@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ADA2C_HUMAN: (2016-01-08 )
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110..-.-....120.......130.......140.......150.......160--........170.......------180...-..--..190.--------.....---.200------...----.--....--210.......220.......230---....-----...---------------.---------.240-..-------...-...----------------------250--------..-------------.--------------....---260-.........270....-...280.......290...-----------....300.------......310.......320........330.......340.......350.......360.----......370..-------.-----....380.......390.......400.......--------410...-....420.......430.......440.......450.......460-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
S
P
A
L
A
A
A
L
A
V
A
AAAGPNASGAGERGSGGVANASGASWGPPRGQYS
A
G
A
V
A
G
L
A
A
V
V
G
F
L
I
V
F
T
V
V
G
N
V
L
V
V
I
A
V
L
T
S
R
A
LRAPQ
N
L
F
L
V
S
LASA
D
I
L
V
A
T
L
V
M
P
F
S
L
A
N
E
L
M
-
A
-
Y
W
Y
F
G
Q
V
W
C
G
V
Y
L
A
L
D
V
L
F
C
T
S
S
I
V
H
L
C
A
I
S
L
D
R
Y
W
S
V
T
Q
A
V
E
YNL---KRTP
R
R
V
K
A
T
I
V
A
V
W
L
I
S
------
A
V
ISFP-
P
L
--
V
S
L
YRQ--------PDGAA---YPQ-------CGL----N--D
E
T
W
--
Y
I
L
S
S
C
I
G
S
F
F
A
P
C
L
I
M
G
L
V
Y
-----
A
R
I
Y
-----
R
V
A
---------------
K
---------
L
R
T
--RT-------LSE-KRA----------------------PVG--------PD-------------G--------------ASPT---T---ENGLGAAAGAGENGHC-APPPADVEPDE
S
S
A
A
A
E
R
R
-----------
R
R
R
G
A
L
RR------GGRRRAGAEGGAGGADG-QGAGPGAAESG
A
L
TASRSPGPGGRLSRASS
R
S
V
E
F
F
L
S
R
R
R
R
A
----
R
S
S
V
C
R
R
K
V
A
Q
-------
A
-----
R
E
K
R
F
T
F
V
L
A
V
V
M
G
V
F
V
L
C
W
F
P
F
F
F
S
Y
S
L
Y
G
I
C
R
--------
E
A
CQVP-
G
P
L
F
K
F
F
F
W
I
G
Y
CNSSLN
P
V
I
Y
TVF
N
Q
D
F
R
R
S
F
K
H
I
L
F
R
R
R
RRGFRQ-
21
PsiBlast_CBE
89.28
33%
-107
- C3 -
3PBL
2
DRD3_HUMAN (first)
B:
[41-470]
---------------------------------------------
Y
A
L
S
Y
C
A
--------
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
-
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
---------
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
------
F
A
V
S
C
P
-
L
L
--
F
G
F
N
T
T
--------
G
D
P
T
V
-------------
C
S
I
----
S
--
N
P
D
F
--
V
I
Y
S
S
V
V
-
S
F
Y
L
P
F
G
V
T
V
L
V
Y
-----
A
R
I
Y
-----
V
V
L
---------------
K
---------
Q
R
R
--
R
K
N
I
F
E
M
L
R
I
D
E
G
L
R
L
----------------------
K
I
Y
--------
K
D
TEGYYTIGIGHLL
T
--------------
K
S
P
S
L
N
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
V
P
-------
L
-----
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
---------
Q
T
C
H
V
S
-
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------
3
PsiBlast_PDB
88.97
28%
-157
- C3 -
3P0G
1
ENLYS_BPT4
A:
[41-480]
--------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
------
G
L
T
S
F
L
-
P
I
Q
-
M
H
W
Y
R
A
--------
T
H
Q
E
A
I
N
C
Y
A
E
ET
C
----
C
D
F
----
F
--
T
N
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-----
S
R
V
F
-----
Q
E
A
---------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L----
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----------
Q
D
N
L
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
R
R
-------
2
PsiBlast_PDB
88.82
33%
-105
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-470]
---------------------------------------------
Y
A
L
S
Y
C
A
--------
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
-
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
------
F
A
V
S
C
P
-
L
L
--
F
G
F
N
T
T
--------
G
D
P
T
V
-------------
C
S
I
----
S
--
N
P
D
F
--
V
I
Y
S
S
V
V
-
S
F
Y
L
P
F
G
V
T
V
L
V
Y
-----
A
R
I
Y
-----
V
V
L
---------------
K
---------
Q
R
R
--
R
K
N
I
F
E
M
L
R
I
D
E
G
L
R
L
----------------------
K
I
Y
--------
K
D
TEG
Y
Y
T
I
G
IGHLL
T
--------------
K
S
P
S
L
N
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
V
P
-------
L
-----
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
---------
Q
T
C
H
V
S
-
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------
4
PsiBlast_PDB
86.14
28%
-91
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
------
G
L
T
S
F
L
-
P
I
Q
-
M
H
W
Y
R
A
--------
T
H
Q
E
A
I
N
C
Y
A
E
ETC----
C
D
F
----
F
--
T
N
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-----
S
R
V
F
-----
Q
E
A
---------------
K
---------
R
Q
L
--
N
I
-------
F
E
M
-
L
R
I
----------------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
-------------
G
YYTIGIGHLLT---
K
S
P
S
L
N
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
----
I
T
T
F
-
R
T
G
T
W
D
-------
A
YKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----------
Q
D
N
L
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------
10
PsiBlast_PDB
85.09
28%
-90
- C3 -
3PDS
8
ADRB2_HUMAN (first)
A:
[9-446]
--------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
C
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
------
G
L
T
S
F
L
-
P
I
Q
-
M
H
W
Y
R
A
--------
T
H
Q
E
A
I
N
C
Y
A
E
ETC----
C
D
F
----
F
--
T
N
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-----
S
R
V
F
-----
Q
E
A
---------------
K
---------
R
Q
L
--
N
I
-------
F
E
M
-
L
R
I
----------------------
D
E
G
LRL
K
I
Y
K
D
T
E
-------------
G
YYTIGIGHLLT---
K
S
P
S
---
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
----
I
T
T
F
-
R
T
G
T
W
D
-------
A
YKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----------
Q
D
N
L
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------
7
PsiBlast_PDB
84.88
27%
-90
- C3 -
3NY9
4
ADRB2_HUMAN (first)
A:
[40-478]
-------------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
------
G
L
T
S
F
L
-
P
I
Q
-
M
H
W
Y
R
A
--------
T
H
Q
E
A
I
N
C
Y
A
E
ETC----
C
D
F
----
F
--
T
N
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-----
S
R
V
F
-----
Q
E
A
---------------
K
---------
R
Q
L
--
N
I
-------
F
E
M
-
L
R
I
----------------------
D
E
G
LRL
K
I
Y
K
D
T
E
-------------
G
YYTIGIGHLLT---
K
S
P
S
L
N
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
----
I
T
T
F
-
R
T
G
T
W
D
-------
A
YKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----------
Q
D
N
L
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------
5
PsiBlast_PDB
84.39
27%
-89
- C3 -
3D4S
6
ENLYS_BPT4
A:
[40-478]
-------------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
------
G
L
T
S
F
L
-
P
I
Q
-
M
H
W
Y
R
A
--------
T
H
Q
E
A
I
N
C
Y
A
E
ETC----
C
D
F
----
F
--
T
N
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-----
S
R
V
F
-----
Q
E
A
---------------
K
---------
R
Q
L
--
N
I
-------
F
E
M
-
L
R
I
----------------------
D
E
G
LRL
K
I
Y
K
D
T
E
-------------
G
YYTIGIGHLLT---
K
S
P
S
L
N
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
----
I
T
T
F
-
R
T
G
T
W
D
-------
A
YKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----------
Q
D
N
L
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------
6
PsiBlast_PDB
84.37
27%
-87
- C3 -
3NY8
7
ENLYS_BPT4
A:
[40-478]
-------------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
------
G
L
T
S
F
L
-
P
I
Q
-
M
H
W
Y
R
A
--------
T
H
Q
E
A
I
N
C
Y
A
E
ETC----
C
D
F
----
F
--
T
N
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-----
S
R
V
F
-----
Q
E
A
---------------
K
---------
R
Q
L
--
N
I
-------
F
E
M
-
L
R
I
----------------------
D
E
G
LRL
K
I
Y
K
D
T
E
-------------
G
Y
Y
T
I
G
IGHLLT---
K
S
P
S
L
N
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
----
I
T
T
F
-
R
T
G
T
W
D
-------
A
YKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----------
Q
D
N
L
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------
13
PsiBlast_PDB
83.72
26%
-91
- C3 -
4DAJ
5
ACM3_RAT (first)
A:
[9-440]
-----------------------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
M
-
N
-
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
------
F
V
L
W
A
P
-
A
I
----
L
F
W
Q
Y
F
V
GKRTV
P
P
G
E
C
---
F
I
Q
-------
F
-
L
----
S
--
E
P
T
---
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-----
W
R
I
Y
-----
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
E
GL
R
---------
L
K
I
--
Y
K
-------
D
T
E
-
G
Y
Y
----------------------
T
I
G
--------
I
G
-------------
H
LLT-----------
K
S
P
S
---
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
----
I
T
T
F
-
R
T
G
T
W
D
-------
A
YLI--
K
E
---
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
---------
D
S
C
-
I
P
-
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
K
T
-------------
8
PsiBlast_PDB
83.49
27%
-88
- C3 -
3NYA
3
ADRB2_HUMAN (first)
A:
[40-478]
-------------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
------
G
L
T
S
F
L
-
P
I
Q-
M
H
W
Y
R
A
--------
T
H
Q
E
A
I
N
C
Y
A
E
ETC----
C
D
F
----
F
--
T
N
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-----
S
R
V
F
-----
Q
E
A
---------------
K
---------
R
Q
L
--
N
I
-------
F
E
M
-
L
R
I
----------------------
D
E
G
LRL
K
I
Y
K
D
T
E
-------------
G
Y
Y
T
I
G
IGHLLT---
K
S
P
S
L
N
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
----
I
T
T
F
-
R
T
G
T
W
D
-------
A
YKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----------
Q
D
N
L
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------
17
PsiBlast_PDB
81.90
26%
-90
- C3 -
4U14
1
ENLYS_BPT4
A:
[8-443]
----------------------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
M
-
N
-
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
------
F
V
L
W
A
P
-
A
I
----
L
F
W
Q
YFVGKRTV
P
P
G
E
C
---
F
I
Q
--------
F
L
----
S
--
E
P
T
---
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-----
W
R
I
Y
-----
K
E
T
E
K
M
N
C
F
E
M
L
R
I
D
EGL
R
---------
L
K
I
--
Y
K
-------
D
C
E
-
G
Y
Y
----------------------
T
I
G
--------
I
G
-------------
H
LLT-----------
K
S
P
S
---
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
C
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
C
P
N
R
A
K
R
V
----
I
T
T
F
-
R
T
G
T
W
D
-------
A
YL
I
--
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
---------
D
S
C
-
I
P
-
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
K
T
L
L
L
----------
14
PsiBlast_PDB
80.94
26%
-86
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[20-457]
-----------------------------------------------
T
F
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
-
G
-
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
---
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
-
F
I
--
V
G
V
R
T
V
--------
E
D
G
E
C
---
Y
I
Q
-------
F
F
S
----
N
--
A
A
V
----
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
-----
W
H
I
S
-----
R
A
S
---------------
K
---------
S
R
I
--
N
I
-------
F
E
M
-
L
R
I
----------------------
D
E
G
LRL
K
I
Y
K
D
T
E
-------------
G
Y
Y
T
I
GIGHLLT---
K
S
P
S
L
N
A
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
P
P
P
-------
S
-----
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
----------
A
P
C
I
P
-
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
----------
35
Fugue
80.43
26%
-85
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
------
G
L
T
S
F
L
-
P
I
--
Q
M
H
W
Y
R
--------
A
T
H
Q
E
---
A
I
N
C
Y
A
EETC
C
D
F
----
F
--
T
N
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-----
S
R
V
F
-----
Q
E
A
---------------
K
---------
R
Q
L
--
N
I
-------
F
E
M
-
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGH
L
L
T
--------
K
S
-------------
P
--------------
S
L
N
A
---
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
-----------
L
R
N
A
K
L
K
P
------
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
-
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
----
K
R
V
I
T
T
F
R
T
G
T
WDAYKFC
L
-----
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
--------
N
--
L
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------
9
PsiBlast_PDB
80.13
28%
-88
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
-----------------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
-
S
-
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
---
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
------
F
L
W
V
I
P
-
I
L
GW
N
H
---------------
R
R
---
E
D
K
-------
C
E
T
----
D
FY
D
V
T
W
--
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
-----
A
K
I
Y
-----
K
A
V
---------------
R
---------
Q
H
C
--
N
I
-------
F
E
M
-
L
R
I
----------------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
-------------
G
Y
Y
T
I
G
IGHLLT---
K
S
P
S
---
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
-------
N
-----
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
--------
N
C
C
N
---
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
---------
15
PsiBlast_PDB
79.43
26%
-91
- C3 -
4U15
6
ACM3_RAT
A:
[8-398]
----------------------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
M
-
N
-
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
------
F
V
L
W
A
P
-
A
I
----
L
F
W
Q
Y
F
V
GKRTV
P
P
G
E
C
---
F
I
Q
--------
F
L
----
S
--
E
P
T
---
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-----
W
R
I
Y
-----
K
E
T
---------------
E
KMN
I
-----
F
E
M
--
L
R
-------
I
D
E
-
G
G
G
----------------------
S
G
G
--------
D
E
-------------
A
--------------
E
K
L
F
---
N
---
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
---------------
A
A
L
I
------
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
-
K
R
V
I
T
T
F
R
T
G
T
W
D
A
----
Y
---------
L
-------
I
-----
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
---------
D
S
C
-
I
P
-
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
K
T
L
------------
1
PsiBlast_PDB
78.42
31%
-96
- C3 -
4IAR
2
C562_ECOLX
A:
[23-398]
-----------------------------------------------------
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
I
S
T
M
Y
T
V
T
-
G
-
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
---
K
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
------
I
S
I
S
L
P
-
P
F
----
F
W
R
Q
--------
A
--------
S
E
-------
C
V
V
----
N
T-
D
H
I
L
--
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
-----
G
R
I
Y
V
E
A
R
S
R
I
A
---------------
D
---------
L
E
D
N
W
E
T
-------
L
N
D
-
N
L
K
----------------------
V
I
E
--------
K
A
-------------
D
--------------
N
A
A
Q
---
V
---
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
-
A
T
P
P
K
--
L
E
D
K
S
P
D
S
P
E
M
K
-----------
D
----
F
R
H
------
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
-
E
G
K
V
K
E
A
Q
A
A
A
--------------------------
E
Q
L
K
T
T
----
R
N
A
Y
I
Q
K
Y
L
A
--------
A
-----
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
-------------
W
F
H
-
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
-
H
K
L
I
R
F
K
-------
36
Fugue
77.14
18%
-77
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------------------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
L
P
F
-
W
A
V
D
A
V
-
A
-
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
---
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
------
L
L
L
T
I
P
-
D
F
--
I
F
A
N
V
S
--------
E
A
D
D
R
---
Y
I
C
-------
D
R
F
Y
PN
D
L
--
W
V
V
V
--
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
-----
C
I
I
I
-----
S
K
L
---------------
S
HSGSN
I
F
E
M
L
R
I
--
D
E
-------
G
L
R
-
L
K
I
----------------------
Y
K
D
--------
T
E
-------------
G
Y
Y
T
I
GIGHLLTKSP
S
L
N
A
---
A
---
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
-
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
L
D
A
V
R
R
------
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
-
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
----
T
W
D
A
Y
G
S
K
--
G
-------
H
-----
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
-
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
16
PsiBlast_PDB
76.00
26%
-92
- C3 -
4U16
2
?
A:
[8-388]
----------------------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
I
M
-
N
-
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
------
F
V
L
W
A
P
-
A
I
----
L
F
W
Q
Y
F
V
GKRTV
P
P
G
E
C
---
F
I
Q
--------
F
L
----
S
--
E
P
T
---
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-----
W
R
I
Y
-----
K
E
T
---------------
E
KMN
I
-----
F
E
M
--
L
R
-------
I
D
E
-
G
G
G
----------------------
S
G
G
--------
D
E
-------------
A
--------------
E
K
L
F
---
N
---
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
---------------
A
A
L
I
------
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
-
K
R
V
I
T
T
F
R
T
G
T
W
D
A
----
Y
---------
L
-------
I
-----
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
---------
D
S
C
-
I
P
-
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
----------------------
12
PsiBlast_PDB
75.75
28%
-110
- C3 -
4NC3
12
C562_ECOLX
A:
[33-407]
------------------------------------------------------
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
F
E
A
-
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
---
Y
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
------
I
G
I
A
I
P
V
P
I
--
K
G
I
E
T
---------
V
D
N
P
N
---
N
I
T
-------
C
V
L
----
T
--
K
E
R
F
G
D
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
-----
K
A
A
---------------
D
---------
L
E
D
N
W
E
T
-------
L
N
D
-
N
L
K
----------------------
V
I
E
--------
K
A
-------------
D
--------------
N
A
A
Q
---
V
---
K
D
A
L
T
K
M
R
A
--------------------------
K
-----------
D
F
R
H
----------------
G
F
D
I
L
V
G
Q
I
D
D
----
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
------
Y
I
Q
K
Y
L
Q
T
----
I
S
N
----------------------
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
--------
S
C
N
Q
T
T
L
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
------
11
PsiBlast_PDB
75.11
28%
-108
- C3 -
4IB4
10
5HT2B_HUMAN (first)
A:
[33-407]
------------------------------------------------------
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
F
E
A
-
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
---
Y
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
------
I
G
I
A
I
P
V
P
I
--
K
G
I
E
T
-----------
N
P
N
---
N
I
T
-------
C
V
L
----
T
--
K
E
R
F
G
D
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
-----
K
A
A
---------------
D
---------
L
E
D
N
W
E
T
-------
L
N
D
-
N
L
K
----------------------
V
I
E
--------
K
A
-------------
D
--------------
N
A
A
Q
---
V
---
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
-------------------
K
-----------
D
F
R
H
----------------
G
F
D
I
L
V
G
Q
I
D
D
----
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
------
Y
I
Q
K
Y
L
Q
T
----
I
S
N
----------------------
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
--------
S
C
N
Q
T
T
L
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
------