@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AGRB2_HUMAN: (2016-01-08 )
MENTGWMGKGHRMTPACPLLLSVILSLRLATAFDPAPSACSALASGVLYGAFSLQDLFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCAHFAPRLLPLDHYLVNFTCLRPSPEEAVAQAESEVGRPEEEEAEAAAGLELCSGSGPFTFLHFDKNFVQLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPGEAGAGSTTTTSPGPPAAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKKAAAGEIIYNKCPPNASGSASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYSGDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDAENKEKWDDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPVSAVSSDITFPMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATSGAAGSPGRGRGPGTVPPGPGHSHQRLLPADPDESSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEPLITVELSYIINGTTDPHCASWDYSRADASSGDWDTENCQTLETQAAHTRCQCQHLSTFAVLAQPPKDLTLELAGSPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGISDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQDVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGSLSFSPLPGNILVPMAASPGLGEPPPPQEANPVYMCGEGGLRQLDLTWLRPTEPGSEGDYMVLPRRTLSLQPGGGGGGGEDAPRARPEGTPRRAAKTVAHTEGYPSFLSVDHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKMGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSTAKREKRWSVSSGGAAERSVCTDKPSPGERPSLSQHRRHQSWSTFKSMTLGSLPPKPRERLTLHRAAAWEPTEPPDGDFQTEV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320......----.330.....--..340---.------......--..350.......360.......370.......380.----......390--..--.----..----..400.......410-.-......420.......430-----.....--...-440.......450.--..--.--.--....460.....-.-.-470.......480.....------..490--.--.-.....500....--...510.......520-.-......530.......540...-....550.......560.......------------570...---....580.......590.......------600.......610.......620.......630....---...640.......650-----......----------..-----------660.......670.......680.---......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.----------------..----------------....840....--...850.--......860.......870....----...880.......890.......-900.......910....-----...920.......930.......940.......950--.......960.......970.......980.....--------..990.......1000......1010.....-.1020---........1030-----.-----.......1040......1050......1060.......1070..-------..--..1080......1090......1100......1110......1120......1130......1140......1150......1160......1170.....-------.1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MENTGWMGKGHRMT
P
A
C
P
L
L
L
S
V
I
L
S
L
R
L
ATAFDPA
P
S
A
C
S
A
L
A
S
G
V
L
Y
G
A
F
S
L
Q
D
L
F
P
T
I
ASG
C
S
W
TLENPDPT
K
Y
S
L
Y
L
R
FN
R
Q
E
Q
V
C
A
H
F
A
P
R
LLPLD
H
Y
L
V
N
F
T
CLRP
S
P
E
E
A
V
A
Q
A
E
S
EVGRP
E
E
E
E
A
E
A
A
A
G
L
E
LCSGSG
P
F
T
F
L
H
FD
K
N
F
V
Q
L
C
LSAEPSEAPRLL
A
P
A
A
L
A
F
R
F
V
E
V
L
L
I
NNNNSS
Q
F
T
C
G
V
L
C
R
W
S
E
E
C
G
R
A
AGRACGFAQPGCSCPGEAGAGSTTTTSPGP
P
A
A
H
T
L
S
NALVPGGPAPPAEADLHSGSSND
L
F
T
T
E
MRYGEEPEEEPKVKTQWPRSADEP
G
L
Y
M
AQTGDPAAEEWSPW
S
V
C
S
LTCGQG----
L
Q
V
R
T
R
S
C
V--SSP-----Y------GTLCSG--PLRETRPCNNSATCPV
H
G
V
W
E
EWGS
W
S
L
C
S
RSCGRG----
S
R
S
R
M
RTCV--PP--Q----HG----GKACEG
P
E
L
Q
T
K
L
C
S
-M-AACPVEGQWLEWGPWGPC------STSCA--N
G
T
-
Q
Q
R
SRKCSVAG--P--AW--
A
--
T
--
C
TGALTDTRECS-N-L-ECPATDSKWGPW
N
A
W
S
L
C
------
S
K
TC
D
--
T
--
G
-
W
Q
R
R
F
R
M
C
Q
ATG--TQGYPCEGTGEEVKPC-S-EKR
C
P
A
F
H
E
M
C
R
D
E
Y
V
M
L
M
T
WK-KAAAG
E
I
I
YNKCPPNASGS
A
S
R
R
C
------------
L
L
SAQ
G
---
V
A
YWG
L
P
S
F
A
R
C
I
S
H
E
Y
R
Y
L
Y
L
S
L
------
R
E
H
L
A
KGQRMLAGE
G
M
S
Q
V
V
R
S
L
Q
E
L
L
A
RRTYYSG
D
L
---
L
F
S
V
D
I
L
R
N
V
T
D
T
F
K
------RATYVP----------
S
A
-----------
D
D
V
Q
R
F
F
Q
V
V
S
F
M
VDAENKEKWDD---AQQVSPGSV
H
L
L
R
V
V
E
D
F
I
H
L
V
G
D
A
L
K
A
F
Q
S
S
L
I
V
TD
N
L
V
I
S
I
QREP
V
S
A
VSSDITFPMRGRRG
M
K
D
W
V
R
HSED
R
L
F
L
P
K
E
V
L
SLSSPGKPATSGAAGSPGRGRGPGTVPPGPGHSHQRLLPADPDES
S
Y
F
V
I
G
A
V
L
Y
R
T
L
G
LILPPPRP----------------P
L
----------------
A
V
T
S
R
V
M
T
V
T
V--RPPTQPP--AE
P
L
I
T
V
E
L
S
Y
I
INGTTDPHCAS----WDYSRADASSGDWDTEN
C
Q
T
L
E
T-QAAH
T
R
C
Q
C
Q
HL
S
T
F
A
V
-----LAQPPK
D
L
T
L
E
LAGSPSV
P
L
V
I
G
C
A
V
S
C
M
A
L
L
T
L
L
A
--
I
Y
A
A
F
W
R
F
I
KSER
S
I
I
L
L
N
F
C
L
S
I
L
AS
N
I
L
I
L
VGQ--------
S
R
V
LSK
G
V
C
T
M
T
A
A
F
L
H
F
F
F
L
S
S
F
C
W
V
L
T
E
A
-
W
Q
S
-----
Y
L
A
V
I
G
R
M
R
T
-------
R
-----
L
V
R
K
R
F
L
C
LGW
G
L
P
A
L
V
V
A
VSVGFTRTKG-YGTS
S
Y
C
W
L
S
LEG
G
-------
L
L
--
Y
A
FV
G
P
A
A
V
I
V
L
V
N
M
L
I
G
I
I
V
F
N
K
L
M
ARDGIS
D
K
S
K
K
QRAGSERCP
W
A
S
L
LLPCSACGAVP
S
P
L
L
S
S
A
S
A
R
N
A
M
A
S
L
W
S
S
C
V
V
L
P
L
L
A
L
T
W
M
S
A
V
L
A
MT
D
R
-------
R
S
V
L
F
Q
A
L
F
A
V
F
NSAQ
G
F
V
I
T
A
V
H
C
F
L
R
R
E
V
Q
D
V
V
K
C
Q
MGVCRADESEDSPDSCKNG
Q
L
Q
I
L
S
D
F
E
K
D
V
D
L
A
C
Q
T
V
L
F
K
EVNTCNPSTI
T
G
T
L
S
RLSLDEDEEPKSCLVGPEGSLSFSPLPG
N
I
L
V
P
MAASPGLGEPPPPQEAN
P
V
Y
M
CGEGG
L
R
Q
L
D
L
T
W
LRPTEPGSEG
D
Y
M
V
L
PR
R
T
L
S
LQPGGGGGGGEDAPRARPEGT
P
R
R
A
A
K
T
VAHTEGYP
S
F
L
S
VDHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKMGS
L
E
R
K
KLRYSDL
D
F
E
K
V
M
H
T
R
K
R
H
S
E
L
Y
H
E
L
N
Q
K
F
H
T
F
D
R
Y
RSQS
T
A
K
R
E
KRWSVSSGGAAERSVCTDKPSPGERP
S
L
S
Q
H
R
R
HQSW
S
T
F
KSMTLGSLPPKP
R
E
R
L
T
L
HRAAAWEPTEPPDGDFQTEV
21
PsiBlast_CBE
91.65
50%
-97
- C2 -
4DLO
6
B:
[7-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
-
S
-
E
Q
R
C
P
A
P
Y
E
I
C
P
E
D
Y
L
M
S
M
V
W
K
-
R
T
P
A
G
D
L
A
F
N
Q
C
P
L
N
A
T
G
T
T
S
R
R
C
------------
S
L
S
L
H
G
---
V
A
F
W
E
Q
P
S
F
A
R
C
I
S
N
E
Y
R
H
L
Q
H
S
I
------
K
E
H
L
A
-------
G
D
G
M
S
Q
V
T
K
T
L
L
D
L
T
Q
R
K
N
F
Y
A
G
D
L
---
L
M
S
V
E
I
L
R
N
V
T
D
T
F
K
------
R
A
S
Y
I
P
----------
A
S
-----------
D
G
V
Q
N
F
F
Q
I
V
S
N
L
L
D
E
E
N
K
E
K
W
E
D
---
A
Q
Q
I
Y
P
G
S
I
E
L
M
Q
V
I
E
D
F
I
H
I
V
G
M
G
M
M
D
F
Q
N
S
Y
L
M
T
G
N
V
V
A
S
I
Q
K
L
P
A
A
S
V
L
T
D
I
N
F
P
M
K
G
R
K
G
M
V
D
W
A
R
N
S
E
D
R
V
V
I
P
K
S
I
F
T
--------------------------------------------
S
V
F
V
L
G
A
V
L
Y
K
N
L
D
L
I
L
P
T
L
R
N
----------------
Y
T
----------------
V
I
N
S
K
I
I
V
V
T
I
--
R
P
E
P
-------
S
F
L
E
I
E
L
A
H
L
A
N
G
T
L
N
P
Y
C
V
L
----
W
D
D
------
L
G
T
W
S
T
Q
G
C
K
T
V
L
T
-
D
A
S
H
T
K
C
L
C
D
R
L
S
T
F
A
I
-----
L
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
67.92
22%
-73
- C2 -
4DLQ
16
A:
[18-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
V
R
R
V
Q
W
P
-
A
T
Q
Q
G
M
L
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
------------
L
-
P
A
L
G
---
L
W
N
P
R
G
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
------
K
----------
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
-
T
R
G
S
I
Y
A
G
D
V
---
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
------
A
Q
L
Q
A
L
RN
K
M
H
K
R
E
R
T
C
K
-----------
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
MN-
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
P
Q
E
Y
A
---------
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
R
N
---------------------------------------
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
A
----------------
T
V
KLA
G
E
A
G
T
GGPGGASL
V
V
N
S
Q
V
I
A
A
S
I
NK
E
S
S
R
V
F
L
--
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
H
F
N
A
N
C
S
F
----
W
N
Y
S
E
R
S
-
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
-
N
K
T
H
T
T
C
A
C
S
H
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.37
19%
-62
- C2 -
4DLQ
16
A:
[23-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
C
E
P
R
E
V
R
R
V
Q
W
P
-
A
T
Q
Q
G
M
L
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
------------
L
-
P
A
L
G
---
L
W
N
P
R
G
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
----------------
A
Q
K
I
K
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
-
T
R
G
S
I
Y
A
G
D
V
---
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
R
-----------------N
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
MN
A
T
E
Q
V
H
T
A
T
M
-
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
P
-------
Q
E
Y
A
S
E
S
S
I
Q
L
-------------------
S
A
N
T
I
K
Q
N
S
R
N
G
V
V
K
----------------------
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
A
TVKLA
G
E
A
G
T
GGPGGA
S
L
----------------
V
V
N
S
Q
V
I
A
A
S
I
--
N
K
E
S
S
R
V
FL
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
H
F
N
A
N
C
S
F
----
W
N
Y
S
E
-
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
-
N
K
T
H
T
T
C
A
C
S
H
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
57.63
34%
53
- C- -
1W0R
-
PROP_HUMAN
A:
[107-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
M
G
G
W
S
G
W
G
P
W
E
P
C
S
V
T
C
S
K
G
----
T
R
T
R
R
R
A
C
N
--
H
P
A
PK---
C
------
G
G
H
C
P
G
--
Q
A
Q
E
S
E
A
C
D
T
Q
Q
V
C
P
T
H
G
A
W
A
T
W
G
P
W
T
P
C
S
A
S
C
H
G
G
P
H
E
P
K
E
T
R
S
R
K
C
S
--
A
P
--
E
P
S
Q
K
P
P
----
G
K
P
C
P
G
L
A
Y
E
Q
R
R
C
T
G
L
-
P
P
C
P
V
A
G
G
W
G
P
W
G
P
V
S
P
C
------
P
V
T
C
G
--
L
G
Q
-
T
M
E
Q
R
T
C
N
H
P
V
PQ
H
--
G
G
--
P
--
F
--
C
A
G
D
A
T
R
T
H
I
C
N
-
T
-
A
V
P
C
P
V
-
D
G
E
W
D
S
W
G
E
W
S
P
C
I
R
RNMK
S
I
S
C
Q
E
I
P
--
G
-
Q
Q
S
R
G
R
T
C
R
G
R
K
--
F
D
G
H
R
C
A
G
Q
Q
Q
D
I
R
H
C
-
Y
S
I
Q
H
C
P
L
-----------
K
G
S
W
S
E
W
S
T
W
G
L
C
-
M
P
P
C
G
P
N
P
T
R
A
R
Q
R
L
C
------------
T
P
L
L
P
K
---
Y
P
P
T
V
S
M
V
E
G
Q
G
E
K
N
V
T
F
W
G
R
P
L
P
------
R
C
E
E
L
Q
G
Q
K
L
V
V
E
E
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
56.38
29%
48
- C- -
1W0S
-
PROP_HUMAN
A:
[115-425]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
P
W
E
P
C
S
V
T
C
S
K
G
----
T
R
T
R
R
R
A
C
N
HP
A
P
K
-----
C
------
G
G
H
C
P
G
--
Q
A
Q
E
S
E
A
C
D
T
Q
Q
V
C
P
T
H
G
A
W
A
T
W
G
P
W
T
P
C
S
A
S
C
H
G
G
P
H
E
P
K
E
T
R
S
R
K
C
S
--
A
P
--
E
----
P
S
Q
K
PP
G
K
P
C
P
G
L
A
Y
E
Q
R
R
C
T
G
L
-
P
P
C
P
V
A
G
G
W
G
P
W
G
P
V
S
P
C
------
P
V
T
C
G
--
L
G
Q
-
T
M
E
Q
R
T
C
N
H
P
V
--
P
--
Q
H
--
G
--
G
PF
C
A
G
D
A
T
R
T
H
I
C
N
-
T
A
V
-
P
C
P
-
V
D
G
E
W
D
S
W
G
E
W
S
P
C
I
R
RNMK
S
I
S
C
Q
--
E
I
P
G
-
Q
Q
S
R
G
R
T
C
R
G
R
K
--
F
D
G
H
R
C
A
G
Q
Q
Q
D
I
R
H
C
Y
S
-
I
Q
H
C
P
-----------
L
K
G
S
W
S
-
E
W
S
T
W
G
L
C
M
P
P
C
G
P
N
P
T
R
A
R
Q
R
L
C
T
P
LLPKY
P
P
T
V
S
M
V
E
G
Q
G
E
K
N
V
T
F
W
G
R
P
-
L
P
R
C
E
E
L
Q
G
Q
K
L
V
V
E
E
------
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
56.38
29%
48
- C- -
1W0R
-
PROP_HUMAN
A:
[115-425]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
P
W
E
P
C
S
V
T
C
S
K
G
----
T
R
T
R
R
R
A
C
N
HP
A
P
K
-----
C
------
G
G
H
C
P
G
--
Q
A
Q
E
S
E
A
C
D
T
Q
Q
V
C
P
T
H
G
A
W
A
T
W
G
P
W
T
P
C
S
A
S
C
H
G
G
P
H
E
P
K
E
T
R
S
R
K
C
S
--
A
P
--
E
----
P
S
Q
K
PP
G
K
P
C
P
G
L
A
Y
E
Q
R
R
C
T
G
L
-
P
P
C
P
V
A
G
G
W
G
P
W
G
P
V
S
P
C
------
P
V
T
C
G
--
L
G
Q
-
T
M
E
Q
R
T
C
N
H
P
V
--
P
--
Q
H
--
G
--
G
PF
C
A
G
D
A
T
R
T
H
I
C
N
-
T
A
V
-
P
C
P
-
V
D
G
E
W
D
S
W
G
E
W
S
P
C
I
R
RNMK
S
I
S
C
Q
--
E
I
P
G
-
Q
Q
S
R
G
R
T
C
R
G
R
K
--
F
D
G
H
R
C
A
G
Q
Q
Q
D
I
R
H
C
Y
S
-
I
Q
H
C
P
-----------
L
K
G
S
W
S
-
E
W
S
T
W
G
L
C
M
P
P
C
G
P
N
P
T
R
A
R
Q
R
L
C
T
P
LLPKY
P
P
T
V
S
M
V
E
G
Q
G
E
K
N
V
T
F
W
G
R
P
-
L
P
R
C
E
E
L
Q
G
Q
K
L
V
V
E
E
------
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
53.06
19%
-84
- C2 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
----------------
C
L
R
N
I
I
H
A
N
L
I
A
------
A
F
I
L
R
N
A
T
W
F
V
--
V
Q
L
T
M
S
P
--
E
V
H
Q
S
N
V
G
W
C
R
L
V
T
A
A
Y
N
Y
F
H
V
T
N
F
F
W
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
GIGHL
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
I
G
R
N
S
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
S
A
L
I
N
M
V
F
Q
--------
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
QT
P
N
R
A
K
R
V
I
A
T
F
R
T
GTW
D
A
Y
D
R
-----
L
R
A
W
M
F
I
C
I
G
W
G
V
P
---
F
P
I
I
V
A
W
A
I
G
K
L
-
Y
Y
D
N
E
K
C
W
A
G
K
R
P
G
-------
V
Y
TD
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
A
S
---------------------------------
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
--
N
E
V
-------
S
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
49.10
35%
84
- C3 -
3R6B
8
A:
[9-123]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
--
S
P
--
S
PQ--
M
N
----
G
K
P
C
E
G
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
G
V
-
Q
K
R
S
R
L
C
N
N
P
T
PQ
F
--
G
G
--
K
--
D
--
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
-
D
C
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
49.02
41%
86
- C3 -
3R6B
8
A:
[11-123]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
--
S
P
SP
Q
----
M
N
----
G
K
P
C
E
G
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
G
V
-
Q
K
R
S
R
L
C
N
N
P
T
--
P
--
Q
F
--
G
GK
D
--
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
-
D
C
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
48.89
42%
94
- C3 -
1LSL
2
A:
[1-113]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
SP
S
P
--
Q
----
M
N
----
G
K
P
C
E
G
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
G
V
-
Q
K
R
S
R
L
C
N
N
P
T
--
P
--
Q
F
GG
K
--
D
--
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
-
D
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
48.33
38%
38
- C- -
1W0R
-
PROP_HUMAN
A:
[162-383]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
C
P
T
H
G
A
W
A
T
W
G
P
W
T
P
C
S
A
S
C
H
G
G
P
H
E
P
K
E
T
R
S
R
K
C
S
--
A
P
E
P
S
Q
K
P
P
------
G
K
P
C
P
G
--
L
A
Y
E
Q
R
R
C
T
G
L
P
P
C
P
V
A
G
G
W
G
P
W
G
P
V
S
P
C
P
V
T
C
G
L
G
----
Q
T
M
E
Q
R
T
C
N
--
H
P
VP
Q
----
H
G
----
G
P
F
C
A
G
D
A
T
R
T
H
I
C
N
-
T
A
V
P
C
P
V
D
G
E
W
D
S
W
G
E
W
S
P
C
I
R
RNMK
S
I
S
C
Q
E
I
P
G
Q
-
Q
S
R
G
R
T
C
R
G
R
K
--
F
--
D
G
--
H
--
R
--
C
A
G
Q
Q
Q
D
I
R
H
C
Y
S
I
-
Q
-
H
C
P
L
-
K
G
S
W
S
E
W
S
T
W
G
L
C
------
M
P
P
C
G
--
P
--
N
P
T
R
A
R
Q
R
L
C
T
P
L
L
--
P
K
Y
P
P
T
V
S
M
V
E
G
Q
G
E
K
-
N
-
V
T
F
W
G
R
P
L
P
R
C
E
E
L
Q
G
Q
K
L
V
V
E
-
E
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
47.45
11%
-112
* C2 *
2Z73
5
OPSD_TODPA
A:
[39-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
--
L
F
T
K
T
-
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
-
I
D
R
-----
Y
N
V
I
G
R
P
M
A
A
-------
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
N
I
L
--
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
K
E
-------------------
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
FGPLEW
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
46.72
41%
94
- C3 -
1LSL
2
A:
[2-113]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
--
S
P
SP
Q
----
M
N
----
G
K
P
C
E
G
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
G
V
-
Q
K
R
S
R
L
C
N
N
P
T
--
P
--
Q
F
--
G
GK
D
--
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
-
D
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
46.64
36%
130
- C3 -
1LSL
2
A:
[3-110]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
W
S
H
W
S
P
W
S
S
C
------
S
V
T
C
G
--
D
G
V
-
I
T
R
I
R
L
C
N
S
P
S
PQ
M
--
N
G
--
K
--
P
--
C
E
G
E
A
R
E
T
K
A
C
K
-
K
-
D
-
A
C
P
I
-
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
--
G
-
V
Q
K
R
S
R
L
C
N
N
P
T
PQ
F
G
G
K
D
C
V
G
D
V
T
E
N
Q
I
C
-
N
-
K
Q
D
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
46.00
43%
104
- C3 -
1LSL
2
A:
[2-109]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
--
S
P
SP
Q
----
M
N
----
G
K
P
C
E
G
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
G
V
-
Q
K
R
S
R
L
C
N
N
P
T
--
P
QF
G
G
--
K
--
D
--
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
-
D
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
45.70
36%
92
- C3 -
3R6B
8
A:
[9-123]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
--
S
P
S
PQM--
N
------
G
K
P
C
E
G
--
E
A
R
E
T
K
A
C
K
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
S
V
T
C
G
G
G
----
V
Q
K
R
S
R
L
C
N
--
N
P
--
T
PQ--
F
G
----
G
K
D
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
D
C
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
43.71
34%
37
- C3 -
3T5O
3
CO6_HUMAN
A:
[8-99]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
Q
W
T
S
C
S
K
T
C
N
S
G
----
T
Q
S
R
H
R
Q
I
V
--
V
D
K
-----
Y
Y
Q
E
N
FC
E
Q
I
C
S
K
----
Q
E
T
R
E
C
-
N
W
Q
R
C
P
I
N
C
L
L
G
D
F
G
P
W
S
D
C
D
P
C
I
E
K
Q
----
S
K
V
R
-
S
V
L
R
--
P
S
--
Q
----
F
G
----
G
Q
P
C
T
A
P
L
V
A
F
Q
P
C
I
-
P
-
S
K
L
C
K
I
E
E
A
D
C
K
N
K
F
R
C
D
------
S
G
R
C
I
--
A
R
K
-
L
E
C
N
G
E
N
D
C
G
D
--
N
--
S
D
--
E
--
R
--
D
C
G
R
T
K
A
V
C
T
R
K
-
Y
-
N
-
P
I
P
S
V
Q
L
M
G
N
G
F
H
F
L
A
G
E
------
P
R
G
E
V
--
L
--
D
-
N
S
F
T
G
G
I
C
K
T
V
K
--
S
S
R
T
S
N
P
Y
R
V
P
A
N
L
E
N
-
V
-
G
F
E
V
Q
T
A
E
D
D
L
K
T
D
F
Y
K
D
L
T
S
L
-
G
H
V
P
I
F
Y
S
S
K
R
S
E
N
I
N
H
N
S
A
F
K
Q
A
------------
I
Q
A
S
H
K
---
K
D
S
S
F
I
R
I
H
K
V
M
K
V
L
N
F
T
T
K
A
K
D
L
------
H
L
S
D
V
F
L
K
A
L
N
H
L
P
L
E
Y
N
S
A
L
Y
S
R
I
F
D
D
F
G
T
H
Y
F
T
S
G
---
S
L
G
G
V
Y
D
L
L
Y
Q
F
S
S
E
------
E
L
K
N
S
G
----------
L
T
-----------
E
E
E
A
K
H
C
V
R
I
E
T
K
K
R
V
L
F
A
K
K
T
K
V
---
E
H
R
C
T
T
N
K
L
S
E
K
H
E
G
S
F
I
Q
G
A
E
K
S
I
S
L
I
R
G
G
R
S
E
Y
G
A
A
L
A
W
E
K
G
S
S
G
L
E
E
K
T
F
S
E
W
L
E
S
V
K
E
N
P
A
V
I
D
F
E
L
A
P
I
V
D
L
V
R
N
I
P
C
A
V
T
K
R
N
N
L
R
K
A
L
Q
E
Y
A
A
K
F
D
P
C
Q
C
A
P
C
P
N
N
G
R
P
T
L
S
G
T
E
C
L
C
V
C
Q
S
G
T
Y
G
E
N
C
E
K
Q
S
P
D
Y
K
S
N
A
V
D
G
----------------
Q
W
----------------
G
C
W
S
S
W
S
T
C
D
A
--
T
Y
K
R
S
R
T
--
R
E
C
N
N
P
A
P
Q
R
G
G
K
R
C
E
G
E
K
R
Q
E
E
----
D
C
T
P
C
I
N
D
D
E
E
D
S
G
C
P
Q
P
V
P
P
E
N
-
G
F
I
R
N
E
K
Q
L
Y
L
V
G
E
D
V
E
-----
I
S
C
L
T
G
F
E
T
V
G
Y
Q
Y
F
R
C
L
P
D
G
T
W
R
Q
G
D
V
E
C
Q
R
T
E
C
I
--
K
P
V
V
Q
E
V
L
T
I
T
P
F
Q
R
L
Y
R
I
G
E
S
I
E
L
T
C
P
K
G
F
V
V
A
G
--------
P
S
R
Y
T
C
Q
G
N
S
W
T
P
P
I
S
N
S
L
T
C
E
K
D
T
G
H
C
Q
L
G
-
Q
K
Q
-----
S
G
S
E
C
I
C
M
S
P
-------
E
-----
E
D
C
S
H
H
S
E
D
L
C
V
F
D
T
D
S
N
D
Y
F
T
S
P
A
C
K
F
L
-
A
E
K
C
L
N
N
Q
Q
L
H
F
L
H
-------
I
G
--
S
C
Q
D
G
R
Q
L
E
W
G
L
E
R
T
R
L
S
S
N
S
T
K
K
E
S
C
G
Y
D
T
C
Y
D
W
E
K
C
S
A
S
T
S
K
C
V
C
L
L
P
P
Q
C
F
K
G
G
N
Q
L
Y
C
V
K
M
G
S
S
T
S
E
K
T
L
N
I
C
E
V
G
T
I
R
C
A
N
R
K
M
E
I
L
H
P
G
K
C
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
42.21
34%
40
- C3 -
4A5W
2
CO6_HUMAN
B:
[8-99]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
Q
W
T
S
C
S
K
T
C
N
S
G
----
T
Q
S
R
H
R
Q
I
V
--
V
D
K
-----
Y
Y
Q
E
N
FC
E
Q
I
C
S
K
----
Q
E
T
R
E
C
-
N
W
Q
R
C
P
I
N
C
L
L
G
D
F
G
P
W
S
D
C
D
P
C
I
E
K
Q
----
S
K
V
R
-
S
V
L
R
--
P
S
--
Q
----
F
G
----
G
Q
P
C
T
A
P
L
V
A
F
Q
P
C
I
-
P
-
S
K
L
C
K
I
E
E
A
D
C
K
N
K
F
R
C
D
------
S
G
R
C
I
--
A
R
K
-
L
E
C
N
G
E
N
D
C
G
D
--
N
--
S
D
--
E
--
R
--
D
C
G
R
T
K
A
V
C
T
R
K
-
Y
-
N
-
P
I
P
S
V
Q
L
M
G
N
G
F
H
F
L
A
G
E
------
P
R
G
E
V
--
L
--
D
-
N
S
F
T
G
G
I
C
K
T
V
K
--
S
S
R
T
S
N
P
Y
R
V
P
A
N
L
E
N
-
V
-
G
F
E
V
Q
T
A
E
D
D
L
K
T
D
F
Y
K
D
L
T
S
L
-
Q
G
G
S
S
F
S
V
P
I
F
Y
S
S
K
R
S
E
N
I
N
H
N
S
------------
A
F
K
Q
A
I
---
Q
A
S
H
K
K
D
S
S
F
I
R
I
H
K
V
M
K
V
L
N
F
T
T
------
K
A
K
D
L
H
L
S
D
V
F
L
K
A
L
N
H
L
P
L
E
Y
N
S
A
L
Y
S
R
I
F
D
D
F
G
T
H
---
Y
F
T
S
G
S
L
G
G
V
Y
D
L
L
Y
------
Q
F
S
S
E
E
----------
L
K
-----------
N
S
G
L
T
E
E
E
A
K
H
C
V
R
I
E
T
H
R
C
T
T
N
K
---
L
S
E
K
H
E
G
S
F
I
Q
G
A
E
K
S
I
S
L
I
R
G
G
E
E
K
T
F
S
E
W
L
E
S
V
K
E
N
P
A
V
I
D
F
E
L
A
P
I
V
D
L
V
R
N
I
P
C
A
V
T
K
R
N
N
L
R
K
A
L
Q
E
Y
A
A
K
F
D
P
C
Q
C
A
P
C
P
N
N
G
R
P
T
L
S
G
T
E
C
L
C
V
C
Q
S
G
T
Y
G
E
N
C
E
K
Q
S
P
D
Y
K
S
N
A
V
D
G
Q
W
G
C
W
S
S
W
S
T
C
D
A
T
Y
K
R
S
R
T
R
E
C
N
N
----------------
P
A
----------------
P
Q
R
G
G
K
R
C
E
G
E
--
K
R
Q
E
E
D
C
--
T
F
S
I
M
E
N
N
G
Q
P
C
I
N
D
D
E
E
M
K
E
V
D
----
L
P
E
I
E
A
D
S
G
C
P
Q
P
V
P
P
E
N
G
F
I
R
N
-
E
K
Q
L
Y
L
V
G
E
D
V
E
I
S
C
L
T
-----
G
F
E
T
V
G
Y
Q
Y
F
R
C
L
P
D
G
T
W
R
Q
G
D
V
E
C
Q
R
T
E
C
I
K
P
V
V
Q
--
E
V
L
T
I
T
P
F
Q
R
L
Y
R
I
G
E
S
I
E
L
T
C
P
K
G
F
V
V
A
G
P
S
R
Y
T
--------
C
Q
G
N
S
W
T
P
P
I
S
N
S
L
T
C
E
K
D
T
L
T
K
L
K
G
H
C
Q
L
G
-
Q
K
Q
-----
S
G
S
E
C
I
C
M
S
P
-------
E
-----
E
D
C
S
H
H
S
E
D
L
C
V
F
D
T
D
S
N
D
Y
F
T
S
P
A
C
K
F
L
-
A
E
K
C
L
N
N
Q
Q
L
H
F
L
H
-------
I
G
--
S
C
Q
D
G
R
Q
L
E
W
G
L
E
R
T
R
L
S
S
N
S
T
K
K
E
S
C
G
Y
D
T
C
Y
D
W
E
K
C
S
A
S
T
S
K
C
V
C
L
L
P
P
Q
C
F
K
G
G
N
Q
L
Y
C
V
K
M
G
S
S
T
S
E
K
T
L
N
I
C
E
V
G
T
I
R
C
A
N
R
K
M
E
I
L
H
P
G
K
C
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
41.47
9%
22
- C2 -
2HQT
2
ARC1_YEAST
A:
[4-121]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
V
T
K
F
E
S
L
I
Y
P
V
SFT
K
E
Q
S
A
Q
A
A
Q
W
E
S
V
L
K
S
G
Q
I
Q
P
H
L
D
Q
L
N
L
V
L
R
D
N
T
F
I
V
S
T
L
YPT
S
T
D
V
H
V
F
E
V
A
L
P
L
I
K
------
D
L
V
A
S
S
KD--------
V
K
-----------
S
T
Y
T
T
Y
R
H
I
L
R
W
I
D
Y
M
Q
N
L
L
E
V
S
S
---
T
D
K
L
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
41.40
28%
-2
- C3 -
3T5O
4
CO6_HUMAN
A:
[2-158]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
C
D
H
Y
A
W
T
Q
W
T
S
C
S
K
T
C
N
S
G
----
T
Q
S
R
H
R
Q
I
V
--
V
D
K
Y
Y
---
Q
------
E
N
F
C
E
Q
IC
S
K
Q
E
T
R
E
C
N
W
-
Q
R
C
P
I
N
C
L
L
G
D
F
G
P
W
S
D
C
D
P
-
C
I
-
E
----
K
Q
S
K
V
R
S
V
L
--
R
P
--
S
Q---
F
G
----
G
Q
P
C
T
A
P
L
V
A
F
Q
P
C
I
-
P
S
K
L
C
K
I
--------
E
E
A
D
C
KN----
K
F
R
C
D
--
S
G
R
C
I
A
R
K
L
E
C
N
G
E
----------
N
--
D
--
C
G
-
D
N
S
D
E
R
D
C
G
-
R
-
T
-
K
A
V
C
T
R
K
Y
N
P
I
P
S
V
Q
L
M
G
------
N
G
F
H
F
--
L
--
A
-
G
E
P
R
G
E
V
L
D
N
S
F
--
T
G
G
I
C
K
T
V
K
S
S
R
T
S
N
P
-
Y
-
R
V
P
A
N
L
E
N
V
G
F
E
V
Q
T
A
E
D
D
L
K
T
-
D
F
Y
K
D
L
T
S
L
G
H
V
P
I
F
Y
S
S
K
R
S
E
N
I
------------
N
H
N
S
A
F
---
K
Q
A
I
Q
A
S
H
K
K
D
S
S
F
I
R
I
H
K
V
M
K
V
L
------
N
F
T
T
K
A
K
D
L
H
L
S
D
V
F
L
K
A
L
N
H
L
P
L
E
Y
N
S
A
L
Y
S
R
I
F
D
D
---
F
G
T
H
Y
F
T
S
G
S
L
G
G
V
Y
------
D
L
L
Y
Q
F
----------
S
S
-----------
E
E
L
K
N
S
G
L
T
E
E
E
A
K
H
C
V
R
I
E
T
K
K
R
---
V
L
F
A
K
K
T
K
V
E
H
R
C
T
T
N
K
L
S
E
K
H
E
G
S
F
I
Q
G
A
E
K
S
I
S
L
I
R
G
G
R
S
E
Y
G
A
A
L
A
W
E
K
G
S
S
G
L
E
E
K
T
F
S
E
W
L
E
S
V
K
E
N
P
A
V
I
D
F
E
L
A
P
I
V
D
L
V
R
N
I
P
C
A
V
T
K
R
N
N
L
R
K
A
L
Q
E
Y
A
A
K
F
D
P
C
Q
C
A
P
C
P
N
N
G
R
P
T
L
S
G
T
E
C
L
C
V
C
Q
S
G
T
Y
G
E
N
C
E
K
Q
S
P
----------------
D
Y
----------------
K
S
N
A
V
D
G
Q
W
G
C
--
W
S
S
W
S
T
C
--
D
A
T
Y
K
R
S
R
T
R
E
C
N
N
P
A
P
Q
R
G
G
K
R
----
C
E
G
E
K
R
Q
E
E
D
C
T
P
C
I
N
D
D
E
E
D
S
G
-
C
P
Q
P
V
P
P
E
N
G
F
I
R
N
E
K
Q
-----
L
Y
L
V
G
E
D
V
E
I
S
C
L
T
G
F
E
T
V
G
Y
Q
Y
F
R
C
L
P
D
G
T
W
R
Q
G
D
--
V
E
C
Q
R
T
E
C
I
K
P
V
V
Q
E
V
L
T
I
T
P
F
Q
R
L
Y
R
I
G
E
S
I
E
L
T
--------
C
P
K
G
F
V
V
A
G
P
S
R
Y
T
C
Q
G
N
S
W
T
P
P
I
S
N
S
L
T
C
E
-
K
D
T
-----
G
H
C
Q
L
G
Q
K
Q
S
-------
G
-----
S
E
C
I
C
M
S
P
E
E
D
C
S
H
H
S
E
D
L
C
V
F
D
T
D
S
N
D
Y
-
F
T
S
P
A
C
K
F
L
A
E
K
C
L
-------
N
N
--
Q
Q
L
H
F
L
H
I
G
S
C
Q
D
G
R
Q
L
E
W
G
L
E
R
T
R
L
S
S
N
S
T
K
K
E
S
C
G
Y
D
T
C
Y
D
W
E
K
C
S
A
S
T
S
K
C
V
C
L
L
P
P
Q
C
F
K
G
G
N
Q
L
Y
C
V
K
M
G
S
S
T
S
E
K
T
L
N
I
C
E
V
G
T
I
R
C
A
N
R
K
M
E
I
L
-------
H
P
G
K
C
L
A
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