@TOME V2.3
(Nov 2016)

Ref. - - Doc.
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3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : 5HT2A_HUMAN: (2016-01-08 )
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV

Atome Classification :

(30 SA) .........10........20........30........40........50........60........70.......---.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180....---...190.......200.....-..210.......----220----......--..230-.---.......240.......250.......260.......270.......-------280-.-----------------------.-------.--------------.----------------------.-------------------------.-------------------..-------------------------.--------------------------------------------290----------------------------------------------.-------------.--.-.---------------------------------------------------.--------.------..-.-----300-------------------.----.-----.--------..---------....310.......320.......330.......340.......350.......360..-.....370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSA---LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRF---NSRTKAFLKIIAVWTISVGIS-MPIPVFGLQDDS----KV-----FKEGSC--LLAD--D---NFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLA-------S---F-----------------------S-------F--------------L----------------------P-------------------------Q-------------------SS-------------------------L--------------------------------------------S------------------------------------------------S-------------E--K-L---------------------------------------------------F--------Q------RS-I-----H---------------------R----E-----P--------GS---------YTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNV-FVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
76 HHSearch 92.5731%-144 - C6 -3PBL DRD3_HUMAN (first) A:[41-472] ----------------------------------------------------------------------------YA---LSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASIWNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS-CPLL-FGFNTT------------GDPTVC--SISN--P---DFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKNIFEMLRIDEGLRLKIYKDT---E-----------------------GYYTIGIGH--------------L----------------------LT------------------------KSPSLNAAKSELDKAIGRNTNGVI-----------------------T--------------------------------------------KDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRML-Q--Q-K---------------------------------------------------R--------WDEAAVNLA-KSRWYNQ---------------------TPNR-A-----KRVITT---FR---------TGTWDAYGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTC---HVSPELYSA-TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC--------------------------------------------------------------------------
70 HHSearch 89.6228%-134 - C6 -2RH1 ADRB2_HUMAN (first) A:[37-477] ----------------------------------------------------------------------EVWVVGMG---IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMK-MWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSL---LTKNKARVIILMVWIVSGLTS-FLPIQMHWYRAT----HQEAINCYAEETC--CDFFTNQ---AYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDEGLRL-------K---IYKDTEGYYTIGIGHLLTKSPSLNA-------AKSELDKAIGRN---T----------------------NGVITKD-------------------E-------------------AEKLFNQDVDAAVRGILRNAKLKPVYDSLDA-----------------------------------------VRRAALINMVF--------------------------------------QMGETGVAGFTNSLRMLQQK---------------------------------------------------RWDEAAVNLA------KSRW-----YNQ-------------------T----P-----NRAKRVITTFR---------TGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN----LIRKEVYIL-LNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL--------------------------------------------------------------------------
69 HHSearch 86.4924%-137 - C6 -3UON ACM2_HUMAN (first) A:[24-457] --------------------------------------------------------------------------VFIV---LVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIG-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVK---RTTKMAGMMIAAAWVLSFILW-APAIL-FWQFIVGV--RT-----VEDGEC--YIQF--FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRINIFEMLRIDEGLRL-------K---I-----------------------Y-------KDTEGYYTIGIGHLLT----------------------KSPSLNAAKSELDKAIGRNTNGVITKD-------------------EA-------------------------EKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGET------------------------------------------------G-------------V--A-G---------------------------------------------------F--------T------NS-L-----RMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITT--------FR---------TGTWDAYPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP----CIPNTVWTI-GYWLCYINSTINPACYALCNATFKKTFKHLLM---------------------------------------------------------------------------
6 PsiBlast_PDB 84.2633%-155 - C6 -2Y03 ADRB1_MELGA A:[4-300] ---------------------------------------------------------------------ELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRG-TWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC-----YQDPGCCDFVTN--R---AYAIASSIISFYIPLLIMI---FVALR-VYREA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------E--Q-I-------------------------------------------------------------------R---------------------------------------------------------------SRVMLM---REHKALKTLGIIMGVFTLCWLPFFLVNIVNVF-----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLLA---------------------------------------------------------------------------
72 HHSearch 84.1426%-136 - C6 -3RZE ENLYS_BPT4 (first) A:[10-443] ---------------------------------------------------------------------------PLV---VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS-KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKY---RTKTRASATILGAWFLSFLWV-IPIL--GWNH-------------RREDKC--ETDF--YDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCNIFEMLRIDEGLRL-------KIYKDTEGYYTIGI--------------G-------H--------------LLTKSPSLNAAKSELDKAIGRNTN-------------------------G-------------------VI-------------------------T--------------------------------------------K------------------------------------------------D-------------E--A-EKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRM----L------QQ-K-----RWDEAAVNLAKSRWYN------Q----T-----P--------NRAKRVITTFRTGTWDAYLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKN----CCNEHLHMF-TIWLGYINSTLNPLIYPLCNENFKKTFKRILHI--------------------------------------------------------------------------
33 PsiBlast_CBE 84.0832%-151 - C6 -2YCW ADRB1_MELGA B:[4-299] ---------------------------------------------------------------------ELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRG-TWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC-----YQDPGCCDFVTN--R---AYAIASSIISFYIPLLIMI---FVALR-VYREA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------E--Q-I-------------------------------------------------------------------RK-I-----D---------------------R-------------------------------ASKRKRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVF-----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLLAF--------------------------------------------------------------------------
25 PsiBlast_CBE 83.9233%-151 - C6 -2Y04 ADRB1_MELGA B:[4-300] ---------------------------------------------------------------------ELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRG-TWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC-----YQDPGCCDFVTN--R---AYAIASSIISFYIPLLIMI---FVALR-VYREA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------E--Q-I-------------------------------------------------------------------RK-I-----D---------------------R----A-----S--------KR---------KTSRVMLM---REHKALKTLGIIMGVFTLCWLPFFLVNIVNVF-----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLLA---------------------------------------------------------------------------
10 PsiBlast_PDB 83.7233%-154 - C6 -3ZPR ADRB1_MELGA A:[4-299] ---------------------------------------------------------------------ELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRG-TWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC-----YQDPGCCDFVTN--R---AYAIASSIISFYIPLLIMI---FVALR-VYREA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------E--Q----------------------------------------------------------------------------------------------------------------------------------------MLM---REHKALKTLGIIMGVFTLCWLPFFLVNIVNVF-----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLL----------------------------------------------------------------------------
5 PsiBlast_PDB 83.4533%-155 - C6 -2Y02 ADRB1_MELGA A:[4-300] ---------------------------------------------------------------------ELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRG-TWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC-----YQDPGCCDFVTN--R---AYAIASSIISFYIPLLIMI---FVALR-VYREA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------E--Q-------------------------------------------------------------------------------------------------------------------------------------SRVMLM---REHKALKTLGIIMGVFTLCWLPFFLVNIVNVF-----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLLA---------------------------------------------------------------------------
26 PsiBlast_CBE 83.2333%-146 - C6 -2Y03 ADRB1_MELGA B:[4-300] ---------------------------------------------------------------------ELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRG-TWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC-----YQDPGCCDFVTN--R---AYAIASSIISFYIPLLIMI---FVALR-VYREA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------E--Q-I-------------------------------------------------------------------RK-I-----D---------------------R----A-----S--------KR---------KTSRVMLM---REHKALKTLGIIMGVFTLCWLPFFLVNIVNVF-----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLLA---------------------------------------------------------------------------
8 PsiBlast_PDB 83.2233%-150 - C6 -4AMJ ADRB1_MELGA A:[4-300] ---------------------------------------------------------------------ELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRG-TWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC-----YQDPGCCDFVTN--R---AYAIASSIISFYIPLLIMI---FVALR-VYREA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------E--Q-------------------------------------------------------------------------------------------------------------------------------------SRVMLM---REHKALKTLGIIMGVFTLCWLPFFLVNIVNVF-----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLLA---------------------------------------------------------------------------