@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AGRF1_HUMAN: (2016-01-08 )
MKVGVLWLISFFTFTDGHGGFLGKNDGIKTKKELIVNKKKHLGPVEEYQLLLQVTYRDSKEKRDLRNFLKLLKPPLLWSHGLIRIIRAKATTDCNSLNGVLQCTCEDSYTWFPPSCLDPQNCYLHTAGALPSCECHLNNLSQSVNFCERTKIWGTFKINERFTNDLLNSSSAIYSKYANGIEIQLKKAYERIQGFESVQVTQFRNGSIVAGYEVVGSSSASELLSAIEHVAEKAKTALHKLFPLEDGSFRVFGKAQCNDIVFGFGSKDDEYTLPCSSGYRGNITAKCESSGWQVIRETCVLSLLEELNKNFSMIVGNATEAAVSSFVQNLSVIIRQNPSTTVGNLASVVSILSNISSLSLASHFRVSNSTMEDVISIADNILNSASVTNWTVLLREEKYASSRLLETLENISTLVPPTALPLNFSRKFIDWKGIPVNKSQLKRGYSYQIKMCPQNTSIPIRGRVLIGSDQFQRSLPETIISMASLTLGNILPVSKNGNAQVNGPVISTVIQNYSINEVFLFFSKIESNLSQPHCVFWDFSHLQWNDAGCHLVNETQDIVTCQCTHLTSFSILMSPFVPSTIFPVVKWITYVGLGISIGSLILCLIIEALFWKQIKKSQTSHTRRICMVNIALSLLIADVWFIVGATVDTTVNPSGVCTAAVFFTHFFYLSLFFWMLMLGILLAYRIILVFHHMAQHLMMAVGFCLGYGCPLIISVITIAVTQPSNTYKRKDVCWLNWSNGSKPLLAFVVPALAIVAVNFVVVLLVLTKLWRPTVGERLSRDDKATIIRVGKSLLILTPLLGLTWGFGIGTIVDSQNLAWHVIFALLNAFQGFFILCFGILLDSKLRQLLFNKLSALSSWKQTEKQNSSDLSAKPKFSKPFNPLQNKGHYAFSHTGDSSDNIMLTQFVSNE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80....---....90........100.......110.......120...--....130.......140.......150......-.160.......170...---....180.......190--.-.-......200...--..-----..210.......220.......230.......240.......250.......260.......270......------.280....----...290.---....-----..300........310.......320.......330----------........340.......350-----------......----------.360.......370.......380.......390.-......400........410.......420.......----------430.......440.......450-------.......460.......470.......480.......490.------------------......500.......510--....-----.....520...--..-..530.......540--...----......550.......560.......570.......580.......590-------.........600.......610.......620.......630.......640.....-----..650.......660.......670.-......680.........690.--.-...-..700.......710.......720.......730.......-740-----.-----------.--------..----.....750.......760--.........770...---.------------...780.......790.......800--........810.----.-------.------------.---...---.820.----..-....830.......840.......850.......860.......870.......880.......890.......900.......910
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
V
G
V
L
W
L
I
S
F
F
T
FTDGHGGFLGKNDGI
K
T
K
K
E
L
I
V
NKKKHLG
P
V
E
E
Y
Q
L
L
L
Q
V
TYRD
S
K
E
K
R
D
L
R
N
F
L
K
LLKPP
L
L
W
S
H
G
L
I
R
I
---
I
RAKATTDCNSLN
G
V
L
Q
C
T
CEDSYTWFPPSCLDPQ
N
C
Y
L
H--TAGALPS
C
E
C
H
L
N
N
L
S
Q
S
V
N
F
C
E
R
T
K
I
W
G
T
F
K
I-
N
E
R
F
T
N
D
LLNS
S
S
A
I
Y
S
---
K
YAN
G
I
E
I
Q
L
K
K
A
Y
E
R
---
I
-Q-GFE
S
V
Q
V
T
Q
FRN--
G
S
-----
I
V
A
G
Y
E
VVGSS
S
A
S
E
L
L
S
A
I
E
H
V
A
E
K
A
K
T
A
L
H
K
LFPLEDG
S
F
R
V
F
GKAQCN
D
I
V
F
GFGSKDD
E
Y
T
LPCSSG------YRG
N
I
T
A
K
----CESS
G
W
Q
---
V
I
R
E
-----
T
C
V
-
L
S
L
L
E
E
L
NKNF
S
M
I
VGN
A
T
E
A
A
V
S
S
F
V
Q
N
L
S
-----------
V
I
I
RQNPST
T
V
G
N
L
A
S
V
V
S
I
L
-----------
S
N
I
S
S
L
----------
S
L
A
S
H
F
RVSN
S
T
M
E
D
V
I
S
I
A
D
N
I
LNSASVT
N
W
T
V
L
-
L
R
EEKY
A
S
-
S
R
L
L
E
T
L
E
N
I
S
T
LVPPTALPLNFSRKFI----------DWKGIPV
N
K
S
Q
L
KRG
Y
S
Y
Q
I
K
MC-------PQNTSI
P
I
R
G
R
V
L
IG
S
D
Q
F
Q
R
S
L
P
E
T
I
I
S
M
A
S
L
TLG
N
I
L
PV------------------SKNGN
A
Q
VNG
P
V
I
S
T
V
I
----QNYS-----
I
N
E
V
F
L
F
F
S
K
I
--
E
S
-NLSQP
H
C
V
F
W
DFS----H
L
Q
----WNDAG
C
H
L
VNETQ
D
I
V
T
C
Q
C
THLT
S
F
S
I
L
MSPFV
P
S
T
I
F
P
V
V
K
W
I
T
Y
---------VG
L
G
I
S
I
G
S
L
I
L
C
L
I
I
E
A
L
F
W
K
Q
I
K
K
SQTSH
T
R
R
I
C
M
V
N
I
A
L
S
L
L
I
A
D
V
W
F
I
VG
A
T
V-----DTTVNP
S
G
V
C
T
A
A
V
F
F
T
H
F
F
Y
L
S
L
F
F
-
W
M
L
M
L
G
I
--
L
L
A
Y
R
I
I
L
V
F
H
H
M
--
A
-
Q
H
L
-
M
M
A
V
G
F
C
L
GYG
C
P
L
I
I
S
V
I
T
I
A
V
TQPSNTYKRK
D
V
C
W
L
NWSN-G-------S-----------K--------
P
L
----
L
A
F
V
V
P
A
L
A
I
V
A
V
N
F
V
----
V
V
L
L
V
L
T
K
LWRP
T
V
G
---
E
------------
R
LSRDD
K
A
T
I
I
R
VGK
S
L
L
I
L
T
P
L
L
G
---
L
T
WGFG
I
G
T
-
I
V----D-------S------------Q---
N
L
A
---
W
H
V
I
F
----
A
L
-
L
N
A
F
Q
G
F
F
I
L
C
F
G
I
L
L
D
S
K
L
R
Q
L
L
F
N
K
L
S
A
L
S
S
W
K
Q
TEKQNSSDLSAKPKFSKPFNPLQNKG
H
Y
A
F
SHTGDSSD
N
I
M
L
T
QFVSNE
40
Fugue
81.46
16%
-83
- C2 -
4DLQ
16
A:
[18-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
V
R
R
V
Q
W
P
A
T
Q
Q
G
M
L
V
E
R
P
C
P
K
G
------
T
R
G
I
A
S
F
Q
----
C
L
P
A
L
G
L
---
W
N
P
R
GPDLS
N
C
T
-
S
P
W
V
N
Q
V
A
Q
K
I
K
------
S
G
E
N
A
A
N
I
A
S
E
L
A
-----------
R
H
T
R
G
S
I
Y
--
A
G
D
V
S
S
S
V
K
L
M
-----------
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
RN
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
M
N
A
T
E
Q
V
H
T
A
-
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
----------
Q
--
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
-------
P
Q
E
Y
A
S
E
--
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
LSTENATVKLA
G
E
A
G
T
GG
P
G
G
A
S
L
V
V
N
S
Q
V
I
A
A
S
I
NKES
S
R
V
F
-----
L
M
D
P
V
I
F
T
V
A
H
LE
A
K
-
N
H
F
N
A
N
C
S
F
W
N
Y
S
ERSM
L
G
Y
----
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
70.01
11%
-138
- C2 -
2Z73
5
OPSD_TODPA
A:
[38-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
F
I
G
---------
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
-
K
S
L
Q
T
-----
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
-
T
M
A
M
I
S
I
--
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
-
S
H
R
-
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
-
R
-------
D
S
T
T
R
S
------
N
I
L
C
M
----
F
I
----
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
--------
I
V
M
S
V
S
N
H
E
K
E
---
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
---
L
S
W
S
P
Y
A
V
V
-
A
L
----
L
A
Q
FGPLE
W
------------
V
---
T
P
Y
---
A
A
Q
L
P
----
V
M
-
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-----------------------------
32
HHSearch
69.30
12%
-139
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[46-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
---------
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
-
S
R
V
G
R
S
-----
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
P
I
W
A
A
S
K
V
---
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
-
L
L
A
C
I
S
V
--
D
R
Y
L
A
I
V
H
A
T
R
T
L
--
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
P
N
N
S
S
P
V
C
Y
E
V
L
G
N
-
D
-------
T
AK---------
W
RMVLRILP
H
T
----
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
--------
G
F
T
L
R
T
L
F
K
A
H
M
------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
---
L
C
W
L
P
Y
N
L
V
-
L
L
A
---
D
T
L
M
----
R
TQVIQE
S
C
E
R
R
N
N
---
I
G
R
---
A
L
D
A
T
----
E
I
-
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------------------------------------
10
PsiBlast_PDB
65.11
21%
-141
- C2 -
4L6R
1
GLR_HUMAN
A:
[208-392]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
R
V
A
A
V
F
M
Q
Y
G
I
V
A
N
Y
C
-
W
L
L
V
E
G
L
--
Y
L
--
H
N
L
L
G
L
A
T
L
--
P
-
E
R
S
-
F
F
S
L
Y
L
G
I
G
W
G
A
P
M
L
F
-
V
V
P
W
A
V
V
K
---
C
L
F
E
N
V
Q
C
W
T
S
N
D
N
M
G
-------
F
-----------
W
--------
W
I
----
L
R
F
--
P
V
F
L
A
I
L
I
N
F
F
----
I
F
V
R
I
V
Q
L
L
V
A
K
L
R
A
---
R
------------
Q
M
H
H
T
D
Y
K
--
F
R
L
A
K
S
T
L
T
L
I
P
L
L
G
V
H
E
V
V
F
A
F
V
T
D
E
-
H
A
----
Q
-------
G
------------
T
---
L
R
S
---
A
K
L
F
F
----
D
L
F
L
S
S
F
Q
G
L
L
V
A
V
L
Y
C
F
L
N
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
-------------------------------------------
24
HHSearch
61.77
14%
-140
- C2 -
2KS9
1
NK1R_HUMAN
A:
[40-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
---------
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
-
H
K
R
M
R
T
-----
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
H
-
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
-
S
M
T
A
V
A
F
--
D
R
Y
M
A
I
I
H
P
L
Q
P
R
--
L
-
S
A
T
-
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
-
T
E
T
M
P
S
R
V
V
C
M
I
E
W
P
E
-
H
-------
P
NKIY
E
K
V
Y
H
I
C
V
--------
T
V
----
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
----
V
G
----
I
T
L
W
A
S
E
I
P
GDS
S
------------
D
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
---
I
C
W
L
P
F
H
I
F
-
F
L
L
P
Y
I
N
-------
P
------------
D
LYL
K
K
F
I
Q
Q
V
Y
L
A
I
----
M
W
-
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-------------
4
PsiBlast_PDB
59.58
24%
-146
- C2 -
4B4A
-
TATC_AQUAE
A:
[36-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
L
K
E
P
I
L
K
S
--
Y
P
E
V
E
L
I
T
L
SPTE
P
L
F
I
L
I
K
I
S
L
A
V
G
F
I
I
A
S
P
V
I
L
Y
Q
F
W
R
F
I
E
P
A
L
Y
S
H
E
K
R
A
F
I
P
L
L
L
G
S
I
L
L
----
F
M
L
G
A
---------------------
L
F
A
Y
F
I
V
L
P
L
A
L
K
F
L
L
G
L
G
F
TQ
L
L
A
T
P
Y
L
S
V
D
M
Y
I
--
S
-
F
V
L
-
K
L
V
V
A
F
G
I
A
F
E
M
P
I
V
L
Y
V
L
Q
K
A
G
V
I
T
P
E
Q
L
A
S
F
R
K
Y
F
I
V
I
A
F
-
V
-------
I
-----------
G
--------
A
I
----
I
A
P
D
V
S
T
Q
V
L
M
A
I
P
L
L
----
L
L
Y
E
I
S
I
F
L
G
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
59.47
11%
-136
- C2 -
1U19
13
OPSD_BOVIN
A:
[75-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
-
S
L
V
V
L
A
I
--
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
-
P
HEETN
N
E
S
-----------
F
--------
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
----
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
---
Q
------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
---
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-
H
-------
Q
GSD---------
F
---
G
P
I
---
F
M
T
I
P
----
A
F
-
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------------------------
3
PsiBlast_PDB
59.24
24%
-150
- C2 -
4HTS
-
TATC_AQUAE
A:
[40-180]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
L
A
A
P
I
L
K
S
--
Y
P
E
V
E
L
I
T
L
SPTE
P
L
F
I
L
I
K
I
S
L
A
V
G
F
I
I
A
S
P
V
I
L
Y
Q
F
W
R
F
I
E
P
A
L
Y
S
H
E
K
R
A
F
I
P
L
L
L
G
S
I
L
L
----
F
M
L
G
A
---------------------
L
F
A
Y
F
I
V
L
P
L
A
L
K
F
L
L
G
L
G
F
TQ
L
L
A
T
P
Y
L
S
V
D
M
Y
I
--
S
-
F
V
L
-
K
L
V
V
A
F
G
I
A
F
E
M
P
I
V
L
Y
V
L
Q
K
A
G
V
I
T
P
E
Q
L
A
S
F
R
K
Y
F
I
V
I
A
F
-
V
-------
I
-----------
G
--------
A
I
----
I
A
P
D
V
S
T
Q
V
L
M
A
I
P
L
L
----
L
L
Y
E
I
S
I
F
L
G
K
L
A
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
56.38
24%
-143
- C2 -
4HTT
-
ENLYS_BPT4 (first)
A:
[38-178]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
L
K
E
P
I
L
K
S
--
Y
P
E
V
E
L
I
T
L
SPTE
P
L
F
I
L
I
K
I
S
L
A
V
G
F
I
I
A
S
P
V
I
L
Y
Q
F
W
R
F
I
E
P
A
L
Y
S
H
E
K
R
A
F
I
P
L
L
L
G
S
I
L
L
----
F
M
L
G
A
---------------------
L
F
A
Y
F
I
V
L
P
L
A
L
K
F
L
L
G
L
G
F
TQ
L
L
A
T
P
Y
L
S
V
D
M
Y
I
--
S
-
F
V
L
-
K
L
V
V
A
F
G
I
A
F
E
M
P
I
V
L
Y
V
L
Q
K
A
G
V
I
T
P
E
Q
L
A
S
F
R
K
Y
F
I
V
I
A
F
-
V
-------
I
-----------
G
--------
A
I
----
I
A
P
D
V
S
T
Q
V
L
M
A
I
P
L
L
----
L
L
Y
E
I
S
I
F
L
G
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
55.26
11%
-13
- C1 -
7REQ
3
MUTA_PROFR
B:
[15-474]
----------------------------
L
T
P
T
T
L
S
L
A
G
D
F
P
K
A
T
E
E
Q
W
E
R
E
V
E
K
V
L
N
R
G
R
P
P
E
K
Q
L
T
F
A
E
C
L
K
R
L
T
V
H
T
V
D
G
I
D
I
V
PM
Y
R
P
K
D
A
P
K
K
L
G
Y
P
G
V
A
P
F
T
R
G
T
T
V
R
N
G
D
M
D
A
W
D
V
R
A
L
H
E
D
PD
E
K
F
T
R
K
A
I
L
E
G
L
E
R
G
V
T
S
L
L
L
R
V
D
P
D
A
I
A
P
E
H
L
-
D
E
V
L
S
D
V
L
L
E
M
T
K
V
E
V
F
S
RY
D
Q
G
A
A
A
E
A
L
V
S
V
Y
E
R
S
---
D
-
K
-
P
A
K
D
L
A
L
N
L
G
L
D
---------
P
I
G
F
A
A
L
Q
G
T
E
P
D
L
T
V
L
G
D
W
V
R
R
L
A
K
F
S
P
D
S
-
R
A
V
T
I
D
A
N
I
Y
H
N
A
G
A
G
D
V
A
E
L
A
W
A
L
A
T
G
A
E
Y
V
R
A
L
V
E
Q
G
------
F
T
A
T
E
A
F
D
T
INF
R
V
T
A
T
H
D
---
Q
F
L
T
-----
I
A
R
-
L
R
A
L
R
E
A
W
A
R
I
G
E
V
F
G
V
D
E
D
K
R
G
A
R
Q
N
A
I
T
S
WRELTRED
P
Y
V
N
I
L
R
G
S
I
A
T
F
S
A
S
V
G
G
A
E
S
I
T
T
L
PFTQALGLP
E
D
D
F
P
L
----------
R
I
A
R
N
T
G
I
V
L
A
E
E
V
N
I
G
R
V
N
D
P
A
G
G
S
Y
Y
V
E
S
L
T
R
S
-
L
A
D
A
A
W
K
E
-
F
Q
E
V
E
K
L
G
G
M
S
K
A
V
M
T
E
H
V
T
K
V
L
D
A
C
N
A
----------
E
R
A
K
R
L
A
N
R
K
Q
P
I
T
A
V
S
E
F
P
M
I
G
-------
A
R
S
I
E
T
K
P
F
P
A
A
P
A
R
K
G
L
A
W
H
R
D
S
E
V
F
E
Q
L
M
D
R
S
T
S
V
S
E
R
P
------------------
K
V
F
L
A
C
L
G
T
R
R
D
F
G
G
R
E
----
G
F
S
S
-----
P
V
W
H
I
A
G
I
D
T
P
--
Q
V
-
E
G
G
T
T
A
E
I
V
E
A
F
K
----
K
S
G
----
A
Q
V
A
D
L
C
S
S
A
K
V
Y
A
Q
Q
G
L
E
V
A
K
A
L
K
A
A
G
A
K
A
L
Y
L
S
G
A
F
K
E
F
G
D
D
A
A
E
---------
A
E
K
L
I
D
G
R
L
F
M
G
M
D
V
V
D
T
L
S
S
T
L
D
I
L
G
V
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
53.58
27%
-50
- C2 -
4K5Y
4
CRFR1_HUMAN (first)
A:
[288-423]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
I
G
W
G
V
P
F
P
I
-
I
V
A
W
A
I
G
K
---
L
Y
Y
D
N
E
K
C
W
A
G
K
R
P
-
G
-------
V
-----------
Y
--------
T
D
----
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
A
S
T
T
S
---
E
------------
T
I
-
Q
A
R
K
A
V
-----
K
A
T
L
V
L
L
P
L
L
G
---
I
T
--
Y
M
L
A
F
-
V
N
------------------------------
E
V
---
S
R
V
V
F
I
Y
F
N
A
F
-
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
-------------------------------------------------------------------
41
Fugue
53.03
14%
-3
- C2 -
2E7V
-
TM11D_MOUSE
A:
[45-163]
-------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
A
Y
F
Y
H
S
S
F
Q
I
L
N
V
E
Y
T
E
A
L
N
S
P
A
T
H
E
Y
R
---
T
L
S
E
R
I
E
A
M
I
T
D
E
F
R
G
SSL
K
-
S
-
E
F
I
R
T
H
V
V
K
L
R
K
E
G
T
G
-----
V
V
A
D
V
V
M
K
F
R
S
N
R
K
V
M
K
T
R
I
Q
S
V
L
R
R
L
S
S
S
G
N
L
E
I
A
P
S
N
E
I
T
S
L
T
D
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
48.80
30%
28
* C3 *
4DLQ
10
A:
[306-381]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
S
Q
V
I
A
A
S
I
----
N
K
E
S
SRVFL
M
D
P
V
I
F
T
V
A
H
L
--
E
A
K
N
H
F
N
A
N
C
S
F
W
N
Y
S
----
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
48.32
18%
55
- C2 -
2LSE
-
?
A:
[1-101]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
E
E
R
K
K
L
-
L
E
K
L
E
K
I
L
D
E
V
T
D
G
A
P
D
---
E
A
R
E
R
I
E
K
L
A
K
D
V
K
D
E
---
L
-
E
E
G
D
A
K
N
M
I
E
K
F
R
D
---
E
-----
M
E
Q
M
Y
K
D
A
P
N
A
V
M
E
Q
L
L
E
E
I
E
K
L
L
K
K
A
G
S
L
V
P
R
G
S
Y
L
E
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
48.26
24%
65
- C2 -
1IVZ
-
?
A:
[11-89]
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
H
F
N
L
N
F
T
I
T
N
L
P
Y
S
Q
D
I
A
Q
P
S
T
T
K
Y
Q
---
Q
T
K
R
S
I
E
N
A
L
N
Q
L
F
R
N
SS-
I
K
S
-
Y
F
S
D
C
Q
V
L
A
F
R
S
--
V
S
NNNN
H
T
G
V
D
S
L
C
N
F
S
P
L
A
R
R
V
D
R
V
A
I
Y
E
E
F
L
R
M
T
H
N
G
T
Q
L
L
N
F
T
L
D
R
K
S
V
F
V
D
S
G
P
S
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
47.60
24%
186
* C4 *
2X57
-
VIPR2_HUMAN
A:
[57-110]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
I
T
C
----
W
R
P
A
N
V
G
E
T
V
T
V
P
C
P
K
V
FSNFYS
K
A
G
N
I
S
K
N
----
C
T
S
D
G
W
S
ETF
P
D
F
V
-----
D
A
C
-
G
Y
S
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
46.58
16%
16
- C2 -
1FEW
-
DBLOH_HUMAN
A:
[12-184]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
S
S
E
A
L
M
R
R
A
V
S
L
V
T
D
S
T
S
T
F
L
S
Q
T
T
Y
A
L
I
E
A
I
T
E
Y
T
K
A
-----
V
Y
T
L
T
S
L
Y
R
Q
Y
T
S
L
-----------
L
G
K
M
N
S
E
----
E
E
D
E
V
W
Q
---
V
I
I
G
-----
A
R
A
E
M
T
S
K
H
Q
E
Y
L
K
L
E
T
T
W
M
T
A
V
G
L
S
E
M
A
A
E
A
A
Y
Q
-----------
T
G
A
D
Q
A
S
I
T
A
R
N
H
I
Q
L
V
K
L
Q
V
-----------
E
E
V
H
Q
L
----------
S
R
K
A
E
T
K
L
A
E
A
Q
I
E
E
L
K
Q
K
T
Q
E
E
G
E
E
R
A
E
S
E
Q
E
A
Y
-
L
R
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
45.89
32%
170
- C3 -
4RH7
-
DYHC2_HUMAN
A:
[2931-2987]
--------------------------------------------------------------------------------------------------------------------------------------
L
P
V
L
E
K
E
L
N
T
L
Q
P
K
D
T
F
----
R
L
W
L
T
A
E
V
-
H
P
N
F
T
P
I
L
L
Q
S
S
L
K
I
T
Y
---
E
S
P
P
G
L
K
K
N
L
M
R
T
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
44.32
26%
155
- C2 -
2ACM
-
MUC1_HUMAN
A:
[1044-1097]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
S
F
H
I
S
N
L
Q
F
N
S
S
L
E
D
P
S
T
D
Y
Y
Q
---
E
L
Q
R
D
I
S
E
M
F
L
Q
I
Y
K
Q
-----
G
-
G
F
L
G
L
S
N
I
K
F
R
P
--
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
43.04
15%
3
- C2 -
1YAR
-
?
O:
[10-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
A
A
L
I
Q
N
L
R
D
S
Y
-----------
T
E
T
S
S
F
----------
A
V
I
E
E
W
A
--
A
G
T
L
Q
E
I
E
G
I
A
K
A
A
A
E
A
H
G
V
I
R
N
S
T
Y
-
G
R
A
Q
A
E
K
S
P
E
Q
L
L
G
V
L
Q
R
Y
Q
D
L
C
H
N
V
Y
C
Q
A
E
T
I
R
T
V
I
AIRIPEHKEE
D
N
L
G
V
A
V
Q
H
A
V
L
K
I
I
D
E
L
E
I
K
T
L
GSGEKSG
S
G
G
A
P
T
P
I
G
M
Y
A
L
R
E
Y
L
S
A
R
S
T
V
E
D
K
L
L
G
G
G
S
Q
S
P
S
L
L
L
E
L
------------------
R
Q
I
D
A
D
F
M
L
K
V
E
L
A
T
T
H
----
L
S
T
M
-----
V
R
A
V
I
N
A
Y
L
L
N
--
W
K
-
K
L
I
Q
P
R
T
G
S
D
H
M
V
----
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------