@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AGRF5_HUMAN: (2016-01-09 )
MKSPRRTTLCLMFIVIYSSKAALNWNYESTIHPLSLHEHEPAGEEALRQKRAVATKSPTAEEYTVNIEISFENASFLDPIKAYLNSLSFPIHGNNTDQITDILSINVTTVCRPAGNEIWCSCETGYGWPRERCLHNLICQERDVFLPGHHCSCLKELPPNGPFCLLQEDVTLNMRVRLNVGFQEDLMNTSSALYRSYKTDLETAFRKGYGILPGFKGVTVTGFKSGSVVVTYEVKTTPPSLELIHKANEQVVQSLNQTYKMDYNSFQAVTINESNFFVTPEIIFEGDTVSLVCEKEVLSSNVSWRYEEQQLEIQNSSRFSIYTALFNNMTSVSKLTIHNITPGDAGEYVCKLILDIFEYECKKKIDVMPIQILANEEMKVMCDNNPVSLNCCSQGNVNWSKVEWKQEGKINIPGTPETDIDSSCSRYTLKADGTQCPSGSSGTTVIYTCEFISAYGARGSANIKVTFISVANLTITPDPISVSEGQNFSIKCISDVSNYDEVYWNTSAGIKIYQRFYTTRRYLDGAESVLTVKTSTREWNGTYHCIFRYKNSYSIATKDVIVHPLPLKLNIMVDPLEATVSCSGSHHIKCCIEEDGDYKVTFHTGSSSLPAAKEVNKKQVCYKHNFNASSVSWCSKTVDVCCHFTNAANNSVWSPSMKLNLVPGENITCQDPVIGVGEPGKVIQKLCRFSNVPSSPESPIGGTITYKCVGSQWEEKRNDCISAPINSLLQMAKALIKSPSQDEMLPTYLKDLSISIDKAEHEISSSPGSLGAIINILDLLSTVPTQVNSEMMTHVLSTVNVILGKPVLNTWKVLQQQWTNQSSQLLHSVERFSQALQSGDSPPLSFSQTNVQMSSMVIKSSHPETYQQRFVFPYFDLWGNVVIDKSYLENLQSDSSIVTMAFPTLQAILAQDIQENNFAESLVMTTTVSHNTTMPFRISMTFKNNSPSGGETKCVFWNFRLANNTGGWDSSGCYVEEGDGDNVTCICDHLTSFSILMSPDSPDPSSLLGILLDIISYVGVGFSILSLAACLVVEAVVWKSVTKNRTSYMRHTCIVNIAASLLVANTWFIVVAAIQDNRYILCKTACVAATFFIHFFYLSVFFWMLTLGLMLFYRLVFILHETSRSTQKAIAFCLGYGCPLAISVITLGATQPREVYTRKNVCWLNWEDTKALLAFAIPALIIVVVNITITIVVITKILRPSIGDKPCKQEKSSLFQISKSIGVLTPLLGLTWGFGLTTVFPGTNLVFHIIFAILNVFQGLFILLFGCLWDLKVQEALLNKFSLSRWSSQHSKSTSLGSSTPVFSMSSPISRRFNNLFGKTGTYNVSTPEATSSSLENSSSASSLLN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220...--....230.......--240.......250...--....260.......270.---......---280..------------.......290.....--.-.300--.......310---.........-320------........330.....----..-----340..------.....350-----------.-----------......--.---360--.....--.----.-370.-.---.-..---..380.......390....--.--..---400....--...410.......-------420---.......430.----......440.-.-.....450......--.---460.-----.---...----.----------.-------.470---..------..-.-.-.---.-.480.......490.......-500........510..-.-....---520.......530.....-..540........550..-.--....560.......570...---....580.......590.-....-..-600.......610..-.-----..-..620.......630.......------640.......650.......660.......670.-----......680.......690.......700.......710-........720.......730.......740.......750----........760.......770.......780.......790.......800.......810..-.....820.......830.......840.......--850.......860.......870.......880.--......890.-......900.......910.---------------......920......---.930.......940.......950.-......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKSPR
R
T
T
L
C
L
M
F
I
V
I
YSS
K
A
A
L
N
WNYESTIH
P
L
SLHEHEPA
G
E
E
A
L
R
Q
K
R
AVATKSPTA
E
E
Y
T
V
N
I
E
I
S
FENAS
F
L
D
P
I
K
A
Y
L
N
SLSFPIHGN
N
T
D
Q
I
T
D
I
L
S
I
N
V
T
T
V
C
RPAGN
E
I
W
C
S
CETGYG
W
P
R
E
R
C
L
H
N
L
I
CQER
D
V
FLPGH
H
C
S
C
L
K
ELPPNG
P
F
C
L
L
QED
V
T
L
N
M
R
V
R
L
NVG
F
Q
E
D
L
M
N
T
S
S
A
L
Y
R
S
Y
K
T
D
L
E
T
A
F
R
KGYGILPGFK
G
V
T
V
T
GFKS--G
S
V
V
V
T
Y
E
VKTTPP--
S
L
E
L
I
H
KA
N
E
Q
V
V
Q
S
L
--
N
Q
T
YKMDYN
S
F
Q
A
V
T
INE---S
N
F
F
V
T
---
P
--
E
I
------------
I
FEGD
T
V
S
L
V
C
E
K
E
V
--L-SSNV--
S
W
R
Y
E
E
Q
Q
-----
L
E
IQNSSR
F
-
S
I
-------
Y
T
A
L
FNNMTS
V
S
K
L
T
I
----
H
N-----ITPG
D
------
A
G
E
Y
V
C
K
------------
L
-----------
I
L
D
I
F
E
--
Y
---
E
C
K--KKIDV--
M
----
P
-
I
Q
I
L-A---N-E
E
---
M
K
V
M
CDNN
P
V
S
L
N
CCSQGN--V--NW---
S
K
V
E
W
KQ--EG
K
I
NIPGTPETD-------IDS---SC
S
R
Y
T
L
KADG----TQCPSGSSG
T
-
T
-
V
I
Y
T
C
E
F
I
S
AYGAR--G---S-
A
N
-----
I
---
K
V
T
----
F
----------
I
-------
S
V
-----
A
N
------
L
T
-I-T-P---D-PISVSEGQ
N
F
S
I
K
C
ISDVSNY-D-
E
V
Y
WNTSA
G
I
K
I
Y
Q
-
R
-
F
Y
T
T
---
R
R
YLDGAE
S
V
L
T
V
K
TSTR-EWN-G
T
Y
H
C
I
F
R
YKNSYS-I--ATK
D
V
I
VHPL
P
L
K
L
N
I
M
V
DP---
L
E
A
T
V
SCSGS
H
H
I
K
C
C
I
E-EDG
D
-
Y
K
-
V
T
F
HTGSSSLP
A
A
KE-V-----NK-
K
Q
V
C
Y
KHNFNA
S
S
V
S
W
C
S
K
T
V
D
------
V
C
CHFTNAANNSVWSPS
M
K
L
N
LVPGENITCQDPV-----IGVG
E
P
G
K
V
I
Q
K
L
C
R
FSNVPSSPESPIG
G
T
I
T
Y
K
CVGS--
Q
W
E
E
K
RNDC
I
S
A
P
I
N
S
L
L
Q
M
A
K
A
L
IKSPSQD
E
M
L
P
T
Y
L
K
D
-----L
S
I
SIDK
A
E
HEISSSPG
S
L
G
A
I
I
N
I
L
D
L
L
S
TVPTQV
N
S
E
M
M
T
H
V
L
S
T
V
N
V
I
LGK
P
V
L
N
T
W
K
V
L
-
Q
Q
QWT
N
Q
S
S
Q
L
L
H
S
V
E
R
F
S
Q
A
L
QSGDSPPLSFSQT--
N
V
Q
M
S
S
M
V
I
KSSH
P
E
T
Y
Q
Q
R
F
V
F
P
Y
F
D
LWG
N
V
V
I--
D
K
S
Y
L
E
N
LQS-DS
S
I
V
T
M
A
F
P
T
L
Q
A
I
L
A
Q
D
I
---------------
Q
ENNFAE
S
L
V
M
T
T
TV---SHNT
T
M
P
F
R
I
S
M
T
FKNNSPSGG
E
T
K
-
C
V
F
W
N
F
R
LANNTGGWDSSG
C
Y
V
EEGDGD
N
V
T
C
I
CDHLT
S
F
S
I
L
MSPDSP
D
P
S
S
L
L
G
I
L
L
D
I
I
S
Y
V
G
V
G
F
S
I
L
S
L
A
A
C
L
V
V
E
A
V
V
W
K
S
VTKN
R
T
S
Y
M
R
H
T
C
I
V
N
I
A
A
S
L
L
VAN
T
W
F
I
V
V
A
A
IQDN
R
Y
I
L
C
K
T
A
C
V
A
A
T
F
F
I
H
F
F
Y
L
S
V
F
F
W
M
L
T
L
G
L
M
L
F
Y
R
L
V
F
I
L
HETSR
S
T
Q
K
A
I
A
F
C
L
GYGC
P
L
A
I
S
V
I
TLGATQPR
E
V
Y
TRK
N
V
C
W
LN
W
E
D
T
K
A
L
L
A
F
A
I
P
A
L
I
I
V
V
V
N
I
T
I
T
I
V
V
I
T
K
I
LRPSIGDK
P
C
K
Q
E
K
S
S
L
F
Q
I
S
K
S
I
G
V
L
T
P
L
L
G
L
T
WGFG
L
T
TVFP
G
T
N
L
V
F
H
I
I
F
A
I
L
N
V
F
Q
G
L
F
I
L
L
F
G
C
L
WD
L
K
V
Q
E
A
L
L
N
K
F
S
L
S
R
WSSQHSKSTSLGSST
P
V
FSMS
S
P
I
S
R
R
F
N
N
LFGKTG
T
Y
NVSTPEATSSSLENSS
S
A
S
S
LLN
28
HHSearch
83.45
16%
-44
- C3 -
3DMK
-
?
A:
[438-803]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
E
T
------------
M
E
P
G
P
S
V
F
L
K
C
V
A
G
G
N-
P
-
T
P
E
I
--
S
W
E
L
D
G
K
K
-----
I
--
A
N
N
D
R
Y
-
Q
V
-------
G
Q
Y
V
T
V
N
G
D
V
V
S
Y
L
N
I
----
T
S
-----
V
H
A
N
D
------
G
G
L
Y
K
C
I
------------
A
-----------
K
S
K
V
G
V
--
A
---
E
H
S
--
A
K
L
N
V
--
Y
----
G
L
P
Y
I
R
-
Q
---
M
-
E
K
---
K
A
I
V
-
A
G
E
T
L
I
V
T
C
P
V
A
G
Y
-----
P
I
---
D
S
I
V
W
E
R
--
D
N
R
A
L
P
I
N
R
K
Q
K
V
-------
F
-------
P
N
G
T
L
I
I
E
N
----
V
E
----
R
N
S
D
-
Q
-
A
T
Y
T
C
V
A
K
N
Q
E
G
Y
S
--
A
---
R
-
G
S
-----
L
---
E
V
Q
----
V
----------
M
-------
V
L
-----
P
R
------
I
I
P
F
-
A
-
F
---
E
-
E
G
P
A
Q
V
G
Q
Y
L
T
L
H
C
S
V
P
G
G
D
L
-
P
L
N
I
D
W
T
L
-
D
G
Q
A
I
S
E
-
D
-
L
G
I
T
---
T
S
R
V
G
R
R
G
S
V
L
T
I
E
A
V
E
A
-
S
H
A
-
G
N
F
T
C
H
A
R
N
L
A
G
H
Q
-
Q
--
F
T
T
P
L
N
V
Y
V
P
P
---
R
W
I
L
E
P
---
T
D
K
A
F
A
Q
G
S
D
A
K
V
E
C
K
A
D
-
G
F
P
K
-
P
Q
-
V
T
W
K
K
A
V
G
D
T
P
G
E
Y
K
-
D
LKK--
S
D
-
N
I
R
V
E
E
G
T
L
H
V
D
N
I
-
Q
K
T
N
E
G
Y
------
Y
L
C
E
A
I
N
G
I
G
S
G
L
S
A
V
I
M
I
S
V
Q
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
83.06
17%
-49
- C1 -
4DLQ
16
A:
[18-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
VRR
V
Q
W
P
A
T
Q
Q
G
M
L
V
E
R
P
C
-----
P
K
G
T
R
----
G
I
A
S
F
Q
C
L
P
A
LG
L
W
N
P
R
G
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
RGSI
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
R
N
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
M
N
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
---
V
Q
E
L
V
F
P
Q
E
Y
A
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
ATVKLA
G
E
A
G
T
GGPG
G
A
S
L
V
V
N
S
Q
V
I
A
A
S
I
NKE
S
S
R
V
F
L
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
H
F
N
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
82.97
19%
-40
- C3 -
3LAF
14
DCC_RAT
A:
[30-400]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
A
V
------------
T
M
R
G
G
N
V
L
L
N
C
S
A
E
S
DR
G
-
V
P
V
I
--
K
W
K
K
D
G
L
I
-----
L
A
L
G
M
D
D
R
K
-
Q
Q
-------
L
--------
P
N
G
S
L
L
I
----
Q
N
I
L
H
S
R
H
H
K
P
D
------
E
G
L
Y
Q
C
E
------------
A
-----------
S
L
G
D
S
G
S
I
I
---
S
R
T
--
A
K
V
M
V
--
A
G
P
--
L
-
R
F
L
S
-
Q
---
T
-
E
S
---
I
T
A
F
-
M
G
D
T
V
L
L
K
C
E
V
I
G
D
-----
P
M
---
P
T
I
H
W
Q
K
--
N
Q
Q
D
L
N
P
I
P
G
D
S
R
-------
V
V
V
----
L
P
S
G
A
L
---------
Q
I
S
R
L
Q
P
G
D
-
S
-
G
V
Y
R
C
S
A
R
N
P
A
S
T
R
--
T
---
G
-
N
E
-----
A
---
E
V
R
----
I
----------
L
-------
S
D
-----
P
G
L
H
R
Q
L
Y
F
L
-
Q
-
R
-
P
---
S
-
N
V
I
A
I
E
G
K
D
A
V
L
E
C
C
V
S
G
Y
P
P
-
P
-
S
F
T
W
L
R
-
G
E
E
V
I
Q
L
-
R
-
S
------
K
K
Y
S
L
L
G
G
S
N
L
L
I
S
N
V
T
D
-
D
D
S
-
G
T
Y
T
C
V
V
T
Y
K
N
E
N
I
-
S
--
A
S
A
E
L
T
V
L
V
P
P
---
W
F
L
N
H
P
---
S
N
L
Y
A
Y
E
S
M
D
I
E
F
E
C
A
V
S
-
G
K
P
V
-
P
T
-
V
N
W
M
K
N
G
D
V
V
I
P
S
D
Y
-
F
-----
Q
----
I
V
G
G
S
N
L
R
I
L
G
V
-
V
K
S
D
E
G
F
------
Y
Q
C
V
A
E
N
E
A
G
N
A
Q
S
S
A
Q
L
I
V
P
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
80.42
16%
-45
- C3 -
3DMK
-
?
A:
[352-740]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
Q
T
------------
V
D
F
G
R
P
A
V
F
T
C
Q
Y
T
G
N
-
P
-
I
K
T
V
--
S
W
M
K
D
G
K
A
-----
I
--
G
H
-----------------------
S
E
S
V
L
R
I
----
E
S
-----
V
K
K
E
D
------
K
G
M
Y
Q
C
F
------------
V
-----------
R
N
D
R
E
S
--
A
---
E
A
S
--
A
E
L
K
L
--
G
GRFD
P
-
P
V
I
R
-
Q
A--
F
-
Q
E
---
E
T
M
E
-
P
G
P
S
V
F
L
K
C
V
A
G
G
N
-----
P
T
---
P
E
I
S
W
E
L
--
D
G
K
K
I
A
N
N
D
R
Y
Q
V
G
Q
Y
V
---
T
V
N
---
G
D
V
V
S
Y
L
N
---------
I
T
S
V
H
A
N
D
-
G
-
G
L
Y
K
C
I
A
K
S
K
V
G
V
A
------
E
-
H
S
-----
A
---
K
L
N
----
V
----------
Y
-------
G
L
-----
P
Y
------
I
R
---
Q
-
M
---
E
-
K
K
A
I
V
A
G
E
T
L
I
V
T
C
P
V
A
G
Y
P
I
-
D
-
S
I
V
W
E
R
-
D
N
R
A
L
P
I
-
N
-
R
K
-------
Q
K
V
F
P
N
G
T
L
I
I
E
N
V
E
R
N
S
D
Q
-
A
T
Y
T
C
V
A
K
N
Q
E
G
Y
S
A
R
--
G
S
L
E
V
Q
V
M
V
L
P
R
--
I
I
P
F
A
F
---
E
E
G
P
A
Q
V
G
Q
Y
L
T
L
H
C
S
V
P
-
G
G
D
L
P
L
N
-
I
D
W
T
L
D
G
Q
A
I
S
E
D
L
G
-
I
-----
T
T
S
R
V
G
R
R
G
S
V
L
T
I
E
A
V
-
E
A
S
H
A
G
N
------
F
T
C
H
A
R
N
L
A
G
H
Q
Q
F
T
T
P
L
N
V
Y
V
P
P
R
W
I
L
E
P
T
--------
D
K
A
F
A
Q
G
S
D
A
K
V
E
C
K
A
D
G
F
P
K
P
Q
V
T
W
K
K
A
V
G
D
T
P
G
E
Y
K
--
D
L
K
K
S
D
N
I
R
V
E
E
G
T
L
H
V
D
N
I
Q
K
T
N
E
G
Y
Y
L
C
E
A
I
N
G
I
G
S
G
L
-----
S
A
V
I
M
I
S
V
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
80.07
14%
-39
- C3 -
3B43
-
A:
[203-564]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
------------
L
A
L
G
E
S
G
T
F
K
C
H
V
T
G
T-
A
-
P
I
K
I
--
T
W
A
K
D
N
R
E
-----
I
--
R
P
G
G
N
Y
-
K
M
-------
T
L
V
-----
E
N
T
A
T
L
T
V
----
L
K
-----
V
T
K
G
D
------
A
G
Q
Y
T
C
Y
------------
A
-----------
S
N
V
A
G
K
--
D
---
S
C
S
--
A
Q
L
G
V
Q
E
P
----
P
-
R
F
I
K
-
K
---
L
-
E
P
---
S
R
I
V
K
Q
D
E
H
T
R
Y
E
C
K
I
G
G
S
-----
P
E
---
I
K
V
L
W
Y
K
--
D
E
T
E
I
Q
E
S
S
K
F
R
M
--------
S
F
---
V
E
S
V
A
V
L
E
---------
M
Y
N
L
S
V
E
D
-
S
-
G
D
Y
T
C
E
A
H
N
A
A
G
S
A
------
S
-
S
S
-----
T
---
S
L
K
----
V
----------
K
-------
E
P
-----
P
V
------
F
R
-
K
-
K
-
P
---
H
-
P
V
E
T
L
K
G
A
D
V
H
L
E
C
E
L
Q
G
T
P
P
-
F
-
Q
V
S
W
H
K
-
D
K
R
E
L
R
S
G
K
-
K
Y
K
-----
I
M
S
E
N
F
L
T
S
I
H
I
L
N
V
D
S
-
A
D
I
-
G
E
Y
Q
C
K
A
S
N
D
V
G
S
D
-
T
--
C
V
G
S
I
T
L
K
A
P
P
---
R
F
V
K
K
L
---
S
D
I
S
T
V
V
G
E
E
V
Q
L
Q
A
T
I
E
-
G
A
E
P
-
I
S
-
V
A
W
F
K
D
K
G
E
I
V
R
E
S
D
N
I
-----
W
I
-
S
Y
S
E
N
I
A
T
L
Q
F
S
R
A
-
E
P
A
N
A
G
K
------
Y
T
C
Q
I
K
N
E
A
G
T
Q
E
C
F
A
T
L
S
V
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
79.65
14%
-38
- C3 -
1CS6
1
CNTN2_CHICK
A:
[20-380]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
E
E
K
V
T
L
T
C
R
A
R
A
N-
P
-
P
A
T
Y
--
R
W
K
M
N
G
T
E
-----
L
K
M
G
P
D
S
R
Y
-
R
L
-------
V
--------
A
G
D
L
V
I
S
----
N
P
-----
V
K
A
K
D
------
A
G
S
Y
Q
C
V
------------
A
-----------
T
N
A
R
G
T
--
V
V
S
R
E
A
S
--
L
R
F
G
F
--
L
----
Q
-
E
F
S
A
-
E
---
E
R
D
P
---
V
K
I
T
-
E
G
W
G
V
M
F
T
C
S
P
P
P
H
--
Y
--
P
A
---
L
S
Y
R
W
L
L
--
N
E
F
P
N
F
I
P
A
D
G
R
R
-------
F
V
S
----
Q
T
T
G
N
L
---------
Y
I
A
K
T
E
A
S
D
-
L
-
G
N
Y
S
C
F
A
T
S
H
I
D
F
I
--
T
K
--
S
-
V
F
S
K
F
S
Q
L
---
S
L
A
AEDA
R
----------
Q
-------
Y
A
-----
P
S
------
I
K
-
A
-
K
F
P
---
A
-
D
T
Y
A
L
T
G
Q
M
V
T
L
E
C
F
A
F
G
N
P
V
-
P
-
Q
I
K
W
R
K
L
D
G
S
Q
-
T
S
------------
K
W
L
S
S
E
P
L
L
H
I
Q
N
V
D
F
-
E
D
E
-
G
T
Y
E
C
E
A
E
N
I
K
G
R
D
-
T
--
Y
Q
G
R
I
I
I
H
A
Q
P
---
D
W
L
D
V
I
---
T
D
T
E
A
D
I
G
S
D
L
R
W
S
C
V
A
S
-
G
K
P
R
-
P
A
-
V
R
W
L
R
D
G
Q
P
L
A
S
Q
N
R
-
I
-----
E
-----
V
S
G
G
E
L
R
F
S
K
L
-
V
L
E
D
S
G
M
------
Y
Q
C
V
A
E
N
K
H
G
T
V
Y
A
S
A
E
L
T
V
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
79.49
15%
-34
- C3 -
3B43
-
A:
[107-499]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
------------
E
T
L
G
F
P
V
A
F
E
C
R
I
N
G
S
-
E
-
P
L
Q
V
--
S
W
Y
K
D
G
E
L
-----
L
--
K
D
D
A
N
L
-
Q
T
-------
S
F
I
-----
H
N
V
A
T
L
Q
I
----
L
Q
-----
T
D
Q
S
H
------
V
G
Q
Y
N
C
S
------------
A
-----------
S
N
P
L
G
T
--
A
---
S
S
S
A
K
L
T
L
S
E
--
H
EV--
P
-
P
F
F
D
L
K
---
P
-
V
S
---
V
D
L
A
-
L
G
E
S
G
T
F
K
C
H
V
T
G
T
-----
A
P
---
I
K
I
T
W
A
K
--
D
N
R
E
I
R
P
G
G
N
Y
K
M
-------
T
-
L
---
V
E
N
T
A
T
L
T
V
L
---------
K
V
T
K
G
D
-
A
-
G
Q
Y
T
C
Y
A
S
N
V
A
G
K
D
------
S
-
C
S
-----
A
---
Q
L
G
----
V
----------
Q
-------
E
P
-----
P
R
------
F
I
-
K
-
K
-
L
---
E
P
S
R
I
V
K
Q
D
E
H
T
R
Y
E
C
K
I
G
G
S
P
E
-
I
-
K
V
L
W
Y
K
-
D
E
T
E
I
Q
E
-
S
-
S
K
F
----
R
M
S
F
V
E
S
V
A
V
L
E
M
Y
N
L
S
V
-
E
D
S
-
G
D
Y
T
C
E
A
H
N
A
A
G
S
A
-
S
--
S
S
T
S
L
K
V
K
E
P
P
---
V
F
R
K
K
P
---
H
P
V
E
T
L
K
G
A
D
V
H
L
E
C
E
L
Q
-
G
T
P
P
-
F
Q
-
V
S
W
H
K
D
K
R
E
L
R
S
G
K
K
-
Y
-----
K
I
-
M
S
E
N
F
L
T
S
I
H
I
L
N
V
-
D
S
A
D
I
G
E
------
Y
Q
C
K
A
S
N
D
V
G
S
D
T
C
V
G
S
I
T
L
K
A
P
P
R
F
V
K
K
L
S
--------
D
I
S
T
V
V
G
E
E
V
Q
L
Q
A
T
I
E
G
A
E
P
I
S
V
A
W
F
K
D
K
G
E
I
V
R
E
S
D
--
N
I
W
I
S
Y
S
E
N
I
A
T
L
Q
F
S
R
A
E
P
A
N
A
G
K
Y
T
C
Q
I
K
N
E
A
G
T
Q
E
C
F
-----
A
T
L
S
V
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.02
21%
55
- C- -
1E07
-
CEAM5_HUMAN
A:
[34-393]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
E
R
V
D
G
N
R
Q
I
I
G
Y
V
I
G
T
Q
Q
A
T
P
G
P
A
Y
S
G
R
E
I
I
Y
P
N
A
S
L
L
I
Q
N
I
IQ
N
D
T
G
F
Y
T
L
H
V
I
K
S
D
L
V
N
E
E
A
T
G
Q
F
R
V
Y
---
P
--
E
L
PKPSISSNNSKP
V
E
D
K
D
A
V
A
F
T
C
E
P
E
T
--
Q
-
D
A
T
Y
--
L
W
W
V
N
N
Q
S
-----
L
P
V
--
S
P
R
L
-
Q
L
-------
S
N
G
---
N
R
T
----
L
T
L
----
F
N
-----
V
T
R
N
D
------
T
A
S
Y
K
C
E
T
Q
N
PVSA
R
R
S
D
S
V
-----------
I
L
N
V
L
Y
--
G
---
P
D
A
--
P
T
I
S
P
--
L
----
N
-
T
S
Y
R
-
S
---
G
-
E
N
---
L
N
L
S
C
H
---
A
A
S
N
P
P
A
Q
Y
S
W
F
V
--
N
G
---
T
F
Q
Q
S
T
Q
--
E
L
F
I
-----
P
N
I
T
-------
V
N
N
---
S
G
S
-
Y
T
C
Q
A
H
N
----
S
D
--
T
G
L
N
R
T
-
T
-
V
T
----
T
I
T
V
Y
-----------
A
E
-----
P
---
P
K
P
----
F
----------
I
-------
T
S
-----
N
N
------
S
N
-
P
-
V
-
E
---
D
-
E
D
A
V
------
A
L
T
C
E
P
E
I
Q
N
T
-
T
-
Y
L
W
W
V
N
N
Q
S
L
P
V
S
P
-
R
-
L
--------
Q
L
S
N
D
N
R
T
L
T
L
L
S
V
T
R
-
N
D
V
-
G
P
Y
E
C
--------
G
-
I
--
Q
N
E
L
S
V
D
H
S
D
P
V
I
L
N
V
L
Y
G
P
---
D
D
P
T
I
S
P
S
Y
T
Y
Y
R
P
G
V
N
L
-
S
L
S
C
-
H
A
-
A
S
N
P
P
A
Q
Y
S
W
L
I
D
G
N
-
I
-----
Q
Q
-
H
T
Q
E
L
F
I
S
N
I
T
E
K
N
S
G
L
Y
T
C
Q
A
------
N
N
S
A
S
G
H
S
R
T
T
V
K
T
I
T
V
S
A
E
L
P
K
P
S
I
S
S
N
N
S
K
P
V
-----
E
D
K
D
A
V
A
F
T
C
E
P
E
A
Q
N
T
T
Y
L
W
W
V
N
G
Q
S
L
P
V
S
P
R
L
Q
L
S
N
--
G
N
R
T
L
T
L
F
N
V
T
R
N
D
A
R
A
Y
V
C
G
I
Q
N
S
V
S
A
N
R
S
D
P
V
T
L
D
V
L
Y
-----
G
P
D
T
P
I
I
S
P
P
D
S
S
Y
L
S
G
A
N
L
N
L
S
C
H
S
A
S
N
P
S
P
Q
Y
S
W
R
I
N
G
I
P
Q
Q
H
T
Q
V
L
F
I
A
K
I
T
P
N
N
N
G
T
Y
A
-
C
F
V
S
N
L
A
T
G
R
N
N
S
I
V
K
S
I
T
V
S
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
75.42
14%
-31
- C3 -
3P3Y
1
NFASC_HUMAN
A:
[13-401]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
Q
P
---
P
T
I
T
K
Q
SAK
D
--
H
I
------------
V
D
P
R
D
N
I
L
I
E
C
E
A
K
G
N-
P
-
A
P
S
F
--
H
W
T
R
N
S
R
F
-----
F
N
I
A
K
D
P
R
V
-
S
M
-------
R
R
-------
R
S
G
T
L
V
I
D
FRS
G
G
-----
R
P
E
E
Y
------
E
G
E
Y
Q
C
F
------------
A
-----------
R
N
K
F
G
T
--
A
L
--
S
N
R
--
I
R
L
Q
V
SK
S
----
P
-
L
W
P
K
-
E
---
N
-
L
D
---
P
V
V
V
Q
E
G
A
P
L
T
L
Q
C
N
P
P
P
G
--
L
--
P
S
---
P
V
I
F
W
M
S
--
S
S
M
E
P
I
T
Q
D
K
R
V
S
-------
Q
G
------
H
N
G
D
L
Y
F
S
---------
N
V
M
L
Q
D
M
Q
-
T
D
Y
S
C
N
A
R
F
H
F
T
H
T
I
Q
Q
---
K
-
N
P
-----
F
---
T
L
K
----
V
----------
L
T
TRGVA
E
R
T
-----
P
S
------
F
M
-
Y
-
P
-
Q
GT
A
S
-
S
Q
M
V
L
R
G
M
D
L
L
L
E
C
I
A
S
G
V
P
T
-
P
-
D
I
A
W
Y
K
-
K
G
G
D
L
P
S
-
D
-
K
A
-------
K
F
E
N
F
N
K
A
L
R
I
T
N
V
S
E
-
E
D
S
-
G
E
Y
F
C
L
A
S
N
K
M
G
S
I
-
R
--
H
T
I
S
V
R
V
K
A
A
P
---
Y
W
L
D
E
P
---
K
N
L
I
L
A
P
G
E
D
G
R
L
V
C
R
A
N
-
G
N
P
K
-
P
T
-
V
Q
W
M
V
N
G
E
P
L
Q
S
A
P
P
-
N
-----
P
--
N
R
E
V
A
G
D
T
I
I
F
R
D
T
-
Q
I
S
S
R
A
V
------
Y
Q
C
N
T
S
N
E
H
G
Y
L
L
A
N
A
F
V
S
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
74.82
14%
-35
- C3 -
3KLD
4
CNTN4_MOUSE
A:
[21-381]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
E
K
K
V
K
L
S
C
E
V
K
G
N-
P
-
K
P
H
I
--
R
W
K
L
N
G
T
D
-----
V
--
D
I
-----
R
Y
-------
S
V
V
------
D
G
S
L
L
I
N
----
N
P
-----
N
K
T
Q
D
------
A
G
T
Y
Q
C
I
------------
A
-----------
T
N
S
F
G
T
--
I
V
S
R
E
A
K
--
L
Q
F
A
Y
--
L
----
E
-
N
F
K
T
-
R
T--
R
-
S
T
---
V
S
V
R
-
R
G
Q
G
M
V
L
L
C
G
P
P
P
H
--
S
--
G
E
---
L
S
Y
A
W
I
F
--
N
E
Y
P
S
Y
Q
D
N
R
R
F
V
-------
S
Q
------
E
T
G
N
L
---------
Y
I
A
K
V
E
K
S
D
-
V
-
G
N
Y
T
C
V
V
T
N
T
V
T
N
H
--
K
V
L
-
G
-
P
P
-----
T
---
P
L
I
----
L
RNDGV
M
G
---
E
-------
Y
E
-----
P
K
------
I
E
-
V
Q
F
-
P
---
E
-
T
V
P
A
E
K
G
T
T
V
K
L
E
C
F
A
L
G
N
P
V
-
P
-
T
I
L
W
R
R
A
D
G
K
P
I
A
R
-
K
-
A
--------
R
R
H
K
S
N
G
I
L
E
I
P
N
F
Q
Q
-
E
D
A
-
G
S
Y
E
C
V
A
E
N
S
R
G
K
N
-
V
--
A
K
G
Q
L
T
F
Y
A
Q
P
---
N
W
V
Q
I
I
---
N
D
I
H
V
A
M
E
E
S
V
F
W
E
C
K
A
N
-
G
R
P
K
-
P
T
-
Y
R
W
L
K
N
G
D
P
L
L
T
R
D
R
-
I
-----
Q
-----
I
E
Q
G
T
L
N
I
T
I
V
-
N
L
S
D
A
G
M
------
Y
Q
C
V
A
E
N
K
H
G
V
I
F
S
S
A
E
L
S
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
72.80
19%
-36
- C3 -
3RJD
7
FCGR1_HUMAN
A:
[1-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
A
V
I
T
-
L
---
Q
-
P
P
---
W
V
S
V
F
Q
E
E
T
V
T
L
H
C
E
V
L
H
L
--
P
--
G
S
---
S
S
T
Q
W
F
L
--
N
G
T
A
T
Q
T
S
T
P
S
Y
R
-------
I
T
S
--------------------
A
S
V
N
D
S
G
-----
E
Y
R
C
Q
R
----
G
L
S
--
G
---
R
-
S
D
-----
P
---
I
Q
L
----
E
----------
I
-------
H
R
-----
G
W
------
L
L
-
L
-
Q
-
V
---
S
-
S
R
V
F
T
E
G
E
P
L
A
L
R
C
H
A
W
K
D
K
---------
L
V
Y
N
V
L
Y
Y
R
-
N
-
G
K
A
F
---
K
F
F
H
W
N
S
N
--
L
T
I
L
K
T
N
I
-
S
H
N
-
G
T
Y
H
C
S
G
M
G
K
H
R
Y
T
-
S
--
A
G
I
S
V
T
V
K
E
L
F
P
A
P
V
L
N
A
S
V
----
T
S
P
L
L
E
G
N
L
V
T
L
S
C
E
T
K
-
L
L
L
Q
-
L
Y
-
F
S
F
Y
M
G
S
K
T
L
R
G
R
N
T
-
S
-----
S
E
-
Y
Q
I
--------
L
T
A
R
R
E
D
S
G
L
Y
------
W
C
E
A
A
T
E
D
G
N
V
L
K
R
S
P
E
L
E
L
Q
V
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
72.77
16%
-25
* C3 *
4W4O
13
FCGR1_HUMAN
C:
[6-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
A
V
I
K
L
Q
---
P
PW
V
S
------------
V
F
Q
E
E
S
V
T
L
H
C
E
V
P
---
G
-
S
S
S
T
--
Q
W
F
L
N
G
T
A
-----
I
Q
T
S
T
P
-------------------------
T
Y
H
I
----
T
S
-----
A
S
E
D
D
------
S
G
E
Y
R
C
Q
------------
R
-------------
G
L
S
G
--
R
---
S
D
P
--
I
Q
L
E
V
--
H
----
R
-
G
W
L
L
-
L
---
Q
-
V
S
---
S
R
V
L
T
E
G
E
P
L
A
L
R
C
H
A
W
K
D
--
K
--
L
V
---
Y
N
V
L
Y
Y
R
--
N
G
------------------------
K
A
F
K
F
F
H
W
N
S
N
----
L
T
I
L
K
T
N
M
S
H
-
S
-
G
T
Y
H
C
S
G
M
G
K
H
R
Y
T
--
S
---
A
G
I
S
-----
V
---
T
V
K
----
E
----------
L
-------
F
P
-----
A
P
------
V
L
-
T
-
A
-
S
---
V
-
T
S
P
L
L
E
G
T
P
V
T
L
S
C
E
T
K
L
L
L
Q
-
R
-
P
---
G
L
Q
L
Y
F
S
F
Y
M
-
G
-
S
K
T
L
---
R
G
R
D
T
S
--
S
E
Y
Q
I
L
T
A
R
R
-
E
D
S
-
G
L
Y
W
C
E
A
A
T
E
D
---------
G
N
V
L
K
R
S
P
E
L
E
L
Q
V
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.92
18%
-2
- C3 -
4U7M
1
A:
[36-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
K
K
D
N
E
V
-----
L
T
N
A
D
M
E
N
F
V
H
V
-------
H
A
----
V
M
E
Y
T
T
I
L
H
L
----
R
Q
-----
V
T
F
G
H
------
E
G
R
Y
Q
C
V
------------
I
T
N
H--------
F
G
S
T
Y
S
--
H
---
K
A
R
--
L
T
V
N
V
--
L
----
P
-
S
F
T
K
-
T
---
P
-
H
D
---
I
T
I
R
T
-
T
T
M
A
R
L
E
C
A
A
T
G
H
--
P
--
N
----
P
Q
I
A
W
Q
K
--
D
G
G
T
D
F
P
A
A
R
E
R
R
-------
M
---------
H
V
M
P
D
D
D
V
F
F
I
T
D
V
K
I
D
D
A
G
-----
V
Y
S
C
T
A
Q
N
S
A
G
S
I
------
S
-
A
N
-----
A
---
T
L
T
----
V
----------
L
-------
E
T
-----
P
S
------
L
V
-
V
-
P
-
L
---
E
-
D
R
V
V
S
V
G
E
T
V
A
L
Q
C
K
A
T
G
N
P
P
-
P
-
R
I
T
W
--
F
K
G
D
R
P
L
S
----
L
T
E
---
R
H
H
L
T
P
D
N
Q
L
L
V
V
Q
N
V
V
A
-
E
D
A
-
G
R
Y
T
C
E
M
S
N
T
L
G
T
E
-
R
--
A
H
S
Q
L
S
V
L
L
E
N
L
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
69.02
14%
-1
- C3 -
1EV2
-
FGFR2_HUMAN
E:
[4-214]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
K
R
A
P
Y
--
W
----
T
-
N
T
E
K
-
M
---
E
-
K
R
---
L
H
A
V
P
A
A
N
T
V
K
F
R
C
P
A
G
G
N
--
P
--
M
----
P
T
M
R
W
L
K
--
N
G
K
E
F
K
Q
E
H
R
I
G
G
-------
Y
K
V
---
R
N
Q
H
W
S
L
I
M
E
S
----
V
V
P
S
D
K
G
-------
N
Y
T
C
V
V
E
N
E
Y
G
-
S
--
I
---
N
-
H
T
-----
Y
---
H
L
D
----
V
----------
V
-------
E
R
-----
S
P
------
H
R
-
P
-
I
-
L
---
Q
-
A
G
L
P
A
N
A
S
D
V
E
F
V
C
K
V
Y
S
D
A
Q
-
P
-
H
I
Q
W
I
K
H
-
V
P
Y
L
K
V
-
L
-
K
A
A
G
---
V
N
T
T
D
K
E
I
E
V
L
Y
I
R
N
V
T
F
-
E
D
A
-
G
E
Y
T
C
L
A
G
--
N
S
I
G
-
I
--
S
F
H
S
A
W
L
T
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
68.57
12%
-36
- C3 -
2EC8
5
?
A:
[36-432]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
---
P
S
I
H
P
G
KS-
D
--
L
I
------------
V
R
V
G
D
E
I
R
L
L
C
T
D
P
G
------
F
V
--
K
W
T
F
E
I
L
D
-----
E
---
T
N
---------------
E
-----
N
K
Q
N
E
W
I
T
----
E
K
-----
A
E
A
T
N
------
T
G
K
Y
T
C
T
------------
N
-----------
K
H
G
L
S
---
N
---
S
I
Y
--
V
F
V
R
D
--
P
----
A
-
K
L
F
L
-
V
---
D
-
R
S
---
L
Y
G
K
-
E
D
N
D
T
L
V
R
C
P
L
T
D
------
P
E
---
V
T
N
Y
S
L
K
GC
Q
G
K
P
L
P
K
D
L
R
F
---------
I
P
D
-----
P
K
A
G
I
M
I
K
S
----
V
K
----
R
A
Y
H
-
R
-
L
C
L
H
C
S
V
D
----
S
V
--
L
---
S
-
E
K
-----
F
---
I
L
K
----
V
----------
R
P
A
FK---
A
V
-----
P
V
------
V
S
-
V
-
S
-
K
---
A
-
S
Y
L
L
R
E
G
E
E
F
T
V
T
C
T
I
K
D
V
S
S
S
V
-
Y
S
T
W
K
R
E
-
N
S
Q
T
K
L
Q
E
-
K
Y
N
S
W
H
H
G
D
F
N
Y
E
R
Q
A
T
L
T
I
S
S
A
R
V
-
N
D
S
-
G
V
F
M
C
Y
A
N
N
T
F
G
S
A
-
N
--
V
T
T
T
L
E
V
V
D
K
G
F
---
I
N
I
F
P
MIN
T
T
V
F
V
N
D
G
E
N
V
D
L
I
V
E
Y
E
-
A
F
P
K
-
P
E
H
Q
Q
W
I
Y
M
N
R
T
F
T
D
K
W
E
-
D
Y
P
KSE
N
E
-
S
N
I
R
Y
V
S
E
L
H
L
T
R
L
-
K
G
T
E
G
G
T
------
Y
T
F
L
V
S
N
S
D
V
N
A
A
I
A
F
N
V
Y
V
N
T
K
P
E
I
L
--------------
T
Y
D
R
L
V
N
G
M
L
Q
C
V
A
A
G
F
P
E
P
T
I
D
W
Y
F
C
V
L
P
V
D
V
Q
T
L
--
N
S
G
P
P
F
G
K
L
V
V
Q
S
S
I
D
S
S
A
F
K
H
C
K
A
Y
N
D
V
G
K
T
S
A
Y
F
N
F
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
67.91
14%
-20
- C3 -
1BIH
1
HEMO_HYACE
A:
[5-394]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
---
P
V
L
K
D
Q
---
P
A
E
V
L
------------
F
R
E
N
N
P
T
V
L
E
C
I
I
E
G
N-
D
Q
G
V
K
Y
--
S
W
K
K
D
G
K
S
-----
Y
N
--
W
Q
E
H
N
-
A
A
-------
L
R
------
K
D
E
G
S
L
V
F
----
L
R
-----
P
Q
A
S
D
------
E
G
H
Y
Q
C
F
------------
A
-----------
E
T
P
A
G
V
--
A
---
S
S
R
--
V
I
S
F
R
--
K
----
T
-
Y
L
I
A
-
S
P
A
K
T
-
H
E
---
K
T
P
-
I
E
G
R
P
F
Q
L
D
C
V
L
P
N
A
--
Y
--
P
K
---
P
L
I
T
W
K
K
--
R
L
S
G
A
D
P
N
A
D
V
T
D
-------
F
D
R
R
I
T
A
G
P
D
G
N
L
Y
F
T
I
------
V
T
K
E
D
V
S
D
-
I
-
Y
K
Y
V
C
T
A
K
N
A
A
V
D
E
--
E
---
V
-
V
L
-----
V
---
E
Y
E
----
I
K
G
V
T
K
D
NSGY
K
-------
G
E
-----
P
V
------
P
Q
-
Y
-
V
-
S
---
K
-
D
M
M
A
K
A
G
D
V
T
M
I
Y
C
M
Y
G
S
N
P
M
-
G
-
Y
P
N
Y
F
K
-
N
G
K
D
V
N
G
-
N
P
E
D
R
I
---
T
R
H
N
R
T
S
G
K
R
L
L
F
K
T
T
L
P
-
E
D
E
-
G
V
Y
T
C
E
V
D
N
G
V
G
K
P
-
Q
K
-
H
S
L
K
L
T
V
V
S
A
P
---
K
Y
E
Q
K
P
E--
K
V
I
V
V
K
Q
G
Q
D
V
T
I
P
C
K
V
T
-
G
L
P
A
-
P
N
-
V
V
W
S
H
N
A
K
P
L
S
G
G
R
A
-
T
-----------
V
T
D
S
G
L
V
I
K
G
V
-
K
N
G
D
K
G
Y
------
Y
G
C
R
A
T
N
E
H
G
D
K
Y
F
E
T
L
V
Q
V
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
67.50
12%
-49
- C3 -
2O26
2
KIT_MOUSE
U:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
P
S
I
H
-
P
---
A
-
Q
S
---
E
L
I
V
E
A
G
D
T
L
S
L
T
C
I
D
P
D
F
--
V
--
R
W
---
T
F
K
T
Y
F
N
--
E
M
V
E
N
K
K
N
-----------------------
E
W
I
Q
E
K
----
A
E
A
T
R
T
G
-------
T
Y
T
C
S
N
----
S
N
G
--
L
---
T
-
S
S
-----
I
---
Y
V
F
----
V
----------
R
-------
D
P
-----
A
K
------
L
F
-
L
-
V
-
G
---
L
-
P
L
F
G
K
E
D
S
D
A
L
V
R
C
P
L
T
D
P
Q
V
-
S
-
Q
Y
S
L
I
E
C
D
G
----
K
-
S
-
L
P
T
D
---
L
T
F
V
P
N
P
K
A
G
I
T
I
K
N
V
K
R
-
A
Y
H
R
L
C
V
R
C
A
A
Q
R
D
G
T
W
L
-
H
SD
K
F
T
L
K
V
R
E
A
I
K
A
I
P
V
V
S
V
P
E
---
T
S
H
L
L
K
K
G
D
T
F
T
V
V
C
T
I
K
D
V
S
T
S
-
V
N
-
S
M
W
L
K
M
N
P
Q
P
Q
H
I
A
Q
-
V
-----
K
H
-
N
S
W
H
R
G
D
F
N
Y
E
R
Q
E
T
L
T
I
S
S
A
R
VDDSGV
F
M
C
Y
A
N
N
T
F
G
S
A
N
V
T
T
T
L
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.27
23%
-6
- C3 -
5A2F
18
?
A:
[36-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
T
I
I
I
P
C
R
L
D
V
--
P
-
Q
N
L
M
F
G
K
W
K
Y
E
K
P
D
G
S
P
V
F
I
A
F
R
S
S
T
K
K
-
S
V
Q
Y
D
DVPE
Y
K
D
R
L
N
-
L
S
E
N
Y
T
L
S
I
----
S
N
-----
A
R
I
S
D
------
E
K
R
F
V
C
M
------------
L
V
T
ED
N
V
F
E
A
P
T
I
V
K
V
F
K
--
Q
---
P
S
K
--
P
E
I
-
V
--
S
----
K
-
A
L
F
L
-
E
---
T
-
E
Q
---
L
K
K
L
G
D
C
--
I
S
E
D
S
Y
P
D
G
N
--
I
--
T
W
Y
R
N
G
K
V
L
H
P
L
--
E
G
A
V
V
I
I
F
K
K
E
M
D
PVTQ
L
Y
T
M
T
S
---
T
L
E
Y
K
T
T
K
A
D
-----
I
Q
M
P
-----------
F
T
C
S
-
V
T
Y
Y
G
P
S
--
G
---
Q
-
K
T
-----
I
H
S
E
Q
A
V
----
F
D
I
Y
Y
P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
65.62
12%
-38
- C3 -
2V5M
3
?
A:
[15-386]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
------------
F
S
N
S
T
G
A
E
I
E
C
K
A
S
G
N-
P
-
M
P
E
I
--
I
W
I
R
S
D
G
T
-----
A
V
-
G
D
V
P
G
L
-
R
Q
-------
I
-------
S
S
D
G
K
L
V
F
----
P
P
-----
F
R
A
E
D
YRQEVH
A
Q
V
Y
A
C
L
------------
A
-----------
R
N
Q
F
G
S
--
I
I
--
S
R
D
--
V
H
V
R
A
--
V
V
A--
Q
-
Y
Y
E
A
-
D
---
V
-
N
K
---
E
H
V
I
-
R
G
N
S
A
V
I
K
C
L
I
P
S
F
--
V
AD
F
V
---
E
V
V
S
W
H
T
--
D
E
E
E
N
Y
F
P
G
A
E
----------
Y
D
----
G
K
Y
L
V
L
P
S
G
E
----
L
H
I
R
E
V
G
P
E
D
-
G
Y
K
S
Y
Q
C
R
T
K
H
R
L
T
G
E
--
T
R
L
S
A
-
T
K
-----
G
---
R
L
V
----
I
----------
T
-------
E
P
I
S
S
S
A
P
R
T-----
P
A
-
L
-
V
-
Q
---
K
-
P
L
E
L
M
V
A
H
T
I
S
L
L
C
P
A
Q
G
F
P
A
-
P
-
S
F
R
W
Y
K
F
-
I
E
G
T
T
R
K
Q
-
A
V
V
L
---
N
D
R
V
K
Q
V
S
G
T
L
I
I
K
D
A
V
V
-
E
D
S
-
G
K
Y
L
C
V
V
N
N
S
V
G
G
E
-
S
--
V
E
T
V
L
T
V
T
A
P
L
---
S
A
K
I
D
P
---
P
T
Q
T
V
D
F
G
R
P
A
V
F
T
C
Q
Y
T
-
G
N
P
I
-
K
T
-
V
S
W
M
K
D
G
K
A
I
G
H
S
-----------------
E
S
V
L
R
I
E
S
V
-
K
K
E
D
K
G
M
------
Y
Q
C
F
V
R
N
D
R
E
S
A
E
A
S
A
E
L
K
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
65.51
11%
-32
- C3 -
2EC8
5
?
A:
[11-508]
-----------------------------------------------------------------------------
L
C
V
L
L
L
L
L
E
P
S
P
P
S
I
H
P
G
K
S
D
L
I
V
R
V
G
D
E
I
R
L
L
C
T
D
P
G
F
V
K
W
T
F
E
--
I
L
D
E
T
N
E
N
K
Q
N
E
W
I
T
E
K
A
E
A
T
N
T
G
-
K
Y
T
C
T
N
K
H
G
L
S
N
S
I
Y
V
F
V
R
D
P
A
K
L
F
L
V
D
R
S
L
Y
G
K
E
D
N
D
T
L
V
R
C
P
L
T
D
P
E
V
T
N
Y
S
L
K
G
C
Q
G
K
P
L
P
--
K
D
L
R
F
I
P
D
P
K
--
A
G
I
M
I
K
-
S
V
K
R
A
Y
H
--
R
L
C
L
H
C
S
V
D
S
V
L
S
E
K
F
--
I
L
K
V
R
P
A
F
K
A
V
P
V
V
S
V
S
K
---
A
S
Y
L
L
R
---
E
-------------------
G
E
E
F
T
V
T
C
T
I
K
D
--
V
-
S
S
S
V
--
Y
S
T
W
K
R
E
N
-----
S
Q
T
K
L
Q
E
K
Y
-
N
S
-------
W
H
H
G
D
F
N
Y
E
R
Q
A
T
L
T
I
----
S
S
-----
A
R
V
N
D
------
S
G
V
F
M
C
Y
------------
A
-----------
N
N
T
F
G
S
--
A
---
N
V
T
--
T
T
L
E
V
--
V
D---
K
-
G
F
I
N
-
I
---
F
-
P
M
INT
T
V
F
V
N
D
G
E
N
V
D
L
I
V
E
Y
E
A
F
--
P
--
K
P
---
E
H
Q
Q
W
I
Y
--
M
N
R
-
T
F
T
D
K
W
E
D
Y
-------
P
K
S
---
E
N
E
S
N
I
R
Y
V
S
E
----
L
H
L
T
R
L
K
G
T
E
-
G
-
G
T
Y
T
F
L
V
S
N
S
D
V
---------------------
N
A
A
----
I
----------
A
-------
F
N
-----
V
Y
------
V
N
-
T
-
K
-
P
---
E
-
I
L
T
Y
D
R
L
V
N
G
M
L
Q
C
V
A
A
G
F
P
E
-
P
-
T
I
D
W
Y
F
C
V
L
P
V
--------
D
V
---
Q
T
L
N
S
G
P
P
F
G
K
L
V
V
Q
S
S
I
-
D
S
S
-
A
F
K
H
C
K
A
Y
N
D
V
G
K
T
-
S
--
A
Y
F
N
F
A
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------