@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AGRB3_HUMAN: (2016-01-08 )
MKAVRNLLIYIFSTYLLVMFGFNAAQDFWCSTLVKGVIYGSYSVSEMFPKNFTNCTWTLENPDPTKYSIYLKFSKKDLSCSNFSLLAYQFDHFSHEKIKDLLRKNHSIMQLCNSKNAFVFLQYDKNFIQIRRVFPTNFPGLQKKGEEDQKSFFEFLVLNKVSPSQFGCHVLCTWLESCLKSENGRTESCGIMYTKCTCPQHLGEWGIDDQSLILLNNVVLPLNEQTEGCLTQELQTTQVCNLTREAKRPPKEEFGMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTGESGVEEWSQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWNQWGHWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCNEQRCPAPYEICPEDYLMSMVWKRTPAGDLAFNQCPLNATGTTSRRCSLSLHGVAFWEQPSFARCISNEYRHLQHSIKEHLAKGQRMLAGDGMSQVTKTLLDLTQRKNFYAGDLLMSVEILRNVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEKWEDAQQIYPGSIELMQVIEDFIHIVGMGMMDFQNSYLMTGNVVASIQKLPAASVLTDINFPMKGRKGMVDWARNSEDRVVIPKSIFTPVSSKELDESSVFVLGAVLYKNLDLILPTLRNYTVINSKIIVVTIRPEPKTTDSFLEIELAHLANGTLNPYCVLWDDSKTNESLGTWSTQGCKTVLTDASHTKCLCDRLSTFAILAQQPREIIMESSGTPSVTLIVGSGLSCLALITLAVVYAALWRYIRSERSIILINFCLSIISSNILILVGQTQTHNKSICTTTTAFLHFFFLASFCWVLTEAWQSYMAVTGKIRTRLIRKRFLCLGWGLPALVVATSVGFTRTKGYGTDHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCGVVSTTALSATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVLHKDIGPCRAATITGTLSRISLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPTGLHMPMSMNELSNPCLKKENSELRRTVYLCTDDNLRGADMDIVHPQERMMESDYIVMPRSSVNNQPSMKEESKMNIGMETLPHERLLHYKVNPEFNMNPPVMDQFNMNLEQHLAPQEHMQNLPFEPRTAVKNFMASELDDNAGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHMELFQELNQKFQTLDRFRDIPNTSSMENPAPNKNPWDTFKNPSEYPHYTTINVLDTEAKDALELRPAEWEKCLNLPLDVQEGDFQTEV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290....---...300.......310....-...320--.----...------.-..--.-330.......340.----......350.......360..----.....370.--..--.----...380..--.....390.-.-.....400-------------------....----...410--.......----420.......--.430---........440....----..-.-450.......460.....------..470--.--..-....480...--.--...490.......500.-..-....510......-----.520.......530...---....540.......550--.........560-........570.......580.......590.......600.......610.......620.......630------.....-------..----------..640.......650.......660.---......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780--------------..-----------------.......790.....--..800..----.....810....--....820.......830.----......840.......850.......860----.........870.......880.......890.......900.......910.......920.....-..930---.--------.----......940.......950.......960.......970....-----..--------.980.......990.......1000...-...1010......1020----..--.......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120-------......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
A
V
R
N
L
L
I
Y
I
F
S
T
Y
L
L
V
M
FGF
N
A
A
Q
D
F
W
C
S
T
L
V
K
G
V
I
YGS
Y
S
V
S
E
MFPKNFTN
C
T
W
T
LENPDPT
K
Y
S
I
Y
L
K
FSKKDLSCSN
F
S
L
L
A
Y
QFDHF
S
H
E
K
I
K
D
L
L
RKN
H
S
I
M
Q
L
CNSKN
A
F
V
F
L
Q
YDKN
F
I
Q
I
RRVFPTNFPGLQKKG
E
E
D
Q
K
S
F
F
E
F
L
V
LNKV
S
P
S
QF
G
C
H
V
L
C
T
W
L
E
S
C
L
K
SENGRTESC
G
I
M
Y
T
KCT
C
P
Q
H
L
G
EWGIDDQ
S
L
I
L
L
N
N
V
V
LPLNEQTE
G
C
L
T
Q
EL
Q
T
T
Q
V
C
N
L
T
R
E
AKRP
P
K
E
E
FGMMGDHTIKSQRPR
S
V
H
E
KRV
P
Q
E
Q
A
D
A
A
K
F
M
A
QTG
E
S
G
V
E
E
---
W
SQWS
T
C
S
V
TCGQGS
Q
V
R
T
R
-
T
CVSP---Y----GTH------C-SG--P-
L
R
E
SRVCNNTALCP----VHGVWEEWSPW
S
L
C
S
F
TCGRG----QRTRTRSCT--PP--Q----YGGRPCEG--PETHHKPC
N
-
I
-
A
LCPVDGQ-------------------
W
Q
EW----SSWS
Q
C
--
S
V
T
CSNG----
T
-
Q
Q
R
S
R
QCT--AAA----HGGSECRGPWAESRE----CY-N-PECTANGQWNQWGHWSGC------SKSCD--G--
G
W
-
E
R
R
I
R
TCQ
G
A
--
V
--
I
TGQQCEG
T
G
E
E
V
R
R
C
N
-EQ-RCPAPYEIC
P
E
D
Y
-----
L
M
S
M
V
WKRTPAGDLAFN---QCPLNATGTTS
R
R
C
S
----
L
S
LH
G
V
A
FWEQ--P
S
F
A
R
C
I
S
N
E
Y
R
H
L
Q
H
S
I
K
E
H
L
A
KGQRMLAGD
G
M
S
Q
V
T
K
T
L
L
D
L
T
Q
RKNFYA
G
D
L
L
M
S
V
E
I
L
R
N
V
T
D
T
F
--------
K
RASY-------IP----------A
S
D
G
V
Q
N
F
F
Q
I
V
S
N
L
LDEE
N
K
E
K
W
E
D
---
A
Q
QIYPG
S
I
E
L
M
Q
V
I
E
D
F
I
H
I
V
G
M
G
M
M
DFQN
S
Y
L
M
T
G
N
V
V
A
S
I
Q
KLP
A
A
S
V
L
TDINFPMKGRKGMVDWARNSED
R
V
V
I
P
K
S
IFTPVSSKELDES
S
V
F
V
L
G
A
V
L
YK
N
L
D
L
I
L
PTLR
N
Y
----------------
T
V
-----------------IN
S
K
I
I
V
V
T
IRPEPK--TTD
S
F
L
E
----
I
E
L
A
H
L-ANGTL--N
P
Y
C
V
L
WDDSKTNESLGT----WSTQG
C
K
T
V
LTDAS
H
T
K
C
L
C
D
R
L
S
T
F
A
------
I
L
A
QQ
P
R
E
I
I
MESSGT
P
S
V
T
L
I
VGSG
L
S
C
L
A
L
I
T
L
A
V
V
Y
A
A
L
W
R
Y
I
RSER
S
I
I
L
I
N
F
C
L
S
I
ISS
N
I
L
-
I
L
V
G----Q--------T----QTHNKS
I
C
T
T
T
T
A
F
L
H
F
F
F
L
A
S
F
C
W
V
L
T
E
A
W
Q
S
Y
M
A
V
T
G
K
I
R
T
-----
R
L
--------
I
R
K
R
F
L
C
LGWG
L
P
A
L
V
V
ATSVGFTRTKG-YGT
D
H
Y
C
W
L
S
LEG
G
-------
L
L
--
Y
A
FVG
P
A
A
A
V
V
L
V
N
M
V
I
G
I
L
V
F
N
K
L
V
SRDG
I
L
D
K
K
L
K
H
RAGQMSEPHS
G
L
T
L
K
C
AKCG
V
V
S
T
T
A
L
SAT
T
A
S
N
A
M
A
S
L
W
S
S
C
V
V
L
P
L
L
A
L
T
W
M
S
A
V
L
A
MTD
K
-------
R
S
I
L
F
Q
I
L
F
A
V
F
D
SL
Q
G
F
V
I
V
M
V
H
C
I
L
R
R
E
V
Q
D
A
F
R
C
R
LRNCQDPINADSSSSFPNG
H
A
Q
I
M
T
D
F
EK
D
V
D
I
A
C
R
S
V
L
H
KDIGPC
R
A
A
T
I
T
G
T
L
S
R
I
SLNDDEEEKGTNPEG
L
S
YSTL
P
G
N
V
I
S
K
V
I
IQQPTGLHMPM
S
M
N
E
LSNPCLKKENS
E
L
R
R
T
V
Y
L
CTDDNLRGADMDIVH
P
Q
E
R
MMESD
Y
I
V
MPRSSVNNQPSM
K
E
E
S
KMNIGMETLPHE
R
L
L
H
Y
KVNPEFNMNPP
V
M
D
Q
FN
M
N
L
E
Q
HL
A
P
Q
E
H
M
QNLPFE
P
R
T
A
V
K
N
F
M
A
S
ELDDNAGLSRSETGST
I
S
M
S
S
L
E
R
R
K
S
RYSDL
D
F
E
K
V
M
H
T
R
K
R
H
M
E
L
F
Q
E
L
N
Q
K
F
Q
T
L
D
R
F
RDIPNTSSMENPAPNKNPWDTFKNPSEYPH
Y
T
T
I
N
V
LDTEA
K
D
A
LELR
P
A
E
W
E
K
C
LNLPLDVQEGDFQTEV
21
PsiBlast_CBE
89.21
99%
-94
- C1 -
4DLO
6
B:
[7-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
S
-
E
Q
-
R
C
P
A
P
Y
E
I
C
P
E
D
Y
-----
L
M
S
M
V
W
K
R
T
P
A
G
D
L
A
F
N
---
Q
C
P
L
N
A
T
G
T
T
S
R
R
C
S
----
L
S
L
H
G
V
A
F
W
E
Q
--
P
S
F
A
R
C
I
S
N
E
Y
R
H
L
Q
H
S
I
K
E
H
L
A
-------
G
D
G
M
S
Q
V
T
K
T
L
L
D
L
T
Q
R
K
N
F
Y
A
G
D
L
L
M
S
V
E
I
L
R
N
V
T
D
T
F
--------
K
R
A
S
Y
-------
I
P
----------
A
S
D
G
V
Q
N
F
F
Q
I
V
S
N
L
L
D
E
E
N
K
E
K
W
E
D
---
A
Q
Q
I
Y
P
G
S
I
E
L
M
Q
V
I
E
D
F
I
H
I
V
G
M
G
M
M
D
F
Q
N
S
Y
L
M
T
G
N
V
V
A
S
I
Q
K
L
P
A
A
S
V
L
T
D
I
N
F
P
M
K
G
R
K
G
M
V
D
W
A
R
N
S
E
D
R
V
V
I
P
K
S
I
F
T
----------
S
V
F
V
L
G
A
V
L
Y
K
N
L
D
L
I
L
P
T
L
R
N
Y
----------------
T
V
-----------------
I
N
S
K
I
I
V
V
T
I
R
P
E
P
------
S
F
L
E
----
I
E
L
A
H
L
-
A
N
G
T
L
--
N
P
Y
C
V
L
W
D
D
------
L
G
T
----
W
S
T
Q
G
C
K
T
V
L
T
D
A
S
H
T
K
C
L
C
D
R
L
S
T
F
A
------
I
L
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
62.88
26%
-59
- C1 -
4DLQ
16
A:
[18-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
-----
V
R
R
V
Q
W
P
A
T
Q
Q
G
M
L
V
E
R
---
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
L
----
P
A
-
L
G
L
W
N
P
R
G
--
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
----------
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
-
R
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
--------
D
A
Q
L
Q
-------
A
L
RN
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
MN-
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
P
Q
E
Y
---------
A
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
-----
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
A
T
VKLA
G
E
A
G
T
GGPGGAS
L
V
-----------------
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
RV
F
L
M
D
P
V
I
----
F
T
V
A
H
L
E
A
K
N
H
F
--
N
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
-
G
Y
----
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.48
24%
-65
- C1 -
4DLQ
16
A:
[18-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
PRE
V
R
R
V
Q
W
P
A
T
Q
Q
G
M
L
V
E
R
---
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
-------
L
P
A
L
G
L
W
N
P
RG
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
----------
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
-
R
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
R-----N
K
M
H
K
R
E
R
T
----------
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
MN
A
T
E
Q
V
H
T
A
T
M
-
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
P
Q
-------
E
Y
A
--
S
E
S
S
I
Q
L
S
A
N
T
I
-----
K
Q
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
-
E
N
A
----------------
T
V
KLA
G
E
A
G
T
GGPGGASLV
V
N
S
Q
V
I
A
A
S
I
N
K
E
----
S
S
R
V
F
L
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
H
F
--
N
A
N
C
S
F
W
N
Y
S
E
R
S
-
M
L
G
Y
----
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
50.50
19%
-56
- C1 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
C
L
R
N
I
I
H
A
N
L
I
A
A
F
I
L
R
N
A
T
W
F
V
V
Q
L
T
M
S
-------
P
E
V
H
Q
S
----------------
N
V
-----------------
G
W
C
R
L
V
T
A
A
Y
N
Y
F
H
V
--
T
N
F
F
W
M
F
----
G
E
G
C
Y
L
-
H
T
A
I
V
L
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
I
GRNSNG
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-------
K
L
K
P
V
Y
D
S
L
----
D
A
V
R
R
S
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
----
L
--------
R
----
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
A
T
F
R
T
G
T
W
D
A
Y
D
-----
R
L
--------
R
A
W
M
F
I
C
I
G
W
G
V
P
F
P
I
I
---
V
A
W
A
I
G
K
L
-
Y
Y
D
N
E
K
C
W
A
G
K
R
P
G
-------
V
Y
TD
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
---------
K
L
R
A
--------------------
S
T
T
----
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
--
N
E
V
-------
S
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
48.08
45%
121
- C3 -
1LSL
2
A:
[2-113]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
G
W
S
H
---
W
S
P
W
S
S
C
S
V
T
C
G
D
G
V
I
T
R
I
R
-
L
C
N
S
P
---
S
PQMN
G
K
P
------
C
-
E
G
--
E
-
A
R
E
T
K
A
C
K
K
D
A
-
C
P
----
I
N
G
G
W
G
P
W
S
P
W
D
I
C
S
V
T
C
G
G
G
----
V
Q
K
R
S
R
L
C
N
NP
T
P
--
Q
----
F
G
G
K
D
C
V
G
--
D
V
T
E
N
Q
I
C
N
-
K
-
Q
D
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
46.47
36%
80
- C- -
1W0R
-
PROP_HUMAN
A:
[109-382]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
G
W
S
G
---
W
G
P
W
E
P
C
S
V
T
C
S
K
G
T
R
T
R
R
R
A
C
N
H
P
A
PK-
C
----
G
G
H
------
C
-
P
G
--
Q
-
A
Q
E
S
E
A
C
D
T
Q
Q
V
C
P
----
T
H
G
A
W
A
T
W
G
P
W
T
P
C
S
A
S
C
H
G
G
P
H
E
P
K
E
T
R
S
R
K
C
S
--
A
P
--
E
P
S
Q
K
P
P
G
K
P
C
P
G
--
L
A
Y
E
Q
R
R
C
T
G
L
-
P
P
C
P
V
A
G
G
-------------------
W
G
P
W
----
G
P
V
S
P
C
--
P
V
T
C
G
L
G
----
Q
-
T
M
E
Q
R
T
C
N
--
H
P
V
PQ--
H
G
G
P
F
C
A
G
D
A
T
R
T
H
I
----
C
N
-
T
A
V
P
C
P
V
D
G
E
W
D
S
W
G
E
W
S
P
C
I
R
RNMK
S
I
S
C
Q
E
I
P
--
G
Q
-
Q
S
R
G
R
T
C
R
G
R
--
K
--
F
D
G
H
R
C
A
G
Q
Q
Q
D
I
R
H
C
Y
S
I
Q
-
H
C
P
L
---------------
K
G
S
W
S
E
W
S
T
W
G
L
C
M
-
P
---
P
C
G
P
N
P
T
R
A
R
Q
R
L
C
T
----
P
L
L
P
K
Y
P
P
T
V
S
--
M
V
E
G
Q
G
E
K
N
V
T
F
W
G
R
P
L
P
R
C
E
E
L
Q
G
Q
K
L
V
V
E
E
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
46.26
46%
114
* C3 *
1LSL
2
A:
[1-113]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
SP
S
P
--
Q
----
M
N
G
K
P
C
E
G
--
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
-------------------
W
G
P
W
----
S
P
W
D
I
C
--
S
V
T
C
G
G
G
----
V
-
Q
K
R
S
R
L
C
N
NP
T
P
Q
----
F
G
G
K
D
C
V
G
D
V
T
E
N
Q
I
----
C
N
-
K
-
Q
D
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
45.43
44%
115
- C3 -
3R6B
8
A:
[11-123]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
G
W
S
H
---
W
S
P
W
S
S
C
S
V
T
C
G
D
G
V
I
T
R
I
R
-
L
C
N
S
P
---
S
PQMN
G
K
P
------
C
-
E
G
--
E
-
A
R
E
T
K
A
C
K
K
D
A
-
C
P
----
I
N
G
G
W
G
P
W
S
P
W
D
I
C
S
V
T
C
G
G
G
----
V
Q
K
R
S
R
L
C
N
NP
T
P
--
Q
----
F
G
G
K
D
C
V
G
--
D
V
T
E
N
Q
I
C
N
-
K
-
Q
D
C
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
45.16
38%
100
- C3 -
3R6B
8
A:
[9-123]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
Q
D
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
--
S
P
--
S
PQ--
M
N
G
K
P
C
E
G
--
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
-------------------
W
G
P
W
----
S
P
W
D
I
C
--
S
V
T
C
G
G
G
----
V
-
Q
K
R
S
R
L
C
N
--
N
P
T
PQ--
F
G
G
K
D
C
V
G
D
V
T
E
N
Q
I
----
C
N
-
K
-
Q
D
C
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
45.15
10%
-106
- C1 -
2Z73
5
OPSD_TODPA
A:
[39-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
-
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
-
N
G
F
P
----
L
M
T
I
S
C
F
L
K
K
----
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
--------
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
N
I
L
--
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
K
E
L
-------------------
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
FGPLEW
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
45.09
38%
145
- C3 -
1LSL
2
A:
[3-110]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-------------------
W
S
H
W
----
S
P
W
S
S
C
--
S
V
T
C
G
D
G
----
V
-
I
T
R
I
R
L
C
N
--
S
P
S
PQ--
M
N
G
K
P
C
E
G
E
A
R
E
T
K
A
----
C
K
-
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
--
G
V
-
Q
K
R
S
R
L
C
N
N
P
--
T
PQ
F
G
G
K
D
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
Q
-
D
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
42.75
33%
35
- C3 -
4E0S
3
CO6_HUMAN
B:
[8-106]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
Q
W
T
S
C
S
K
T
C
N
S
G
T
Q
S
R
H
R
Q
I
V
V
D
K
---
Y
----
Y
Q
E
N
FCEQI
C
-
S
K
-----
Q
E
T
R
E
C
-
N
W
Q
R
C
P
----
I
N
C
L
L
G
D
F
G
P
W
S
D
C
D
P
C
I
E
K
Q
----
S
K
V
R
S
-
V
L
R
--
P
S
--
Q
----
F
G
G
Q
P
C
T
A
--
P
L
V
A
F
Q
P
C
I
-
P
-
S
K
L
C
K
I
E
E
-------------------
A
D
C
K
----
N
K
F
R
C
D
--
S
G
R
C
I
A
R
----
K
-
L
E
C
N
G
E
N
D
--
C
G
D
----
N
S
D
E
R
D
C
G
R
T
K
A
V
C
T
----
R
K
-
Y
-
N
P
I
P
S
V
Q
L
M
G
N
G
F
H
F
L
A
G
------
E
P
R
G
E
--
V
--
L
D
-
N
S
F
T
G
G
I
C
K
T
--
V
--
K
S
S
R
T
S
N
P
Y
R
V
P
A
N
L
E
N
-
V
G
-
F
E
V
Q
T
A
E
D
D
L
K
T
D
-----
F
Y
K
D
L
T
S
L
G
H
N
E
N
Q
Q
G
V
---
P
I
F
Y
S
S
K
R
S
E
N
I
N
H
N
----
S
A
F
K
Q
A
I
Q
A
S
H
--
K
K
D
S
S
F
I
R
I
H
K
V
M
K
V
L
N
F
T
T
K
A
K
D
L
H
L
S
D
V
F
L
K
A
L
N
H
L
P
L
E
Y
N
S
A
L
Y
S
R
I
F
D
D
F
G
T
H
Y
F
T
S
G
S
L
G
G
V
Y
D
--------
L
L
Y
Q
F
-------
S
S
----------
E
E
L
K
N
S
G
L
T
E
E
E
A
K
H
C
V
R
I
E
T
K
K
R
V
L
---
F
A
K
K
T
K
V
E
H
R
C
T
T
N
K
L
S
E
K
H
E
G
S
F
I
Q
G
A
E
K
S
I
S
L
I
R
G
G
R
S
E
Y
G
A
A
L
A
W
E
K
G
S
S
G
L
E
E
K
T
F
S
E
W
L
E
S
V
K
E
N
P
A
V
I
D
F
E
L
A
P
I
V
D
L
V
R
N
I
P
C
A
V
T
K
R
N
N
L
R
K
A
L
Q
E
Y
A
A
K
F
D
P
C
Q
C
A
P
C
----------------
P
N
-----------------
N
G
R
P
T
L
S
G
T
E
C
L
C
V
C
--
Q
S
G
T
Y
G
E
----
N
C
E
K
Q
S
-
P
D
Y
K
S
--
N
A
V
D
G
Q
W
G
C
W
S
S
W
S
T
C
D
A
----
T
Y
K
R
S
R
T
R
E
C
N
N
P
A
P
Q
R
G
G
K
R
C
E
G
E
K
R
------
Q
E
E
D
C
T
F
S
I
M
E
N
N
G
Q
P
C
I
N
D
D
E
E
M
K
E
V
D
L
P
E
I
E
A
D
S
G
C
P
Q
P
V
P
P
E
N
G
F
I
R
N
E
K
Q
L
Y
L
V
G
E
D
V
E
I
S
C
L
-
T
G
F
E
----
T
--------
V
----
G
Y
Q
Y
F
R
C
L
P
D
G
T
W
R
Q
G
D
V
E
C
Q
R
T
E
C
I
K
P
V
V
Q
E
V
L
T
I
T
P
F
Q
R
L
Y
-----
R
I
--------
G
E
S
I
E
L
T
C
P
K
G
F
V
V
A
G
P
S
R
Y
T
C
Q
G
N
S
W
T
-
P
P
I
S
N
S
L
T
C
E
K
D
T
L
-------
G
H
--
C
Q
L
G
Q
K
Q
S
G
S
E
C
I
C
M
S
P
E
E
D
C
S
H
H
S
E
D
L
C
V
F
D
T
D
S
N
D
Y
F
T
S
P
A
C
K
F
L
A
E
K
C
L
N
N
Q
Q
L
H
F
L
H
I
G
S
C
Q
D
G
R
Q
L
E
W
G
L
E
R
T
R
L
S
S
N
S
T
K
K
E
S
C
G
Y
D
T
C
Y
D
W
E
K
C
-------
S
A
S
T
S
K
C
V
C
L
L
P
P
Q
C
F
K
G
G
N
Q
L
Y
C
V
K
M
G
S
S
T
S
E
K
T
L
N
I
C
E
V
G
T
I
R
C
A
N
R
K
M
E
I
L
H
P
G
K
C
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
42.08
36%
64
- C- -
1W0R
-
PROP_HUMAN
A:
[50-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
R
W
S
L
---
W
S
T
W
A
P
C
S
V
T
C
S
E
G
S
Q
L
R
Y
R
R
C
V
G
W
N
---
G
QCS-
G
K
V
------
A
-
P
G
--
T
L
E
W
Q
L
Q
A
C
E
D
Q
Q
C
C
P
----
E
M
G
G
W
S
G
W
G
P
W
E
P
C
S
V
T
C
S
K
G
----
T
R
T
R
R
R
A
C
N
--
H
P
--
A
P---
K
C
G
G
H
C
P
G
--
Q
A
Q
E
S
E
A
C
D
-
T
Q
Q
V
C
P
T
H
G
A
-------------------
W
A
T
W
----
G
P
W
T
P
C
--
S
A
S
C
H
G
G
P
H
E
P
K
-
E
T
R
S
R
K
C
S
--
A
P
E
P
S
Q
K
P
P
G
K
P
C
P
G
L
A
Y
E
Q
R
R
----
C
T
G
L
-
P
P
C
P
V
A
G
G
W
G
P
W
G
P
V
S
P
C
------
P
V
T
C
G
--
L
--
G
Q
-
T
M
E
Q
R
T
C
N
H
P
VP
Q
--
H
G
G
P
F
C
A
G
D
A
T
R
T
H
I
C
N
-
T
A
V
P
C
P
V
D
G
E
W
D
S
W
G
E
-----
W
S
P
C
I
R
R
N
M
K
S
I
S
C
Q
E
I
---
P
G
Q
Q
S
R
G
R
T
C
R
G
R
K
F
----
D
G
H
R
C
A
G
Q
Q
Q
D
--
I
R
H
C
Y
S
I
Q
H
C
P
L
K
G
S
W
S
E
W
S
T
W
G
L
C
M
P
P
C
G
P
N
P
T
R
A
R
Q
R
L
C
T
P
L
L
P
K
Y
P
P
T
V
S
M
V
E
G
Q
G
E
K
N
V
T
F
W
G
R
P
--------
L
P
R
C
E
-------
E
L
----------
Q
G
Q
K
L
V
V
E
E
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
---
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
41.99
37%
118
- C3 -
3R6B
8
A:
[9-123]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
G
G
W
S
H
---
W
S
P
W
S
S
C
S
V
T
C
G
D
G
V
I
T
R
I
R
L
C
N
S
P
S
PQM
N
----
G
K
P
------
C
-
E
G
--
E
-
A
R
E
T
K
A
C
K
-
K
D
A
C
P
----
I
N
G
G
W
G
P
W
S
P
W
D
I
C
S
V
T
C
G
G
G
----
V
Q
K
R
S
R
L
C
N
--
N
P
--
T
PQ--
F
G
G
K
D
C
V
G
--
D
V
T
E
N
Q
I
C
N
-
K
-
Q
D
C
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
40.89
30%
12
- C3 -
3T5O
4
CO6_HUMAN
A:
[2-158]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
C
D
H
Y
A
---
W
T
Q
W
T
S
C
S
K
T
C
N
S
G
T
Q
S
R
H
R
Q
I
V
V
D
K
Y
Y
-
Q
----
E
N
F
------
C
-
E
Q
IC
S
-
K
Q
E
T
R
E
C
N
-
W
Q
R
C
P
----
I
N
C
L
L
G
D
F
G
P
W
S
D
C
D
P
-
C
I
-
E
----
K
Q
S
K
V
R
S
V
L
--
R
P
--
S
Q---
F
G
G
Q
P
C
T
A
--
P
L
V
A
F
Q
P
C
I
-
P
S
K
L
C
K
I
-------------------------------
E
E
A
D
C
KN
K
F
R
C
D
S
G
----
R
C
I
A
R
K
L
E
C
N
--
G
--------
E
N
D
C
G
-
D
N
S
D
E
R
D
----
C
G
-
R
-
T
K
A
V
C
T
R
K
Y
N
P
I
P
S
V
Q
L
M
------
G
N
G
F
H
--
F
--
L
A
-
G
E
P
R
G
E
V
L
D
N
--
S
--
F
T
G
G
I
C
K
T
V
K
S
S
R
T
S
N
P
-
Y
R
-
V
P
A
N
L
E
N
V
G
F
E
V
Q
-----
T
A
E
D
D
L
K
T
D
F
Y
K
D
L
T
S
L
---
G
H
V
P
I
F
Y
S
S
K
R
S
E
N
I
----
N
H
N
S
A
F
K
Q
A
I
Q
--
A
S
H
K
K
D
S
S
F
I
R
I
H
K
V
M
K
V
L
N
F
T
T
K
A
K
D
L
H
L
S
D
V
F
L
K
A
L
N
H
L
P
L
E
Y
N
S
A
L
Y
S
R
I
F
D
D
F
G
T
H
Y
F
T
S
G
S
L
G
G
--------
V
Y
D
L
L
-------
Y
Q
----------
F
S
S
E
E
L
K
N
S
G
L
T
E
E
E
A
K
H
C
V
R
I
E
T
K
K
---
R
V
L
F
A
K
K
T
K
V
E
H
R
C
T
T
N
K
L
S
E
K
H
E
G
S
F
I
Q
G
A
E
K
S
I
S
L
I
R
G
G
R
S
E
Y
G
A
A
L
A
W
E
K
G
S
S
G
L
E
E
K
T
F
S
E
W
L
E
S
V
K
E
N
P
A
V
I
D
F
E
L
A
P
I
V
D
L
V
R
N
I
P
C
A
V
T
K
R
N
N
L
R
K
A
L
Q
E
Y
A
A
K
F
D
P
C
Q
C
----------------
A
P
-----------------
C
P
N
N
G
R
P
T
L
S
G
T
E
C
L
--
C
V
C
Q
S
G
T
----
Y
G
E
N
C
E
-
K
Q
S
P
D
--
Y
K
S
N
A
V
D
G
Q
W
G
C
W
S
S
W
S
T
----
C
D
A
T
Y
K
R
S
R
T
R
E
C
N
N
P
A
P
Q
R
G
G
K
R
C
E
G
------
E
K
R
Q
E
E
D
C
T
P
C
I
N
D
D
E
E
D
S
G
C
P
Q
P
V
P
P
E
N
G
F
I
R
N
E
K
Q
L
Y
L
V
G
E
D
V
E
I
S
C
L
T
G
F
E
T
V
G
Y
Q
Y
F
R
C
L
P
D
G
-
T
W
R
Q
----
G
--------
D
----
V
E
C
Q
R
T
E
C
I
K
P
V
V
Q
E
V
L
T
I
T
P
F
Q
R
L
Y
R
I
G
E
S
I
E
L
T
C
P
K
G
F
V
V
A
-----
G
P
--------
S
R
Y
T
C
Q
G
N
S
W
T
P
P
I
S
N
S
L
T
C
E
K
D
T
G
H
C
Q
-
L
G
Q
K
Q
S
G
S
E
C
I
C
M
S
-------
P
E
--
E
D
C
S
H
H
S
E
D
L
C
V
F
D
T
D
S
N
D
Y
F
T
S
P
A
C
K
F
L
A
E
K
C
L
N
N
Q
Q
L
H
F
L
H
I
G
S
C
Q
D
G
R
Q
L
E
W
G
L
E
R
T
R
L
S
S
N
S
T
K
K
E
S
C
G
Y
D
T
C
Y
D
W
E
K
C
S
A
S
T
S
K
C
V
C
L
L
P
P
Q
C
F
K
G
-------
G
N
Q
L
Y
C
V
K
M
G
S
S
T
S
E
K
T
L
N
I
C
E
V
G
T
I
R
C
A
N
R
K
M
E
I
L
H
P
G
K
C
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
40.67
13%
-74
- C1 -
3PBL
1
DRD3_HUMAN (first)
A:
[47-221]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
-
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
-
V
M
P
W
V
V
Y
L
E
--------
V
T
GGV
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
-----
Q
H
G
T
G
Q
SS
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
--
F
N
T
-
T
G
D
P
T
V
C
S
I
S
N
P
D
F
V
I
Y
S
---
S
V
--
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
-------
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
40.21
52%
183
- C3 -
1LSL
2
A:
[3-89]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
--
S
P
SP
Q
----
M
N
G
K
P
C
E
G
--
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
-------------------
W
G
P
W
----
S
P
W
D
I
C
--
S
V
T
C
G
G
G
----
V
-
Q
K
R
S
R
L
C
N
--
N
P
T
----
P
Q
F
G
G
K
D
C
V
G
D
V
T
E
N
----
Q
I
-
C
-
N
K
Q
D
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
40.19
18%
16
* C2 *
3GHM
3
ATS13_HUMAN
A:
[15-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
P
G
L
Y
Y
S
A
N
E
Q
C
R
V
A
F
G
P
K
A
V
A
CMC
Q
A
L
S
--
C
H
T
D
P
L
D
Q
S
S
C
S
R
L
-
L
V
P
L
L
---
D
----
G
T
E
------
C
G
V
E
--
K
-
W
C
S
K
G
R
C
R
S
L
V
E
L
T
PIA
A
V
H
G
R
W
S
S
W
G
P
R
S
P
C
S
R
S
C
G
G
G
----
V
V
T
R
R
R
Q
C
N
--
N
P
--
R
PA--
F
G
G
R
A
C
V
G
--
A
D
L
Q
A
E
M
C
N
-
T
-
Q
A
C
E
K
T
Q
L
E
F
M
S
Q
Q
C
A
R
T
DGQPLS
F
Y
H
W
G
A
A
VPH
S
Q
G
D
A
L
C
--
R
H
M
C
R
A
I
----
G
-
E
S
F
I
M
K
R
G
--
D
S
F
----
L
D
G
T
R
C
M
P
S
G
P
R
E
D
G
T
L
S
L
C
V
-
L
-
G
S
C
R
T
F
G
--------------------
C
D
--
G
RM
D
S
-
Q
Q
V
W
D
R
C
Q
V
C
--
G
--
G
D
N
S
T
C
S
P
R
K
G
S
F
T
A
G
R
-
A
R
-
E
Y
V
T
F
L
T
V
T
P
N
L
T
-----
S
V
Y
I
A
N
H
R
P
L
F
T
H
L
A
V
R
I
GG
R
Y
V
V
A
G
K
M
S
I
S
P
N
T
T
YPSL
L
E
D
G
R
V
E
Y
R
V
A
--
L
T
E
D
R
L
P
R
L
E
E
I
R
I
W
G
P
L
Q
E
D
A
D
I
Q
V
Y
R
R
Y
G
E
E
Y
G
N
L
T
R
P
D
I
T
F
T
Y
F
Q
P
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
39.99
33%
42
- C3 -
3T5O
3
CO6_HUMAN
A:
[8-106]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
Q
W
T
S
C
S
K
T
C
N
S
G
T
Q
S
R
H
R
Q
I
V
V
D
K
---
Y
----
Y
Q
E
N
FCEQI
C
-
S
K
-----
Q
E
T
R
E
C
-
N
W
Q
R
C
P
----
I
N
C
L
L
G
D
F
G
P
W
S
D
C
D
P
C
I
E
K
Q
----
S
K
V
R
S
-
V
L
R
--
P
S
--
Q
----
F
G
G
Q
P
C
T
A
--
P
L
V
A
F
Q
P
C
I
-
P
-
S
K
L
C
K
I
E
E
-------------------
A
D
C
K
----
N
K
F
R
C
D
--
S
G
R
C
I
A
R
----
K
-
L
E
C
N
G
E
N
D
--
C
G
D
----
N
S
D
E
R
D
C
G
R
T
K
A
V
C
T
----
R
K
-
Y
-
N
P
I
P
S
V
Q
L
M
G
N
G
F
H
F
L
A
G
------
E
P
R
G
E
--
V
--
L
D
-
N
S
F
T
G
G
I
C
K
T
--
V
--
K
S
S
R
T
S
N
P
Y
R
V
P
A
N
L
E
N
-
V
G
-
F
E
V
Q
T
A
E
D
D
L
K
T
D
-----
F
Y
K
D
L
T
S
L
G
H
V
P
I
F
Y
S
S
---
K
R
S
E
N
I
N
H
N
S
A
F
K
Q
A
----
I
Q
A
S
H
K
K
D
S
S
F
--
I
R
I
H
K
V
M
K
V
L
N
F
T
T
K
A
K
D
L
H
L
S
D
V
F
L
K
A
L
N
H
L
P
L
E
Y
N
S
A
L
Y
S
R
I
F
D
D
F
G
T
H
Y
F
T
S
G
S
L
G
G
V
Y
D
L
L
Y
Q
F
S
--------
S
E
E
L
K
-------
N
S
----------
G
L
T
E
E
E
A
K
H
C
V
R
I
E
T
K
K
R
V
L
F
A
K
K
T
K
---
V
E
H
R
C
T
T
N
K
L
S
E
K
H
E
G
S
F
I
Q
G
A
E
K
S
I
S
L
I
R
G
G
R
S
E
Y
G
A
A
L
A
W
E
K
G
S
S
G
L
E
E
K
T
F
S
E
W
L
E
S
V
K
E
N
P
A
V
I
D
F
E
L
A
P
I
V
D
L
V
R
N
I
P
C
A
V
T
K
R
N
N
L
R
K
A
L
Q
E
Y
A
A
K
F
D
P
C
Q
C
A
P
C
P
N
N
G
R
P
----------------
T
L
-----------------
S
G
T
E
C
L
C
V
C
Q
S
G
T
Y
G
--
E
N
C
E
K
Q
S
----
P
D
Y
K
S
N
-
A
V
D
G
Q
--
W
G
C
W
S
S
W
S
T
C
D
A
T
Y
K
R
S
R
----
T
R
E
C
N
N
P
A
P
Q
R
G
G
K
R
C
E
G
E
K
R
Q
E
E
D
C
T
------
P
C
I
N
D
D
E
E
D
S
G
C
P
Q
P
V
P
P
E
N
G
F
I
R
N
E
K
Q
L
Y
L
V
G
E
D
V
E
I
S
C
L
T
G
F
E
T
V
G
Y
Q
Y
F
R
C
L
P
D
G
T
W
R
Q
G
D
V
E
C
-
Q
R
T
E
----
C
--------
I
----
K
P
V
V
Q
E
V
L
T
I
T
P
F
Q
R
L
Y
R
I
G
E
S
I
E
L
T
C
P
K
G
F
V
V
A
G
P
S
R
Y
T
C
Q
G
-----
N
S
--------
W
T
P
P
I
S
N
S
L
T
C
E
K
D
T
G
H
C
Q
L
G
Q
K
Q
S
G
S
E
-
C
I
C
M
S
P
E
E
D
C
S
H
H
S
-------
E
D
--
L
C
V
F
D
T
D
S
N
D
Y
F
T
S
P
A
C
K
F
L
A
E
K
C
L
N
N
Q
Q
L
H
F
L
H
I
G
S
C
Q
D
G
R
Q
L
E
W
G
L
E
R
T
R
L
S
S
N
S
T
K
K
E
S
C
G
Y
D
T
C
Y
D
W
E
K
C
S
A
S
T
S
K
C
V
C
L
L
P
P
Q
C
F
K
G
G
N
Q
L
Y
C
V
K
M
-------
G
S
S
T
S
E
K
T
L
N
I
C
E
V
G
T
I
R
C
A
N
R
K
M
E
I
L
H
P
G
K
C
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
39.29
26%
23
- C3 -
3T5O
4
CO6_HUMAN
A:
[2-158]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
C
D
H
Y
A
W
T
Q
W
T
S
C
S
K
T
C
N
S
G
----
T
Q
S
R
H
R
Q
I
V
--
V
D
--
K
Y
---
Y
Q
E
N
F
C
E
Q
IC
S
K
Q
E
T
R
E
C
N
-
W
-
Q
R
C
P
I
N
C
L
-------------------
L
G
D
F
----
G
P
W
S
D
C
--
D
P
-
C
I
-
E
----
K
-
Q
S
K
V
R
S
V
L
--
R
P
S
Q---
F
G
G
Q
P
C
T
A
P
L
V
A
F
Q
P
----
C
I
-
P
S
K
L
C
K
I
--------
E
E
A
D
C
KN----
K
F
R
C
D
--
S
--
G
R
C
I
A
R
K
L
E
C
N
G
E
--------
N
D
C
G
-
D
N
S
D
E
R
D
C
G
-
R
T
-
K
A
V
C
T
R
K
Y
N
P
I
P
S
-----
V
Q
L
M
G
N
G
F
H
F
L
A
G
E
P
R
G
---
E
V
L
D
N
S
F
T
G
G
I
C
K
T
V
----
K
S
S
R
T
S
N
P
Y
R
V
--
P
A
N
L
E
N
V
G
F
E
V
Q
T
A
E
D
D
L
K
T
D
F
Y
K
D
L
T
S
L
G
H
V
P
I
F
Y
S
S
K
R
S
E
N
I
N
H
N
S
A
F
K
Q
A
I
Q
A
S
H
K
K
D
S
S
F
I
R
I
H
K
--------
V
M
K
V
L
-------
N
F
----------
T
T
K
A
K
D
L
H
L
S
D
V
F
L
K
A
L
N
H
L
P
L
E
Y
N
S
---
A
L
Y
S
R
I
F
D
D
F
G
T
H
Y
F
T
S
G
S
L
G
G
V
Y
D
L
L
Y
Q
F
S
S
E
E
L
K
N
S
G
L
T
E
E
E
A
K
H
C
V
R
I
E
T
K
K
R
V
L
F
A
K
K
T
K
V
E
H
R
C
T
T
N
K
L
S
E
K
H
E
G
S
F
I
Q
G
A
E
K
S
I
S
L
I
R
G
G
R
S
E
Y
G
A
A
L
A
W
E
K
G
S
S
G
L
E
E
K
T
----------------
F
S
-----------------
E
W
L
E
S
V
K
E
N
P
A
V
I
D
F
--
E
L
A
P
I
V
D
----
L
V
R
N
I
P
-
C
A
V
T
K
--
R
N
N
L
R
K
A
L
Q
E
Y
A
A
K
F
D
P
C
----
Q
C
A
P
C
P
N
N
G
R
P
T
L
S
G
T
E
C
L
C
V
C
Q
S
G
T
Y
------
G
E
N
C
E
K
Q
S
P
D
Y
K
S
N
A
V
D
G
Q
W
G
C
W
S
S
W
S
T
C
D
A
T
Y
K
R
S
R
T
R
E
C
N
N
P
A
P
Q
R
G
G
K
R
C
E
G
E
K
R
Q
E
E
D
C
T
P
C
I
-
N
D
D
E
----
E
--------
D
----
S
G
C
P
Q
P
V
P
P
E
N
G
F
I
R
N
E
K
Q
L
Y
L
V
G
E
D
V
E
I
S
C
L
T
G
F
E
T
V
G
Y
Q
Y
F
-----
R
C
--------
L
P
D
G
T
W
R
Q
G
D
V
E
C
Q
R
T
E
C
I
K
P
V
V
Q
E
V
L
T
-
I
T
P
F
Q
R
L
Y
R
I
G
E
S
I
-------
E
L
--
T
C
P
K
G
F
V
V
A
G
P
S
R
Y
T
C
Q
G
N
S
W
T
P
P
I
S
N
S
L
T
C
E
K
D
T
G
H
C
Q
L
G
Q
K
Q
S
G
S
E
C
I
C
M
S
P
E
E
D
C
S
H
H
S
E
D
L
C
V
F
D
T
D
S
N
D
Y
F
T
S
P
A
C
K
F
L
A
E
K
C
L
N
N
Q
Q
L
H
F
L
H
I
G
S
-------
C
Q
D
G
R
Q
L
E
W
G
L
E
R
T
R
L
S
S
N
S
T
K
K
E
S
C
G
Y
D
T
C
Y
D
W
E
K
C
S
A
S
T
S
K
C
V
C
L
L
P
P
Q
C
F
K
G
G
N
Q
L
Y
C
V
K
M
G
S
S
T
S
E
K
T
L
N
I
C
E
V
G
T
I
R
C
A
N
R
K
M
E
I
L
H
P
G
K
C
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------