@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT1A_HUMAN: (2016-01-08 )
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100........110---.........120........130.......140..---.....150....-...160......-.170..-..------..----..180-----..--....------..190..---.--......200----.-......210.......------------------220----------------.......230.......240.......250.......260-------------...-----....270...-------------------.------------.--..280......-----------.-----290.....--------..300.......310.......320..--------------.....330...-.----------.------------.--------------------------------------------.-----340.......350.......360.......370...----....380.........390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDVLSPGQGNNTTSPPAPFETGGNTTGI
S
D
V
T
V
S
Y
Q
V
I
T
S
L
L
L
G
T
L
I
F
C
A
V
LG
N
A
C
V
V
A
A
I
A
L
E
R
S
L
Q
N
V
A
N
Y
L
I
G
S
L
A
V
T
D
L
M
V
S
V
L
V
L
P
M
A
A
L
Y
Q
V
L
N
K-WTL
G
Q
V
T
C
D
-----
L
F
I
A
L
D
V
L
C
C
T
-
S
S
I
L
H
L
C
A
I
A
L
DRYWAITD
P
I
D
Y
---
V
NKRTP
R
R
A
A
A
L
-
I
S
L
T
W
L
I
G
F
L
I
S-IP-PML-GW------RT----PEDR------SD--PD
A
C
------
T
IS--KD---H--
G
Y
T
I
Y
S
T
F
G
----
A
-
F
Y
I
P
L
L
L
M
L
V
L
Y
G
R
I
F
------------------
R
A
A
----------------
R
F
R
I
R
K
T
V
K
K
V
E
KTGADTRHGASPAPQPKKSVNGESGSRN-------------
W
R
L
-----
G
V
ESKAG
G
A
L
-------------------C------------A--NGAVRQGDDG
A
-----------
A
-----
L
E
V
I
E
V
H
R--------VGNSKEHLPLPSEAGPTPCAPASFERK--------------NER
N
A
E
A
K
R
K
M
-
A
----------
L
------------
A
--------------------------------------------
R
-----
E
R
K
T
V
K
T
L
G
I
I
M
G
T
F
I
L
C
W
L
P
F
F
I
V
A
L
V
L
P
F
C
ESSC----H
M
P
T
L
--
L
G
A
I
I
N
W
LGYS
N
S
L
L
N
P
V
I
Y
A
Y
F
N
K
D
F
Q
N
A
F
K
K
I
I
K
C
KFCRQ
1
PsiBlast_PDB
85.50
40%
-108
- C4 -
4IAR
2
C562_ECOLX
A:
[15-398]
------------------------------
I
S
L
P
W
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
I
S
T
M
Y
T
V
T
G
R
-
W
T
L
G
Q
V
V
C
D
-----
F
W
L
S
S
D
I
T
C
C
T
-
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
---
S
A
K
R
T
P
K
R
A
A
V
M
-
I
A
L
V
W
V
F
S
I
S
I
S
-
L
P
-
P
F
F
--
W
------
R
Q
----
A
--------------
S
E
C
------
V
V
N
--
T
D
---
H
I
-
L
Y
T
V
Y
S
T
V
G
----
A
-
F
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
------------------
V
E
A
----------------
R
S
R
I
-----------
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
-------------
V
K
D
-----
A
L
T
K
M
R
A
A
A
L
-------------------
D
------------
A
--
Q
K
A
T
P
P
K
L
E
D
K
-----------
S
-----
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
--------------
T
T
R
N
A
Y
I
Q
K
Y
L
-
A
-----------------------
A
--------------------------------------------
R
-----
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
---------
W
F
H
L
A
--
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
----
9
PsiBlast_PDB
83.79
28%
-168
- C4 -
3P0G
1
ENLYS_BPT4
A:
[46-476]
----------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
-
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
------
Y
R
----
A
T
H
Q
E
A
I
N
C
Y
A
E
--
E
T
C
C
------
D
F
F
--
T
N
---
Q
--
A
Y
A
I
A
S
S
I
V
----
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------------------
Q
E
A
K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------------------------------------------------
K
-----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
--
I
--
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
R
R
---
4
PsiBlast_PDB
81.05
31%
-118
- C4 -
4NC3
13
C562_ECOLX
A:
[33-415]
---------------------------------------
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
-----
A
W
L
F
L
D
V
L
F
S
T
-
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
----
A
N
Q
Y
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
-
I
P
V
P
I
K
-
G
I
------
E
T
-----
V
D
N
------
P
N
--
N
I
T
C
------
V
L
T
--
K
E
---
R
F
G
D
F
M
L
F
G
S
L
A
----
A
-
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
---------------------------------------------
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
-------------
V
K
D
-----
A
L
T
K
M
R
A
------------------------------------------------------------------------
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
--------------
T
T
R
N
A
Y
I
Q
K
Y
L
Q
T
----------
I
------------
S
--------------------------------------------
N
-----
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
-
S
C
----
N
Q
T
T
L
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
--
12
PsiBlast_PDB
80.41
28%
-106
- C4 -
3PDS
8
ADRB2_HUMAN (first)
A:
[14-444]
----------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
C
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
-
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
------
Y
R
----
A
T
H
Q
E
A
I
N
C
Y
A
E
--
E
T
C
C
------
D
F
F
--
T
N
---
Q
--
A
Y
A
I
A
S
S
I
V
----
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------------------
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
EGL
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------------
F
R
T
G
T
W
D
A
Y
K
F
-
C
----------
L
---------------------------------------------------------
K
-----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
--
I
--
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----
17
PsiBlast_PDB
80.37
32%
-108
- C4 -
4EIY
25
AA2AR_HUMAN (first)
A:
[45-428]
-------------------------------------------------
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
---------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
---
N
G
L
V
T
G
T
R
A
K
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
-
P
M
L
-
G
W
------
N
N
CGQP
K
E
G
K
------
N
H
--
S
Q
G
C
GEGQVA
C
L
F
--
E
D
VVP
M
--
N
Y
M
V
Y
F
N
F
F
----
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
------------------
L
A
A
----------------
R
R
Q
L
-----------
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
-------------
V
K
D
-----
A
L
T
K
M
R
A
A
A
L
-------------------
D
------------
A
--
Q
K
-------------------------------
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
--------------
T
T
R
N
A
Y
I
Q
K
Y
L
-
E
----------
R
------------
A
--------------------------------------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
A
P
L
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
---
19
PsiBlast_PDB
80.26
29%
-106
- C4 -
3EML
13
ENLYS_BPT4
A:
[35-472]
-------------------------------------------------
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
---------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
---
N
G
L
V
T
G
T
R
A
K
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
-
P
M
L
-
G
W
------
N
N
CGQ---------------
S
Q
G
C
GEGQVA
C
L
F
--
E
D
VVP
M
--
N
Y
M
V
Y
F
N
F
F
----
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
------------------
L
A
A
R
RQLN
I
F
E
M
L
R
I
D
E
GL
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------------
F
R
T
G
T
W
D
A
Y
R
S
-
T
----------
L
------------
Q
--------------------------------------------
K
-----
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
A
P
L
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
3
PsiBlast_PDB
80.20
31%
-115
- C4 -
4IB4
11
5HT2B_HUMAN (first)
A:
[33-415]
---------------------------------------
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
-----
A
W
L
F
L
D
V
L
F
S
T
-
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
----
A
N
Q
Y
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
-
I
P
V
P
I
K
-
G
I
------
E
T
-------
N
------
P
N
--
N
I
T
C
------
V
L
T
--
K
E
---
R
F
G
D
F
M
L
F
G
S
L
A
----
A
-
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
---------------------------------------------
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
-------------
V
K
D
-----
A
L
T
K
M
R
A
A
A
L
-------------------
D
------------
A
--
Q
K
--------------------------------
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
--------------
T
T
R
N
A
Y
I
Q
K
Y
L
Q
T
----------
I
------------
S
--------------------------------------------
N
-----
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
-
S
C
----
N
Q
T
T
L
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
--
10
PsiBlast_PDB
80.14
28%
-107
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[45-475]
----------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
-
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
------
Y
R
----
A
T
H
Q
E
A
I
N
C
Y
A
E
--
E
T
C
C
------
D
F
F
--
T
N
---
Q
--
A
Y
A
I
A
S
S
I
V
----
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------------------
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------------
F
R
T
G
T
W
D
A
Y
K
F
-
C
----------
L
---------------------------------------------------------
K
-----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
--
I
--
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----
6
PsiBlast_PDB
79.89
28%
-104
- C4 -
3NY8
7
ENLYS_BPT4
A:
[46-476]
----------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
-
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
------
Y
R
----
A
T
H
Q
E
A
I
N
C
Y
A
E
--
E
T
C
C
------
D
F
F
--
T
N
---
Q
--
A
Y
A
I
A
S
S
I
V
----
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------------------
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
E
GL
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------------
F
R
T
G
T
W
D
A
Y
K
F
-
C
----------
L
---------------------------------------------------------
K
-----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
--
I
--
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----
5
PsiBlast_PDB
79.34
28%
-106
- C4 -
3D4S
6
ENLYS_BPT4
A:
[46-476]
----------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
-
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
------
Y
R
----
A
T
H
Q
E
A
I
N
C
Y
A
E
--
E
T
C
C
------
D
F
F
--
T
N
---
Q
--
A
Y
A
I
A
S
S
I
V
----
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------------------
Q
E
A
K
R
QLN
I
F
E
M
L
R
I
D
EGL
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------------
F
R
T
G
T
W
D
A
Y
K
F
-
C
----------
L
---------------------------------------------------------
K
-----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
--
I
--
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----
20
PsiBlast_PDB
79.23
29%
-105
- C4 -
3QAK
3
ENLYS_BPT4
A:
[35-470]
-------------------------------------------------
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
---------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
---
N
G
L
V
T
G
T
R
A
K
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
-
P
M
L
-
G
W
------
N
N
CG-----------------
Q
G
C
GEGQVA
C
L
F
--
E
D
VVP
M
--
N
Y
M
V
Y
F
N
F
F
----
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
------------------
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------------
F
R
T
G
T
W
D
A
Y
R
S
-
T
----------
L
------------
Q
--------------------------------------------
K
-----
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
A
P
L
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
--
18
PsiBlast_PDB
79.06
27%
-106
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
G
Y
-
W
P
L
G
P
V
V
C
D
-----
L
W
L
A
L
D
Y
V
V
S
N
-
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
---
P
V
K
R
T
T
K
M
A
G
M
M
-
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
-
A
I
L
-
F
W
Q
F
I
V
GV
R
T
----
V
E
D
------------
G
E
C
------
Y
I
Q
FF
S
N
---
A
--
A
V
T
F
G
T
A
I
A
----
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
------------------
R
A
S
KSRIN
I
F
E
M
L
R
I
D
EGL
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
-------------
T
N
------
G
V
I
T
K
D
E
A
E
K
-------------------
L
------------
F
--
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
-----
L
D
A
V
R
R
A
A
--------
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
-
T
----------
T
F
R
TGTWDAYPPP
S
--------------------------------------------
R
-----
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
-
A
P
C
-----
I
P
N
T
--
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
------
8
PsiBlast_PDB
78.67
28%
-105
- C4 -
3NYA
3
ADRB2_HUMAN (first)
A:
[46-476]
----------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
-
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
------
Y
R
----
A
T
H
Q
E
A
I
N
C
Y
A
E
--
E
T
C
C
------
D
F
F
--
T
N
---
Q
--
A
Y
A
I
A
S
S
I
V
----
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------------------
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
E
GL
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------------
F
R
T
G
T
W
D
A
Y
K
F
-
C
----------
L
---------------------------------------------------------
K
-----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
--
I
--
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----
7
PsiBlast_PDB
78.51
28%
-103
- C4 -
3NY9
4
ADRB2_HUMAN (first)
A:
[46-476]
----------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
-
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
------
Y
R
----
A
T
H
Q
E
A
I
N
C
Y
A
E
--
E
T
C
C
------
D
F
F
--
T
N
---
Q
--
A
Y
A
I
A
S
S
I
V
----
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------------------
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
E
GL
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
GF
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------------
F
R
T
G
T
W
D
A
Y
K
F
-
C
----------
L
---------------------------------------------------------
K
-----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
--
I
--
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----
2
PsiBlast_PDB
78.36
30%
-104
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[48-472]
---------------------------------------------
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
-----
V
F
V
T
L
D
V
M
M
C
T
-
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
-
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
-
L
L
F
-
G
F
------
N
T
----
T
---------
G
D
--
P
T
V
C
------
S
I
S
---
N
---
P
--
D
F
V
I
Y
S
S
V
V
----
S
-
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
G
L
----------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
-
N
R
A
K
R
V
I
T
--------------
T
F
R
T
G
T
W
D
A
Y
G
-
V
----------
P
------------
L
--------------------------------------------
R
-----
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
-
C
----
H
V
S
P
E
--
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-----
15
PsiBlast_PDB
78.30
28%
-105
- C4 -
4DAJ
5
ACM3_RAT (first)
A:
[9-440]
--------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
M
N
R
-
W
A
L
G
N
L
A
C
D
-----
L
W
L
S
I
D
Y
V
A
S
N
-
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
---
R
A
K
R
T
T
K
R
A
G
V
M
-
I
G
L
A
W
V
I
S
F
V
L
W
-
A
P
-
A
I
L
-
F
W
------
Q
Y
----
F
V
G
K
------
R
T
VP
P
G
E
C
------
F
I
Q
--
F
L
---
S
--
E
P
T
I
--
T
F
G
T
A
I
A
A
-
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
------------------
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
E
GL-
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
-------------
T
N
------
G
V
I
T
K
D
E
A
E
K
-------------------
L
------------
F
--
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAK
L
K
P
V
Y
D
S
-----
L
D
A
V
R
R
A
A
--------
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
-
T
T
F
R
T
GTWDAY
L
------------
I
--------------------------------------------
K
-----
E
---
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
S
C
------
I
P
K
T
--
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
K
T
---------
13
PsiBlast_PDB
77.17
29%
-101
- C4 -
4U15
6
ACM3_RAT
A:
[8-398]
-------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
M
N
R
-
W
A
L
G
N
L
A
C
D
-----
L
W
L
S
I
D
Y
V
A
S
N
-
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
---
R
A
K
R
T
T
K
R
A
G
V
M
-
I
G
L
A
W
V
I
S
F
V
L
W
-
A
P
-
A
I
L
-
F
W
------
Q
Y
----
F
V
G
K
------
R
T
VP
P
G
E
C
------
F
I
Q
--
F
L
---
S
--
E
P
T
I
--
T
F
G
T
A
I
A
A
-
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
------------------
K
E
T
----------------
E
K
M
N
I
F
E
M
L
R
I
D
E
G
G
G
S
G
G
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-------------
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
-------------------
I
---------------
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
---
K
R
V
--------------
I
T
T
F
R
T
G
T
W
D
A
-
Y
----------
L
------------
I
--------------------------------------------
K
-----
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
S
C
------
I
P
K
T
--
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
K
T
L
--------
81
Fugue
76.94
29%
-110
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
-----
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
-
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
-
P
I
Q
M
H
W
------
Y
R
----
A
T
H
Q
E
A
I
N
C
Y
A
E
--
E
T
C
C
------
D
F
F
--
T
N
---
Q
--
A
Y
A
I
A
S
S
I
V
----
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------------------
Q
E
A
----------------
K
R
Q
L
N
-
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-------------
P
S
L
-----
N
A
A
K
S
E
L
D
K
A
-------------------
I
GRNTNGVIT
K
D
E
A
--
E
K
L
F
N
Q
D
V
D
A
A
-----------
V
-----
R
G
I
L
R
N
A
K
--------
L
---
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
--------------
E
T
G
V
A
G
F
T
N
S
L
-
R
----------
M
------------
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
-----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
------
R
K
E
--
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----
16
PsiBlast_PDB
76.93
28%
-114
- C4 -
4U14
1
ENLYS_BPT4
A:
[8-443]
-------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
M
N
R
-
W
A
L
G
N
L
A
C
D
-----
L
W
L
S
I
D
Y
V
A
S
N
-
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
---
R
A
K
R
T
T
K
R
A
G
V
M
-
I
G
L
A
W
V
I
S
F
V
L
W
-
A
P
-
A
I
L
-
F
W
------
Q
Y
----
F
V
G
K
------
R
T
VP
P
G
E
C
------
F
I
Q
--
F
L
---
S
--
E
P
T
I
--
T
F
G
T
A
I
A
A
-
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
------------------
K
E
T
E
K
M
N
C
F
E
M
L
R
I
D
EGL-
R
L
K
I
Y
K
D
C
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
L
D
A
V
R
R
--
C
------------
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
---
A
K
S
R
W
Y
N
Q
C
P
N
R
A
K
R
V
--------------
I
T
T
F
R
T
G
T
W
D
A
-
Y
----------
L
------------
I
--------------------------------------------
K
-----
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
S
C
------
I
P
K
T
--
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
K
T
L
L
L
------
11
PsiBlast_PDB
76.05
29%
-105
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[13-443]
----------------------------------------
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
S
K
-
W
S
L
G
R
P
L
C
L
-----
F
W
L
S
M
D
Y
V
A
S
T
-
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
---
L
K
Y
R
T
K
T
R
A
S
A
T
-
I
L
G
A
W
F
L
S
F
L
W
V
-
I
--
P
I
L
-
G
W
NH------------
R
R
------
E
D
--
K
C
E
T
------
D
F
Y
--
D
V
---
T
--
W
F
K
V
M
T
A
I
I
----
N
-
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
------------------
K
A
V
RQHCN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
------------
I
--
N
M
V
F
Q
M
G
E
T
G
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
--------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
-
N
R
A
K
R
V
I
T
--------------
T
F
R
T
G
T
W
D
A
Y
L
-
H
----------
M
------------
N
--------------------------------------------
R
-----
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
C
NE
H
L
H
M
F
T
I
--------
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-----