@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT1B_HUMAN: (2016-01-08 )
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180...---.--------..----.190--..-----.....200..-.....210.......220.......230.......240...--------..------------------------------..250.--..-----------------------..-------------..260-------.--.-----.-----...-..-.270.------------------------------------------...-----------.-----------.-----------------.----280----..-----...--.---------..290--------..--------------.--------------......300--------......--------------------------------------------..310.......320.......330.......340..--.....350.......360.......370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKD
Y
I
YQDSISL
P
W
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
LSN
A
F
V
I
A
T
V
Y
R
TRKLHT
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
MPI
S
T
M
Y
T
VTGR
W
T
L
G
Q
V
V
C
D
F
W
LSSD
I
T
C
C
T
A
S
I
L
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
YSAKRTP
K
R
A
A
V
M
I
A
L
V
W
V
F
S
ISISLP
P
F
---
F
--------
W
R
----QA
K
A
--
E
E
-----
E
V
S
E
C
VVNTD-
H
I
L
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
S
R
I
L
K
QTPN--------RT------------------------------GKR
L
T
R
--
A
Q
-----------------------
L
I
-------------TDS---------P--G-----S-----TSS-VT-SINSR------------------------------------------VPD-----------V-----------P-----------------S----ES-----GS-----
P
V
Y
--
V
---------
N
Q
V
----------
K
V
--------------
R
--------------
V
S
D
A
L
L
E
K
---------
K
K
L
M
A
A
--------------------------------------------
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
CKD
A
C
--
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
YTMS
N
E
D
F
K
Q
A
F
H
K
L
I
R
FKCTS
1
PsiBlast_PDB
88.26
76%
-137
- C5 -
4IAR
2
C562_ECOLX
A:
[9-398]
-------------------------------------
Y
I
Y
Q
D
S
I
S
L
P
W
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
I
S
T
M
Y
T
V
T
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
F
---
F
--------
W
R
----
Q
A
-------------
S
E
C
V
V
N
T
D
-
H
I
L
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
------------------------------
I
E
K
A
D
N
--
A
A
-----------------------
Q
V
-------------
K
D
A
L
T
K
M
R
A
A
A
L
D
--
A
-----
Q
-----
K
A
T
-
P
P
-
K
L
E
D
K
------------------------------------------
S
P
D
-----------
S
-----------
P
-----------------
E
MKD
F
R
H
-----
G
F
-----
D
I
L
--
V
---------
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
--------------
K
--------------
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
--------------------------------------------
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
-------
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
---
61
HHSearch
67.91
30%
-114
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
---
L
F-------
W
Q
----
F
I
V
G
VR
T
V
-----
E
D
G
E
C
Y
I
Q
F
F
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
--------
R
I
------------------------------
D
E
G
L
R
L
K
I
Y
K
-----------------------
D
T
EG
Y
Y
T
I
GIGHLLT
K
S
P
---------
S
L
N
A
A
K
S
E
L
D
K
A
I
GR
N
T
N
-
G
V
-
I
T
K
D
E
------------------------------------------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
----
E
T
-----
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
----------
K
S
--------------
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
---------
A
Y
P
P
P
S
--------------------------------------------
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
----
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----
34
PsiBlast_CBE
67.32
34%
-142
- C5 -
2Y02
12
ADRB1_MELGA
B:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
I
D
--------
R
A
------------------------------
S
K
R
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
9
PsiBlast_PDB
66.75
34%
-153
- C5 -
2Y02
13
ADRB1_MELGA
A:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
10
PsiBlast_PDB
66.50
34%
-153
- C5 -
2Y03
9
ADRB1_MELGA
A:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
14
PsiBlast_PDB
66.45
34%
-150
- C5 -
3ZPR
11
ADRB1_MELGA
A:
[4-299]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
------
24
PsiBlast_CBE
66.24
34%
-145
- C5 -
2YCW
6
ADRB1_MELGA
B:
[4-299]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
MMH
W
--------
W
R
DEDP
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
I
D
--------
R
A
------------------------------
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
PD
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
F
----
31
PsiBlast_CBE
66.14
34%
-140
- C5 -
3ZPQ
13
ADRB1_MELGA
B:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
I
D
--------
R
A
------------------------------
S
K
R
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
8
PsiBlast_PDB
66.08
34%
-152
- C5 -
2Y01
12
ADRB1_MELGA
A:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
33
PsiBlast_CBE
65.89
34%
-140
- C5 -
2Y03
8
ADRB1_MELGA
B:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
I
D
--------
R
A
------------------------------
S
K
R
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
7
PsiBlast_PDB
65.88
34%
-151
- C5 -
2Y00
13
ADRB1_MELGA
A:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
30
PsiBlast_CBE
65.86
34%
-142
- C5 -
3ZPR
12
ADRB1_MELGA
B:
[4-299]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
I
D
--------
R
A
------------------------------
S
K
R
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
------
12
PsiBlast_PDB
65.86
34%
-149
- C5 -
4AMJ
12
ADRB1_MELGA
A:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
3
PsiBlast_PDB
65.85
34%
-139
- C5 -
2YCW
7
ADRB1_MELGA
A:
[4-299]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
I
D
--------
R
A
------------------------------
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
F
----
35
PsiBlast_CBE
65.82
34%
-143
- C5 -
2Y01
12
ADRB1_MELGA
B:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
I
D
--------
R
A
------------------------------
S
K
R
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
11
PsiBlast_PDB
65.82
34%
-152
- C5 -
2Y04
13
ADRB1_MELGA
A:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
63
HHSearch
65.80
32%
-117
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
-------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
---
Q
M
H------
W
Y
----
R
A
T
H
--
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
-
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
--------
R
I
------------------------------
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
-------------
E
L
D
---------
K
--
A
-----
I
-----
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
-----------
E
-----------
T
G
V
A
G
F
T
N
S
---------
L
----
R
M
L
Q
Q
KR
W
D
-----
E
A
A
--
V
---------
N
L
A
----------
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
--------------
T
F
R
T
G
T
W
D
---------
A
Y
K
F
C
L
--------------------------------------------
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----
36
PsiBlast_CBE
65.79
34%
-142
- C5 -
2Y00
12
ADRB1_MELGA
B:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
I
D
--------
R
A
------------------------------
S
K
R
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
13
PsiBlast_PDB
65.73
34%
-151
- C5 -
3ZPQ
11
ADRB1_MELGA
A:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
32
PsiBlast_CBE
65.62
34%
-141
- C5 -
2Y04
12
ADRB1_MELGA
B:
[4-300]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
--
I
D
--------
R
A
------------------------------
S
K
R
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
A
-----
51
Fugue
65.60
31%
-123
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
---
Q
M
HWYRATH
Q
E
----
A
I
N
C
--
Y
A
-----
E
E
T
C
C
D
F
F
T
N
--
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
--------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
--
L
D
-----------------------
K
A
I
GRNTNGVI----
T
K
D
---------
E
--
A
-----
E
-----
K
L
F
-
N
Q
-
D
V
D
A
A
------------------------------------------
V
R
G
-----------
I
-----------
L
R
N
A
K
L
K
P
V
Y
D
S
LD----
A
----
V
R
-----
R
A
-----
A
L
I
--
N
---------
M
V
F
----------
Q
M
--------------
G
--------------
E
T
G
V
A
G
F
T
---------
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----
29
PsiBlast_CBE
64.04
34%
-149
- C5 -
4AMI
6
ADRB1_MELGA
B:
[4-299]
-----------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
--------
W
R
DED
P
Q
A
L
K
--
C
Y
-----
Q
D
P
G
C
C
D
F
V
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
--------------------------------------------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
-
P
D
F
R
K
A
F
K
R
L
L
------