@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT2C_HUMAN: (2016-01-08 )
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
Atome Classification :
(36 SA)
.........10........20........30........40........50..-....---..60........---70........80........90........100.......110.......120.......130.......140.......150.......160...---....170.......180....-...190--......----.---200---......-..210-.---.---......220.......230.......240......----------------------------------.250..-----------------------------------.....---------------260-----------------..----------------------.-------------.------------------.------------------------.------------.-------.----------270----...--------.--------.-------------------------------------------------.---------------------------------------------.---------------------------------------------.----------------------------280---.---.-------..------------.---.--------..---------------.------290----------....--...300.......310.......320.......330.......340.......350-.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
N
L
R
N
A
V
H
S
F
L
V
H
L
I
G
L
L
V
W
QCDISV
S
P
V
A
A
I
V
T
D
I
FNTSDGG
R
F
KFPDGVQ-NWPA---
L
S
I
V
I
I
I
I
M
TIG---G
N
I
L
V
I
M
A
V
S
M
E
K
K
LH
N
A
T
N
Y
F
L
M
S
L
A
I
A
D
M
L
V
G
L
L
V
M
P
L
S
L
L
A
I
L
Y
D
Y
VW
P
L
P
R
Y
L
C
P
V
W
I
S
L
D
V
L
F
S
T
A
S
I
M
H
L
C
A
ISLD
R
Y
V
A
IRNP
I
E
H
S
RF---
N
S
R
T
K
A
I
M
K
I
A
I
V
W
A
I
SIGVS-VPI
P
V
I--GLRDE
E
----
K
---
V
F
----VNN
T
T
C
-
V
LND--P---
N
---
F
V
L
I
G
S
F
V
A
F
F
I
P
L
T
I
M
V
I
T
Y
C
L
T
I
Y
V
L
R
R
Q
A
L
M
L
----------------------------------LHGHTE-----------------------------------EPPGL---------------
S
L
------------------
D
F
----------------------
L
-------------
K
------------------
C
------------------------C------------K-------R----------N-T----AEE--------E--------N-------------------------------------------------S---------------------------------------------A---------------------------------------------N----------------------------P-----N---
Q
-------
D
Q
------------
N
---
A
--------
R
R
---------------
R
------
K
K
K
----------ERRP--RG
T
M
Q
A
I
NN
E
R
K
A
S
K
V
L
G
I
V
F
F
V
F
L
I
M
W
C
P
F
F
I
T
N
I
L
S
V
L
C
E
KSC
N
Q
K
L
M
E
K
L
L
N
V
-
F
V
W
I
G
Y
V
C
SG
I
N
P
L
V
Y
T
L
F
N
K
I
Y
R
R
A
F
S
N
Y
L
R
C
N
Y
K
VEKKP
P
V
R
Q
I
P
R
V
A
A
TALSG
R
E
L
N
V
N
I
Y
RHTNEPVIEKASDNEPG
I
E
M
Q
V
E
N
L
ELPVN
P
S
S
V
V
S
E
R
I
SSV
1
PsiBlast_PDB
88.14
47%
-144
- C4 -
4IB4
11
5HT2B_HUMAN (first)
A:
[30-416]
------------------------------------------------------
H
W
A
A
---
L
L
I
L
M
V
I
I
P
T
I
G
---
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
Y
---
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
-
I
P
V
P
I
K
--
G
I
E
T
----------
N
-----
P
N
N
I
T
C
-
V
L
T
K
--
E
RF
G
D
---
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
ADN
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
-----------------------------------------K
D
F
R
H
----------
G
F
------------------
D
I
----------------------
L
-------------
V
------------------
G
------------------------
Q
------------
I
-------
D
----------
D
-
A
----
L
K
L
--------
A
--------
N
-------------------------------------------------
E
---------------------------------------------
G
---------------------------------------------
K
----------------------------
V
-----
K
---
E
-------
A
Q
------------
A
---
A
--------
A
E
---------------
Q
------
L
K
T
----------
T
R
N
A
Y
I
Q
K
Y
L
Q
T
I
S
N
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
-
S
C
N
Q
T
T
L
Q
M
L
L
E
I
-
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
----------------------------------------------------------------------
2
PsiBlast_PDB
87.84
47%
-148
- C4 -
4NC3
13
C562_ECOLX
A:
[30-416]
------------------------------------------------------
H
W
A
A
---
L
L
I
L
M
V
I
I
P
T
I
G
---
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
Y
---
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
-
I
P
V
P
I
K
--
G
I
E
T
-
V
----
D
---
N
-----
P
N
N
I
T
C
-
V
L
T
K
--
E
RF
G
D
---
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
ADN
A
A
Q
V
K
D
A
L
T
K
M
RA------------------------------------------------K
D
F
R
H
----------
G
F
------------------
D
I
----------------------
L
-------------
V
------------------
G
------------------------
Q
------------
I
-------
D
----------
D
-
A
----
L
K
L
--------
A
--------
N
-------------------------------------------------
E
---------------------------------------------
G
---------------------------------------------
K
----------------------------
V
-----
K
---
E
-------
A
Q
------------
A
---
A
--------
A
E
---------------
Q
------
L
K
T
----------
T
R
N
A
Y
I
Q
K
Y
L
Q
T
I
S
N
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
-
S
C
N
Q
T
T
L
Q
M
L
L
E
I
-
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
----------------------------------------------------------------------
78
HHSearch
86.37
33%
-137
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------
Y
A
---
L
S
Y
C
A
L
I
L
A
I
V
F
---
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
L
L
F
---
G
F
N
T
T
G
---------------
D
P
T
V
C
-
S
I
S
N
--
P
---
D
---
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
----------------------------------
I
F
E
M
L
R
-----------------------------------
I
D
E
G
L
---------------
R
L
K
I
Y
K
D
-------------
T
E
----------------------
G
-------------
Y
------------------
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
------------
G
-------
R
----------
N
-
T
NGVI
T
K
D
--------
E
--------
A
-------------------------------------------------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
----------------
V
---------------------------------------------
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
-----
R
---
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
-------
Q
---
T
--------
P
N
---------------
R
A
K
R
V
I
-
T
T
F
----------
R
T
G
T
--
W
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
---
H
V
S
P
E
L
Y
S
A
-
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------------------------------------------------------------
75
HHSearch
82.25
29%
-126
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
----------------------------------------------------
V
-
V
G
M
G
---
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
--
H
W
Y
R
A
T
----
H
---
Q
E
A
I
N
C
Y
A
E
E
T
C
-
C
D
F
F
TN
Q
---
A
---
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
----------------------------------
E
M
L
R
I
D
-----------------------------------
E
G
L
R
L
---------------
K
I
Y
K
D
TEGYYTIGIGHLLTK
S
P
----------------------
S
-------------
L
------------------
N
------------------------
A
A
K
S
E
L
D
K
A
I
G--
R
-------
N
----------
T
-
N
----
G
V
I
T
K
D
E
----
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
---
R
---------------------------------------------
M
---------------------------------------------
L
----------------------------
Q
-----
Q
KR
W
D
-------
E
A
------------
A
V
N
L
A
K
S
R
-----
W
Y
N
Q
T
P
N
R
A
K
R
V
-----
I
------
T
T
F
----------
R
T
G
T
--
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
----
L
I
R
K
E
V
Y
I
L
-
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------------------------------
3
PsiBlast_PDB
81.29
28%
-127
- C4 -
4IAR
2
C562_ECOLX
A:
[9-396]
---------------------------------------------
Y
I
Y
Q
D
S
I
S
L
P
W
K
V
---
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
I
S
T
M
Y
T
V
T
G
R
-
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
-
L
P
-
P
F
F
WR
Q
A
---------------------
S
E
C
-
V
V
N
T
--
D
---
H
I
L
-
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
-
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
S
R
I
A
D
----------------------------------
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
ADN
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
PDSPEMKD
F
R
H
G
F
------------------
D
I
----------------------
L
-------------
V
------------------
G
------------------------
Q
------------
I
-------
D
----------
D
-
A
----
L
K
L
--------
A
--------
N
-------------------------------------------------
E
---------------------------------------------
G
---------------------------------------------
K
----------------------------
V
-----
K
---
E
-------
A
Q
------------
A
---
A
--------
A
E
---------------
Q
------
L
K
T
----------
T
R
N
A
--
Y
I
Q
K
Y
L
A
A
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
-----
W
F
H
L
--
A
I
F
D
F
-
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
------------------------------------------------------------------------
74
HHSearch
79.26
26%
-138
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------------
P
L
V
---
V
V
L
S
T
I
C
L
V
T
V
G
---
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
S
-
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
-
I
P
I
L
G
W
--
N
H
------------------
R
R
E
D
K
C
-
E
T
D
F
--
Y
---
D
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
----------------------------------
E
M
L
R
I
D
-----------------------------------
E
G
L
R
L
---------------
K
I
------------------
Y
K
----------------------
D
-------------
T
EG
Y
Y
T
I
G
IGHLLTKSPS
L
N
------------------------
A
A
K
S
E
L
D
K
A
I
GRN
T
-------
N
----------
G
-
V
I---
T
K
D
--------
E
--------
A
-------------------------------------------------
E
---------------------------------------------
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
----------------------------
A
G
F
T
--
N
---
S
L
------
R
M
------------
L
---
Q
--------
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
------
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
--
W
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
----
C
N
E
H
L
H
M
F
-
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------------------------------------------------------------
12
PsiBlast_PDB
77.13
32%
-155
- C4 -
2Y03
9
ADRB1_MELGA
A:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
11
PsiBlast_PDB
76.97
32%
-155
- C4 -
2Y02
13
ADRB1_MELGA
A:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
14
PsiBlast_PDB
76.78
32%
-151
- C4 -
4AMJ
12
ADRB1_MELGA
A:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
9
PsiBlast_PDB
76.75
32%
-155
- C4 -
2Y00
13
ADRB1_MELGA
A:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
15
PsiBlast_PDB
76.48
32%
-155
- C4 -
3ZPQ
11
ADRB1_MELGA
A:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
16
PsiBlast_PDB
76.40
32%
-157
- C4 -
3ZPR
11
ADRB1_MELGA
A:
[8-299]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
---------------------------------------------------------------------------
24
PsiBlast_CBE
76.34
31%
-147
- C4 -
2YCW
6
ADRB1_MELGA
B:
[8-299]
----------------------------------------------------
Q
-
Q
W
E
A
GMS
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
PQAL
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
K
---------------
I
------
D
R
A
----------
S
K
R
K
--
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------------------------------------------------------
10
PsiBlast_PDB
76.16
32%
-156
- C4 -
2Y01
12
ADRB1_MELGA
A:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
13
PsiBlast_PDB
76.01
32%
-154
- C4 -
2Y04
13
ADRB1_MELGA
A:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
7
PsiBlast_PDB
75.83
31%
-148
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
K
---------------
I
------
D
R
A
----------
S
K
R
K
--
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------------------------------------------------------
29
PsiBlast_CBE
75.82
32%
-153
- C4 -
4AMI
6
ADRB1_MELGA
B:
[8-299]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-------------------------------------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
---------------------------------------------------------------------------
79
HHSearch
75.52
24%
-126
- C4 -
3EML
13
ENLYS_BPT4
A:
[20-472]
---------------------------------------------------
G
S
-
S
V
Y
I
---
T
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
P
M
L
---
G
W
N
N
C
G
----
Q
SQG
C
G
----
E
G
Q
V
A
C
-
L
F
E
D
--
V
VP
M
N
Y
--
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
----------------------------------
E
M
L
R
I
D
-----------------------------------
E
G
L
R
L
---------------
K
I
------------------
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
-------------
K
------------------
S
E
L
D
K
A
I
GR----------------
N
------------
T
-------
N
----------
G
-
V
IT--
K
D
E
A
E
K
L
F
N
Q
D
V
--------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
---------------------------------------------
Q
---------------------------------------------
K
----------------------------
R
-----
W
---
D
-------
E
A
A
V
N
---------
L
---
A
K
S
R
W
Y
N
Q
T
P
N
---------------
R
A
K
R
V
I
T
T
F
R
----------
T
G
T
W
--
D
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
-
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------------------------------------------------------
17
PsiBlast_PDB
75.39
31%
-144
- C4 -
4BVN
11
ADRB1_MELGA
A:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
K
----------
T
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
K
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
72
HHSearch
75.38
24%
-132
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
------------------------------------------------------
V
F
I
V
---
L
V
A
G
S
L
S
L
V
T
I
I
---
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
-
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
F
---
W
Q
F
I
V
G---
V
---
R
T
----
V
E
D
G
E
C
-
Y
I
Q
F
--
F
SN
A
A
---
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
----------------------------------
E
M
L
R
I
D
-----------------------------------
E
G
L
R
L
---------------
K
I
------------------
Y
K
----------------------
D
TEG
Y
Y
T
I
GIGHLL
T
------------------
K
------------------------
S
------------
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN
G
V
I
----
T
K
D
--------
E
--------
A
-------------------------------------------------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
---------------------------------------------
V
----------------------------
A
G
F
T
N
S
L
---
R
M
L
-----
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
---
R
--------
W
Y
N
Q
T
P
N
R
A
K
R
V
-----
I
------
T
T
F
----------
R
T
G
T
--
W
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
----
I
P
N
T
V
W
T
I
-
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------------------------------------------------
31
PsiBlast_CBE
75.33
32%
-144
- C4 -
3ZPQ
13
ADRB1_MELGA
B:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-------------------------------------------------
K
---------------------------------------------
I
---------------------------------------------
D
-------------------------------------------------------------------------
R
A
---------------
S
------
K
R
K
----------
T
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
36
PsiBlast_CBE
75.28
32%
-143
- C4 -
2Y00
12
ADRB1_MELGA
B:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-------------------------------------------------
K
---------------------------------------------
I
---------------------------------------------
D
-------------------------------------------------------------------------
R
A
---------------
S
------
K
R
K
----------
T
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
32
PsiBlast_CBE
75.20
32%
-145
- C4 -
2Y04
12
ADRB1_MELGA
B:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-------------------------------------------------
K
---------------------------------------------
I
---------------------------------------------
D
-------------------------------------------------------------------------
R
A
---------------
S
------
K
R
K
----------
T
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
28
PsiBlast_CBE
75.20
32%
-145
- C4 -
4AMJ
11
ADRB1_MELGA
B:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-------------------------------------------------
K
---------------------------------------------
I
---------------------------------------------
D
-------------------------------------------------------------------------
R
A
---------------
S
------
K
R
K
----------
T
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
35
PsiBlast_CBE
75.12
32%
-145
- C4 -
2Y01
12
ADRB1_MELGA
B:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-------------------------------------------------
K
---------------------------------------------
I
---------------------------------------------
D
-------------------------------------------------------------------------
R
A
---------------
S
------
K
R
K
----------
T
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
33
PsiBlast_CBE
75.12
32%
-143
- C4 -
2Y03
8
ADRB1_MELGA
B:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-------------------------------------------------
K
---------------------------------------------
I
---------------------------------------------
D
-------------------------------------------------------------------------
R
A
---------------
S
------
K
R
K
----------
T
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
5
PsiBlast_PDB
75.10
31%
-146
- C4 -
2YCW
7
ADRB1_MELGA
A:
[8-299]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
K
---------------
I
------
D
R
A
----------
S
K
R
K
--
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------------------------------------------------------
6
PsiBlast_PDB
75.04
31%
-143
- C4 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
K
---------------
I
------
D
R
A
----------
S
K
R
K
--
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
------------------------------------------------------------------------------
34
PsiBlast_CBE
75.00
32%
-144
- C4 -
2Y02
12
ADRB1_MELGA
B:
[8-300]
----------------------------------------------------
Q
-
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----------
E
-
A
----
K
E
Q
--------
I
--------
R
-------------------------------------------------
K
---------------------------------------------
I
---------------------------------------------
D
-------------------------------------------------------------------------
R
A
---------------
S
------
K
R
K
----------
T
S
R
V
-------
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
25
PsiBlast_CBE
74.96
31%
-159
- C4 -
2VT4
8
ADRB1_MELGA
D:
[11-297]
--------------------------------------------------------
E
A
GMS
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
PQAL
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
---------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
---------------------------------------------------------------------------
22
PsiBlast_CBE
74.79
31%
-145
- C4 -
2YCY
6
ADRB1_MELGA
B:
[9-299]
------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
K
---------------
I
------
D
R
A
----------
S
K
R
K
--
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------------------------------------------------------
27
PsiBlast_CBE
74.70
31%
-158
- C4 -
2VT4
9
ADRB1_MELGA
B:
[9-299]
------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
---------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------------------------------------------------------
4
PsiBlast_PDB
74.63
31%
-158
- C4 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
-------------------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
---------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
8
PsiBlast_PDB
74.54
31%
-145
- C4 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
-------------------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
P
Q
A
L
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
-----------------------
D
R
A
----------
S
K
R
K
--
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------------------------------------------------------
23
PsiBlast_CBE
73.85
31%
-144
- C4 -
2YCX
4
ADRB1_MELGA
B:
[9-298]
------------------------------------------------------
Q
W
E
A
GMS
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
PQAL
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
K
---------------
I
------
D
R
A
----------
S
K
R
K
--
R
V
M
L
M
---
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------
26
PsiBlast_CBE
72.50
31%
-159
- C4 -
2VT4
7
ADRB1_MELGA
C:
[9-286]
------------------------------------------------------
Q
W
E
A
GMS
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
--
W
W
R
D
E
D
PQAL
K
---
C
Y
----
Q
D
P
G
C
C
D
F
V
T
N
--
R
---
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
-
A
L
R
V
Y
---
R
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
------------
Q
---
I
--------
R
---------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
--------------------------------------------------------------------------------------