@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_NR4A2_HUMAN: (2016-03-19 )
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250......-.260.......270.......280.......290...--....300.......310.......320.......330....-...340.......350.......360.------------------------------------......370.......380-........390.......400.......410.......420.......430.......440.......450.......460.......470--...-....480.....-..490.......500.......510.-.-.....520.......530.......540.......550.......560.......570.......580.......590......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFL
T
P
E
F
V
K
F
SMDLTN
T
E
I
T
A
T
TSLP
S
F
S
T
F
M
DNYSTGYDVKPP
C
L
Y
QMPLSGQQS
S
I
K
V
E
D
I
Q
MHN
Y
Q
Q
HSHLPP
Q
S
EEMMPHS
G
S
V
Y
Y
KPSSPPTPTTPG
F
Q
V
QHSPMWDDPG
S
L
H
N
F
H
Q
N
Y
V
A
T
T
H
M
I
E
Q
RKT
P
V
S
R
L
S
L
FSFKQSPPGTPVS
S
C
Q
M
R
FDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIG
H
A
S
Q
L
L
DTQVPSPPSRGSPS-NE
G
L
C
A
VCGDN
A
A
C
Q
HYGVRT
C
E
G
C
K
G
F
F
K
R
T
V
QKNA--
K
Y
V
C
L
ANKNCPV
D
K
R
R
R
N
R
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
V
K
E
V
V
R
TD-SLKGRRGRLPSKPKSPQEPSPPSP
P
V
S
------------------------------------
L
I
S
A
L
V
R
A
HVDSNPAMTS--LD
Y
S
RFQANPDYQMSGD
D
T
Q
H
I
Q
Q
F
Y
D
L
L
TG
S
M
E
I
I
R
G
W
A
E
KIPGFADLPKA
D
Q
D
L
L
F
E
S
A
F
L
E
L
F
V
L
R
L
A
YRSNPVE
G
K
L
I
F
CN
G
V
V
L
H
R
--
L
Q
C
-
V
R
G
F
G
E
W
I
D
S
I
V
-
E
F
S
SNLQN
M
N
I
D
I
S
A
F
S
C
I
A
A
L
A
M
V
T
-
E
-RHGLKE
P
K
R
V
E
E
L
Q
N
K
I
V
N
C
L
K
D
HVTFNNGGLNR
P
N
Y
L
S
K
L
L
GKL
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
DLVP
P
P
A
I
I
D
K
L
F
L
DTLPF
23
HHSearch
92.92
100%
-143
- C2 -
1OVL
-
NR4A2_HUMAN
A:
[36-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------
L
I
S
A
L
V
R
A
H
V
D
S
N
P
A
M
T
S
--
L
D
Y
S
R
F
Q
A
N
--------
D
T
Q
H
I
Q
Q
F
Y
D
L
L
T
G
S
M
E
I
I
R
G
W
A
E
K
I
P
G
F
A
D
L
P
K
A
D
Q
D
L
L
F
E
S
A
F
L
E
L
F
V
L
R
L
A
Y
R
S
N
P
V
E
G
K
L
I
F
C
N
G
V
V
L
H
R
--
L
Q
C
-
V
R
G
F
G
E
W
I
D
S
I
V
-
E
F
S
S
N
L
Q
N
M
N
I
D
I
S
A
F
S
C
I
A
A
L
A
M
V
T
-
E
-
R
H
G
L
K
E
P
K
R
V
E
E
L
Q
N
K
I
V
N
C
L
K
D
H
V
T
F
N
N
G
G
L
N
R
P
N
Y
L
S
K
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
A
I
I
D
K
L
F
L
D
T
L
P
F
1
PsiBlast_PDB
92.71
99%
-143
- C2 -
1OVL
-
NR4A2_HUMAN
A:
[36-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------
L
I
S
A
L
V
R
A
H
V
D
S
N
P
A
M
T
S
--
L
D
Y
S
R
F
Q
A
N
--------
D
T
Q
H
I
Q
Q
F
Y
D
L
L
T
G
S
M
E
I
I
R
G
W
A
E
K
I
P
G
F
A
D
L
P
K
A
D
Q
D
L
L
F
E
S
A
F
L
E
L
F
V
L
R
L
A
Y
R
S
N
P
V
E
G
K
L
I
F
C
N
G
V
V
L
H
R
--
L
Q
C
-
V
R
G
F
G
E
W
I
D
S
I
V
-
E
F
S
S
N
L
Q
N
M
N
I
D
I
S
A
F
S
C
I
A
A
L
A
M
V
T
-
E
-
R
H
G
L
K
E
P
K
R
V
E
E
L
Q
N
K
I
V
N
C
L
K
D
H
V
T
F
N
N
G
G
L
N
R
P
N
Y
L
S
K
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
A
I
I
D
K
L
F
L
D
T
L
P
F
8
PsiBlast_PDB
82.98
65%
-134
- C2 -
4REE
2
?
B:
[12-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
H
--
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
G
E
P
--
A
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
12
PsiBlast_PDB
82.69
64%
-134
- C2 -
4RZF
1
B:
[11-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
H
F
G
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
W
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
------
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
7
PsiBlast_PDB
82.47
65%
-131
- C2 -
4RZG
1
B:
[11-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
-
F
G
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
G
E
P
--
A
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
13
PsiBlast_PDB
82.20
64%
-138
- C2 -
4RZE
1
B:
[12-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
----
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
W
L
L
E
S
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
G
----
A
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
E
T
L
P
F
3
PsiBlast_PDB
82.20
65%
-132
- C2 -
3V3E
1
B:
[12-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
H
F
G
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
G
E
P
Q
-
A
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
4
PsiBlast_PDB
81.97
65%
-134
- C2 -
4KZI
1
B:
[12-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
H
--
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
G
E
P
--
A
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
6
PsiBlast_PDB
81.94
65%
-132
- C2 -
4WHG
1
?
B:
[12-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
---
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
--
P
Q
-
A
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
9
PsiBlast_PDB
81.35
64%
-133
- C2 -
4KZM
1
B:
[12-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
---
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
-----
A
S
C
L
A
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
11
PsiBlast_PDB
80.98
64%
-132
- C2 -
4REF
1
?
B:
[11-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
H
F
G
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
W
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
G
E
---
A
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
2
PsiBlast_PDB
80.70
65%
-128
- C2 -
2QW4
-
NR4A1_HUMAN
A:
[32-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
H
F
G
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
G
---
P
A
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
---
10
PsiBlast_PDB
80.52
64%
-133
- C2 -
4KZJ
1
B:
[13-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
H
---
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
W
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
-----
A
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
5
PsiBlast_PDB
80.27
65%
-130
- C2 -
4WHF
1
?
B:
[12-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
N
------------------------------------
L
L
T
S
L
V
R
A
H
L
D
S
G
P
S
T
A
K
--
L
D
Y
S
K
F
Q
E
L
V
L
P
---
K
E
D
A
G
D
V
Q
Q
F
Y
D
L
L
S
G
S
L
E
V
I
R
K
W
A
E
K
I
P
G
F
A
E
L
S
P
A
D
Q
D
L
L
L
E
S
A
F
L
E
L
F
I
L
R
L
A
Y
R
S
K
P
G
E
G
K
L
I
F
C
S
G
L
V
L
H
R
--
L
Q
C
-
A
R
G
F
G
D
W
I
D
S
I
L
-
A
F
S
R
S
L
H
S
L
L
V
D
V
P
A
F
A
C
L
S
A
L
V
L
I
T
-
D
-
R
H
G
L
Q
E
P
R
R
V
E
E
L
Q
N
R
I
A
S
C
L
K
E
H
V
A
A
V
A
------
S
C
L
S
R
L
L
G
K
L
P
E
L
R
T
L
C
T
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
P
P
P
I
I
D
K
I
F
M
D
T
L
P
F
28
HHSearch
80.22
61%
-129
- C2 -
1PDU
-
HR38_DROME
A:
[321-548]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------
L
I
T
A
L
V
R
S
H
V
D
T
T
P
D
P
S
C
--
L
D
Y
S
H
Y
E
E
Q
-----
S
M
S
E
A
D
K
V
Q
Q
F
Y
Q
L
L
T
S
S
V
D
V
I
K
Q
F
A
E
K
I
P
G
Y
F
D
L
L
P
E
D
Q
E
L
L
F
Q
S
A
S
L
E
L
F
V
L
R
L
A
Y
R
A
R
I
D
D
T
K
L
I
F
C
N
G
T
V
L
H
R
--
T
Q
C
-
L
R
S
F
G
E
W
L
N
D
I
M
-
E
F
S
R
S
L
H
N
L
E
I
D
I
S
A
F
A
C
L
C
A
L
T
L
I
T
-
E
-
R
H
G
L
R
E
P
K
K
V
E
Q
L
Q
M
K
I
I
G
S
L
R
D
H
V
T
Y
N
A
E
A
Q
K
K
Q
H
Y
F
S
R
L
L
G
K
L
P
E
L
R
S
L
S
V
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
A
P
A
L
I
E
N
M
F
V
T
T
---
14
PsiBlast_PDB
80.01
59%
-128
- C2 -
1PDU
-
HR38_DROME
A:
[319-548]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
S
------------------------------------
L
I
T
A
L
V
R
S
H
V
D
T
T
P
D
P
S
C
--
L
D
Y
S
H
Y
E
-----
E
Q
S
M
S
E
A
D
K
V
Q
Q
F
Y
Q
L
L
T
S
S
V
D
V
I
K
Q
F
A
E
K
I
P
G
Y
F
D
L
L
P
E
D
Q
E
L
L
F
Q
S
A
S
L
E
L
F
V
L
R
L
A
Y
R
A
R
I
D
D
T
K
L
I
F
C
N
G
T
V
L
H
R
--
T
Q
C
-
L
R
S
F
G
E
W
L
N
D
I
M
-
E
F
S
R
S
L
H
N
L
E
I
D
I
S
A
F
A
C
L
C
A
L
T
L
I
T
-
E
-
R
H
G
L
R
E
P
K
K
V
E
Q
L
Q
M
K
I
I
G
S
L
R
D
H
V
T
Y
N
A
E
A
Q
K
K
Q
H
Y
F
S
R
L
L
G
K
L
P
E
L
R
S
L
S
V
Q
G
L
Q
R
I
F
Y
L
K
L
E
D
L
V
P
A
P
A
L
I
E
N
M
F
V
T
T
---
46
Fugue
77.26
29%
-103
- C2 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
P
A
P
K
M
L
G
H
E
-----
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
AR
R
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
S
P
V
G
P
Q
G
SSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQEL
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
DQ
P
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
DD
F
H
R
-
A
G
L
Q
V
E
F
I
N
P
I
F
-
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
-
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
--
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
-----
17
PsiBlast_PDB
73.73
32%
-106
- C2 -
4NQA
1
RXRA_HUMAN
A:
[31-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
T
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
--
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
-
R
Q
R
G
------------
S
S
A
N
E
D
M
P
----------------------------------------
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
--
Y
-
E
A
N
M
G
L
N
P
S
S
--
P
N
D
P
V
T
N
I
C
Q
A
A
D
---
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
--
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
-
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
--
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
----
I
D
T
F
L
M
E
M
L
--
15
PsiBlast_PDB
72.61
32%
-119
- C2 -
3DZU
1
RXRA_HUMAN
A:
[137-460]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
--
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
-
R
Q
R
---------------
A
N
E
D
M
P
----------------------------------------
V
E
R
I
L
E
A
E
L
A
-------------------------
D
P
V
T
N
I
C
Q
A
A
D
---
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
--
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
-
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
--
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
----
I
D
T
F
L
M
E
M
L
--
16
PsiBlast_PDB
71.72
32%
-116
- C2 -
3E00
1
RXRA_HUMAN
A:
[137-460]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
--
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
-
R
Q
R
---------------
A
N
E
D
M
P
----------------------------------------
V
E
R
I
L
E
A
E
L
A
V
E
-------------------------
V
T
N
I
C
Q
A
A
D
---
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
--
N
S
A
H
S
A
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
-
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
--
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
----
I
D
T
F
L
M
E
M
L
--