A
V
S
A
L
C
Q
V
V
N
K
Q
L
F
Q
M
V
E
Y
A
R
M
M
P
H
F
A
Q
V
P
L
D
D
Q
V
I
L
L
K
A
A
W
I
E
L
L
I
A
N
V
A
W
C
S
I
V
S
L
--------------------QPQQLFLNQ
S
F
SY
H
R
--
N
SA
I
K
A
G
V
-
S
A
I
F
D
R
I
L
S
E
L
S
V
K
M
K
R
L
N
L
D
R
R
E
L
S
C
L
K
A
I
I
L
Y
N
--
P
D
I
--
R
G
---
I
-------
K
S
R
A
E
I
E
M
C
R
E
K
V
Y
A
C
L
D
E
H
C
R
L
E
H
---
P
---
G
--
D
D
G
R
--
F
A
Q
L
L
L
R
L
P
A
L
R
S
I
S
L
K
C
Q
D
H
L
F
L
F
R
-
I
T
S
D
R
P
L
E
E
L
---
F
L
E
Q
L
E
A
P
P
P
--------
53
Fugue
63.01
16%
-73
- C3 -
1SKX
1
NR1I2_HUMAN
A:
[25-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
-
T
F
S
H
F
K
N
F
R
L
P
G
V
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
--------------
V
F
N
A
E
T
G
T
W
E
C
---------------
G
--
R
--
L
S
Y
C
L
-
E
L
-
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
--
P
D
R
--
P
G
---
V
-------
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
---
P
---
Q
--
P
A
H
R
FL
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
-
D
I
H
P
----
F
A
T
P
L
M
Q
E
L
F
G
I
-----------
35
HHSearch
62.91
21%
-108
- C3 -
1OVL
-
NR4A2_HUMAN
A:
[72-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
Q
H
I
Q
Q
F
Y
D
L
L
T
G
S
M
E
I
I
R
G
W
A
E
K
I
P
G
F
A
D
L
P
K
A
D
Q
D
L
L
F
E
S
A
F
L
E
L
F
V
L
R
L
A
Y
R
S
N
P
V
-
E
G
K
L
I
F
-
C
N
G
V
V
L
H
--
R
L
Q
---------------------
C
V
R
G
F
-
G
E
-
W
I
D
S
I
V
E
F
S
S
N
L
Q
N
M
N
I
D
I
S
A
F
S
C
I
A
A
L
A
M
V
T
---
E
R
--
H
G
---
L
-------
K
E
P
K
R
V
E
E
L
Q
N
K
I
V
N
C
L
K
D
H
V
T
F
N
N
---
G
GL-
N
--
R
P
N
Y
--
L
S
K
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
-
L
E
D
L
V
P
P
P
A
I
---
I
D
K
L
F
L
D
-----------
37
HHSearch
62.31
18%
-108
- C3 -
3U9Q
-
PPARG_HUMAN
A:
[278-475]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
---
K
D
G
V
L
I
-
S
E
G
Q
G
F
M
T
-
R
E
F
-----------
L
--
K
---
S
--
L
R
K
P
F
-
G
D
-
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
--
G
D
R
--
P
G
---
L
-------
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
---
P
---
E
--
S
S
Q
L
--
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
---
L
Q
E
I
Y
K
D
-----------
44
HHSearch
62.28
18%
-96
- C3 -
1FCY
2
RARG_HUMAN
A:
[42-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
-
Q
D
T
M
T
F
-
S
D
G
L
T
L
N
--
R
T
Q
M
---------
H
----------
N
A
G
-
F
-
G
P
-
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
--
G
D
R
--
M
D
---
L
-------
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
---
P
---
S
--
Q
P
Y
M
--
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
-
M
E
I
P
G
P
M
P
P
L
---
I
R
E
M
L
E
------------
33
HHSearch
61.69
23%
-93
- C3 -
2OCF
1
A:
[38-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
-
P
G
K
L
L
F
-
A
P
N
L
L
L
D
--
R
N
Q
G
---------
K
----------
C
V
E
G
M
-
V
E
-
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
--
S
G
V
YT---------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
LTL
Q
---
Q
--
Q
H
Q
R
--
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-
C
K
N
V
V
P
L
S
D
L
---
L
L
E
M
L
D
A
H
----------
30
HHSearch
61.66
22%
-100
- C3 -
1L2J
1
ESR2_HUMAN
A:
[56-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
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C
W
M
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V
L
M
M
G
L
M
W
R
S
I
D
H
-
P
G
K
L
I
F
-
A
P
D
L
V
L
D
--
R
D
E
G
---------
K
----------
C
V
E
G
I
-
L
E
-
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
--
S
---------
L
VTATQDA
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
---
I
SSQ
Q
--
Q
S
M
R
--
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
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V
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Y
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---
L
L
E
M
L
N
A
H
V
---------