@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT5A_HUMAN: (2016-01-08 )
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150---.......160.......170.......180-------...---..-.------.190..-..--.--.---------.-200.......210.......220.......230------------------------------------.......--..240----------------------.-------------------------------.----------------.------------------------.----------.----.------------------------------------.-------------250----...-----------------------------.--------------------.---------------------------------------------.------------------------..-----.-----260--..---.------------------.--------------.---------------....--------------270------------.....-----------------------------..--------------------------------------------.280.......290.......300.......310-.......320-----.......330.......340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDLPV
N
L
T
S
FSLSTPSPLETNHSLGKDDLRPSS
P
L
L
S
V
F
G
V
L
I
L
T
L
L
G
F
L
V
A
A
T
F
A
W
N
L
L
V
L
A
T
I
L
R
V
R
T
F
H
RV
P
H
N
L
V
A
S
M
A
V
S
D
V
L
V
A
A
L
V
M
P
L
S
L
V
H
E
LSGR
R
W
Q
L
G
R
R
L
C
Q
L
W
I
A
C
D
V
L
C
CTASIW
N
V
T
A
I
A
L
D
R
Y
W
S
I
T
R
H
M
E
Y
T
L
R
---
T
R
K
C
V
S
N
V
M
I
A
L
T
W
A
L
S
A
V
I
S
L
A
P
L
L
FGWG-------ETY---SE-G------
S
E
E
CQV-SR--E--P---------S-
Y
A
V
F
S
T
V
G
A
F
Y
L
P
L
C
V
V
L
F
V
Y
W
K
I
Y
K
A
A
K
F
R--------------------------------------VGSRKTN--SVSP
I
----------------------
S
-------------------------------
E
----------------
A
------------------------
V
----------
E
----V------------------------------------K-------------D------SAK-----------------------------Q--------------------
P
---------------------------------------------
Q
------------------------
M
V
-----
F
-----
T
----
V
R
---
H
------------------
A
--------------
T
---------------
V
T
F
Q--------------PE-------------G
D
T
W
R
-----------------------------
E
Q
--------------------------------------------
K
E
Q
R
A
A
L
M
V
G
I
L
I
G
V
F
V
L
C
W
I
P
F
F
L
T
E
L
I
S
P
L
CS-C
D
I
P
A
I
W
K
S
I
-----
F
L
W
LGYSNSFFN
P
L
I
Y
T
AFNKN
Y
N
S
A
F
K
N
F
FSRQH
1
PsiBlast_PDB
94.36
33%
-150
- C2 -
4IAR
2
C562_ECOLX
A:
[21-394]
----------------------------------------
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
I
S
T
M
Y
T
V
T
G
R
-
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
--
F
F
W
R
-------
Q
A
---------------
S
E
C
V
V
-
N
T
--
D
--
H
---------
I
L
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
S
R
--------------------------------------
I
A
D
L
E
D
N
W
E
T
L
N
D
N
----------------------
L
-------------------------------
K
----------------
V
------------------------
I
----------
E
----
K
------------------------------------
A
-------------
D
------
N
A
A
-----------------------------
Q
--------------------
V
---------------------------------------------
K
------------------------
D
A
-----
L
-----
T
K
---
M
R
---
A
------------------
A
--------------
A
---------------
L
D
A
Q
K
A
TPPKL
E
D
K
S
PDS
P
E
-------------
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
GK
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
-----------------------------
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
---------
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
-
37
HHSearch
92.61
34%
-136
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
-
L
F
G
F
N
-------
T
T
G
------
D
------
P
T
V
C
S
I
-
S
N
-----
P
---------
D
-
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
--------------------------------------
R
R
K
N
I
F
E
--
M
L
R
I
D
E
GLRL-----------------
K
-------------------------------
I
Y
K
--------------
D
------------------------
T
----------
E
----
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
-------------
D
------
E
A
E
-----------------------------
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
---------------------------------------------
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
-----
M
----
L
Q
---
Q
------------------
K
--------------
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G--
T
W
-------------
D
A
Y
G
V
-----------------------------
P
L
--------------------------------------------
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
H
V
S
P
E
L
Y
S
A
-----
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--
49
Fugue
90.33
27%
-142
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
RATH
Q
E
A
I
N
C
---
Y
A
-
E
------
E
T
C
C
D
F
-
F
T
--
N
--
Q
---------
A
-
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
--
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
-------------------------------
A
----------------
V
------------------------
R
----------
G
----
I
------------------------------------
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
------
V
R
R
-----------------------------
A
--------------------
A
---------------------------------------------
L
------------------------
I
N
-----
M
-----
V
----
F
Q
---
M
------------------
G
--------------
E
---------------
T
G
V
A
--------------
G
F
-------------
T
N
S
L
R
-----------------------------
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
-
N
L
I
R
K
E
V
Y
I
L
-----
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--
32
HHSearch
90.28
27%
-128
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-------
R
A
T
---
H
Q
-
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
--
N
--
Q
---------
A
-
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--------------------------------------
L
N
I
F
E
M
L
--
R
I
D
E
G
----------------------
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
----------------
L
------------------------
D
----------
K
A
I
GR
N
------------------------------------
T
-------------
N
GVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
-------------------
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
-----------------------
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
----------
A
K
-----
S
-----
R
----
W
Y
N
--
Q
------------------
T
--------------
P
N
R
A
K
R
V
I
T
T
------
F
R
T
G
--------------
T
W
-------------
D
A
Y
K
F
-----------------------------
C
L
--------------------------------------------
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
-
N
L
I
R
K
E
V
Y
I
L
-----
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--
3
PsiBlast_PDB
87.95
29%
-144
- C2 -
2YCW
7
ADRB1_MELGA
A:
[17-298]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
------------------------------------------------------------------------------------------------------------
E
----------------
Q
------------------------
I
----------
R
----
K
------------------------------------
I
-------------
D
------
R
A
S
-----------------------------
K
--------------------
R
---------------------------------------------
K
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--
5
PsiBlast_PDB
87.64
29%
-144
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[17-298]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
------------------------------------------------------------------------------------------------------------
E
----------------
Q
------------------------
I
----------
R
----
K
------------------------------------
I
-------------
D
------
R
A
S
-----------------------------
K
--------------------
R
---------------------------------------------
K
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--
9
PsiBlast_PDB
87.60
29%
-153
- C2 -
2Y02
13
ADRB1_MELGA
A:
[17-300]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---
7
PsiBlast_PDB
87.59
29%
-153
- C2 -
2Y00
13
ADRB1_MELGA
A:
[17-300]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---
2
PsiBlast_PDB
87.54
29%
-150
- C2 -
2VT4
8
ADRB1_MELGA
A:
[17-298]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
------------------------------------------------------------------------------------------------------------
E
----------------
Q
------------------------
I
----------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---
10
PsiBlast_PDB
87.33
29%
-154
- C2 -
2Y03
9
ADRB1_MELGA
A:
[17-300]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------
I
--
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---
6
PsiBlast_PDB
87.17
29%
-145
- C2 -
2YCY
6
ADRB1_MELGA
A:
[17-298]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
------------------------------------------------------------------------------------------------------------
E
----------------
Q
------------------------
I
----------
R
-------------------------------------------------------
D
------
R
A
S
-----------------------------
K
--------------------
R
---------------------------------------------
K
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--
13
PsiBlast_PDB
87.03
29%
-147
- C2 -
3ZPQ
11
ADRB1_MELGA
A:
[17-300]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---
8
PsiBlast_PDB
86.73
29%
-153
- C2 -
2Y01
12
ADRB1_MELGA
A:
[17-300]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---
4
PsiBlast_PDB
86.49
29%
-144
- C2 -
2YCX
3
ADRB1_MELGA
A:
[17-294]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
------------------------------------------------------------------------------------------------------------
E
----------------
Q
------------------------
I
----------
R
----
K
------------------------------------
I
-------------
D
------
R
A
S
-----------------------------
K
--------------------
R
---------------------------------------------
K
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
-------
12
PsiBlast_PDB
86.43
29%
-149
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[17-300]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---
11
PsiBlast_PDB
86.35
29%
-153
- C2 -
2Y04
13
ADRB1_MELGA
A:
[17-300]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---
14
PsiBlast_PDB
85.75
29%
-150
- C2 -
3ZPR
11
ADRB1_MELGA
A:
[17-299]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
D
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
----
33
HHSearch
85.71
28%
-132
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
-
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
-
I
P
I
-
L
G
W
N
-------
H
-------R
R
------
E
D
K
C
E
T
-
D
F
--
Y
DV
T
---------
W
-
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
--------------------------------------
C
N
I
F
E
M
L
--
R
I
D
E
G
----------------------
L
R
L
K
I
Y
K
D
TE----------------------
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN---------
G
----------
V
----
I
------------------------------------
T
K
------------
D
------
E
A
E
-----------------------------
K
--------------------
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
------------------------
G
F
-----
T
-----
N
S
L
R
M
L
Q
---
Q
------------------
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
---------------
N
Q
T
P
--------------
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
L
H
-----------------------------
M
N
--------------------------------------------
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
-
N
C
C
N
E
H
L
H
M
F
-----
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--
15
PsiBlast_PDB
85.44
29%
-145
- C2 -
4BVN
11
ADRB1_MELGA
A:
[17-300]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
G
T
-
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
-------
R
-----
D
E
-
D
------
P
Q
A
L
K
C
-
Y
Q
--
D
--
P
GCCDFVTN
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------
I
--
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
-----------------------------
K
--------------------
T
---------------------------------------------
S
------------------------
R
V
-----
M
-----
L
----
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
L
V
P
K
W
L
F
V
A
-----
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
---
31
HHSearch
84.61
25%
-128
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[26-457]
------------------------------------------
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
-
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
-
I
L
F
W
Q
-------
F
I
V
GVR
T
V
-
E
------
D
G
E
C
Y
I
-
Q
F
FS
N
--
A
---------
A
-
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
--------------------------------------
I
N
I
F
E
M
L
--
R
I
D
E
G
----------------------
L
RL
K
I
Y
--------------------------
K
----------------
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN
G
VI--
T
------------------------------------
K
-------------
D
------
E
A
E
-----------------------------
K
--------------------
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG----
E
------------------------
T
G
-----
V
A
G
F
T
N
S
----
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
--------------
P
---------------
N
R
A
K
R
V
I
T
T
F
R
TG-----
T
W
-------------
D
A
Y
P
P
-----------------------------
P
S
--------------------------------------------
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
-
P
C
I
P
N
T
V
W
T
I
-----
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---