@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT2A_HUMAN: (2016-01-08 )
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70.......---.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180....---...190.......200.....-..210.......----220----......--..230-.---.......240.......250.......260.......270.......-------280-.-----------------------.-------.--------------.----------------------.-------------------------.-------------------..-------------------------.--------------------------------------------290----------------------------------------------.-------------.--.-.---------------------------------------------------.--------.------..-.-----300-------------------.----.-----.--------..---------....310.......320.......330.......340.......350.......360..-.....370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDILCEENTSLS
S
T
T
N
S
L
MQLNDDT
R
L
YSNDFNSGEANTSD
A
F
N
W
T
VDSENRTNLSCEGCL
S
P
S
C
L
S
L
L
H
LQEK
N
W
S
A
---
L
L
T
A
V
V
I
I
L
TIAG
N
I
L
V
I
M
A
V
S
L
E
K
K
L
Q
N
A
T
N
Y
F
L
M
S
L
A
I
A
D
M
L
L
G
F
L
V
M
P
V
S
M
L
T
I
L
Y
GYRWPL
P
S
K
L
C
A
V
W
I
Y
L
D
V
L
F
S
T
A
S
I
M
H
L
C
A
ISL
D
R
Y
V
A
IQNP
I
H
H
S
RF---
N
S
R
T
K
A
F
L
K
I
I
A
V
W
T
I
S
VGIS-MPI
P
V
FGLQD
D
S
----
K
V
-----
F
KEG
S
C
--
L
LAD--D---
N
F
V
L
I
G
S
F
V
S
F
F
I
P
L
T
I
M
V
I
T
Y
F
L
T
I
K
S
L
Q
K
E
A
T
L
C
V
S
D
LGTRAKL
A
-------
S
---
F
-----------------------S-------F--------------L----------------------P-------------------------Q-------------------SS-------------------------L--------------------------------------------
S
------------------------------------------------
S
-------------
E
--
K
-
L
---------------------------------------------------
F
--------
Q
------
R
S
-I-----H---------------------R----E-----P--------GS---------YTG
R
R
T
M
Q
S
I
S
N
E
Q
K
A
C
K
V
L
G
I
V
F
F
L
F
V
V
M
W
C
P
F
F
I
T
N
I
M
A
V
I
C
K
ESCN
E
D
V
I
G
A
L
L
N
V
-
F
V
W
I
G
Y
L
S
S
A
V
N
P
L
V
Y
T
L
F
N
K
T
Y
R
S
A
F
S
R
Y
I
Q
C
Q
YKENKK
P
L
Q
L
I
L
VNTI
P
A
L
AYK
S
S
Q
LQMGQKKNSKQDAKTTDNDC
S
M
V
A
LGKQH
S
E
EASKDNSDGVNEKVSCV
76
HHSearch
92.57
31%
-144
- C6 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------------------------
Y
A
---
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
L
L
-
F
G
F
N
T
T
------------
G
D
P
T
V
C
--
S
I
S
N
--
P
---
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
G
L
RL
K
I
Y
K
D
T
---
E
-----------------------
G
Y
Y
T
I
G
IG
H
--------------
L
----------------------
L
T------------------------
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNT
N
G
VI-----------------------
T
--------------------------------------------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
-
Q
--
Q
-
K
---------------------------------------------------
R
--------
W
D
E
A
A
V
N
L
A
-
K
S
R
W
Y
N
Q
---------------------
T
P
N
R
-
A
-----
K
R
V
I
T
T
---
F
R
---------
T
G
T
W
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
---
H
V
S
P
E
L
Y
S
A
-
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------------------------------------
70
HHSearch
89.62
28%
-134
- C6 -
2RH1
16
ADRB2_HUMAN (first)
A:
[37-477]
----------------------------------------------------------------------
E
V
W
V
V
G
M
G
---
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
W
Y
R
A
T
----
H
Q
E
A
I
N
C
Y
A
E
E
T
C
--
C
D
F
F
TN
Q
---
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
-------
K
---
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
-------
A
K
S
E
L
D
K
A
I
GRN---
T
----------------------
N
GVIT
K
D
-------------------
E
-------------------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
-----------------------------------------
V
R
R
A
A
L
I
N
M
V
F
--------------------------------------
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
---------------------------------------------------
R
W
D
E
A
A
V
N
L
A
------
K
S
R
W
-----
Y
N
Q
-------------------
T
----
P
-----
N
R
A
K
R
V
I
T
T
F
R
---------
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
-
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------
69
HHSearch
86.49
24%
-137
- C6 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------------------------------------------
V
F
I
V
---
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
G
-
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
-
F
W
Q
F
I
V
GV--
R
T
-----
V
E
D
G
E
C
--
Y
I
Q
F
--
F
SN
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
E
G
L
R
L
-------
K
---
I
-----------------------
Y
-------
K
D
TEG
Y
Y
T
I
GIGHLL
T
----------------------
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
-------------------
E
A
-------------------------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
------------------------------------------------
G
-------------
V
--
A
-
G
---------------------------------------------------
F
--------
T
------
N
S
-
L
-----
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
--------
F
R
---------
T
G
T
W
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
----
C
I
P
N
T
V
W
T
I
-
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------------
6
PsiBlast_PDB
84.26
33%
-155
- C6 -
2Y03
9
ADRB1_MELGA
A:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
---------------------------------------------------------------
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
72
HHSearch
84.14
26%
-136
- C6 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------------------------------------
P
L
V
---
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
S
-
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
-
I
P
I
L
--
G
W
N
H
-------------
R
R
E
D
K
C
--
E
T
D
F
--
Y
DV
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
-------
K
I
Y
K
D
TEG
Y
Y
T
I
G
I--------------
G
-------
H
--------------
L
LTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNT
N
-------------------------
G
-------------------
V
I
-------------------------
T
--------------------------------------------
K
------------------------------------------------
D
-------------
E
--
A
-
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
----
L
------
Q
Q
-
K
-----
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
------
Q
----
T
-----
P
--------
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
----
C
C
N
E
H
L
H
M
F
-
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------------------------------------
33
PsiBlast_CBE
84.08
32%
-151
- C6 -
2YCW
6
ADRB1_MELGA
B:
[4-299]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
GMS
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
PQAL
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
-------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------
25
PsiBlast_CBE
83.92
33%
-151
- C6 -
2Y04
12
ADRB1_MELGA
B:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
----
A
-----
S
--------
K
R
---------
K
T
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
10
PsiBlast_PDB
83.72
33%
-154
- C6 -
3ZPR
11
ADRB1_MELGA
A:
[4-299]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
----------------------------------------------------------------------------------------------------------------------------------------
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
----------------------------------------------------------------------------
5
PsiBlast_PDB
83.45
33%
-155
- C6 -
2Y02
13
ADRB1_MELGA
A:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
26
PsiBlast_CBE
83.23
33%
-146
- C6 -
2Y03
8
ADRB1_MELGA
B:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
----
A
-----
S
--------
K
R
---------
K
T
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
8
PsiBlast_PDB
83.22
33%
-150
- C6 -
4AMJ
12
ADRB1_MELGA
A:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
29
PsiBlast_CBE
82.98
33%
-148
- C6 -
2Y00
12
ADRB1_MELGA
B:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
----
A
-----
S
--------
K
R
---------
K
T
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
3
PsiBlast_PDB
82.97
33%
-154
- C6 -
2Y00
13
ADRB1_MELGA
A:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
9
PsiBlast_PDB
82.95
33%
-152
- C6 -
3ZPQ
11
ADRB1_MELGA
A:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
23
PsiBlast_CBE
82.93
33%
-150
- C6 -
3ZPR
12
ADRB1_MELGA
B:
[4-299]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
----
A
-----
S
--------
K
R
---------
K
T
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
----------------------------------------------------------------------------
24
PsiBlast_CBE
82.87
33%
-147
- C6 -
3ZPQ
13
ADRB1_MELGA
B:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
----
A
-----
S
--------
K
R
---------
K
T
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
7
PsiBlast_PDB
82.70
33%
-155
- C6 -
2Y04
13
ADRB1_MELGA
A:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
4
PsiBlast_PDB
82.58
33%
-155
- C6 -
2Y01
12
ADRB1_MELGA
A:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
21
PsiBlast_CBE
82.50
33%
-147
- C6 -
4AMJ
11
ADRB1_MELGA
B:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
----
A
-----
S
--------
K
R
---------
K
T
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
28
PsiBlast_CBE
82.40
33%
-150
- C6 -
2Y01
12
ADRB1_MELGA
B:
[4-300]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
----
A
-----
S
--------
K
R
---------
K
T
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
15
PsiBlast_PDB
82.18
32%
-151
- C6 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
---------------------------------------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
--------
D
---------------------
R
-------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------
31
PsiBlast_CBE
82.06
32%
-150
- C6 -
2YCY
6
ADRB1_MELGA
B:
[9-299]
--------------------------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
-------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------
22
PsiBlast_CBE
81.92
33%
-153
- C6 -
4AMI
6
ADRB1_MELGA
B:
[4-299]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
--------------------------------------------------------------
S
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
----------------------------------------------------------------------------
32
PsiBlast_CBE
81.54
32%
-150
- C6 -
2YCX
4
ADRB1_MELGA
B:
[9-298]
--------------------------------------------------------------------------
Q
W
E
A
GMS
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
PQAL
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
-------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
13
PsiBlast_PDB
81.38
32%
-149
- C6 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
--------------------------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
-------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
-------------------------------------------------------------------------------
12
PsiBlast_PDB
81.15
32%
-149
- C6 -
2YCW
7
ADRB1_MELGA
A:
[4-299]
---------------------------------------------------------------------
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
K
-
I
-----
D
---------------------
R
-------------------------------
A
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------
34
PsiBlast_CBE
79.96
32%
-158
- C6 -
2VT4
8
ADRB1_MELGA
D:
[11-297]
----------------------------------------------------------------------------
E
A
GMS
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
PQAL
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
-------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
----------------------------------------------------------------------------
36
PsiBlast_CBE
79.69
32%
-158
- C6 -
2VT4
9
ADRB1_MELGA
B:
[9-299]
--------------------------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
-------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------
11
PsiBlast_PDB
79.69
32%
-157
- C6 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
---------------------------------------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
-------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------
35
PsiBlast_CBE
78.45
32%
-161
- C6 -
2VT4
7
ADRB1_MELGA
C:
[9-286]
--------------------------------------------------------------------------
Q
W
E
A
GMS
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
PQAL
K
C
-----
Y
Q
D
P
G
C
CD
F
V
T
N
--
R
---
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
---
F
V
A
L
R
-
V
Y
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------
E
--
Q
-
I
-------------------------------------------------------------------
R
-------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
---------------------------------------------------------------------------------------