@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_PPARA_MOUSE: (2016-03-19 )
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90.......-.100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260...-....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVDTESPICPLSPL
E
A
D
D
LES
P
L
S
E
E
F
L
Q
E
MG
N
I
Q
E
I
S
Q
SIGEESSGSFGF
A
D
Y
Q
Y
L
GSCPGSEG
S
V
I
T
DTLSPASSPSSVSCPVIPASTDESPG
S
A
L
-
N
I
E
C
R
I
CGDKASGYHYGV
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
V
Y
DKCDRS
C
K
IQKKNR
N
K
C
Q
Y
C
R
F
H
K
C
L
S
VGMSHNAIRFGRMP
R
S
E
K
A
K
L
K
A
E
I
L
T
CEHDLKDS
E
T
A
D
L
K
S
L
G
K
R
I
H
E
A
Y
L
K
NFNMN
K
V
K
A
R
V
I
L
A
GKTSNNP
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
M
V
ANGVED-KEA
E
V
R
F
F
H
C
CQCM
S
V
E
T
V
T
E
L
T
E
F
A
K
AIPGFANLDLND
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
T
M
L
S
S
L
MNKD
G
M
L
I
A
YGN
G
F
I
T
R
E
F
L
K
N
L
R
K
P
F
C
D
IMEPKF
D
F
A
M
K
F
N
A
L
ELDD
S
D
I
S
L
F
V
A
A
I
I
CCGDRPGLL
N
I
G
Y
I
E
K
L
Q
E
G
I
V
H
V
L
K
L
H
L
QSNHPDDT
F
L
F
P
K
L
L
Q
K
M
V
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
V
I
K
KTESD
A
A
L
H
P
L
L
Q
E
I
Y
R
DMY
26
PsiBlast_CBE
90.63
91%
-150
- C- -
3KDT
1
PPARA_HUMAN
B:
[4-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
25
PsiBlast_CBE
90.41
91%
-148
- C- -
3KDU
1
PPARA_HUMAN
B:
[4-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
31
PsiBlast_CBE
90.18
91%
-140
- C3 -
2NPA
1
PPARA_HUMAN
C:
[199-468]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
A
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
---
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
27
PsiBlast_CBE
90.02
92%
-135
- C3 -
3ET1
1
PPARA_HUMAN
B:
[22-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
15
PsiBlast_PDB
89.53
92%
-139
- C3 -
2P54
1
PPARA_HUMAN
A:
[1-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
6
PsiBlast_PDB
88.90
91%
-137
- C3 -
3SP6
1
PPARA_HUMAN
A:
[13-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
---
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
3
PsiBlast_PDB
88.78
91%
-150
- C3 -
4CI4
1
PPARA_HUMAN
A:
[10-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
-----------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
1
PsiBlast_PDB
88.68
91%
-139
- C3 -
1K7L
-
PPARA_HUMAN
A:
[22-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
5
PsiBlast_PDB
88.62
91%
-151
- C- -
3KDU
1
PPARA_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
------
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
4
PsiBlast_PDB
88.43
91%
-154
- C- -
3KDT
1
PPARA_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
------
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
10
PsiBlast_PDB
88.20
62%
-123
- C3 -
3E00
1
PPARG_HUMAN
D:
[49-419]
--------------------------------------------------------------------------------------------------M
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
-
S
S
D
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
--------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
14
PsiBlast_PDB
87.76
91%
-132
- C3 -
2NPA
1
PPARA_HUMAN
A:
[199-467]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
A
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
8
PsiBlast_PDB
87.75
92%
-137
- C3 -
3ET1
1
PPARA_HUMAN
A:
[22-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
-------
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
24
PsiBlast_CBE
87.62
91%
-141
- C3 -
4BCR
3
PPARA_HUMAN
B:
[2-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
2
PsiBlast_PDB
87.48
91%
-138
- C3 -
4BCR
3
PPARA_HUMAN
A:
[10-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
--
34
HHSearch
86.90
92%
-138
- C3 -
3VI8
1
PPARA_HUMAN
A:
[7-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
12
PsiBlast_PDB
86.90
92%
-138
- C3 -
3VI8
1
PPARA_HUMAN
A:
[7-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
11
PsiBlast_PDB
86.24
92%
-138
- C3 -
2ZNN
1
PPARA_HUMAN
A:
[7-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
16
PsiBlast_PDB
86.21
92%
-144
- C3 -
3FEI
1
PPARA_HUMAN
A:
[1-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
---------------
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
7
PsiBlast_PDB
86.21
92%
-145
- C3 -
3G8I
1
PPARA_HUMAN
A:
[4-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
--------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
9
PsiBlast_PDB
86.19
62%
-127
- C3 -
3DZU
1
PPARG_HUMAN
D:
[50-419]
---------------------------------------------------------------------------------------------------
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
-
S
S
D
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
28
PsiBlast_CBE
83.97
92%
-130
- C3 -
1KKQ
1
PPARA_HUMAN
D:
[1-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
29
PsiBlast_CBE
83.95
92%
-134
- C3 -
1KKQ
1
PPARA_HUMAN
C:
[1-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
30
PsiBlast_CBE
83.86
92%
-137
- C3 -
1KKQ
1
PPARA_HUMAN
B:
[1-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
13
PsiBlast_PDB
83.27
92%
-134
- C3 -
1KKQ
1
PPARA_HUMAN
A:
[1-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
18
PsiBlast_PDB
81.32
66%
-141
- C3 -
2XYW
2
PPARD_HUMAN
A:
[21-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
----
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
19
PsiBlast_PDB
80.95
66%
-141
- C3 -
2XYX
2
PPARD_HUMAN
A:
[23-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
----
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
20
PsiBlast_PDB
80.88
66%
-139
- C3 -
3ET2
4
PPARD_HUMAN
A:
[18-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
---
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
17
PsiBlast_PDB
79.31
66%
-128
- C3 -
2XYJ
4
PPARD_HUMAN
A:
[20-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
--
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
---
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-