@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT7R_HUMAN: (2016-01-08 )
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.---......200.......210..-.....-220...----.--------.-------..230------..-------..--..---...240.......250.......260......----------------------------------------.270-.......280-------..-------------------------.-------------.----------------------------.-----------------------------.-----------.290-----..------.---------------.------------------------------------------..--------------------------------------------------.----------------------------------------------.--------------------------------------------.--------------------------300------------.---------------.---.------------------------.--.------------.----------.---------.310.......320--.........330.......340.......350.......-360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMDVNSSGR
P
D
L
Y
G
H
L
R
S
F
L
L
P
E
VGRGLPDLSPDGGADPVAGS
W
A
P
H
L
L
S
E
V
TASPAPTWDAPPDNASGCGEQINY
G
R
V
E
K
V
V
I
G
S
I
L
T
L
I
T
L
L
T
IAG
N
C
L
V
V
I
S
V
C
F
V
K
K
LRQPS
N
Y
L
I
V
S
L
A
L
A
D
L
S
V
A
V
A
V
M
P
F
V
S
V
T
D
LIGGK
W
I
F
G
H
F
F
C
N
V
F
I
A
M
D
V
M
C
C
T
A
S
I
M
T
L
C
V
I
S
I
D
R
YLGITRPLTYPVR---QN
G
K
C
M
A
K
M
I
L
S
V
W
L
L
SASIT-LPPLF-GWAQNV----N--------D-------D
K
V
--------
C
L
-------
I
S--QD---F
G
Y
T
I
Y
S
T
A
V
A
F
Y
I
P
M
S
V
M
L
F
M
Y
Y
Q
I
Y
K
A
A
R
K
----------------------------------------SAAK-HKFPGFPRVE-------PD-------------------------
S
-------------
V
----------------------------
I
-----------------------------
A
-----------
L
N
-------
G
I
------
V
---------------
K
------------------------------------------
L
Q
--------------------------------------------------
K
----------------------------------------------
E
--------------------------------------------
V
--------------------------
E
-
E
------------
C
---------------
A
---
N
------------------------
L
--
S
------------
R
----------
L
---------
L
K
H
E
RKNI
S
I
F
K
----
R
E
Q
KA
A
T
T
L
G
I
I
V
G
A
F
T
V
C
W
L
P
F
F
L
L
STARP
F
I
CGTSC
S
-
C
I
P
L
W
V
E
R
T
F
L
W
L
G
Y
A
N
S
L
I
N
P
F
I
Y
A
F
FNR
D
L
R
T
T
Y
R
S
L
L
Q
C
Q
Y
R
N
INR
K
L
S
A
A
G
M
H
E
A
L
K
L
AERPER
P
E
F
V
L
R
A
C
T
R
R
V
LLRPEKRP
P
V
S
V
W
V
LQSPDHH
N
W
L
A
D
K
M
L
T
T
V
E
K
K
V
MIHD
74
HHSearch
91.05
35%
-136
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
L
L
F
-
G
F
N
T
T
G
-------------
D
-------
P
T
V
--------
C
S
-------
I
S
--
N
----
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
----------------------------------------
R
R
R
K
-
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
-------------------------
T
-------------
E
----------------------------
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GR
N
-----------
T
N
-------
G
V
------
I
---------------
T
------------------------------------------
K
D
--------------------------------------------------
E
----------------------------------------------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
-------------
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
------------
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
---
T
P
N
----------------------
R
--
A
K
R
V
I
T
-------
T
----------
F
---------
R
T
G
T
W
D
A
Y
G
V
P
L
----
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
---
C
-
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------------------------------------------------------------------
1
PsiBlast_PDB
89.33
36%
-145
- C5 -
4IAR
2
C562_ECOLX
A:
[20-396]
--------------------------------------------------------------------------------
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
-
I
S
T
M
Y
T
V
T
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
-
L
P
P
F
F
--
W
R
Q
A
-------------------------S
E
------
C
V
-------
V
N
--
T
D
H--
I
L
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
ADN
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
-
A
T
P
P
K
L
E
D
K
S
-------
P
D
-------------------------
S
PEMKD
F
R
H
G
F
D
I
L
V
----------------------------
G
-----------------------------
Q
-----------
I
D
-------
D
A
------
L
---------------
K
------------------------------------------
L
A
--------------------------------------------------
N
----------------------------------------------
E
GK------------------------------------------
V
--------------------------
K
-
E
------------
A
---------------
Q
---
A
------------------------
A
--
A
------------
E
----------
Q
---------
L
K
T
T
R
-
N
A
Y
I
Q
K
Y
L
A
A
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
-
I
-------
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
-----------------------------------------------------------------------------
67
HHSearch
88.92
31%
-144
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
------------------------------------------------------------------------------
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
-
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
W
Y
R
A
T
----
H
Q
-------
E
A
I
N
C
Y
A
E
E
T
C
--------
C
D
-------
F
F
--
T
N
---
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
----------------------------------------
Q
L
N
I
-
F
E
M
L
R
I
D
E
G
L
-------
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
-------------
A
----------------------------
K
S
----------------------------
E
L
D
K
A
I
G-----
R
N
-------
T
N
GVIT
K
D
E
---------------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
--------------------------------------------------
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K------------------------------
R
--------------------------------------------
W
--------------------------
D
-
E
A
A
V
N
L
-------
A
---------------
K
---
S
R
-----------------------
W
--
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
----------
F
---------
R
T
G
T
W
D
A
Y
K
F
C
L
----
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
----
N
-
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------
66
HHSearch
83.82
31%
-129
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[22-457]
-------------------------------------------------------------------------------
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
-
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
-
F
W
Q
F
I
V
GVRT
V
--------
E
-------
D
G
E
--------
C
Y
-------
I
Q
--
F
F
SN-
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
----------------------------------------
R
I
N
I
-
F
E
M
L
R
I
D
E
G
L
-------
R
L
-------------------------
K
I
Y
K
D
TE-------
G
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
G
R
-----------------------------
N
-----------
T
N
-------
G
V
------
I
---------------
T
------------------------------------------
K
D
--------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
--------------------------------------------
G
--------------------------
V
-
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S----
R
---
W
------------------------
Y
N
Q
T
------------
P
N
R
A
K
R
V
I
T
T
-
F
---------
R
T
G
T
W
D
A
Y
P
P
P
S
----
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
-----
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------------------------------------------------
70
HHSearch
79.97
30%
-128
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
-
L
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
-
I
P
I
L
--
G
W
N
H
------
R
--------
R
-------
E
D
K
--------
C
E
-------
T
D
--
F
Y
DV-
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
----------------------------------------
H
C
N
I
-
F
E
M
L
R
I
D
E
G
L
-------
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS--
L
-------------
N
----------------------------
A
-----------------------------
A
K
S
E
L
D
K
A
I
GRN
T
N
-------
G
V
------
I
---------------
T
------------------------------------------
K
D
--------------------------------------------------
E
----------------------------------------------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
--------------------------
T
-
G
------------
V
---------------
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
--
T
------------
P
----------
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
N
----
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
-----
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------------------------------------------------------------------
72
HHSearch
79.94
28%
-133
- C5 -
3EML
13
ENLYS_BPT4
A:
[20-472]
-------------------------------------------------------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
-
S
--
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
P
M
L
-
G
W
N
N
C
G
----
Q
----------------
S
Q
G
--------
C
G
EGQVACL
F
E
--
D
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
----------------------------------------
Q
L
N
I
-
F
E
M
L
R
I
D
E
G
L
-------
R
L
-------------------------
K
-------------
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
-----
A
-----------------------------
A
-----------
K
S
E
L
D
K
A
I
G
R
N
------
T
NGVIT
K
D
E
A
E
K
L
F
N
Q
D
------------------------------------------
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
----------------------------------------------
K
R
W
------------------------------------------
D
--------------------------
E
-
A
------------
A
V
N
L
------------
A
---
K
S
R
W
Y
--------------------
N
--
Q
T-----------
P
N
R
A
K
R
V
I
T
T
F
R
---------
T
G
T
W
D
A
Y
R
S
T
L
Q
----
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
-
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------------------------------------
16
PsiBlast_PDB
79.32
31%
-149
- C5 -
3SN6
1
R:
[164-489]
---------------------------------------------------
I
T
T
F
R
T
G
T
W
D
A
---------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
-
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-
H
W
Y
R
---------------
Q
-------
E
A
I
NCYAEETC
C
D
-------
F
F
--
T
N
---
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
----------------------------------------
Q
L
Q
K
I
D
K
S
E
G
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
----
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----
Q
D
N
-
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-------------------------------------------------------------------------------
15
PsiBlast_PDB
79.18
33%
-136
- C5 -
4BVN
11
ADRB1_MELGA
A:
[17-300]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
------------------------------------------------------------------
K
R
K
T
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
K
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
14
PsiBlast_PDB
78.96
33%
-145
- C5 -
3ZPR
11
ADRB1_MELGA
A:
[17-299]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
-------------------------------------------------------------------------------------------------------
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--------------------------------------------------------------------------------
38
PsiBlast_CBE
78.67
31%
-170
- C5 -
4MQT
2
ACM2_HUMAN
A:
[39-334]
-------------------------------------------------------------------------------
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
G
-
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
-
F
W
Q
F
I
V
----
G
VRTV----
E
-------
D
G
E
--------
C
Y
-------
I
Q
FF
S
N
---
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
-------
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
-----
V
L
I
N
T
F
C
A
P
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
C
------------------------------------------------------------------------------
27
PsiBlast_CBE
78.40
34%
-147
- C5 -
2VT4
9
ADRB1_MELGA
B:
[17-299]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
----------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------
7
PsiBlast_PDB
78.17
33%
-145
- C5 -
2Y00
13
ADRB1_MELGA
A:
[17-300]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
---------------------------------------------------------------------------------------------------
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
12
PsiBlast_PDB
78.13
33%
-143
- C5 -
4AMJ
12
ADRB1_MELGA
A:
[17-300]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
---------------------------------------------------------------------------------------------------
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
10
PsiBlast_PDB
78.09
33%
-148
- C5 -
2Y03
9
ADRB1_MELGA
A:
[17-300]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
----------------------------------------------------------------------
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
5
PsiBlast_PDB
77.95
34%
-139
- C5 -
2YCZ
2
ADRB1_MELGA
A:
[17-299]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
---
K
------------------------
I
--
D
------------
R
----------
A
---------
S
K
R
K
R
---
V
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------
8
PsiBlast_PDB
77.90
33%
-144
- C5 -
2Y01
12
ADRB1_MELGA
A:
[17-300]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
---------------------------------------------------------------------------------------------------
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
13
PsiBlast_PDB
77.89
33%
-143
- C5 -
3ZPQ
11
ADRB1_MELGA
A:
[17-300]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
---------------------------------------------------------------------------------------------------
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
31
PsiBlast_CBE
77.88
33%
-138
- C5 -
3ZPQ
13
ADRB1_MELGA
B:
[17-300]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
---
K
------------------------
I
--
D
------------
R
----------
A
---------
S
K
R
K
T
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
36
PsiBlast_CBE
77.86
33%
-139
- C5 -
2Y00
12
ADRB1_MELGA
B:
[17-300]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
---
K
------------------------
I
--
D
------------
R
----------
A
---------
S
K
R
K
T
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
9
PsiBlast_PDB
77.84
33%
-145
- C5 -
2Y02
13
ADRB1_MELGA
A:
[17-300]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
---------------------------------------------------------------------------------------------------
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
22
PsiBlast_CBE
77.71
34%
-138
- C5 -
2YCY
6
ADRB1_MELGA
B:
[17-299]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
---
K
------------------------
I
--
D
------------
R
----------
A
---------
S
K
R
K
R
---
V
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------
25
PsiBlast_CBE
77.69
34%
-145
- C5 -
2VT4
8
ADRB1_MELGA
D:
[17-297]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
PQALKCYQ
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
----------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--------------------------------------------------------------------------------
29
PsiBlast_CBE
77.24
33%
-144
- C5 -
4AMI
6
ADRB1_MELGA
B:
[17-299]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
P
Q
A
L
K
C
Y
Q
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
---
K
------------------------------------------------------------------
S
R
V
-
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
--------------------------------------------------------------------------------
23
PsiBlast_CBE
76.60
34%
-136
- C5 -
2YCX
4
ADRB1_MELGA
B:
[17-298]
--------------------------------------------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
D
E
----
D
PQALKCYQ
D
-------
P
G
C
--------
C
D
-------
F
V
--
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
------------
I
---------------
R
---
K
------------------------
I
--
D
------------
R
----------
A
---------
S
K
R
K
R
---
V
M
L
M
----
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
-
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------