@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT1E_HUMAN: (2016-01-08 )
MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80...-...-..90........100.......110.......120.......130.---......140.......150....-.-.---.--160-----...-.----..-..----.170.....------..-180........190.......200.......210---------------.-----------------.------------.......220......-------.-----.------.-----------230-------------.----------------.---..-----..--------------.--------------.-----.-----240.---------------------.--.-.-------..-----.---.--------------------250-----------------.-------------------.-..-----------.-------------.-----------.-260-----.--..--------------.-.--.----------.-------------------.------270---..----------.----------.----------...------------------------------------------------------------------------------.--------------------.280..-----------.-------------....290.......300.......310......---.320....--...330.......340.......350.......360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNITNCTTEA
S
M
A
IRP
K
T
I
T
E
K
M
L
I
C
M
T
L
V
V
I
T
T
L
T
T
L
L
N
L
A
V
I
M
AIGT
T
K
KLHQPANY
L
I
C
S
L
A
V
T
D
L
L
V
A
V
L
V
M
P
L
S
I
I
Y
I
V
-
M
DR-W
K
L
G
Y
F
L
C
E
V
W
L
SVD
M
T
C
C
T
C
S
I
L
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
N
A
I
E
Y
A
R
K
---
R
TAK
R
A
A
L
M
I
L
T
V
W
T
I
S
I
F
ISM
P
-
P
-
L
---
F
--
W
-------
R
SH-R----RL-SP----PPS
Q
C
T
I
QH------D
H
-
V
-
I
Y
T
I
Y
S
T
L
G
A
F
Y
I
P
L
T
L
I
L
I
L
Y
Y
R
I
Y
H
A
A
K
-----------------
S
-----------------
L
------------
Y
Q
KRGSSR--HLSNRS-------T-----D------S-----------Q---------------N----------------S---FA-----
S
C
--------------
K
--------------
L
-----
T
-----
Q
T
-
F
---------------------
C
--V-S-------DF-----S---T--------------------SDP-----------------T-------------------
T
-
E
F
-----------
E
-------------
K
-----------
F
-
H
A
------
S
--IR--------------I-P--P----------F-------------------D------N-----DL----------D----------H----------PG
E
------------------------------------------------------------------------------
R
--------------------
Q
Q
I
S
S
T
-----------
R
-------------
E
R
K
A
A
R
I
L
G
L
I
L
G
A
F
I
L
S
W
L
P
F
F
I
K
E
L
I
VG
L
S
I
---
Y
T
V
S
S
E
V
A
--
D
F
L
T
W
L
G
Y
V
N
S
L
I
N
P
L
L
YTSFN
E
D
F
K
L
A
F
K
K
L
I
R
CREHT
1
PsiBlast_PDB
90.60
44%
-140
- C5 -
4IAR
2
C562_ECOLX
A:
[20-398]
---------------------
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
I
S
T
M
Y
T
V
-
T
G
R
-
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
-
P
-
F
---
F
--
W
-------
R
-
Q
-
A
---------------
S
E
C
V
V
N
T
------
D
H
-
I
-
L
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
-----------------
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
------------
I
E
K
A
D
N
A
A
--
Q
V
K
D
A
L
-------
T
-----
K
------
M
-----------
R
---------------
A
----------------
A
---
A
L
-----
D
A
--------------
Q
--------------
K
-----
A
-----
T
P
-
P
---------------------
K
--
L
-
E
-------
D
K
-----
S
---
P
--------------------
D
S
P
-----------------
E
-------------------
M
-
K
D
-----------
F
-------------
R
-----------
H
-
G
F
------
D
--
I
L
--------------
V
-
G
--
Q
----------
I
-------------------
D
------
D
-----
A
L
----------
K
----------
L
----------
A
N
E
------------------------------------------------------------------------------
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
-----------
R
-------------
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
--------
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
---
3
PsiBlast_PDB
81.61
28%
-130
- C5 -
4U15
6
ACM3_RAT
A:
[8-398]
-----------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
-
M
N
R
-
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
-
A
I
L
---
F
--
W
-------
Q
Y
F
V
G
----
K
R
-
T
V
----
P
P
G
E
C
F
I
Q
F
L-----
S
E
-
P
-
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
-----------------
K
-----------------
M
N
I
F
E
M
L
R
I
D
E
GG
G
S
G
G
D
E
A
E
--
K
L
F
N
Q
D
-------
V
-----
D
------
A
A
V
---------
R
---------------
G
----------------
I
---
L
R
-----
N
A
--------------
K
--------------
L
-----
K
-----
P
V
-
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
--
V
-
A
-------
G
F
-----
T
---
N
--------------------
S
L
R
-----------------
M
-------------------
L
-
Q
Q
-----------
K
-------------
R
-----------
W
D
E
A
------
A
--
V
N
--------------
L
-
A
--
K
----------
S
-------------------
R
------
W
-----
Y
N
----------
Q
----------
T
----------
P
N
R
------------------------------------------------------------------------------
A
--------------------
K
R
V
I
T
T
F
R
T
GTWDAYL
I
K
-------------
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
---
S
C
I
P
K
T
Y
W
--
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
K
T
L
-------
68
HHSearch
80.12
31%
-136
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
-
I
---
Q
M
H
W
-------
Y
R
A
-
T
----
H
Q
-
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
------
T
N
-
Q
-
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-----------------
R
-----------------
Q
------------
L
N
I
F
E
M
L
R
--
I
D
E
G
L
R
-------
L
-----
K
I
Y
K
D
TE
G
YYTIGIGHLLT
K
---------------
S
----------------
P
S
L
N
A
A
-----
K
S
--------------
E
--------------
L
-----
D
K
A
I
GR
N
T
-
N
GV-------------------
I
--
T
K
D
-------
E
A
-----
E
K
L
F
N
--------------------
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
---------------
V
R
R
A
-----------
A
L
I
N
M
V
F
-------
Q
-----------
M
-
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
-
K
S
R
W
----------
Y
-------------------
N
------
Q
-----
T
P
----------
N
R
A
K
R
V
I
T
T
F
R
T
----------
G
T
W
------------------------------------------------------------------------------
D
--------------------
A
Y
K
F
C
L
-----------
K
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
---
N
L
I
R
K
E
V
Y
--
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----
71
HHSearch
79.88
30%
-138
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
-
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
-
L
-
L
---
F
G-
F
-------
N
T
T
----------
G
----
D
P
T
V
C
S
I
S
N
------
P
----
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
-----------------
Q
-----------------
R
------------
R
R
K
N
I
F
E
M
--
L
R
I
D
E
G
LRL
K
I
Y
K
D
-----
T
------
E
-----------
G
---------------
Y
Y
T
I
G
IGHL--------
L
---
T
K
-----
S
P
--------------
S
L
N
------------
A
A
K
S
E
L
D
K
A
I
G-
R
N
T
N
---------------------
G
VI
T
-
K
-------
D
E
-----
A
---
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
-----------
V
-------------------
R
-
R
A
-----------
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
-
R
W
------
D
--
E
A
--------------
A
-
V
--
N
----------
L
-------------------
A
K
S
R
W
Y
N
Q
-----
T
P
N
---------
R
A
K
R
V
I
T
T
F
R
-
T
----------
G
T
W
------------------------------------------------------------------------------
D
--------------------
A
Y
G
V
P
L
-----------
R
-------------
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T--
C
H
V
S
P
E
L
Y
--
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----
15
PsiBlast_PDB
79.31
27%
-141
- C5 -
4NC3
12
C562_ECOLX
A:
[38-414]
----------------------------
M
V
I
I
P
T
I
G
G
--
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
-
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
Y
---
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
-
I
---
K
--
G
-------
I
E
T
------
V
D
-
N
P
----
N
N
I
T
C
V
L
T
K
------
E
R
-
F
G
D
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
-----------------
V
------------
I
E
K
A
D
N
A
A
--
Q
V
K
D
A
L
-------
T
-----
K
------
M
-----------
R
---------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
-----------
F
-------------
R
-----------
H
-
G
F
------
D
--
I
L
--------------
V
-
G
--
Q
----------
I
-------------------
D
------
D
-----
A
L
----------
K
----------
L
----------
A
N
E
------------------------------------------------------------------------------
G
K
V
K
E
A
Q
A
A
A
-----------
E
Q
L
K
T
T
-----------
R
N
A
Y
I
Q
K
Y
L
Q
T
I
S
N
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
SCN
Q
T
T
L
Q
M
L
L
--
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
-
2
PsiBlast_PDB
79.07
31%
-159
- C5 -
3SN6
1
R:
[185-490]
----------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
--
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
T
K
T
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
-
I
---
Q
--
M
-------
H
W
Y
-
R
--------
Q
----
E
A
I
N
C
Y
A
E
E
TCCDFF
T
N
-
Q
-
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-----------------
R
-----------------
Q
------------
L
Q
K
I
D
K
S
E
GR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
-----------
K
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
---
N
L
I
R
K
E
V
Y
--
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----
7
PsiBlast_PDB
78.72
31%
-163
- C5 -
3ZPQ
11
ADRB1_MELGA
A:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-----
67
HHSearch
78.50
29%
-131
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
----------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
-
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
-
I
-
L
---
G
--
W
-------
N
H
-----------
R
----
R
E
D
K
C
E
T
D
F
------
Y
D
V
T
-
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
-----------------
Q
-----------------
H
------------
C
N
I
F
E
M
L
R
--
I
D
E
G
L
R
-------
L
-----
K
------
I
Y
----------
K
---------------
D
TEG
Y
Y
T
I
G
IGHLLTKS
P
---
S
L
-----
N
A
A
K
S
E
L
D
K
A
I
GRNTN
G
--------------
V
IT
K
--
D
-----
E
A
-
E
---------------------
K
--
L
-
F
-------
N
Q
-----
D
---
V
--------------------
D
A
A
-----------------
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
-
R
A
-----------
A
-------------
L
I
N
M
V
F
Q
MG---
E
-
T
G
------
V
--
A
G
--------------
F
-
T
--
N
----------
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
---
Q
-----
T
P
----------
N
----------
R
A
K
R
V
I
T
T
F
R
T
G
T
W
------------------------------------------------------------------------------
D
--------------------
A
Y
L
H
M
N
-----------
R
-------------
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
---
N
C
C
N
E
H
L
H
--
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----
56
Fugue
78.47
29%
-135
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
-
I
---
Q
--
M
HWYRATH
Q
E
A
-
I
----
N
C
-
Y
A
----
E
E
T
C
C
D
F
F
T
------
N
--
Q
-
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-----------------
R
-----------------
Q
------------
L
N
I
F
E
M
L
R
--
I
D
E
G
L
R
-------
L
-----
K
------
I
-----------
Y
K
D
TEGYYTIGIGHLL
T
----------------
K
---
S
P
-----
S
L
--------------
N
--------------
A
-----
A
-----
K
S
-
E
---------------------
L
--
D
-
K
-------
A
I
-----
G
---
R
--------------------
N
T
N
-----------------
G
-------------------
V
-
I
T
-----------
K
-------------
D
-----------
E
-
A
E
------
K
--
L
F
--------------
N
-
Q
--
D
----------
V
-------------------
D
------
A
-----
A
V
----------
R
----------
G
----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
--------------------
A
Y
K
F
C
L
-----------
K
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
---
N
L
I
R
K
E
V
Y
--
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----
6
PsiBlast_PDB
78.22
31%
-166
- C5 -
4AMJ
12
ADRB1_MELGA
A:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-----
31
PsiBlast_CBE
78.10
32%
-125
- C5 -
2YCY
6
ADRB1_MELGA
B:
[14-297]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
---
M
--
M
-------
H
W
W
-
R
----
D
E
-
D
P
----
Q
A
L
K
C
---------------------------------------------------------------------------------------------
Y
Q
D
P
G
C
C
D
--
F
V
T
N
R
A
Y
A
I
----
A
-----
S
------
S
-----------
I
---------------
I
----------------
S
---
F
Y
-----
I
P
--------------
L
--------------
L
-----
I
-----
M
I
-
F
---------------------
V
--
A
-------------------------------------------------------------
L
-------------------
R
-
V
Y
-----------
R
-------------
E
-----------
A
-
K
E
------
Q
--
I
R
---------------------------------------------------------------
K
I
----------
D
----------
R
----------
A
S
K
------------------------------------------------------------------------------
R
--------------------
K
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----
5
PsiBlast_PDB
78.08
31%
-169
- C5 -
2Y03
9
ADRB1_MELGA
A:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
I
--
R
----------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-----
4
PsiBlast_PDB
78.06
28%
-134
- C5 -
4U16
2
?
A:
[8-388]
-----------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
-
M
N
R
-
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
-
A
I
L
---
F
--
W
-------
Q
Y
F
V
G
----
K
R
-
T
V
----
P
P
G
E
C
F
I
Q
F
L-----
S
E
-
P
-
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
-----------------
K
-----------------
M
N
I
F
E
M
L
R
I
D
E
GG
G
S
G
G
D
E
A
E
--
K
L
F
N
Q
D
-------
V
-----
D
------
A
A
V
---------
R
---------------
G
----------------
I
---
L
R
-----
N
A
--------------
K
--------------
L
-----
K
-----
P
V
-
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
--
V
-
A
-------
G
F
-----
T
---
N
--------------------
S
L
R
-----------------
M
-------------------
L
-
Q
Q
-----------
K
-------------
R
-----------
W
D
E
A
------
A
--
V
N
--------------
L
-
A
--
K
----------
S
-------------------
R
------
W
-----
Y
N
----------
Q
----------
T
----------
P
N
R
------------------------------------------------------------------------------
A
--------------------
K
R
V
I
T
T
F
R
TGTWDAYL
I
K
-------------
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
---
S
C
I
P
K
T
Y
W
--
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
-----------------
66
HHSearch
77.93
27%
-138
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
-
A
-
I
---
L
F-
W
-------
Q
F
I
-
V
----
G
V
R
T
V
----
E
D
G
E
C
Y
I
Q
F
------
F
S
N
A
-
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
-----------------
S
-----------------
R
------------
I
N
I
F
E
M
L
R
--
I
D
E
G
L
R
-------
L
K
I
Y
K
D
T
------
E
-----------
G
---------------
Y
Y
T
I
GIGHLLT------
K
---
S
P
S
L
N
A
A
K
S
--------------
E
L
D
K
A
I
GRNTNGVIT
K
-----
D
-----
E
A
-
E
---------------------
K
L
F
N
-
Q
D
V
D
A
A
V
R
G
I
L
R
NAK
L
---
K
--------------------
P
V
Y
D
S
LD
A
V
-----------
R
-------------------
R
-
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
------------
A
G
----------
F
-
T
N
------
S
--
L
R
--------------
M
L
Q
--
Q
KR
W
D
E
A
A
V
N
L
A
-------------------
K
------
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
----------
T
----------
G
T
W
------------------------------------------------------------------------------
D
--------------------
A
Y
P
P
P
S
-----------
R
-------------
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
---
P
C
I
P
N
T
V
W
--
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----
8
PsiBlast_PDB
77.65
31%
-166
- C5 -
3ZPR
11
ADRB1_MELGA
A:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
------
25
PsiBlast_CBE
77.12
31%
-157
- C5 -
2Y04
12
ADRB1_MELGA
B:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
I
--
R
K
I
D
R
A
-------
S
-----
K
------
R
-----------
K
---------------
T
----------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-----
27
PsiBlast_CBE
77.06
31%
-158
- C5 -
2Y02
12
ADRB1_MELGA
B:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
I
--
R
K
I
D
R
A
-------
S
-----
K
------
R
-----------
K
---------------
T
----------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-----
29
PsiBlast_CBE
76.98
31%
-158
- C5 -
2Y00
12
ADRB1_MELGA
B:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
I
--
R
K
I
D
R
A
-------
S
-----
K
------
R
-----------
K
---------------
T
----------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-----
36
PsiBlast_CBE
76.88
32%
-130
- C5 -
2VT4
9
ADRB1_MELGA
B:
[14-297]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
---
M
--
M
-------
H
W
W
-
R
----
D
E
-
D
P
----
Q
A
L
K
C
---------------------------------------------------------------------------------------------
Y
Q
D
P
G
C
C
D
--
F
V
T
N
R
A
Y
A
I
----
A
-----
S
------
S
-----------
I
---------------
I
----------------
S
---
F
Y
-----
I
P
--------------
L
--------------
L
-----
I
-----
M
I
-
F
---------------------
V
--
A
-------------------------------------------------------------
L
-------------------
R
-
V
Y
-----------
R
-------------
E
-----------
A
-
K
E
------
Q
--
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----
23
PsiBlast_CBE
76.67
31%
-157
- C5 -
3ZPR
12
ADRB1_MELGA
B:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
I
--
R
K
I
D
R
A
-------
S
-----
K
------
R
-----------
K
---------------
T
----------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
------
22
PsiBlast_CBE
76.20
31%
-164
- C5 -
4AMI
6
ADRB1_MELGA
B:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
I
--
R
K
---------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
------
35
PsiBlast_CBE
74.45
32%
-131
- C5 -
2VT4
7
ADRB1_MELGA
C:
[14-286]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
---
M
--
M
-------
H
W
W
-
R
----
D
E
-
D
P
----
Q
A
L
K
C
---------------------------------------------------------------------------------------------
Y
Q
D
P
G
C
C
D
--
F
V
T
N
R
A
Y
A
I
----
A
-----
S
------
S
-----------
I
---------------
I
----------------
S
---
F
Y
-----
I
P
--------------
L
--------------
L
-----
I
-----
M
I
-
F
---------------------
V
--
A
-------------------------------------------------------------
L
-------------------
R
-
V
Y
-----------
R
-------------
E
-----------
A
-
K
E
------
Q
--
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
-----------------
16
PsiBlast_PDB
74.41
30%
-159
- C5 -
4BVN
11
ADRB1_MELGA
A:
[14-299]
----------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
--
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
-
I
M
M
H
W
--
W
-------
R
D
E
-
D
P
Q
A
L
K
C
-
Y
Q
----
D
P
G
C
C
D
F
V
T
------
N
R
-
A
--
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
-----------------------------------------
V
------------
Y
R
E
A
K
E
Q
I
--
R
------------------
K
------
R
-----------
K
---------------
T
----------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
M
L
M
-----------
R
-------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
L
V
P
K
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-----