@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_THB_RAT: (2016-03-20 )
VGMSEACLHRKSHVERRGALKNEQTSSHLIQATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGQVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180...----------------------------....190.......200.-......210.......220.......230....-----...240.......250.......260.......270.......280.......290.......300.......310.......-320.......330.......340.......350.......360.......370.......380.....--..390.......400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VGM
S
E
A
C
L
H
R
K
S
H
V
E
R
RGALKNEQTSS
H
L
I
Q
A
TW
A
S
S
I
F
HLDPDDVNDQSVSS
A
Q
T
F
Q
T
E
E
K
K
C
KGY
I
P
S
YLDKD
E
L
C
V
V
CGDKAT
G
Y
H
Y
R
C
I
T
C
E
G
C
K
G
F
F
R
R
T
I
Q
K
SLHPSYS
C
K
YE
G
K
C
I
I
D
K
V
T
R
N
Q
C
Q
E
C
R
F
K
K
C
I
Y
V
G
M
A
T
D
L
V
LD
D
S
K
R
L
A
K
R
K
L
I
E
E
N
R
E
K
R
R
R
E
E
L
Q
K
S
IGHKPEP----------------------------T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
VAT-NAQG
S
H
W
K
Q
K
R
KF
L
P
E
DIGQAPIVNAPEG
G
Q
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
KL
P
M
F
CELPCED
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
YDPDS
E
T
L
T
LNG
E
M
A
V
TRGQLKNGG
L
G
V
-
V
S
D
A
I
F
D
L
GM
S
L
SSFNL
D
D
T
E
V
A
L
L
Q
A
V
L
L
MSSDRP
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
HAS
R
F
L
H
M
K
VEC
P
T
ELF
P
P
L
F
L
E
V
FED
4
PsiBlast_PDB
90.81
98%
-133
- C3 -
1NQ0
6
THB_HUMAN
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
T
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
----------
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
10
PsiBlast_PDB
90.72
99%
-130
- C3 -
1NAX
1
THB_HUMAN
A:
[3-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
-
2
PsiBlast_PDB
90.46
99%
-131
- C3 -
1XZX
1
THB_HUMAN
X:
[22-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
------------
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
-
3
PsiBlast_PDB
90.15
99%
-129
- C3 -
1Y0X
1
THB_HUMAN
X:
[22-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
------------
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
-
5
PsiBlast_PDB
90.10
98%
-126
- C3 -
1NQ2
6
THB_HUMAN
A:
[5-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
--------
G
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
T
A
V
R
Y
E
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
-
23
PsiBlast_CBE
90.08
98%
-130
- C3 -
2PIN
2
THB_HUMAN
B:
[3-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
R
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
-
6
PsiBlast_PDB
89.98
98%
-128
- C3 -
1NQ1
2
THB_HUMAN
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
Q
K
F
L
P
D
D
I
G
Q
----------
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
12
PsiBlast_PDB
89.74
98%
-131
- C3 -
2PIN
2
THB_HUMAN
A:
[2-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
------
G
G
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
R
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
-
22
PsiBlast_CBE
89.72
99%
-140
- C3 -
1N46
1
THB_HUMAN
B:
[8-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
---
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
---------
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
13
PsiBlast_PDB
89.68
98%
-133
- C3 -
3D57
1
THB_HUMAN
A:
[16-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
------
G
G
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
R
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
-
8
PsiBlast_PDB
89.68
99%
-135
- C3 -
1Q4X
2
THB_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
--------------
G
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
7
PsiBlast_PDB
89.46
99%
-128
- C3 -
1N46
1
THB_HUMAN
A:
[8-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
---
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
47
Fugue
88.28
99%
-132
- C3 -
1BSX
1
THB_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
--------
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
1
PsiBlast_PDB
88.28
99%
-132
- C3 -
1BSX
1
THB_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
--------
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
21
PsiBlast_CBE
88.07
99%
-132
- C3 -
1BSX
1
THB_HUMAN
B:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
--------
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
14
PsiBlast_PDB
88.02
84%
-123
- C3 -
3UVV
1
THA_CHICK
A:
[4-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
I
K
S
L
Q
H
R
P
S
P
----------------------------
S
A
E
E
W
E
L
I
H
V
V
T
E
A
H
R
S
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
--------
P
D
-
D
K
V
D
-----
L
E
A
F
S
E
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
S
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
S
G
E
M
A
V
K
R
E
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
K
S
L
S
A
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
T
G
L
I
C
V
D
K
I
E
K
C
Q
E
T
Y
L
L
A
F
E
H
Y
I
N
Y
R
K
H
N
I
P
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
9
PsiBlast_PDB
87.74
98%
-72
- C- -
2J4A
1
THB_HUMAN
A:
[3-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
----------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
-
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
-----
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
S
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
--
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
50
Fugue
79.36
32%
-106
- C3 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
----------------------------------------------------------------
K
G
P
A
P
K
M
L
G
H
-
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
R
R
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
--
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
S
P
V
G
P
Q
G
S
S
SSASGPGASPGGSEAGSQGSGEGEGVQL
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
-
N
K
R
--
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
-----
Q
S
R
D
A
R
-----
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
--
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
--
L
P
P
L
L
S
E
I
W
D
V
48
Fugue
66.88
26%
-117
- C3 -
1SKX
1
NR1I2_HUMAN
A:
[25-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----------------------------
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
---
L
P
G
V
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
YKPPI
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
-
G
R
L
S
Y
C
L
E
L
L
---------
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
RF
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
--
F
A
T
P
L
M
Q
E
L
F
G
I
29
HHSearch
65.80
37%
-139
- C3 -
3KMR
1
RARA_HUMAN
A:
[66-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
-
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
--
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
-
P
G
S
M
P
P
L
I
Q
E
M
L
E
-