@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AGRE2_HUMAN: (2016-01-08 )
MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITTPMETCDDINECATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKLKPEDPKLCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDELLEAPGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAGTELSLEVQKQVDRSVTLRQNQAVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLVLEPEKQMLLHETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTFSHRSVIPRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHLLFLVAIDQTGHKVLCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSINRFMKKLMFPVGYGVPAVTVAISAASRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVLFLVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQVGPAARVMAYLFTIINSLQGVFIFLVYCLLSQQVREQYGKWSKGIRKLKTESEMHTLSSSAKADTSKPSTVN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140....-....150.......160.......170....---...180.......190........200-----.......210........-----220.......230----.......240.......250....---...260.......270.......280......----------.290.......300.......310.......--320.......330.......340.......350.......360.......370......-----.380.......390.......400.......410.......420.......430.......440.......450.-......460.......470.......480......-.490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......--------590.......600.......610.......620.......630.......640.......650.......660.......--670.......680-------.......690.......700.......710......------------.720.......730.......740.......750..--------.....760.......770.......780.......790.......800.......810.......820.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGG
R
V
F
L
V
F
L
A
F
C
V
W
LTLPGAETQDSRG
C
A
RWCPQDSSCVNA
T
A
C
RCNP
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
L
SKVSCGKF
S
D
CWNTEGS
Y
D
C
V
CSPGYEPVSGAKTFKNESEN
T
C
Q
D
V
D
E
C
Q
QN
P
R
L
C
K
S
Y
G
T
C
V
N
T
L
-
G
S
Y
T
C
-QCLPGFKLKPEDP
K
L
C
T
D
V
N
E
CTSGQNPCHS---S
T
H
C
LNNVG
S
Y
Q
C
R
-CRPGWQPIPGSP-----NGPNN
T
V
C
E
-
D
V
D
E
CSSG-----QHQCDSS
T
V
C
F
NT----VGS
Y
S
C
RCRPGWKPRHGIPNNQKD---TVCEDMTFSTWTPPPGV
H
S
Q
T
L
S
R
F
F
D
K
V
Q
D
L----------GRDYKPGLAN
N
T
I
Q
S
I
L
Q
A
L
D
E
L
L
EAPG
D
L
E
--
T
L
P
R
L
Q
Q
H
C
V
A
S
H
L
L
D
G
L
E
D
V
L
R
G
L
S
K
N
L
SNG
L
L
N
FSYPAG
T
E
L
S
L
E
V
Q
K
QVDR
S
V
T
L
R-----QN
Q
A
V
M
Q
LDW
N
Q
AQKSGDPGP
S
V
V
G
L
VSIP
G
M
G
K
L
L
AEA
P
L
V
LEP
E
K
Q
M
L
L
H
E
T
H
Q
G
L
LQDGSP
I
L
L
S
D
V
I
S
A
F
L-SNNDTQNLSS
P
V
T
F
T
FSHRSVIPRQ
K
V
L
C
V
F
W
EHG-QNGCGHWATTGCSTIGTRD
T
S
T
I
C
R
C
T
H
L
S
S
F
A
V
L
M
A
HYDVQEED
P
V
L
T
V
I
T
Y
MG
L
S
V
S
L
L
C
L
L
L
A
A
L
T
F
L
L
C
K
A
I
QNTS
T
S
L
H
L
Q
L
S
L
C
L
F
L
A
H
L
L
F
L
V
A
--------IDQT
G
H
K
V
L
C
S
I
I
A
G
T
L
H
Y
L
Y
L
A
T
L
T
W
M
L
L
E
A
L
Y
L
F
L
TARN
L
T
V
V
N
Y
S
S
I
N
R
F
M
K
K
L
M
F
PVGYGV
P
A
V
T
V
A
I
SAASRPHL--YGT
P
S
R
C
W
LQPEK-------
G
F
I
W
G
F
L
G
P
V
C
A
I
F
S
V
N
L
V
L
F
L
V
T
L
W
I
L
K
N
R
L
S
S
L
N
------------
S
E
V
S
T
LRNT
R
M
L
A
F
KAT
A
Q
L
F
I
L
G
C
T
W
C
L
G
I
L
QVG
P
--------
A
A
R
V
M
A
Y
L
F
T
I
I
N
S
L
Q
G
V
F
I
F
L
V
Y
C
L
L
S
Q
Q
V
R
E
QYG
K
W
S
K
G
I
R
K
LK
T
E
S
E
M
H
T
LSSSAKADTSKPSTVN
94
Fugue
66.00
19%
-49
- C2 -
4DLQ
16
A:
[18-381]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
-
C
E
P
--
R
E
V
R
R
V
Q
-----
W
P
A
T
Q
Q
G
M
L
-
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
L
P
A
L
G
L
W
N
P
----
R
G
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
R
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
RN
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
M
N
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
PQEY
A
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
A
T
V
K
L
A
G
-----
E
A
G
T
G
G
P
G
G
A
S
L
V
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
R
V
F
L
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
H
F
N
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
65.83
86%
-27
- C7 -
2BO2
3
AGRE2_HUMAN
A:
[4-130]
---------------------------
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
L
S
K
V
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
R
P
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.67
86%
-23
- C7 -
2BOX
4
AGRE2_HUMAN
A:
[3-130]
--------------------------
R
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
----
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
--
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
64.26
86%
-23
- C7 -
2BOU
5
AGRE2_HUMAN
A:
[3-130]
--------------------------
R
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
----
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
R
P
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
63.92
86%
-23
- C7 -
2BOU
5
AGRE2_HUMAN
A:
[3-130]
--------------------------
R
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
----
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
R
P
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
63.86
86%
-22
- C7 -
2BO2
2
AGRE2_HUMAN
B:
[4-130]
---------------------------
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
L
S
--
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
R
P
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
57.70
37%
-35
- C7 -
4XLW
2
NOTC1_RAT
E:
[3-109]
------------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
G
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
57.33
37%
-27
- C7 -
4XL1
8
D:
[2-110]
----------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
56.89
37%
-40
- C7 -
4XLW
1
G:
[3-109]
------------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
G
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
55.76
37%
-38
- C7 -
4XLW
7
NOTC1_RAT
A:
[3-109]
------------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
54.93
37%
-25
- C7 -
4XL1
9
NOTC1_RAT
A:
[4-110]
------------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.82
37%
-24
- C7 -
2VJ3
6
A:
[3-112]
---------------------------------------------------------------------------------------------------------------------
Q
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
-----
N
----------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
54.60
37%
-23
- C7 -
4CUF
4
A:
[4-112]
----------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
S
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
-----
N
----------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
53.84
37%
-33
- C7 -
4XLW
14
NOTC1_RAT
C:
[3-109]
------------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
G
R
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
53.70
37%
-21
- C7 -
4D0F
4
A:
[3-112]
---------------------------------------------------------------------------------------------------------------------
Q
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
A
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
-----
N
----------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
---
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
53.30
37%
-23
- C7 -
4CUD
5
?
A:
[4-112]
----------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
-----
N
----------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
---
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
52.99
37%
-24
- C7 -
4D0E
5
A:
[4-112]
----------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
-----
N
----------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
---
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
52.10
37%
-20
- C7 -
4CUE
3
?
A:
[4-112]
----------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
V
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
-----
N
----------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
---
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
49.90
27%
-36
- C7 -
1YO8
3
A:
[4-141]
------------------------------------------------------------------------------------------------------------------------
D
G
C
L
S
N
--
P
C
F
P
G
A
Q
C
S
S
F
P
D
G
S
W
S
C
G
F
C
P
V
G
F
L
G
N
---
G
T
H
C
E
D
L
D
E
C
A
L
V
P
D
I
C
F
S
TSK
V
P
R
C
V
N
T
Q
P
G
F
H
C
L
P
C
P
P
R
Y
R
G
N
Q
P
V
G
V
G
L
E
A
A
K
T
E
K
Q
V
C
E
-
P
E
N
P
C
K
D
K
-----
T
H
N
C
H
K
H
A
E
C
I
Y
L
GHFS
D
P
M
Y
K
C
E
C
Q
T
G
Y
A
G
D
G
L
I
C
G
E
D
S
D
---
L
D
G
W
P
N
L
N
L
V
C
A
T
N
A
T
Y
H
C
I
K
D
N
C
P
H
L
P
N
S
G
Q
----------
E
D
F
D
K
D
G
I
G
D
A
C
D
D
D
D
D
N
D
G
V
T
D
E
K
D
N
C
Q
L
L
--
F
N
P
R
Q
A
D
Y
D
K
D
E
V
G
D
R
C
D
N
C
P
Y
V
H
N
P
A
Q
I
D
T
D
N
N
G
E
G
D
A
C
S
V
D
I
D
G
D
D
V
F
N
E
R
D
N
C
P
Y
V
-----
Y
N
T
D
Q
R
D
T
D
G
D
G
V
G
D
H
C
D
N
C
P
L
V
H
N
P
D
Q
T
D
V
D
N
D
L
V
G
D
Q
C
D
N
N
E
D
I
D
D
D
G
H
Q
N
N
Q
D
N
C
P
Y
I
S
N
A
N
Q
A
D
H
D
R
D
G
Q
G
-
D
A
C
D
P
D
D
D
N
D
G
V
P
D
D
R
D
N
C
R
L
V
F
N
P
D
Q
E
D
L
D
G
D
G
R
-
G
D
I
C
K
D
D
F
D
N
D
N
I
P
D
I
D
D
V
C
P
E
N
N
A
I
S
E
T
D
F
R
N
F
Q
M
V
P
L
D
P
K
G
T
T
Q
I
D
P
N
W
V
I
R
H
Q
G
K
E
L
V
Q
T
A
N
S
D
P
G
I
A
V
G
F
D
E
F
G
S
V
D
F
S
G
T
F
Y
V
N
T
D
R
D
D
D
Y
A
G
F
V
F
--------
G
Y
Q
S
S
S
R
F
Y
V
V
M
W
K
Q
V
T
Q
T
Y
W
E
D
Q
P
T
R
A
Y
G
Y
S
G
V
S
L
K
V
V
N
S
T
T
G
T
G
E
H
L
R
N
A
L
W
H
T
G
N
T
P
G
Q
V
R
T
L
W
H
D
P
R
N
I
G
W
K
D
Y
T
A
--
Y
R
W
H
L
T
H
R
P
K
T
G
Y
-------
I
R
V
L
V
H
E
G
K
Q
V
M
A
D
S
G
P
I
Y
D
Q
T
Y
A
G
G
R
L
G
L
F
V
F
S
Q
E
------------
M
V
Y
F
S
D
L
K
Y
E
C
R
D
----------------------------------------------------------------------------------------------------
66
HHSearch
47.59
8%
-136
* C9 *
2Z73
5
OPSD_TODPA
A:
[35-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
-
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
RD
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
FGPLEW
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
--