@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_PRGR_RAT: (2016-03-19 )
MTELQAKDPRTLHTSGAAPSPTHVGSPLLARLDPDPFQGSQHSDASSVVSPIPISLDRLLFSRSCQAQELPDEKTQNQQSLSDVEGAFSGVEASRRRSRNPRAPEKDSRLLDSVLDTLLAPSGPEQSQTSPPACEAITSWCLFGPELPEDPRSVPATKGLLSPLMSRPESKAGDSSGTGAGQKVLPKAVSPPRQLLLPTSGSAHWPGAGVKPSQQPATVEVEEDGGLETEGSAGPLLKSKPRALEGMCSGGGVTANAPGAAPGGVTLVPKEDSRFSAPRVSLEQDAPVAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGAAAQVPFAPPRGSPSAPSPPVPCGDFPDCTYPPEGDPKEDGFPVYGEFQPPGLKIKEEEEGTEAASRSPRPYLLAGASAATFPDFPLPPRPPRAPPSRPGEAAVAAPSAAVSPVSSSGSALECILYKAEGAPPTQGSFAPLPCKPPAASSCLLPRDSLPAAPTSSAAPAIYPPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVMRALDGVALPQSVAFPNESQTLGQRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIRELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRALAVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760..---.....770.......780-.......790.......800.......810.......820.........830.......840.......850.......860.......870.......880.......890.......900.......910.......920.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTELQAKDP
R
T
LHTSGAAPSPTHVGS
P
L
L
ARLDPDPFQGSQHS
D
A
S
SVVSPIP
I
S
L
D
R
L
L
F
SRSCQAQELPDEKTQ
N
Q
Q
S
L
S
D
V
E
G
A
F
S
G
V
E
A
S
R
RRSRNPRAP
E
K
D
S
R
L
L
D
S
V
L
D
T
L
LAPSGPEQSQTSP
P
A
C
E
A
I
T
S
W
C
LFGPELPEDPRSVPA
T
K
G
L
L
S
P
L
M
SRPESKAGDSSGTGAGQKVLPKAVSP
P
R
Q
L
L
LPTSGSAHWPGAGVKPSQQP
A
T
V
E
V
EEDGGLETEGSAGPLLKSKP
R
A
L
E
GMCSGGGVTANAPGAAPG
G
V
T
L
VPKEDSRFSAPRVSLEQDAPVAPGRS
P
L
A
T
T
V
V
D
F
IHVPILP
L
N
H
A
L
L
A
A
R
T
R
Q
L
LEGDSYDGGAAAQVPFAPPRGSPSAPSPPVPCGDFPDCTYPPEGDPKEDG
F
P
V
YGEFQPPG
L
K
I
KEEEEGTEAASRSPR
P
Y
L
L
AGASAATFPDFPLPPRPPRAPPSRPGEAAVAAPSAAVSPVSSSG
S
A
L
E
C
I
L
Y
KAEGAPPTQGSFAPLPCKPPAASSCLLPRDSLPAAPTSSAAPAIYPPLGLNGLPQLG
Y
Q
A
A
V
L
K
DSLPQVY
P
P
Y
L
N
YLRPDSEASQSPQY
G
F
D
S
L
P
Q
K
I
C
L
I
CGDEASG
C
H
Y
G
V
L
TCG
S
C
K
V
F
F
K
R
A
MEGQH
N
Y
L
CAGRN
D
C
I
V
D
K
I
RRKNC
P
A
C
R
L
R
K
C
C
Q
AGMVLGG
R
K
F
K
K
F
N
K
V
R
V
M
R
A
LDGVALPQSVAFPNES
Q
T
LG
Q
R
I
TFSPNQ
E
I
Q
LV
P
P
L
I
N
L
L
MSIEP
D
V
V
Y
AGHDNTKPD
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
SLPGFRNLHIDD
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
GLGWR
S
Y
KHVS
G
Q
---
M
L
Y
FA
P
D
L
IL
N
E
Q
R
M
K
E
L
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
T
H
E
E
F
L
C
M
K
V
L
L
L
L
NTI--
P
L
EGLR
S
Q
S
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
IGLRQKGVVP
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
SR
A
L
A
VE
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
LFHKK
13
PsiBlast_PDB
91.97
96%
-125
- C3 -
1A28
1
PRGR_HUMAN
A:
[5-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
28
PsiBlast_CBE
90.82
96%
-126
- C3 -
4A2J
1
B:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
3
PsiBlast_PDB
90.64
95%
-127
- C3 -
1E3K
1
PRGR_HUMAN
A:
[7-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
30
PsiBlast_CBE
90.59
96%
-121
- C3 -
3ZRA
1
B:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
10
PsiBlast_PDB
90.56
96%
-123
- C3 -
3ZRB
3
PRGR_HUMAN
A:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
12
PsiBlast_PDB
90.46
96%
-124
- C3 -
4APU
1
PRGR_HUMAN
A:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
29
PsiBlast_CBE
90.41
96%
-131
- C3 -
3ZRB
2
B:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
25
PsiBlast_CBE
90.33
95%
-125
- C3 -
1ZUC
1
PRGR_HUMAN
A:
[8-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
84
HHSearch
90.28
96%
-127
- C3 -
1SQN
1
PRGR_HUMAN
A:
[10-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
2
PsiBlast_PDB
90.26
95%
-125
- C3 -
3G8O
1
PRGR_HUMAN
A:
[12-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
-
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
11
PsiBlast_PDB
90.17
96%
-129
- C3 -
4A2J
1
PRGR_HUMAN
A:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
8
PsiBlast_PDB
90.15
96%
-129
- C3 -
3ZR7
6
PRGR_HUMAN
A:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
6
PsiBlast_PDB
90.08
95%
-131
- C3 -
1ZUC
1
B:
[8-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
1
PsiBlast_PDB
90.07
95%
-127
- C3 -
1SQN
1
PRGR_HUMAN
A:
[10-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
31
PsiBlast_CBE
90.04
96%
-126
- C3 -
3ZR7
5
B:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
----
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
33
PsiBlast_CBE
90.01
96%
-131
- C3 -
3HQ5
2
B:
[5-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
22
PsiBlast_CBE
89.92
95%
-131
- C3 -
3G8O
1
B:
[13-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
23
PsiBlast_CBE
89.80
95%
-129
- C3 -
3D90
1
B:
[8-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
34
PsiBlast_CBE
89.66
96%
-127
- C3 -
1A28
1
B:
[6-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
21
PsiBlast_CBE
89.52
95%
-129
- C3 -
1SQN
1
B:
[11-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
K
35
PsiBlast_CBE
89.50
96%
-131
- C3 -
3KBA
1
B:
[2-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
5
PsiBlast_PDB
89.49
95%
-126
- C3 -
1SR7
1
PRGR_HUMAN
A:
[8-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
9
PsiBlast_PDB
89.41
96%
-129
- C3 -
3ZRA
1
PRGR_HUMAN
A:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
27
PsiBlast_CBE
89.20
96%
-128
- C3 -
4APU
1
B:
[10-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
16
PsiBlast_PDB
89.14
96%
-132
- C3 -
3HQ5
2
PRGR_HUMAN
A:
[5-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
---
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
-
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
-
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
4
PsiBlast_PDB
89.06
95%
-123
- C3 -
3D90
1
PRGR_HUMAN
A:
[7-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
26
PsiBlast_CBE
88.71
95%
-129
- C3 -
1SR7
2
B:
[9-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
24
PsiBlast_CBE
88.42
95%
-130
- C3 -
1E3K
1
B:
[8-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
15
PsiBlast_PDB
86.44
96%
-127
- C3 -
2OVM
1
A:
[5-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
--------
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
14
PsiBlast_PDB
86.30
96%
-125
- C3 -
2OVH
1
A:
[4-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
---------
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
17
PsiBlast_PDB
85.62
96%
-122
- C3 -
4OAR
1
A:
[7-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
-
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
---------
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
106
Fugue
84.27
84%
-121
- C3 -
1A28
1
PRGR_HUMAN
A:
[5-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
---------------------
V
I
Y
A
G
H
D
N
-------
T
K
P
D
T
---------
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
-QML
Y
F
A
--
P
D
L
I
L
N
E
Q
R
M
K
-
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
PL--
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
20
PsiBlast_PDB
81.08
67%
-121
- C3 -
4FN9
6
?
A:
[6-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
-
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
--
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
85
HHSearch
78.60
56%
-124
- C3 -
3MNP
3
A:
[14-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
-
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
--
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
K
-
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-