@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT1F_HUMAN: (2016-01-08 )
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80....-....90........100.......110.......120.......130..---.....140.......150......--.---160--..---.---.---..-----..170....-.-..180.......190.......200.......210------------........220...-----...---.----230-----.-------.-...-------------...--.---------------240.....------..--------------250---------...---------.------------------------------..----------..--------------260-----------...-----.--------...-------------.---270---------.----........280-...-----...------...290.......300.......310.......320.......330.......340.......350.......360....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDFLNSSDQNL
T
S
E
E
L
L
N
RM
P
S
K
I
L
V
S
L
TLSG
L
A
L
M
T
T
T
I
N
S
L
V
I
A
A
I
I
V
T
R
KLHHPANY
L
I
C
S
L
A
V
T
D
F
L
V
A
V
L
V
M
P
F
S
I
V
Y
I
V
-
R
ESW
I
M
G
Q
V
V
C
D
I
WLS
V
D
I
T
C
C
T
C
S
I
L
H
L
S
A
I
A
L
D
R
Y
R
A
I
T
D
A
V
E
Y
A
R
K---RTPKHA
G
I
M
I
T
I
V
W
I
I
S
V
F
ISMP
P
--
L
---
F
-
W
--RH---Q---G---TS-----RDD
E
C
I
I
K
H
-
D
-
H
I
V
S
T
I
Y
S
T
F
G
A
F
Y
I
P
L
A
L
I
L
I
L
Y
Y
K
I
Y
R
A
A
K
T
L
-------------
Y
H
K
R
Q
A
S
R
I
A
K
E
EV-----N
G
Q
---
V
----
L
-------
L
-------E-SGE-------------KST--K---------------SVST
S
Y
V
L
------
E
K--------------SL----------SDP---------S------------------------------T
D
----------
F
D
--------------
K
I
------------
H
S
T
-----
V
--------
R
S
L
-------------
R
---
S
-----------
E
----
F
K
H
E
K
S
W
R
R
---
Q
KI-----SGT------
R
E
R
K
A
A
T
T
L
G
L
I
L
G
A
F
V
I
C
W
L
P
F
F
V
K
E
L
V
V
N
V
C
D
KC
K
I
S
E
E
M
S
N
F
L
A
W
L
G
Y
L
N
S
L
I
N
P
L
I
Y
T
I
F
N
E
D
F
K
K
A
F
Q
K
L
V
RCRC
1
PsiBlast_PDB
93.98
46%
-137
- C4 -
4IAR
2
C562_ECOLX
A:
[17-398]
-------------------
L
P
W
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
I
S
T
M
Y
T
V
-
T
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
--
F
---
F
-
W
--
R
Q
---
A
----------------
S
E
C
V
V
N
T
-
D
-
H
I
L
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
---------------------
S
R
I
A
D
L
E
D
-----
N
W
E
---
T
----
L
N
D
N
----
L
-------
K
-
V
I
E
-------------
K
A
D
--
N
---------------
A
A
Q
V
K
D
A
L
------
T
K
M
R
A
A
A
L
D
A
Q
K
A
TPP
K
L
----------
E
D
K
---------
S
------------------------------
P
D
SPEMKD
F
R
H
G
F
D
--------------
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
-----
V
--------
K
E
A
-------------
Q
---
A
-----------
A
----
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
-----
L
A
A
------
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
----
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
-
2
PsiBlast_PDB
85.42
29%
-127
- C4 -
4U15
6
ACM3_RAT
A:
[13-398]
-----------------------
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
-
L
---
F
-
W
--
Q
Y
F
V
G
K
---
R
---
T
V
-----
P
P
G
E
C
F
I
Q
F
L
S
-
E
P
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
E
GGG
S
G
G
D
E
A
E
K
L
F
N
Q
D
V
-----
D
A
A
---
V
----
R
G
I
L
R
NAK
L
-------
K
-
P
V
Y
-------------
D
S
L
--
D
---------------
A
V
R
R
A
A
L
I
------
N
M
--------------
V
F
----------
Q
M
G
---------
E
------------------------------
T
G
----------
V
A
--------------
G
F
------------
T
N
S
-----
L
--------
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
---
S
-----------
R
----
W
Y
N
Q
T
P
N
R
A
---
K
R
V
I
T
T
F
R
T
G
T
WDAYL
I
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
S
C
-
I
P
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
K
T
L
-----
57
HHSearch
82.12
29%
-118
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
----------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
--
I
---
L
F
W
--
Q
F
---
I
---
V
GVR
T
V
-----
E
D
G
E
C
Y
I
Q
F
-
F
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
-------------
I
N
I
F
E
M
L
R
I
D
E
G
L
R
-----
L
K
I
Y
K
D
T
EG
Y
Y
T
I
GI----
G
HLLT---
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GR
N
T
N
--
G
VIT
K
D
----------
E
A
E
K
L
F
N
Q
------
D
V
--------------
D
A
----------
A
V
R
---------
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
----------
G
V
A
G
F
-----------
T
N
------------
S
L
R
M
L
Q
--
Q
K-------
R
W
D
E
A
-----------
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
---
A
Y
P
-----
P
P
S
------
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
-
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---
8
PsiBlast_PDB
81.91
31%
-139
- C4 -
2YCY
6
ADRB1_MELGA
A:
[14-297]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
--------------------------
A
K
E
Q
I
-----
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
A
S
K
R
---
K
R
V
-----
M
L
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--
12
PsiBlast_PDB
81.62
31%
-156
- C4 -
2Y03
9
ADRB1_MELGA
A:
[14-299]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------
K
E
Q
I
R
---------------------------------------------------------------------------------
S
R
V
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
7
PsiBlast_PDB
81.41
31%
-143
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[14-297]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
--------------------------
A
K
E
Q
I
-----
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
D
R
A
S
K
R
---
K
R
V
-----
M
L
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--
61
HHSearch
81.26
32%
-125
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
--
L
---
F
G
F
--
N
T
---
T
--------
G
-----
D
P
T
V
C
S
I
S
N
-
P
---
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
-------------
R
R
K
N
I
F
E
M
L
R
I
D
E
G
LRL
K
I
Y
K
D
---
T
----
E
-------
G
Y
Y
T
I
G
IG
H
-
L
L
T
-------------
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
--------------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
------------------------------
A
A
----------
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
------------
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
-------------
R
---
W
Y
N
Q
T
P
N
R
----
A
K
R
V
I
T
T
F
R
T
G
T
W
D
---
A
Y
G
-----
V
P
L
------
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--
3
PsiBlast_PDB
81.26
29%
-129
- C4 -
4U16
2
?
A:
[13-388]
-----------------------
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I-
L
---
F
-
W
--
Q
Y
F
V
G
K
---
R
---
T
V
-----
P
P
G
E
C
F
I
Q
F
L
S
-
E
P
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
E
GGG
S
G
G
D
E
A
E
K
L
F
N
Q
D
V
-----
D
A
A
---
V
----
R
G
I
L
R
N
A
K
L
-------
K
-
P
V
Y
-------------
D
S
L
--
D
---------------
A
V
R
R
A
A
L
I
------
N
M
--------------
V
F
----------
Q
M
G
---------
E
------------------------------
T
G
----------
V
A
--------------
G
F
------------
T
N
S
-----
L
--------
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
---
S
-----------
R
----
W
Y
N
Q
T
P
N
R
A
---
K
R
V
I
T
T
F
R
T
G
T
WDAYL
I
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
S
C
-
I
P
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
---------------
9
PsiBlast_PDB
81.16
32%
-147
- C4 -
3SN6
1
R:
[185-490]
-------------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
IQ
M
---
H
-
W
YR-----
Q
EAI
N
---
C
Y
-----
A
E
E
T
C
C
D
F
F
-
T
-
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
------------------
K
R
Q
L
Q
K
I
D
K
S
E
G
-----
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
----
L
K
----------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
-
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
---
22
PsiBlast_CBE
81.08
31%
-137
- C4 -
2YCY
6
ADRB1_MELGA
B:
[14-297]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
--------------------------
A
K
E
Q
I
-----
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
D
R
A
S
K
R
---
K
R
V
-----
M
L
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--
34
PsiBlast_CBE
80.75
31%
-145
- C4 -
2Y02
12
ADRB1_MELGA
B:
[14-299]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------
K
E
Q
I
R
K
I
-----------------------------------------
D
-------------
R
A
S
--
K
---------------
R
K
T
S
R
V
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
15
PsiBlast_PDB
80.72
31%
-151
- C4 -
3ZPR
11
ADRB1_MELGA
A:
[14-299]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------
K
E
Q
--------------------------------------------------------------------------------------
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
----
14
PsiBlast_PDB
80.41
31%
-151
- C4 -
3ZPQ
11
ADRB1_MELGA
A:
[14-299]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------
K
E
Q
-----------------------------------------------------------------------------------
S
R
V
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
36
PsiBlast_CBE
80.37
31%
-146
- C4 -
2Y00
12
ADRB1_MELGA
B:
[14-299]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------
K
E
Q
I
R
K
I
-----------------------------------------
D
-------------
R
A
S
--
K
---------------
R
K
T
S
R
V
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
23
PsiBlast_CBE
80.37
31%
-143
- C4 -
2YCX
4
ADRB1_MELGA
B:
[14-297]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
MMH
W
-
W
--
R
D
---
E
---
D
---
P
Q
ALKCY
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
--------------------------
A
K
E
Q
I
-----
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
D
R
A
S
K
R
---
K
R
V
-----
M
L
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
13
PsiBlast_PDB
80.30
31%
-152
- C4 -
4AMJ
12
ADRB1_MELGA
A:
[14-299]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------
K
E
Q
-----------------------------------------------------------------------------------
S
R
V
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
24
PsiBlast_CBE
80.25
31%
-143
- C4 -
2YCW
6
ADRB1_MELGA
B:
[14-297]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
MMH
W
-
W
--
R
D
---
E
---
D
---
P
Q
ALKCY
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
--------------------------
A
K
E
Q
I
-----
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
D
R
A
S
K
R
---
K
R
V
-----
M
L
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--
16
PsiBlast_PDB
80.09
30%
-143
- C4 -
4BVN
11
ADRB1_MELGA
A:
[14-299]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------
K
E
Q
I
R
--------------------------------------------------------------
K
---------------
R
K
T
S
R
V
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
K
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
28
PsiBlast_CBE
80.01
31%
-145
- C4 -
4AMJ
11
ADRB1_MELGA
B:
[14-299]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------
K
E
Q
I
R
K
I
-----------------------------------------
D
-------------
R
A
S
--
K
---------------
R
K
T
S
R
V
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---
30
PsiBlast_CBE
80.00
31%
-144
- C4 -
3ZPR
12
ADRB1_MELGA
B:
[14-299]
-------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--
I
M
M
H
W
-
W
--
R
D
---
E
---
D
---
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
-
T
-
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
------------------
K
E
Q
I
R
K
I
-----------------------------------------
D
-------------
R
A
S
--
K
---------------
R
K
T
S
R
V
M
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
----