@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : 5HT6R_HUMAN: (2016-01-08 )
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN

Atome Classification :

(25 SA) .........10........20........30........40........50........60........70........80........-90........100.......110.......120.......130.....---..140.......150.......160.......170.---.----.------....180....---.--...190.......200.......210.......220.......230-----.------------------------.-------------------.--------------------------.---------------------------------.----------------------.------.240--------------------------------------------------------------.----------------------------------------------.-----------.---------------------------------------------------------.------------------.--.---------------------.---------------.----------.-----------250.------------.......260.......270.......280.......290..-.---.-...300.......310.......320-.........330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALY-GRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLR---MTPLRALALVLGAWSLAALASFLPLLLGWHELGHAR---P----P------VPGQCR-LLAS---L--PFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQ-----A------------------------S-------------------E--------------------------T---------------------------------L----------------------Q------VP----------------------------------------------------------------R----------------------------------------------T-----------P---------------------------------------------------------R------------------P--G---------------------V---------------E----------S-----------AD-S------------RRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVC-D---C-ISPGLFDVLTWLGYCNSTMNPIIY---PLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
43 HHSearch 92.7730%-145 - C5 -2RH1 ADRB2_HUMAN (first) A:[40-477] -------------------------VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILM-KMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSL---LTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINC----Y------AEETCCDFFTN---Q--AYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDEGLR-----L------------------------KIYKDTEGYYTIGIGHLLTKSPSLN----------------------AAKSELD---------------------------KAIGR------------------N------TNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVA-------GFTNSLRML--------------------------------------QQKRWDEAAVNLA---------------------------------------------------------K------------------SRWYN--------------------Q---------------TPNRAKRVITTF-----------RT-G------------TWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQ-DN--L-IRKEVYILLNWIGYVNSGFNPLIY---C-RSPDFRIAFQELLCL-------------------------------------------------------------------------------------------------------
50 HHSearch 89.4231%-149 - C5 -3PBL DRD3_HUMAN (first) A:[41-472] ----------------------------YALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASIWNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVS-CPLLFGFNTTG------------------DPTVCS-ISN----P--DFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKNIFEMLRIDEGLRLKIY------------------------K-------------------D--------------------------TEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTN----------------------GVIT---KD----------------------------------------------------------------E----------------------------------------------A-----------EKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQ--T---------------------P---------------N----------RAKRVITTF---RT-G------------TWDAYGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHC-QTC-H-VSPELYSATTWLGYVNSALNPVIY---TTFNIEFRKAFLKILSC-------------------------------------------------------------------------------------------------------
45 HHSearch 85.9730%-143 - C5 -3RZE ENLYS_BPT4 (first) A:[9-443] --------------------------MPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLM-SKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKY---RTKTRASATILGAWFLSFLWV-IPIL-GWNH-------------R------REDKCE-TDFY---DVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCNIFEMLRIDEGLR-----LKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGR-------N--------------------------T---------------------------------NGVITK-----------------D------EA----------------------------------------------------------------EKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGV-----------AGFTNSLRML------------------------------------------------Q------------------Q--K---------------------RWDEAAVNLAKSRW--Y----------N-----------QTPNRAKRVITTFRTGTWDAYLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFC-K---NCCNEHLHMFTIWLGYINSTLNPLIY---PLCNENFKKTFKRILHI-------------------------------------------------------------------------------------------------------
48 HHSearch 85.5724%-145 - C5 -3EML ENLYS_BPT4 A:[20-472] ------------------------GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST---GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGL---VTGTRAKGIIAICWVLSFAIGLTPML-GWNNCGQ-----------SQGCGEGQVACL-FEDVVPMN--YMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLNIFEMLRIDEGLR-----L------------------------K-------------------IYKDTEGYYTIGIGHLLTKSPSLNAAKSE--------------------------------L----------------------DKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRM----------------------------------------------L-----------Q---------------------------------------------------------Q------------------K--R---------------------WDEAAVNLAKSRWYNQT----------PNRAKRVITTFRTG-T------------WDAYRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFC-PDCSH-APLWLMYLAIVLSHTNSVVNPFIY---AYRIREFRQTFRKIIRSHVLRQ--------------------------------------------------------------------------------------------------
41 HHSearch 84.0425%-143 - C5 -3UON ACM2_HUMAN (first) A:[23-457] -------------------------VVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVI-GYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVK---RTTKMAGMMIAAAWVLSFILW-APAILFWQFIVGVR---T----V------EDGECY-IQFFSN-A--AVTFGTAIAAFYLPVIIMTVLYWHISRASKSRINIFEMLRIDEGLR-----L------------------------KIYKDTEGYYTIGIGHLLTKS--------------------------P---------------------------------SLNAAKSELDKAIGRNTNGVITKD------EA----------------------------------------------------------------EKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGET-G-----------V---------------------------------------------------------AGFTNS-------------L--RMLQQKRWDEAAVNLAKSRWYNQ---------------T----------PNRAKRVITTF-RT-G------------TWDAYPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFC-AP--C-IPNTVWTIGYWLCYINSTINPACY---ALCNATFKKTFKHLLM--------------------------------------------------------------------------------------------------------
8 PsiBlast_PDB 83.6635%-164 - C5 -2Y02 ADRB1_MELGA A:[18-300] --------------------------------MALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVR-GTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQ---ALKCYQ------DPGCCD-FVTN---R--AYAIASSIISFYIPLLIMIFVALRVYREAKEQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVMLMREHKALK---TLGIIMGVFTLCWLPFFLVNIVNVFNRD---L-VPDWLFVAFNWLGYANSAMNPIIYCRSP----DFRKAFKRLLA--------------------------------------------------------------------------------------------------------
24 PsiBlast_CBE 82.9834%-152 - C5 -2YCW ADRB1_MELGA B:[18-299] --------------------------------MALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVR-GTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQ---ALKCYQ------DPGCCD-FVTN---R--AYAIASSIISFYIPLLIMIFVALRVYREAKEQIRKID---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----------A-----------SK-R------------KRVMLMREHKALK---TLGIIMGVFTLCWLPFFLVNIVNVFNRD---L-VPDWLFVAFNWLGYANSAMNPIIYCRSP----DFRKAFKRLLAF-------------------------------------------------------------------------------------------------------
11 PsiBlast_PDB 82.8635%-157 - C5 -4AMJ ADRB1_MELGA A:[18-300] --------------------------------MALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVR-GTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQ---ALKCYQ------DPGCCD-FVTN---R--AYAIASSIISFYIPLLIMIFVALRVYREAKEQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVMLMREHKALK---TLGIIMGVFTLCWLPFFLVNIVNVFNRD---L-VPDWLFVAFNWLGYANSAMNPIIYCRSP----DFRKAFKRLLA--------------------------------------------------------------------------------------------------------
10 PsiBlast_PDB 82.8535%-164 - C5 -2Y04 ADRB1_MELGA A:[18-300] --------------------------------MALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVR-GTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQ---ALKCYQ------DPGCCD-FVTN---R--AYAIASSIISFYIPLLIMIFVALRVYREAKEQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVMLMREHKALK---TLGIIMGVFTLCWLPFFLVNIVNVFNRD---L-VPDWLFVAFNWLGYANSAMNPIIYCRSP----DFRKAFKRLLA--------------------------------------------------------------------------------------------------------
6 PsiBlast_PDB 82.7735%-165 - C5 -2Y00 ADRB1_MELGA A:[18-300] --------------------------------MALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVR-GTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQ---ALKCYQ------DPGCCD-FVTN---R--AYAIASSIISFYIPLLIMIFVALRVYREAKEQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVMLMREHKALK---TLGIIMGVFTLCWLPFFLVNIVNVFNRD---L-VPDWLFVAFNWLGYANSAMNPIIYCRSP----DFRKAFKRLLA--------------------------------------------------------------------------------------------------------