@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ADA2A_HUMAN: (2016-01-08 )
MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Atome Classification :
(20 SA)
.........10........20..-..-....30.....------...40.....----...50........60........70........80.....-...90.....-.-..100.......110.......120.......130...---....140.---......150.......160.....-..170.......180..------..---.-..190-..------..--....200.......210....-...220.......230...-------------------..---..240-.-....-..250.......260.......270....-----------...280.......290.......300....-----...310-.......320......-.330.--....--------..340.--------......--------350.......360...----------------------.----------------------...370--..-------------------.....380.......390.......--.--400----.--....-...410.......420.......430.....-..-440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGSLQPDAGNASWNGTEAPGGGA-RA-T
P
Y
S
L
Q
V
T
L
T
L
------
V
C
L
A
G
L
L
M
L
L
----
T
V
FGN
V
L
V
I
I
A
V
F
T
S
R
A
LKAPQ
N
L
F
L
V
S
LASA
D
I
L
V
A
T
L
V
-
I
P
F
S
L
A
N
E
V
M
-
G
-
Y
W
Y
F
G
K
A
W
C
E
I
Y
L
A
L
D
V
L
F
C
T
S
S
I
V
H
L
C
A
I
S
L
D
R
Y
W
S
I
---
T
Q
A
I
E
Y
N
L---KRTPR
R
I
K
A
I
I
I
T
V
W
V
I
S
A
V
ISFP-P
L
I
S
I
E
KKGGGGGPQPA------EP---R-CEIN--DQ------
K
W
--
Y
V
I
S
S
C
I
G
S
F
F
A
P
C
L
I
M
I
L
V
Y
-
V
R
I
Y
Q
I
A
K
R
RTRVPPSRRG-------------------PD---AVAAP-P-GGTE-RRPNGLGPERSAGPGGAEAEPLPTQLNGA-----------PGEPAPAGPRDTDALDLEESSSSDHAERPP-----GPRRPE-RGPRGKGKARASQVKP-GDSLP--RRGP--------GATGIG--------TPAAGP--------G
E
E
RVG
A
A
K
A
S
R
WRGR----------------------Q----------------------NR
E
K
R
F
--
T
F
-------------------
V
L
A
V
V
I
G
V
F
V
V
C
W
F
P
F
-
F
F
T
Y
T
L
T
A--V--GC-----S--
V
P
R
T
-
L
F
K
F
F
F
W
F
G
Y
CNSSLN
P
V
I
Y
T
I
F
N
H
D
F
R
R
A
F
-
K
K
-
I
LCRGDRKRIV
4
PsiBlast_PDB
92.01
31%
-162
- C4 -
3P0G
1
ENLYS_BPT4
A:
[47-477]
----------------------------------------------
V
M
S
L
I
V
L
A
----
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
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T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
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L
C
V
I
A
V
D
R
Y
F
A
I
---
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
---
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
---
C
-
C
D
F
F
--
T
N
------
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L
K
E
H
K
A
L
K
-----------
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
--
I
--
Q
D
-----
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
-
L
L
C
L
R
R
-----
6
PsiBlast_PDB
90.62
31%
-94
- C4 -
3NY8
7
ENLYS_BPT4
A:
[47-477]
----------------------------------------------
V
M
S
L
I
V
L
A
----
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
---
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
---
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
---
C
-
C
D
F
F
--
T
N
------
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
-------------------
D
E
---
G
L
R
L
K
-
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P---------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
--
I
--
Q
D
-----
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
-
L
L
C
L
-------
3
PsiBlast_PDB
90.12
31%
-93
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[46-476]
----------------------------------------------
V
M
S
L
I
V
L
A
----
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
---
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
---
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
---
C
-
C
D
F
F
--
T
N
------
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
-------------------
D
E
---
G
L
R
L
K
-
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P
---------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
--
I
--
Q
D
-----
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
-
L
L
C
L
-------
5
PsiBlast_PDB
90.05
31%
-98
- C4 -
3D4S
6
ENLYS_BPT4
A:
[47-477]
----------------------------------------------
V
M
S
L
I
V
L
A
----
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
---
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
---
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
---
C
-
C
D
F
F
--
T
N
------
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
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R
I
-------------------
D
E
---
G
L
R
L
K
-
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
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F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P
---------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
--
I
--
Q
D
-----
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
-
L
L
C
L
-------
7
PsiBlast_PDB
89.90
31%
-93
- C4 -
3NY9
4
ADRB2_HUMAN (first)
A:
[47-477]
----------------------------------------------
V
M
S
L
I
V
L
A
----
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
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C
V
T
A
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---
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A
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---
C
-
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--
T
N
------
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
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P
L
V
I
M
V
F
V
Y
-
S
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F
Q
E
A
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R
Q
L
N
I
F
E
M
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R
I
-------------------
D
E
---
G
L
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L
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-
I
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D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
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D
A
V
R
R
A
A
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I
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M
G
E
T
G
V
A
GF
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P---------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
--
I
--
Q
D
-----
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
-
L
L
C
L
-------
2
PsiBlast_PDB
89.45
32%
-95
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------
Y
A
L
S
Y
C
------
A
-----
L
I
L
A
----
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
-
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
---
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
-
L
L
F
G
F
N
T
T
G
--------------
D
P
---
T
V
C
S
I
S
--
N
P
------
D
---
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
-
A
R
I
Y
V
V
L
K
Q
R
R
R
----
K
N
I
-------------------
F
E
---
M
L
R
I
D
-
E
-
G
L
R
L
-
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-
P
S
-
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
--------
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
--
T
Q
-------------------
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
-
F
L
T
H
V
L
N
T
H
C
Q
--
T
C
-----
H
--
V
S
P
E
-
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
-
L
K
-
I
L
S
C
-------
8
PsiBlast_PDB
89.43
31%
-95
- C4 -
3NYA
3
ADRB2_HUMAN (first)
A:
[47-477]
----------------------------------------------
V
M
S
L
I
V
L
A
----
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
---
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
---
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
---
C
-
C
D
F
F
--
T
N
------
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
-------------------
D
E
---
G
L
R
L
K
-
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P
---------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
--
I
--
Q
D
-----
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
-
L
L
C
L
-------
9
PsiBlast_PDB
89.22
31%
-95
- C4 -
3PDS
8
ADRB2_HUMAN (first)
A:
[15-445]
----------------------------------------------
V
M
S
L
I
V
L
A
----
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
---
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
---
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
---
C
-
C
D
F
F
--
T
N
------
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
-------------------
D
E
---
G
L
R
L
K
-
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P
---------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
--
I
--
Q
D
-----
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
-
L
L
C
L
-------
21
PsiBlast_CBE
87.65
32%
-99
- C4 -
3PBL
2
DRD3_HUMAN (first)
B:
[41-472]
--------------------------------
Y
A
L
S
Y
C
------
A
-----
L
I
L
A
----
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
-
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
---
V
M
P
---------
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
-
L
L
F
G
F
N
T
T
G
--------------
D
P
---
T
V
C
S
I
S
--
N
P
------
D
---
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
-
A
R
I
Y
V
V
L
K
Q
R
R
R
----
K
N
I
-------------------
F
E
---
M
L
R
I
D
-
E
-
G
L
R
L
-
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-
P
S
-
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
--------
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGVP
L
R
E
K
K
A
--
T
Q
-------------------
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
-
F
L
T
H
V
L
N
T
H
C
Q
--
T
C
-----
H
--
V
S
P
E
-
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
-
L
K
-
I
L
S
C
-------
11
PsiBlast_PDB
84.65
27%
-95
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-441]
-------------------------------------
L
------
V
V
V
L
S
T
I
C
L
V
----
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
-
S
-
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
---
Q
Q
P
L
R
Y
L
K
---
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
-
I
L
------
G
W
N
H
-----RR----
E
D
---
K
-
C
E
T
D
FY
D
V
------
T
W
--
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
-
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
-------------------
D
E
---
G
L
R
L
K
I
Y
-
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH
M
----------------------
N
R
E
R
K
A
--
A
K
-------------------
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
-
F
I
F
F
M
V
I
A
--
F
CK
N
C
-----
C
---
N
E
H
-
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
-
K
R
-
I
L
H
I
-------
15
PsiBlast_PDB
84.64
25%
-90
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[20-456]
-------------------------------
T
F
E
V
V
F
I
------
V
L
V
A
G
S
L
S
L
V
----
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
-
G
-
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
---
T
K
P
L
T
Y
P
V
---
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
-
A
I
L
F
W
Q
F
I
V
G
V
R
T
V
E
D
G
------
E
C
---
Y
-
I
Q
F
F
--
S
N
------
A
A
--
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
-
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
-------------------
D
E
---
G
L
R
L
K
-
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP
S
R
E
K
K
V
--
T
R
-------------------
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
--
Y
N
V
M
V
L
I
N
--
T
--
F
C
-----
A
PC
I
P
N
T
-
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
-
K
H
-
L
L
M
--------
10
PsiBlast_PDB
83.65
27%
-81
- C4 -
4DAJ
5
ACM3_RAT (first)
A:
[18-440]
----------------------------------------------
L
T
G
F
L
A
L
V
----
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
-
N
-
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
---
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
-
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
------
E
C
---
F
-
I
Q
F
L
--
S
E
------
P
T
--
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
-------------------
E
G
---
L
R
L
K
I
-
Y
-
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
T
P
---------------------
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYLIKEAQ-----
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
--
C
--
D
S
-----
C
--
I
P
K
T
-
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
-
K
T
------------
1
PsiBlast_PDB
82.78
32%
-83
- C4 -
4IAR
2
C562_ECOLX
A:
[9-395]
-----------------------------
Y
I
Y
Q
D
S
I
S
L
P
W
K
V
L
L
V
M
L
L
A
L
I
T
L
A
----
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
T
-
G
-
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
---
T
D
A
V
E
Y
S
A
---
K
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
-
P
F
F
W
R
Q
A
-----------------
S
---
E
-
C
V
V
N
T-
D
H
------
I
L
--
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
-
G
R
I
Y
V
E
A
R
S
R
----------------------------------
I
A
D
L
-
E
-
D
N
W
E
-
T
L
N
D
N
L
K
V
I
E
K
A
D
-
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
-----------
A
L
D
A
Q
K
A
T
P
P
-----
K
L
E
D
K
S
---------------
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
-
A
L
K
L
A
--
N
E
G
K
--------
V
K
-------------
E
A
Q
A
A
--------
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
----------------------
A
----------------------
A
R
E
R
K
A
--
T
K
-------------------
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
-
F
I
I
S
L
V
M
P
--
I
---------
W
--
F
H
L
A
-
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
-
H
K
-
L
I
R
F
K
------
14
PsiBlast_PDB
82.29
27%
-81
- C4 -
4U14
1
ENLYS_BPT4
A:
[18-443]
----------------------------------------------
L
T
G
F
L
A
L
V
----
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
-
N
-
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
---
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
-
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
------
E
C
---
F
-
I
Q
F
L
--
S
E
------
P
T
--
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-
W
R
I
Y
K
E
T
E
K
M
N
C
F
E
M
L
R
I
D
-------------------
E
G
---
L
R
L
K
I
-
Y
-
K
D
C
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
----------
L
N
A
A
-----------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
-----
I
T
K
D
E
A
E
K
L
F
-----
N
---
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
C
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--------
D
E
A
A
V
N
L
A
K
-
S
R
W
Y
N
Q
----------------------
C
P---------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL
I
K
E
K
K
A
A
Q
--
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
--
C
--
D
S
-----
C
--
I
P
K
T
-
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
-
K
T
L
L
L
---------
64
Fugue
78.36
25%
-71
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------
D
E
V
W
V
V
G
M
------
G
I
V
M
S
L
I
V
L
A
----
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
---
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
------
Y
A
EET
C
-
C
D
F
F
--
T
N
------
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIG
I
G
---
H
L
L
T
K
-
S
-
P
S
L
N
-
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
-----------
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
-
D
E
A
A
V
--
N
L
A
K
--------
S
R
W
Y
N
Q
--------
T
P
N
R
A
K
--------
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
----------------------
C
----------------------
L
K
E
H
K
A
--
L
K
-------------------
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
-
Q
--
D
N
-----
L
--
I
R
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
-
Q
E
-
L
L
C
L
-------
16
PsiBlast_PDB
78.05
24%
-82
- C4 -
4U15
6
ACM3_RAT
A:
[18-398]
----------------------------------------------
L
T
G
F
L
A
L
V
----
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
-
N
-
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
---
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
-
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
------
E
C
---
F
-
I
Q
F
L
--
S
E
------
P
T
--
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
-------------------
E
G
---
G
G
S
G
G
-
D
-
E
A
E
K
-
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
--
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
-----
A
K
S
R
W
Y
-
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
-
G
T
---------------------------------------------------------
W
D
A
Y
----------------------
L
----------------------
I
K
E
K
K
A
--
A
Q
-------------------
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
--
C
--
D
S
-----
C
--
I
P
K
T
-
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
-
K
T
L-----------
13
PsiBlast_PDB
76.69
29%
-94
- C4 -
4NC3
12
C562_ECOLX
A:
[32-414]
-----------------------------------------------
A
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
L
T
I
M
F
E
A
-
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
Y
N
----
S
R
A
T
A
F
I
K
--
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
I
K
G
I
E
T
-
V
D
N
----
P
N
------
N
I
---
T
-
C
V
L
T
--
K
E
------
R
F
G
D
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
-------------------
L
N
D
N
L
K
V
I
E
K
-
A
-
D
N
A
A
-
Q
V
K
D
A
L
T
K
M
R
A
-----------------------------------
K
D
F
R
--
H
G
F
D
I
L
V
G
Q
I
D
D
-----------
A
L
K
L
A
N
-
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
-
T
R
N
---------------------------------------------------
A
Y
I
Q
K
Y
L
Q
T
----------------------
I
----------------------
S
N
E
Q
R
A
--
S
K
-------------------
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
-
F
I
T
-
N
I
T
L
--
V
--
L
C
DSCN
Q
T
--
T
L
Q
M
-
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
-
I
T
C
N
Y
R
-----
17
PsiBlast_PDB
75.96
24%
-84
- C4 -
4U16
2
?
A:
[18-388]
----------------------------------------------
L
T
G
F
L
A
L
V
----
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
-
N
-
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
---
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
-
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
------
E
C
---
F
-
I
Q
F
L
--
S
E
------
P
T
--
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
-------------------
E
G
---
G
G
S
G
G
-
D
-
E
A
E
K
-
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
--
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
-----
A
K
S
R
W
Y
-
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
-
G
T
---------------------------------------------------------
W
D
A
Y
----------------------
L
----------------------
I
K
E
K
K
A
--
A
Q
-------------------
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
--
C
--
D
S
-----
C
--
I
P
K
T
-
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
----------------------
12
PsiBlast_PDB
75.54
29%
-91
- C4 -
4IB4
10
5HT2B_HUMAN (first)
A:
[32-414]
-----------------------------------------------
A
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
L
T
I
M
F
E
A
-
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
Y
N
----
S
R
A
T
A
F
I
K
--
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
I
K
G
I
E
T
---
N
----
P
N
------
N
I
---
T
-
C
V
L
T
--
K
E
------
R
F
G
D
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
-------------------
L
N
D
N
L
K
V
I
E
K
-
A
-
D
N
A
A
-
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
----------------------------
K
D
F
R
--
H
G
F
D
I
L
V
G
Q
I
D
D
-----------
A
L
K
L
A
N
-
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
-
T
R
N
---------------------------------------------------
A
Y
I
Q
K
Y
L
Q
T
----------------------
I
----------------------
S
N
E
Q
R
A
--
S
K
-------------------
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
-
F
I
T
-
N
I
T
L
--
V
--
L
C
DSCN
Q
T
--
T
L
Q
M
-
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
-
I
T
C
N
Y
R
-----
85
HHSearch
73.00
22%
-116
- C4 -
2Z73
5
OPSD_TODPA
A:
[12-333]
------------
W
Y
N
P
S
I
V
V
H
P
H
W
R
E
F
D
Q
V
P
D
A
V
Y
Y
S
L
------
G
I
F
I
G
I
C
G
I
I
----
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
-
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
---
G
R
P
M
A
A
S
K
---
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
-
P
I
F
G
W
G
A
Y
T
L
E
----
G
V
------
L
C
---
N
-
C
S
F
D
--
Y
I
SRD
S
T
T
R
S
--
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
-
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
-------------------
R
L
---
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
R
K
A
Q
A
G
----------------------
A
----------------------
N
A
E
M
R
L
--
A
K
-------------------
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
-
A
V
V
A
L
L
A
Q
--
F
--
G
P
LE---
W
--
V
T
P
Y
-
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
-
S
Q
-
T
F
P
W
V
L
T
C
C
Q
F