@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_NR2E3_HUMAN: (2016-03-19 )
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80....-....90........100.......110.......120.-......130.......140----.......150.......160.......170.......180.......190.......200.......------210.......220.......230.......240.......250.......260.....-..270.......280.......---------------290.........300.......310..---.....320.......330-........340.......350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
METR
P
T
A
L
M
S
S
T
V
AAAAPAAGAASRKESPGRWGLGEDPTGVSP
S
L
Q
C
R
VCGDSSSG
K
H
Y
G
I
Y
A
CNG
C
S
G
F
F
K
R
S
V
R
R
R
L
I
Y
R
C
QV-GAGMCPV
D
K
A
H
R
N
Q
C
Q
A
C
R
L
K
K
C
L
Q
AGMN
Q
D
A
V
QNERQ-PRS
T
A
Q
V
H
L
DSMESNTESR----PESLVAPPAPAGRSPRGPT
P
M
S
A
A
R
A
L
G
H
H
F
M
A
S
L
I
T
A
E
T
C
AKLEPEDADENIDVTSNDPEFPSSPY------SSSSPCGL
D
S
I
H
E
T
S
A
R
L
L
F
M
A
V
K
W
AKNLPVFSSLPFRD
Q
V
I
L
L
E
E
A
W
S
E
L
F
L
L
G
A
I
Q
-WSLPLDSCPLLAPPEASAAGGA---------------Q--
G
R
L
T
L
A
S
M
E
T
R
V
L
Q
E
T
I
S
R
F
R
ALA---VD
P
T
E
F
A
C
M
K
A
L
V
L
FKP--ETRGLK
D
P
E
H
V
E
A
L
Q
D
Q
S
Q
V
M
L
S
Q
HSKAHHPSQ
P
V
R
F
G
K
L
L
L
L
LPS
L
R
F
I
T
A
E
R
I
E
L
L
F
F
R
K
T
IGNT
P
M
E
K
L
L
C
D
M
FKN
1
PsiBlast_PDB
87.35
99%
-139
- C4 -
4LOG
-
NR2E3_HUMAN
A:
[375-568]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
I
H
E
T
S
A
R
L
L
F
M
A
V
K
W
A
K
N
L
P
V
F
S
S
L
P
F
R
D
Q
V
I
L
L
E
E
A
W
S
E
L
F
L
L
G
A
I
Q
-
W
S
L
P
L
D
S
C
P
L
L
A
P
P
----------------------------
L
T
L
A
S
M
E
T
R
V
L
Q
E
T
I
S
R
F
R
A
L
A
---
V
D
P
T
E
F
A
C
M
K
A
L
V
L
F
K
P
--
E
T
R
G
L
K
D
P
E
H
V
E
A
L
Q
D
Q
S
Q
V
M
L
S
Q
H
S
K
A
H
H
P
S
Q
P
V
R
F
G
K
L
L
L
L
L
P
S
L
R
F
I
T
A
E
R
I
E
L
L
F
F
R
K
T
I
G
N
T
P
M
E
K
L
L
S
D
M
F
K
N
2
PsiBlast_PDB
76.19
36%
-83
- C4 -
4NQA
1
RXRA_HUMAN
A:
[38-359]
----------------------------------------------
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
-
N
K
D
-
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
G
-----------
S
S
A
N
E
D
M
----
P
V
E
R
I
L
E
-
A
E
L
A
V
E
P
K
T
E
T
Y
-
E
A
N
M
G
L
-------------------------------
N
P
S
S
P
N
D
P
V
------
T
N
--------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
-
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
-
4
PsiBlast_PDB
75.52
36%
-96
- C4 -
3E00
1
RXRA_HUMAN
A:
[140-460]
----------------------------------------------
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
-
N
K
D
-
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R--------------
A
N
E
D
M
----
P
V
E
R
I
L
E
-
A
E
L
A
V
E
----------------------------------------------------
V
------
T
N
--------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--
3
PsiBlast_PDB
74.45
36%
-94
- C4 -
3DZU
1
RXRA_HUMAN
A:
[140-460]
----------------------------------------------
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
-
N
K
D
-
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R--------------
A
N
E
D
M
----
P
V
E
R
I
L
E
-
A
E
L
A
----------------------------------------------------
D
P
V
------
T
N
--------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--
46
Fugue
73.90
27%
-74
- C4 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
--------------------------
K
G
P
A
P
K
M
L
G
H
E
L
--------
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
R
R
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
-
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
SPVG
P
Q
G
S
S
S
S
A
S
G
P
G
A
S
P
G
G
S
E
A
G
S
Q
G
S
G
E
G
E
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
GADPQS
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
--------------------
K
--
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
RLG
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
--
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
-
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
32
HHSearch
72.09
46%
-129
- C4 -
3CJW
-
COT2_HUMAN
A:
[207-401]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
I
E
N
I
C
E
L
A
A
R
M
L
F
S
A
V
E
W
A
R
N
I
P
F
F
P
D
L
Q
I
T
D
Q
V
A
L
L
R
L
T
W
S
E
L
F
V
L
N
A
A
Q
-
C
S
M
P
L
H
V
A
P
----------------------------------
V
A
F
M
D
H
I
R
I
F
Q
E
Q
V
E
K
L
K
A
L
H
---
V
D
S
A
E
Y
S
C
L
K
A
I
V
L
F
T
S
--
D
A
C
G
L
S
D
V
A
H
V
E
S
L
Q
E
K
S
Q
C
A
L
E
E
Y
V
R
S
Q
Y
P
N
Q
P
T
R
F
G
K
L
L
L
R
L
P
S
L
R
T
V
S
S
S
V
I
E
Q
L
F
F
V
R
L
V
G
K
T
P
I
E
T
L
I
R
D
M
L
L
-
5
PsiBlast_PDB
66.41
48%
-105
- C4 -
4XAJ
-
MALE_ECO57 (first)
A:
[376-574]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
C
E
S
A
A
R
L
L
F
M
S
I
K
W
A
K
S
V
P
A
F
S
T
L
S
L
Q
D
Q
L
M
L
L
E
D
A
W
R
E
L
F
V
L
G
I
A
Q
-
W
A
I
P
V
D
A
N
T
L
L
A
V
S
G
M
N
G
D
N
T
D
---------------
S
--
Q
R
L
T
L
I
I
S
E
I
Q
A
L
Q
E
V
V
A
R
F
R
Q
L
R
---
L
D
A
T
E
F
A
C
L
K
C
I
V
T
F
K
A
VP-
L
R
S
F
R
N
A
A
A
I
A
A
L
Q
D
E
A
Q
L
T
L
N
S
Y
I
H
T
R
Y
P
T
Q
P
V
R
F
G
K
L
L
L
L
L
P
A
L
R
S
I
S
P
S
T
I
E
E
V
F
F
K
K
T
I
G
N
V
P
I
T
R
L
L
S
D
M
Y
K
-
44
HHSearch
63.36
37%
-108
- C4 -
2P1T
1
RXRA_HUMAN
A:
[41-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
-
G
I
L
L
A
T
G
L
H
V
H
R
N
S
---------------
A
--
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
-
20
PsiBlast_PDB
62.85
37%
-77
- C4 -
4J5X
-
D:
[10-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
---------
N
D
P
--
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
-
31
HHSearch
62.37
32%
-112
- C4 -
2NXX
-
?
A:
[36-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
T
V
N
N
I
C
Q
A
T
H
K
Q
L
F
Q
L
V
Q
W
A
K
L
V
P
H
F
T
S
L
P
L
T
D
Q
V
Q
L
L
R
A
G
W
N
E
L
L
I
A
A
F
S
H
-
R
S
M
Q
A
-
Q
D
A
I
V
L
A
T
G
L
T
V
N
K
S
T
---------------
A
--
H
A
V
G
V
G
N
I
Y
D
R
V
L
S
E
L
V
N
K
M
K
E
M
K
---
M
D
K
T
E
L
G
C
L
R
A
I
I
L
Y
N
P
--
D
V
R
G
I
K
S
V
Q
E
V
E
M
L
R
E
K
I
Y
G
V
L
E
E
Y
T
R
T
T
H
P
N
E
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
V
P
I
D
T
F
L
M
E
M
L
E
G
39
HHSearch
61.74
27%
-99
- C4 -
2E2R
4
ERR3_HUMAN
A:
[48-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
-
R
S
L
S
F
E
-
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
------------------
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
---
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
--
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
A
G
Q
H
M
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
10
PsiBlast_PDB
61.26
37%
-78
- C4 -
1FM9
1
RXRA_HUMAN
A:
[12-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
S
------
S
P
N
D
P
--
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
-
33
HHSearch
61.12
27%
-114
- C4 -
1HG4
1
USP_DROME
A:
[47-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
V
S
A
L
C
Q
V
V
N
K
Q
L
F
Q
M
V
E
Y
A
R
M
M
P
H
F
A
Q
V
P
L
D
D
Q
V
I
L
L
K
A
A
W
I
E
L
L
I
A
N
V
A
W
-
C
S
I
V
S
L
----------------QPQQLFLNQSFSYHR
N
SA
I
K
A
G
V
S
A
I
F
D
R
I
L
S
E
L
S
V
K
M
K
R
L
N
---
L
D
R
R
E
L
S
C
L
K
A
I
I
L
Y
N
P
--
D
I
R
G
I
K
S
R
A
E
I
E
M
C
R
E
K
V
Y
A
C
L
D
E
H
C
R
L
E
H
P
G
D
D
G
R
F
A
Q
L
L
L
R
L
P
A
L
R
S
I
S
L
K
C
Q
D
H
L
F
L
F
R
I
T
S
D
R
P
L
E
E
L
F
L
E
Q
L
E
A
9
PsiBlast_PDB
60.25
37%
-75
- C4 -
1FM6
1
RXRA_HUMAN
A:
[12-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
S
------
S
P
N
D
P
--
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
-
17
PsiBlast_PDB
59.47
37%
-68
- C4 -
1XLS
1
RXRA_HUMAN
A:
[10-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
S
------
S
P
N
D
P
--
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
-
28
HHSearch
59.46
23%
-99
- C4 -
1XDK
1
RARB_MOUSE
B:
[72-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
-
R
Y
T
P
E
-
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
------------------
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
---
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
--
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-
13
PsiBlast_PDB
59.27
37%
-73
- C4 -
1K74
1
RXRA_HUMAN
A:
[12-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
S
------
S
P
N
D
P
--
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
-
14
PsiBlast_PDB
59.01
37%
-77
- C4 -
1MZN
1
RXRA_HUMAN
A:
[14-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
--------------
N
D
P
--
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
-
26
HHSearch
58.45
23%
-95
* C4 *
3KMR
1
RARA_HUMAN
A:
[69-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
-
R
Y
T
P
E
-
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
------------------
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
---
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
--
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-
19
PsiBlast_PDB
58.22
37%
-66
- C4 -
1XVP
1
RXRA_HUMAN
A:
[10-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
S
------
S
P
N
D
P
--
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
-
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
---------------
H
--
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
---
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
--
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
-