@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AGRG4_HUMAN: (2016-01-09 )
MKEHIIYQKLYGLILMSSFIFLSDTLSLKGKKLDFFGRGDTYVSLIDTIPELSRFTACIDLVFMDDNSRYWMAFSYITNNALLGREDIDLGLAGDHQQLILYRLGKTFSIRHHLASFQWHTICLIWDGVKGKLELFLNKERILEVTDQPHNLTPHGTLFLGHFLKNESSEVKSMMRSFPGSLYYFQLWDHILENEEFMKCLDGNIVSWEEDVWLVNKIIPTVDRTLRCFVPENMTIQEKSTTVSQQIDMTTPSQITGVKPQNTAHSSTLLSQSIPIFATDYTTISYSNTTSPPLETMTAQKILKTLVDETATFAVDVLSTSSAISLPTQSISIDNTTNSMKKTKSPSSESTKTTKMVEAMATEIFQPPTPSNFLSTSRFTKNSVVSTTSAIKSQSAVTKTTSLFSTIESTSMSTTPCLKQKSTNTGALPISTAGQEFIESTAAGTVPWFTVEKTSPASTHVGTASSFPPEPVLISTAAPVDSVFPRNQTAFPLATTDMKIAFTVHSLTLPTRLIETTPAPRTAETELTSTNFQDVSLPRVEDAMSTSMSKETSSKTFSFLTSFSFTGTESVQTVIDAEATRTALTPEITLASTVAETMLSSTITGRVYTQNTPTADGHLLTLMSTRSASTSKAPESGPTSTTDEAAHLFSSNETIWTSRPDQALLASMNTTTILTFVPNENFTSAFHENTTYTEYLSATTNITPLKASPEGKGTTANDATTARYTTAVSKLTSPWFANFSIVSGTTSITNMPEFKLTTLLLKTIPMSTKPANELPLTPRETVVPSVDIISTLACIQPNFSTEESASETTQTEINGAIVFGGTTTPVPKSATTQRLNATVTRKEATSHYLMRKSTIAAVAEVSPFSTMLEVTDESAQRVTASVTVSSFPDIEKLSTPLDNKTATTEVRESWLLTKLVKTTPRSSYNEMTEMFNFNHTYVAHWTSETSEGISAGSPTSGSTHIFGEPLGASTTRISETSFSTTPTDRTATSLSDGILPPQPTAAHSSATPVPVTHMFSLPVNGSSVVAEETEVTMSEPSTLARAFSTSVLSDVSNLSSTTMTTALVPPLDQTASTTIVIVPTHGDLIRTTSEATVISVRKTSMAVPSLTETPFHSLRLSTPVTAKAETTLFSTSVDTVTPSTHTLVCSKPPPDNIPPASSTHVISTTSTPEATQPISQVEETSTYALSFPYTFSGGGVVASLATGTTETSVVDETTPSHISANKLTTSVNSHISSSATYRVHTPVSIQLVTSTSVLSSDKDQMTISLGKTPRTMEVTEMSPSKNSFISYSRGTPSLEMTDTGFPETTKISSHQTHSPSEIPLGTPSDGNLASSPTSGSTQITPTLTSSNTVGVHIPEMSTSLGKTALPSQALTITTFLCPEKESTSALPAYTPRTVEMIVNSTYVTHSVSYGQDTSFVDTTTSSSTRISNPMDINTTFSHLHSLRTQPEVTSVASFISESTQTFPESLSLSTAGLYNDGFTVLSDRITTAFSVPNVPTMLPRESSMATSTPIYQMSSLPVNVTAFTSKKVSDTPPIVITKSSKTMHPGCLKSPCTATSGPMSEMSSIPVNNSAFTPATVSSDTSTRVGLFSTLLSSVTPRTTMTMQTSTLDVTPVIYAGATSKNKMVSSAFTTEMIEAPSRITPTTFLSPTEPTLPFVKTVPTTIMAGIVTPFVGTTAFSPLSSKSTGAISSIPKTTFSPFLSATQQSSQADEATTLGILSGITNRSLSTVNSGTGVALTDTYSRITVPENMLSPTHADSLHTSFNIQVSPSLTSFKSASGPTKNVKTTTNCFSSNTRKMTSLLEKTSLTNYATSLNTPVSYPPWTPSSATLPSLTSFVYSPHSTEAEISTPKTSPPPTSQMVEFPVLGTRMTSSNTQPLLMTSWNIPTAEGSQFPISTTINVPTSNEMETETLHLVPGPLSTFTASQTGLVSKDVMAMSSIPMSGILPNHGLSENPSLSTSLRAITSTLADVKHTFEKMTTSVTPGTTLPSILSGATSGSVISKSPILTWLLSSLPSGSPPATVSNAPHVMTSSTVEVSKSTFLTSDMISAHPFTNLTTLPSATMSTILTRTIPTPTLGGITTGFPTSLPMSINVTDDIVYISTHPEASSRTTITANPRTVSHPSSFSRKTMSPSTTDHTLSVGAMPLPSSTITSSWNRIPTASSPSTLIIPKPTLDSLLNIMTTTSTVPGASFPLISTGVTYPFTATVSSPISSFFETTWLDSTPSFLSTEASTSPTATKSTVSFYNVEMSFSVFVEEPRIPITSVINEFTENSLNSIFQNSEFSLATLETQIKSRDISEEEMVMDRAILEQREGQEMATISYVPYSCVCQVIIKASSSLASSELMRKIKSKIHGNFTHGNFTQDQLTLLVNCEHVAVKKLEPGNCKADETASKYKGTYKWLLTNPTETAQTRCIKNEDGNATRFCSISINTGKSQWEKPKFKQCKLLQELPDKIVDLANITISDENAEDVAEHILNLINESPALGKEETKIIVSKISDISQCDEISMNLTHVMLQIINVVLEKQNNSASDLHEISNEILRIIERTGHKMEFSGQIANLTVAGLALAVLRGDHTFDGMAFSIHSYEEGTDPEIFLGNVPVGGILASIYLPKSLTERIPLSNLQTILFNFFGQTSLFKTKNVTKALTTYVVSASISDDMFIQNLADPVVITLQHIGGNQNYGQVHCAFWDFENNNGLGGWNSSGCKVKETNVNYTICQCDHLTHFGVLMDLSRSTVDSVNEQILALITYTGCGISSIFLGVAVVTYIAFHKLRKDYPAKILINLCTALLMLNLVFLINSWLSSFQKVGVCITAAVALHYFLLVSFTWMGLEAVHMYLALVKVFNIYIPNYILKFCLVGWGIPAIMVAITVSVKKDLYGTLSPTTPFCWIKDDSIFYISVVAYFCLIFLMNLSMFCTVLVQLNSVKSQIQKTRRKMILHDLKGTMSLTFLLGLTWGFAFFAWGPMRNFFLYLFAIFNTLQGFFIFVFHCVMKESVREQWQIHLCCGWLRLDNSSDGSSRCQIKVGYKQEGLKKIFEHKLLTPSLKSTATSSTFKSLGSAQGTPSEISFPNDDFDKDPYCSSP
Atome Classification :
(20 SA)
.........10........20........30........40.-......--.--------.---50.-........60.......-----.70....-------....80........90..--.-...-..100.---...--.-.--------.110------........120.......130.......140-..-..-.--..-.-150--.......160.......170---.--......180.......190......----.200-----..-------.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440...--...2450..------....2460......2470......2480......2490......2500......2510......2520......------2530......2540.......2550--.........2560......2570......2580......---2590......2600........2610....-..2620......2630......2640......2650......2660......2670--.........2680......2690......2700......2710---.....-..2720......2730-......2740...------...2750......2760......2770......2780......2790..-----..-..-----2800--.........2810......2820......2830......2840...---.-.--..2850......2860......2870......2880......2890.-------.-------..----.----.----...--2900......2910......2920..----------.-----.--..2930......2940......2950......--2960--..---.------------......2970......2980......2990......3000......3010......3020......3030......3040......3050......3060......3070......3080
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
E
H
I
I
Y
Q
K
L
Y
G
L
I
L
M
S
S
F
I
F
LSDTLSLKG
K
K
L
D
F
FGRGD-
T
-
Y
V
S
L
I
D
--
T
--------
I
---
P
-
E
-
L
S
R
F
T
A
C
I
D
L
V
F
MDDNS-----
R
Y
W
M
A
F
S
-------YITNNALLGREDIDLGLA--G-D
H
Q
-
Q
L
I
L
Y
R---LGK--
T
-
F
--------
S
I
-
R
------
H
HLASF
Q
W
H
T
I
C
L
I
WDGVKG
K
L
E
L
F
L
N
K
E
R
--
I
L
-
E
V-T--DQ-P-HNL--TPH
G
T
L
F
L
G
H
F
LKN
E
S
S
E
V
K
---
S
--
M
M
R
SFPG
S
L
Y
Y
F
Q
L
W
D
H
I
LE
N
E
E
F
M
----
K
C
-------LD-------GNIVSWE
E
D
V
W
L
V
N
K
I
I
P
T
V
D
R
T
L
R
C
FVPEN
M
T
I
QEKSTTV
S
Q
QIDMTTPSQITGVKPQNTAH
S
S
T
L
LSQSI
P
I
F
A
T
D
Y
T
T
I
SYSNTTSP
P
L
E
T
M
T
A
Q
K
I
L
K
T
L
V
DETA
T
F
A
V
D
V
LSTSSAISLPT
Q
S
I
S
IDNTTN
S
M
KKTKSPSSES
T
K
T
T
K
M
V
E
A
M
A
T
E
IFQPPTPSNFLSTSRFTKNSVV
S
T
T
S
A
IKSQSA
V
T
K
T
T
S
L
F
S
T
I
E
STSMSTTPCLKQKSTNTG
A
L
PI
S
T
A
G
Q
E
F
I
E
S
TAAGT
V
P
W
F
T
V
EKTSPASTHVGTASSFPPE
P
V
L
I
STAAPVDSVFPRNQTAF
P
L
A
TT
D
M
K
I
A
F
T
V
HSLTL
P
T
R
L
IETTPAPRTAETELTSTNFQDVSL
P
R
V
E
D
A
M
S
T
SMSKETSSK
T
F
S
F
L
T
S
FSFTG
T
E
S
V
Q
T
V
I
DAEATRTALTP
E
I
T
L
A
S
T
V
A
E
T
M
L
S
S
TIT
G
R
V
Y
TQNTPTADG
H
L
L
T
L
M
STRSASTSKAPESGPTST
T
D
E
A
A
H
L
FSSNE
T
I
WTSRP
D
Q
A
L
L
ASMNT
T
T
I
L
T
F
VPNEN
F
T
S
A
F
HENT
T
Y
T
E
Y
LSATTNITPLKASPEGKGTTANDATT
A
R
Y
T
T
A
V
S
KLTSPWFA
N
F
S
I
VSGTTSITNMP
E
F
K
L
T
T
L
L
L
K
TIPMSTKPANELPLTPRETVVP
S
V
D
I
I
S
T
L
A
CIQPNFSTEESASETTQTEIN
G
A
I
V
FGGTTTPVPKSATT
Q
R
L
N
A
T
V
TRKEA
T
S
H
Y
L
M
R
K
S
T
I
A
A
VAEVSP
F
S
T
M
L
E
VTDESA
Q
R
V
T
A
S
V
T
VSSFP
D
I
E
K
LSTPLDNKT
A
T
T
E
V
R
E
S
W
L
L
T
K
L
V
KTTPR
S
S
Y
N
E
M
T
E
M
FNFN
H
T
Y
V
A
H
WTSETSEGISAGSPTSGS
T
H
I
F
GEPLGAST
T
R
I
SETSFSTTPTDRTATSLSDGILPPQPTAAHSSATPV
P
V
T
H
M
F
SLPVNGSS
V
V
A
EET
E
V
TMSE
P
S
T
L
A
R
A
F
S
T
S
V
L
S
D
V
S
N
LSST
T
M
T
T
ALVPPLDQTA
S
T
T
I
V
I
VPTHGD
L
I
RTTSE
A
T
V
I
S
V
R
KTSMAVPSLTETPFH
S
L
RLSTPVTAK
A
E
T
T
L
F
STSVDTVTPST
H
T
L
V
CSKPPPDNIPPASS
T
H
V
I
STTSTPEATQ
P
I
S
Q
V
EET
S
T
Y
A
L
S
F
P
Y
T
FSGG
G
V
V
A
S
LATGTTE
T
S
VVDETTPSHI
S
A
N
K
L
T
T
S
V
N
SHISSS
A
T
Y
R
VHT
P
V
S
I
Q
L
V
T
STSVLSSDK
D
Q
M
T
I
SLGKTPR
T
M
E
V
TEMSPSKN
S
F
I
S
YSRGTPSLEMTDTGFPETTKISSHQTHSPSEIPLGTPSDGNLASSPTSGS
T
Q
I
T
P
T
LTSS
N
T
V
G
V
HIP
E
M
S
T
SLGKTALPSQ
A
L
T
I
T
T
F
LCPEKESTSALPAYTPR
T
V
E
M
I
VNS
T
Y
V
T
H
S
VSYGQDT
S
F
V
D
TTTSSSTRISNPMDI
N
T
T
F
S
H
L
H
S
LRTQP
E
V
T
S
V
A
S
F
I
S
E
S
T
Q
T
F
P
E
SLSLSTAGLYND
G
F
T
V
L
S
DRI
T
T
AFSVPNVPTMLPRESSMATSTP
I
Y
Q
MSSL
P
V
N
V
T
A
F
TSKKVSDTP
P
I
V
I
TKSSKTMHPGCLKSPCTATSG
P
M
S
E
M
SSIPVNNSAFT
P
A
TVSSDTST
R
V
G
L
F
S
T
L
L
S
SVTPR
T
T
M
T
M
Q
TSTLDVT
P
V
I
Y
AGATSKN
K
M
V
S
S
A
F
T
T
E
M
IEAPSRITPTTFLSPTEPTLP
F
V
KT
V
P
T
T
I
M
A
G
I
V
TPFVGTTAFSPLSSKSTGAISSIPK
T
T
F
S
P
F
L
S
A
T
QQSSQADE
A
T
T
L
G
I
L
S
G
I
TNR
S
L
STVNSGT
G
V
A
L
TDTYS
R
I
TV
P
E
N
MLSPTHADSL
H
T
S
F
N
I
Q
VSPSLTSFKSASGPTKN
V
K
T
T
T
NCFSS
N
T
R
K
M
T
S
L
L
E
K
TSLTNYATSLNTPVSYPPWTPSSAT
L
P
S
L
T
S
F
VYSPHSTEAEISTPKTSPPPTSQ
M
V
EFPVLGTRMTSSNTQ
P
L
L
M
T
SWNIPTAEGSQF
P
I
S
T
T
I
NVPTSNEME
T
E
T
L
H
LVPGPL
S
T
FTASQTGL
V
S
K
D
V
M
A
M
SSIPMSGILPNHGLSENPS
L
S
T
S
L
R
A
I
T
S
T
L
A
D
V
K
H
T
F
E
K
M
TTSVTPGT
T
L
P
S
I
L
SGATSGSVISK
S
P
I
L
T
W
L
L
S
SLPSGSPPATVSNAP
H
V
M
TS
S
T
V
E
VSKSTFLT
S
D
M
ISAHPFTNLTTL
P
S
A
T
M
S
T
I
L
TRTIPTPTLGGITTGFPTSL
P
M
S
I
NVTD
D
I
V
Y
I
STHPEASSR
T
T
I
T
ANPRTVSHPSSFSRKTMSPSTTD
H
T
L
SVGAMPLPSSTITSSWNRIPTASSP
S
T
L
I
I
PKP
T
L
D
S
L
L
N
I
M
TTTSTVPGASF
P
L
I
STGVT
Y
P
F
TATV
S
S
P
I
S
S
F
F
E
T
TWLDSTP
S
F
LSTEASTSPTAT
K
S
T
V
S
F
Y
N
V
E
M
S
F
S
V
F
V
EEPRI
P
I
T
S
V
I
N
E
F
T
E
N
S
L
N
S
I
F
QNSE
F
S
L
A
T
L
E
T
Q
IKSRDI
S
E
E
E
M
V
M
D
R
A
I
L
E
Q
REGQ
E
M
A
T
I
SYV
P
Y
S
C
V
C
Q
V
I
I
KASSSL
A
S
S
E
L
M
R
K
I
K
S
K
IHGNFTHGNF
T
Q
D
Q
L
T
L
L
V
NC
E
H
V
A
V
K
KLEPGNCKADE
T
A
S
KYK
G
T
Y
K
W
L
LTNPTE
T
A
Q
T
R
C
IKNEDGN
A
T
R
F
C
S
I
S
INTGKSQWEK
P
K
F
K
Q
C
K
--
L
L
Q
EL
P
D
K
I
------
V
D
LA
N
I
T
ISDE
N
A
E
D
V
A
E
H
I
L
N
L
INESPALG
K
E
E
T
K
I
I
V
S
K
I
S
D
I
S
Q
C
D
E
I
S
M
N
L
T
H
V
M
L
Q
I
I
N
V
V
L
EKQNNS
A
------
S
D
L
H
E
I
S
N
E
I
L
R
I
-
I
E
RTG
H
K
M
-----EFSGQIAN
L
T
V
A
G
L
A
L
A
V
LRGDHTFD
G
M
A
F
S
I
H
SYEEGT---DP
E
I
F
LGNVP
V
-
G
-
G
I
L
A
S
I
YL
P
K
S
L
T
E
RI-
P
L
S
N
L
Q
T
I
L
F
N
F
FGQTSLFKTK
N
V
T
K
A
L
T
T
Y
V
V
SASIS
D
D
M
F
I
Q
NLAD
P
V
V
I
T
-----
L
Q
HIGGNQNY
G
Q
V
H
C
A
F
W
DFENNNGLGGWNSSG
C
K
V
K
ETNV
N
----
Y
T
I
C
Q-CDHL
T
H
F
G
V
L
M
D
L
S
R
S
-
T
V
D
S
V
N
E
Q
I
L
A
L
I
------
T
YTGC
G
I
S
S
I
F
L
G
V
A
V
V
T
Y
I
A
F
H
K
L
R
KDY
P
A
K
I
L
I
N
L
C
T
A
L
L
M
L
N
L
V
F
L
-----
I
N
-
S
W
-----
L
-----
S
S
F
Q
K
V
G
V
C
I
T
A
A
V
A
L
H
Y
F
L
L
V
S
F
T
W
M
G
L
E
A
V
H
M
Y
L
A
L
V
K
-
V
F
N
I
Y---I-
P
--
N
Y
I
L
K
F
C
L
V
GW
G
I
P
A
I
M
V
A
I
T
V
S
V
K
K
D
LYGTLSPTT
P
F
C
W
IKD---D-------
S
-------
I
F
----
Y
----
I
----
S
V
V
--
A
Y
F
C
L
I
F
L
M
N
L
S
M
F
C
T
V
L
V
Q
L
N
S
V
K
S
----------
Q
-----
I
--
Q
K
T
R
R
K
M
I
L
H
DLKG
T
M
S
L
T
F
L
L
G
L
T
W
G
F
A
F
FA--W-----
G
P
---
M
------------
R
N
F
F
L
Y
L
F
A
I
F
N
T
L
Q
G
F
F
I
F
V
F
H
C
V
M
K
E
S
V
R
E
Q
W
Q
I
H
L
C
C
G
W
L
R
LDNSSDGS
S
R
C
Q
I
K
VG
Y
K
Q
E
G
L
K
K
I
F
E
HKLLTPSLKSTA
T
S
S
T
F
K
S
L
GSAQGTPSEISFPNDDFDKDPYCSSP
23
HHSearch
81.56
22%
-5
- C6 -
3FLP
2
?
A:
[1-207]
------------------------
A
V
D
I
R
D
V
K
I
S
F
P
G
T
Q
N
P
K
-
F
P
H
L
R
F
M
Q
T
--------
L
---
P
-
A
-
V
R
Q
L
T
V
C
Q
R
I
K
P
F
H
--
R
-----
N
T
G
Y
I
F
S
-------
C
A
T
S
N
---
Q
D
N
Q
F
I
T
S
M
Y
V
K
S
-
D
G
T
L
N
L
G
L
Q
V
---
N
A
S
S
N
K
Y
I
--------
S
C
-
P
------
I
E
I
E
L
G
Q
W
Y
H
V
C
H
V
W
S
G
V
D
G
R
M
A
V
Y
A
N
G
S
P
--
C
G
-
T
M
-
E
NV
G
K
-
G
-
H
Q
I
--
S
A
G
G
T
V
V
I
G
Q
E
Q
D
K
I
G
G
G
F
E
------
E
Q
E
S
W
S
G
E
L
S
D
L
Q
V
W
D
E
A
L
T
T
H
Q
V
S
T
V
A
-
S
C
NGIR---
P
R
-------
G
N
V
I
S
W
M
E
D
S
F
V
A
D
D
G
V
I
V
G
I
S
H
M
C
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
80.00
16%
8
- C3 -
4DLQ
16
A:
[18-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
V
R
R
V
Q
W
P
A
T
Q
Q
G
M
L
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
L
P
--
A
L
G
L
W
N
P
R
G
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
S
GEN
A
A
N
I
A
S
E
L
A
R
H
T
R
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
R
N
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
MN
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
-
L
E
E
G
A
F
L
L
A
D
N
VR
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
P
Q
E
Y
A
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
R
N
-
G
-
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
-
S
T
E
N
A
T
V
---
K
L
A
G
E
A
G
T
G
G
P
G
G
A
S
L
V
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
R
V
F
L
M
D
P
V
I
F
T
-----
V
A
H
L
E
A
K
N
H
F
N
A
-
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
----
H
T
T
C
A
-
C
S
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
74.08
20%
-8
- C6 -
1SAC
3
SAMP_HUMAN
A:
[1-204]
------------------------
H
T
D
L
S
G
K
V
F
V
F
P
R
E
S
V
-
T
D
H
V
N
L
I
T
--
P
--------
L
---
E
-
K
P
L
Q
N
F
T
L
C
F
R
A
Y
S
D
L
S
-------
R
A
Y
S
L
F
S
-------
Y
N
T
Q
----
G
R
D
N
E
L
L
V
Y
K
--
E
-
R
V
G
-
E
Y
S
L
Y
I
---
G
R
H
--
K
-
V
--------
T
S
-
K
------
V
I
E
K
F
P
A
P
V
H
I
C
V
S
W
E
S
S
S
G
I
A
E
F
W
I
N
G
T
P
--
L
V
-
K
K
-
G
--
L
R
-
Q
G
Y
F
V
--
E
A
Q
P
K
I
V
L
G
Q
E
Q
D
S
Y
G
G
K
-
F
---
D
--
R
S
Q
S
F
V
G
E
I
G
D
L
Y
M
W
D
S
V
L
P
P
E
N
I
L
----
S
A
-------
Y
Q
GTPLP--
A
N
I
L
D
W
Q
A
L
N
Y
E
I
R
G
Y
V
I
I
K
P
L
V
W
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.98
24%
19
- C6 -
4PBP
4
?
A:
[6-194]
--------------------------
N
L
S
G
K
V
L
Q
F
K
T
A
T
D
N
S
-
Y
V
K
L
Y
P
--
E
--------
K
---
P
L
S
-
L
S
A
F
T
L
C
M
R
V
A
T
E
L
P
L
D
-----
R
E
V
I
L
F
A
-------
Y
Y
T
P
D
V
----
D
E
L
N
V
W
R
E
--
R
-
D
G
R
-
V
S
L
Y
I
Q
---
S
S
K
DA
A
-
F
--------
F
R
-
L
------
P
P
L
S
T
L
Q
T
H
-
L
C
V
A
W
E
S
A
T
G
L
T
A
F
W
M
D
G
R
R
--
S
L
H
Q
V
-
Y
--
R
K
-
G
-
Y
S
I
--
R
S
G
G
T
V
V
L
G
---
Q
D
P
D
S
Y
V
G
---
S
FD
V
D
Q
S
F
V
G
E
I
A
N
L
Q
M
W
D
Y
V
L
S
S
A
Q
I
K
----
A
V
Y
Y
NQDNR
V
K
-------
G
N
V
F
D
W
D
T
I
E
Y
D
V
T
G
N
V
L
V
V
P
D
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
72.87
19%
-2
- C6 -
3PVN
3
CRP_HUMAN
A:
[4-200]
---------------------------
M
S
R
K
A
F
V
F
P
K
E
S
D
T
S
-
Y
V
S
L
K
A
--
P
--------
L
T--
K
-
P
-
L
K
A
F
T
V
C
L
H
F
Y
T
E
L
S
S
T
-----
R
G
Y
S
I
F
S
-------
Y
A
T
K
R
-----
Q
D
N
E
I
L
I
F
W
-
S
-
K
D
I
-
G
Y
S
F
T
V
---
G
G
S
--
E
-
I
--------
L
F
-
E
------
V
P
E
V
T
V
A
P
V
H
I
C
T
S
W
E
S
A
S
G
I
V
E
F
W
V
D
G
K
P
--
R
V
-
R
K
S
L
--
K
K
-
G
-
Y
T
V
--
G
A
E
A
S
I
I
L
G
Q
E
Q
D
S
F
G
G
N
F
E
------
G
S
Q
S
L
V
G
D
I
G
N
V
N
M
W
D
F
V
L
S
P
D
E
I
N
T
I
Y
L
G
G
P
------
F
S
-------
P
N
V
L
N
W
R
A
L
K
Y
E
V
Q
G
E
V
F
T
K
P
Q
L
W
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
72.30
17%
-54
- C3 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
-
S
L
V
A
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
C
L
R
N
I
I
H
A
N
L
I
A
A
F
I
L
R
N
A
T
W
F
V
V
Q
L
T
M
S
P
E
V
H
Q
S
NV
G
W
C
R
L
V
T
A
A
Y
N
Y
F
H
V
T
N
F
F
W
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
T
N
I
F
E
M
L
R
I
D
EGLR
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
I
GRNSNG
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
S
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
-
G
F
-----
T
-----
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
A
T
F
R
T
G
T
W
D
A
Y
---
D
-
R
--
L
R
A
W
M
F
I
C
I
G
W
G
V
P
F
P
I
I
V
-
A
W
A
I
G
K
L
Y
Y
D
N
E
K
-----
C
W
A
G
K
---
R
-------
P
-------
G
V
----
Y
----
T
----
D
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
----------
A
-----
S
--
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
--
E
------
V
---
S
------------
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
-----------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.88
20%
16
- C6 -
3FLR
2
?
A:
[21-204]
-------------------------------------------
H
L
R
F
M
Q
--
T
--------
L
---
P
-
A
-
V
R
Q
L
T
V
C
Q
R
I
K
P
F
H
R
N
T
-----
G
Y
I
F
S
C
A
T
SNQDNQ
F
I
T
S
M
Y
V
K
S
D
G
T
L
N
L
G
L
Q
--
V
-
N
A
S
-
S
---------
N
K
--
Y
-
I
--------
S
C
-
P
------
I
E
I
E
L
G
Q
W
Y
H
V
C
H
V
W
S
G
V
D
G
R
M
A
V
Y
A
N
G
S
P
C
G
T
M
-
E
N
-
V
--
G
K
-
G
-
H
Q
I
--
S
A
G
G
T
V
V
I
G
Q
----
E
Q
D
K
I
G
GGF
E
--
E
Q
E
S
W
S
G
E
L
S
D
L
Q
V
W
D
E
A
L
T
T
H
Q
V
S
----
T
V
-------
A
S
CNGIRPR
G
N
V
I
S
W
M
E
D
S
F
V
A
D
D
G
V
I
V
G
I
S
H
M
C
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.51
24%
15
- C6 -
4PBO
-
?
A:
[3-191]
--------------------------
N
L
S
G
K
V
L
Q
F
K
T
A
T
D
N
S
-
Y
V
K
L
Y
P
--
E
--------
K
---
P
L
S
-
L
S
A
F
T
L
C
M
R
V
A
T
E
L
P
L
D
-----
R
E
V
I
L
F
A
-------
Y
Y
T
P
D
V
----
D
E
L
N
V
W
R
E
--
R
-
D
G
R
-
V
S
L
Y
I
Q
---
S
S
K
D
A
A
-
F
--------
F
R
-
L
------
P
P
L
S
T
L
Q
T
H
-
L
C
V
A
W
E
S
A
T
G
L
T
A
F
W
M
D
G
R
R
--
S
L
H
Q
V
-
Y
--
R
K
-
G
-
Y
S
I
--
R
S
G
G
T
V
V
L
G
---
Q
D
P
D
S
Y
V
G
---
S
FD
V
D
Q
S
F
V
G
E
I
A
N
L
Q
M
W
D
Y
V
L
S
S
A
Q
I
K
----
A
V
Y
Y
NQDNR
V
K
-------
G
N
V
F
D
W
D
T
I
E
Y
D
V
T
G
N
V
L
V
V
P
D
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
70.23
20%
11
- C6 -
3FLP
2
?
A:
[21-204]
-------------------------------------------
H
L
R
F
M
Q
--
T
--------
L
---
P
-
A
-
V
R
Q
L
T
V
C
Q
R
I
K
P
F
H
R
N
T
-----
G
Y
I
F
S
C
A
T
SNQDNQ
F
I
T
S
M
Y
V
K
S
D
G
T
L
N
L
G
L
Q
--
V
-
N
A
S
-
S
---------
N
K
--
Y
-
I
--------
S
C
-
P
------
I
E
I
E
L
G
Q
W
Y
H
V
C
H
V
W
S
G
V
D
G
R
M
A
V
Y
A
N
G
S
P
C
G
T
M
-
E
N
-
V
--
G
K
-
G
-
H
Q
I
--
S
A
G
G
T
V
V
I
G
Q
----
E
Q
D
K
I
G
GGF
E
--
E
Q
E
S
W
S
G
E
L
S
D
L
Q
V
W
D
E
A
L
T
T
H
Q
V
S
----
T
V
-------
A
S
CNGIRPR
G
N
V
I
S
W
M
E
D
S
F
V
A
D
D
G
V
I
V
G
I
S
H
M
C
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.95
20%
14
- C6 -
3FLT
4
?
A:
[21-204]
-------------------------------------------
H
L
R
F
M
Q
--
T
--------
L
---
P
-
A
-
V
R
Q
L
T
V
C
Q
R
I
K
P
F
H
R
N
T
-----
G
Y
I
F
S
C
A
T
SNQDNQ
F
I
T
S
M
Y
V
K
S
D
G
T
L
N
L
G
L
Q
--
V
-
N
A
S
-
S
---------
N
K
--
Y
-
I
--------
S
C
-
P
------
I
E
I
E
L
G
Q
W
Y
H
V
C
H
V
W
S
G
V
D
G
R
M
A
V
Y
A
N
G
S
P
C
G
T
M
-
E
N
-
V
--
G
K
-
G
-
H
Q
I
--
S
A
G
G
T
V
V
I
G
Q
----
E
Q
D
K
I
G
GGF
E
--
E
Q
E
S
W
S
G
E
L
S
D
L
Q
V
W
D
E
A
L
T
T
H
Q
V
S
----
T
V
-------
A
S
CNGIRPR
G
N
V
I
S
W
M
E
D
S
F
V
A
D
D
G
V
I
V
G
I
S
H
M
C
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
61.21
16%
9
- C6 -
3VUO
-
?
A:
[873-1029]
----------------------------
N
G
E
S
L
Y
L
K
S
P
N
--
E
-
T
V
E
F
S
N
--
N
FFT-----
N
---
G
-
L
-
T
N
N
F
T
I
C
F
W
L
R
F
T
G
K
D
D
-----
D
K
T
R
L
I
G
-------
N
K
V
-----
N
N
C
G
W
E
I
Y
F
E
--
D
-
N
G
L
-
V
F
E
I
I
D
S--
N
G
N
--
Q
-
E
--------
S
V
Y
L
------
S
N
V
I
N
N
N
W
Y
Y
I
S
I
S
V
D
R
L
K
D
Q
L
L
I
F
I
N
D
K
N
--
V
A
-
N
V
S
I
--
E
Q
-
I
-
L
N
I
--
Y
S
T
N
V
I
S
L
V
N
K
------------------
N
N
S
I
Y
V
E
E
L
S
V
L
D
K
P
V
A
S
E
E
V
I
----
R
N
-------
Y
F
-------
S
Y
L
D
N
S
Y
I
R
D
S
S
K
S
L
L
E
Y
N
K
N
Y
Q
L
Y
N
Y
V
F
P
E
T
S
L
Y
E
V
N
D
N
N
K
S
Y
L
S
L
K
N
T
D
G
I
N
I
P
S
V
K
F
K
L
I
N
I
D
E
S
K
G
Y
V
Q
K
W
D
E
C
I
I
C
V
S
D
G
T
E
K
Y
L
D
I
S
E
N
N
R
I
Q
L
V
S
S
K
D
N
A
K
K
I
T
V
N
T
D
L
F
R
P
D
C
I
T
F
S
Y
N
D
K
Y
F
S
L
S
L
R
D
G
D
Y
N
W
M
I
C
N
N
K
V
P
K
G
A
H
L
W
I
L
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
59.74
12%
-84
- C3 -
2Z73
5
OPSD_TODPA
A:
[35-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
------
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
-
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-----
F
P
L
M
T
-----
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-
P
M
A
A
S
K
K
M
S
-
H
--
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
-
E
G
V
L
C
N
C
S
F
D
Y
---
I
-------
S
RD
S
T
T
R
S
N
I
L
C
M
F
I
----
L
----
G
F
F
--
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
-----
K
--
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
--
A
L
L
A
Q
F
G
P
LEW
V
------------
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
---------------------------------------------------
39
HHSearch
58.76
15%
27
* C6 *
3PME
1
?
A:
[39-211]
---------------------------
Y
T
N
D
-
F
K
L
S
S
S
G
D
K
I
-
I
V
N
L
N
N
--
N
--------
I
LYS
A
-
I
-
Y
E
N
S
S
V
S
F
W
I
K
I
S
K
D
L
T
N
SH--
N
E
Y
T
I
I
N
-------
S
I
K
Q
-----
N
S
G
W
K
L
C
I
R
--
N
-
G
N
I
-
E
W
I
L
Q
D
I--
N
R
K
--
Y
-
K
S
L
I
F
DYSE
S
L
-
S
------
H
T
G
Y
T
N
K
W
F
F
V
T
I
T
N
N
I
M
G
Y
-
M
K
L
Y
I
N
G
E
L
--
K
Q
-
S
E
R
I
--
E
D
-
L
-
D
E
V
--
K
L
D
K
T
I
V
F
G
I
D
E
N
-------------
I
D
E
N
Q
M
L
W
I
R
D
F
N
I
F
S
K
E
L
S
N
E
D
I
N
----
I
V
-------
Y
E
-------
G
Q
I
L
R
N
V
I
K
D
Y
W
G
N
P
L
K
F
D
T
E
Y
Y
M
I
N
Y
N
Y
I
D
R
Y
I
A
P
K
N
N
I
L
V
L
V
Q
Y
S
D
I
S
K
L
Y
T
K
N
P
I
T
I
K
S
A
A
N
K
N
P
Y
S
R
I
L
N
G
D
D
I
M
F
H
M
L
Y
D
S
R
E
Y
M
I
I
R
D
T
D
T
I
Y
A
T
Q
G
G
Q
C
S
K
N
C
V
Y
A
L
K
L
Q
S
N
L
G
N
Y
G
I
G
I
F
S
I
K
N
I
V
S
Q
Y
C
S
Q
I
F
S
S
F
M
K
N
T
M
L
L
A
D
I
Y
K
P
W
R
F
S
F
E
N
A
Y
T
P
V
A
V
T
N
Y
E
T
K
L
L
S
T
S
S
F
W
K
F
I
S
R
D
P
G
W
V
E
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
57.59
13%
-68
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[41-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
I
A
------
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
-
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
P
-----
I
W
-
A
A
-----
S
K
V
N
--
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
-
A
T
R
T
L
---
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
A
Y
H
P
N
-
N
S
S
P
V
C
Y
E
V
L
GN-
D
-------
T
AKWR---
M
V
LR--
I
----
L
PHTF
G
F
I
--
V
P
L
F
V
M
----
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
------------------------
M
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
--
L
L
A
D
T
L
M
R
---
T
QVIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
---------------------------------------------------------------------------
29
HHSearch
56.64
14%
-80
- C3 -
1U19
14
OPSD_BOVIN
A:
[43-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
A
Y
------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-----
T
T
-
T
L
Y
T
S
L
H
G
-----
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-
P
M
S
N
F
R
F
-
G
-
E
--
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
-
G
M
Q
C
S
C
G
I
D
Y
---
Y
TPHEETN
N
E
S
-----
F
V
----
I
Y
M
F
V
V
----
H
F
I
--
I
P
L
I
V
I
----
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
----------
Q
-----
Q
QE
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
--
H
Q
GSD
F
------------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------------------------------
35
HHSearch
56.03
11%
-71
- C3 -
2KS9
1
NK1R_HUMAN
A:
[37-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
------
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
-
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
-----
V
V
-
N
F
T
Y
A
V
H
N
-----
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
-
P
L
Q
P
R
---
L
S
A
--
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
M
---
P
S
R
V
V
C
M
I
E
W
PEH
P
-------
N
KIY
E
K
V
-
Y
H
----
I
C
V
T
V
L
----
I
Y
F
--
L
P
L
L
V
I
G
Y
A
Y
T
V
V
----
G
I
T
L
W
A
S
E
I
----------
P
GDSSD
R
--
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
--
F
L
L
P
Y
I
N
P
---
D
LYLKKF------
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----------------------------------
33
HHSearch
55.65
12%
-5
- C6 -
2V73
3
?
A:
[12-186]
--------------------------
I
A
N
Y
G
N
L
K
I
T
K
E
E
--
E
-
R
V
N
I
T
G
--
D
--------
L
EKF
S
-
S
-
L
E
E
G
T
I
V
T
R
F
N
M
N
--
D
T
-----
S
I
Q
S
L
I
G
-------
L
S
D
G
N
--
K
A
N
N
Y
F
S
L
Y
V
S
-----
G
G
-
K
V
G
Y
E
L
---
R
R
Q
--
E
-
G
NG
D
F
N
V
H
H
S
A
-
D
------
V
T
F
N
R
G
-
I
N
T
L
A
L
K
I
E
K
G
-
I
G
A
K
I
F
L
N
G
S
L
--
V
K
-
T
V
-
S
D-
P
N
-
I
-
K
F
L
NA
I
N
L
N
S
G
F
I
G
K
T
D
R
A
N
---
G
Y
------
N
E
Y
L
F
R
G
N
I
D
F
M
N
I
Y
D
K
P
V
S
D
N
Y
L
L
----
R
K
-------
T
G
-------
E
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
55.64
11%
14
- C6 -
1MS9
-
?
A:
[463-634]
----------------------------
V
P
N
G
L
K
F
A
G
V
G
--
G
-
G
A
L
W
P
V
--
S
QQGQNQRY
H
---
F
-
A
-
N
H
A
F
T
L
V
A
S
V
T
I
H
E
V
P
K
-----
G
A
S
P
L
L
G
-------
A
S
L
D
S
---
S
G
G
K
K
L
L
G
L
S
--
Y
D
K
R
H
-
Q
W
Q
P
I
Y
---
G
S
T
--
P
-
V
--------
T
P
-
T
------
G
S
W
E
M
G
K
R
Y
H
V
V
L
T
M
A
N
--
K
I
G
S
V
Y
I
D
G
E
P
--
L
E
-
G
S
G
Q
T-
V
V
P
D
-
E
R
T
--
P
D
I
S
H
F
Y
V
G
G
Y
K
R
S
---------
G
--
M
P
T
D
S
R
V
T
V
N
N
V
L
L
Y
N
R
Q
L
N
A
E
E
I
R
----
T
L
-------
F
L
-------
S
Q
D
L
I
G
T
E
A
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
53.67
21%
125
- C3 -
3ZTA
-
?
A:
[8-146]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
N
I
V
E
K
A
I
N
L
L
S
K
E
D
Q
A
G
--------------
V
H
F
N
E
I
S
-
A
L
T
R
D
F
C
R
A
I
L
S
D
L
E
Q
S
G
F
T
T
------
S
E
L
E
K
E
I
A
D
K
V
K
I
M
F
A
Q
-
G
Y
H
I
-----
E
V
L
Q
L
I
L
E
K
I
L
D
S
F
I
S
V
I
R
E
Q
Y
H
D
----
L
Q
A
A
A
S
Y
I
T
T
V
---
R
D
H
I
F
K
G
T
S
F
L
L
K
M
A
L
Q
T
Q
R
E
V
I
Q
K
Q
N
E
A
L
M
E
L
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
53.20
11%
8
- C6 -
3RSJ
-
?
A:
[39-213]
----------------------------
R
N
Q
-
F
G
I
Y
S
S
K
P
-
S
-
E
V
N
I
A
Q
NN
D
--------
I
IYN
G
-
R
-
Y
Q
N
F
S
I
S
F
W
V
R
I
P
K
Y
F
N
KVNLN
N
E
Y
T
I
I
D
-------
C
I
R
N
------
N
N
S
G
W
K
I
S
--
L
-
N
Y
N
-
K
I
I
W
T
L
Q
D
T
A
G
N
--
N
-
Q
K
L
------
V
F
-
N
Y
T
QMIS
I
S
D
Y
I
N
K
W
I
F
V
T
I
T
N
N
R
L
-
G
N
S
R
I
Y
I
N
G
N
L
--
I
D
-
E
K
-
S
I-
S
N
-
L
-
G
D
I
--
H
V
S
D
N
I
L
F
K
I
V
G
--------------
C
N
D
T
R
Y
V
G
I
R
Y
F
K
V
F
D
T
E
L
G
K
T
E
I
E
----
T
L
-------
Y
S
-------
D
E
P
D
P
S
I
L
K
D
F
W
G
N
Y
L
L
Y
N
K
R
Y
Y
L
L
N
L
L
R
T
D
K
S
I
T
Q
N
S
N
F
L
N
I
N
Q
Q
R
G
V
Y
Q
K
P
N
I
F
S
N
T
R
L
Y
T
G
V
E
V
I
I
R
K
N
G
N
T
D
N
F
V
R
K
N
D
L
A
Y
I
N
V
V
D
R
D
V
E
Y
R
L
Y
A
D
I
S
I
A
K
P
E
K
I
I
K
L
I
R
T
S
N
N
S
L
G
Q
I
I
V
M
D
S
I
G
N
N
C
T
M
N
F
Q
N
N
N
G
G
N
I
G
L
L
G
F
H
S
N
N
L
V
A
S
S
W
Y
Y
N
N
I
R
K
N
T
S
S
N
G
C
F
W
S
F
I
S
K
E
H
G
W
Q
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------