@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AGRG5_HUMAN: (2016-01-09 )
MDHCGALFLCLCLLTLQNATTETWEELLSYMENMQVSRGRSSVFSSRQLHQLEQMLLNTSFPGYNLTLQTPTIQSLAFKLSCDFSGLSLTSATLKRVPQAGGQHARGQHAMQFPAELTRDACKTRPRELRLICIYFSNTHFFKDENNSSLLNNYVLGAQLSHGHVNNLRDPVNISFWHNQSLEGYTLTCVFWKEGARKQPWGGWSPEGCRTEQPSHSQVLCRCNHLTYFAVLMQLSPALVPAELLAPLTYISLVGCSISIVASLITVLLHFHFRKQSDSLTRIHMNLHASVLLLNIAFLLSPAFAMSPVPGSACTALAAALHYALLSCLTWMAIEGFNLYLLLGRVYNIYIRRYVFKLGVLGWGAPALLVLLSLSVKSSVYGPCTIPVFDSWENGTGFQNMSICWVRSPVVHSVLVMGYGGLTSLFNLVVLAWALWTLRRLRERADAPSVRACHDTVTVLGLTVLLGTTWALAFFSFGVFLLPQLFLFTILNSLYGFFLFLWFCSQRCRSEAEAKAQIEAFSSSQTTQ
Atome Classification :
(20 SA)
----------------.........10........20........30......-..40........50........60.....---...70........80........90....--....100.----------......110.......-120.......130........140...-....150.......160.......170.......--180.......190--........200.....------------..210.......220.......230.......240.......250.......260.......270.......280.......290.-----.--.....300---.-----.-----.---....310.-----......320.......330.......340.......---350-.------.--...--------....360.......370.......380.......390.......400....--..---.-----------410--------........---------.420.......430......-.440..-----------.....450...-....460.......470......-----.-----------------480-----.........490.......500.......510.......520......-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MDH
C
G
A
L
F
L
C
L
C
L
L
T
LQNA
T
T
E
T
W
E
E
L
L
S
Y
M
E
N
M
Q
VS-RG
R
S
S
V
F
S
S
R
Q
L
H
Q
L
E
Q
M
L
LNTSFPG
Y
N
L
---
T
LQTPT
I
Q
S
L
A
F
K
L
SCDFSGLS
L
T
S
A
T
L
K
--RVPQAGGQ----------HARG
Q
H
A
M
Q
F
P
A
E
L
T
R
-
D
A
C
KTRP
R
E
L
R
-
L
I
C
I
Y
FSN
T
H
F
F
KDE-NN
S
S
L
L
N
N
Y
V
LGAQLSHGHVNNLRDP
V
N
I
S
F
W
HN--QSLE
G
Y
T
L
T
C
V
F
---WKEGARKQPWGGWSPE------------GCRTEQP
S
H
S
Q
V
L
C
RCN
H
L
T
Y
F
A
V
L
M
QL
S
P
AL
V
P
A
E
L
L
A
P
L
T
Y
I
S
L
VG
C
S
I
S
I
V
A
S
L
I
T
V
L
L
H
F
H
FRKQSDS
L
T
R
I
H
M
N
L
H
A
S
V
L
L
-----
L
--
N
I
A
F
L
LS
P
---
A
-----
F
-----A---MSPVP
G
S
A
-----
C
T
A
L
A
A
A
L
H
Y
A
L
L
S
C
L
T
W
M
A
IEG
F
N
L
Y
L
L
L
G
R
V
Y
N
I
---
Y
---
I
------
R
--
R
Y
V
--------
F
K
LGVLGW
G
A
P
A
L
L
V
L
L
S
LSVKSSVYGP
C
T
I
P
VFDSWENGTGFQN
M
S
I
C
W
V--RS---
P
-----------
V
----------
V
H
S
V
L
V
MG---------YG
G
L
T
S
L
F
N
L
V
V
L
A
W
A
L
W
T
L
-
R
R
L
R
E
R-----------ADAPS
V
R
A
C
H
D
-
T
V
T
V
L
G
L
T
V
L
L
G
T
T
W
A
L
A
F
F
S
F
G
-----
V
-----------------
F
-------
L
L
P
Q
L
F
L
F
T
I
L
N
S
L
Y
G
F
F
L
F
L
W
F
C
S
Q
R
C
R
S
E
A
E
A
K
A
Q
I
E
AFSSSQTTQ-----------
25
Fugue
80.96
16%
-103
- C4 -
4B3X
3
IF2_THET8
A:
[1-363]
----------------
M
A
K
-------
V
R
I
Y
Q
L
A
K
E
L
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
V
A
Y
K
S
H
A
S
T
L
E
E
K
D
A
E
A
V
R
E
L
V
K
E
Q
R
G
L
Q
E
K
L
---
A
E
E
E
R
R
---------------------------------------------------------------
K
S
L
P
R
R
P
P
-
V
V
V
I
M
G
H
V
D
H
-------
G
K
T
T
L
L
D
Y
L
R
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R
I
A
E
K
E
G
G
G
I
T
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--
G
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V
--
K
T
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Q
G
---
T
V
V
F
---
I
D
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G
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-
E
A
F
T
T
I
R
Q
R
------------
G
A
K
V
A
---------------
D
I
A
V
I
V
I
A
A
D
D
G
I
M
P
Q
T
E
E
A
I
A
H
A
K
A
A
G
------
A
K
L
I
F
A
I
N
K
I
D
L
P
Q
A
D
P
E
K
V
K
R
Q
L
M
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R
G
F
V
-----------
P
E
E
Y
G
G
D
---
A
-----
I
-----
V
---
I
P
-----------------------
I
S
A
K
T
-----------------------------------------------------
G
Q
G
V
Q
D
L
L
E
M
I
L
L
L
A
E
L
E
D
Y
R
A
------
D
P
N
A
E
P
R
G
V
I
L
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S
K
L
D
K
--
Q
A
---
G
-----------
I
----------
I
A
N
M
L
V
Q
E
-----------
G
T
F
R
V
G
D
Y
V
V
A
G
E
A
Y
G
R
I
-
R
A
M
M
D
A
-----------
D
G
N
Q
R
K
E
A
G
P
G
S
A
V
Q
V
L
G
F
Q
E
L
P
H
A
-------
G
D
V
-----
V
-----------------
E
-------
W
V
P
D
----------------
L
E
A
A
K
E
I
A
E
E
R
K
E
E
R
K
A
R
E
E
E
E
K
A
R
R
P
R
TMAELLR----
31
Fugue
66.90
11%
-116
- C1 -
4JO0
8
?
A:
[1-534]
S
H
M
R
Y
S
LRQD
I
A
V
E
P
V
I
A
G
W
Y
G
W
S
Y
L
L
P
P
Q
T
L
A
R
F
V
H
N
R
F
N
R
I
V
E
S
Y
L
D
------------
D
P
Q
V
H
A
A
A
V
R
Q
R
R
M
H
G
G
P
W
I
H
A
---
H
E
H
R
D
A
I
E
A
W
Y
R
E
T
A
P
R
R
E
R
L
D
E
L
F
E
A
V
R
--
R
L
E
E
D
I
L
P
----------
R
H
H
G
E
C
L
D
P
V
Y
Q
E
L
---------
P
A
A
L
A
G
R
V
E
V
F
Y
G
R
D
N
---------------------
R
T
A
D
Y
R
F
V
E
P
L
M
Y
A
S
E
Y
Y
D
--
E
S
W
Q
Q
V
R
F
R
P
V
-------
T
E
D
A
R
E
F
A
L
T
T
P
M
--------------
L
E
Y
G
P
E
Q
L
L
V
N
V
P
L
N
S
-
P
L
L
D
A
V
F
R
G
G
L
T
G
T
E
L
D
D
L
A
A
R
--
F
G
L
D
G
E
R
A
A
R
F
A
S
Y
F
E
P
---------
T
P
E
E
D
V
L
E
Y
V
G
H
A
C
V
F
A
-----
R
H
R
G
T
T
F
L
V
D
P
---
V
-----
L
-----
S
---
Y
S
G
Y
P
G
G
A
ENRFT
F
A
D
L
P
E
R
I
D
H
L
L
I
T
H
N
H
Q
D
H
M
L
F
E
T
L
L
R
I
R
H
R
V
G
R
V
---
L
---
V
------
P
--
K
S
T
NASLVDPG
L
G
G
I
L
R
R
L
G
F
T
D
V
V
E
V
D
D
L
E
T
L
S
C
G
S
A
E
V
V
A
L
P
F
L
G
E
H
G
D
L
R
I
R
S
K
T
G
W
L
I
--
R
F
---
G
-----------
E
-----------
R
S
V
L
F
A
A
DSTNISPT
M
Y
T
K
V
A
E
V
I
G
P
V
D
T
V
F
I
G
M
E
S
-
I
G
A
A
A
S
-----------
W
I
Y
G
P
L
Y
G
E
P
L
-
D
R
R
T
D
Q
S
R
R
L
N
G
S
N
F
P
Q
A
R
E
I
V
D
-----
A
-----------------
L
-------
E
P
D
E
V
Y
V
Y
A
M
G
L
E
P
W
M
G
V
V
M
A
V
D
Y
D
E
S
H
P
A
I
V
D
S
D
L
L
V
R
H
V
Q
D
K
G
G
T
A
E
RLH
L
R
R
T
L
R
L
7
HHSearch
62.28
16%
-119
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[49-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
-----
F
--
V
I
T
L
P
F
W
A
---
V
-----
D
-----
A
V
A-
N
W
Y
F
G
N
F
L
-----
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
---
Q
R
P
R
K
------
L
--
L
A
E
--------
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
A
----------------
D
D
R
Y
I
C
D
R
--
F
Y
---
P
-----------
N
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
---------
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
-
S
N
I
F
E
M
-----------
L
R
I
D
E
G
L
R
L
K
I
-
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
-----
A
-----------------
A
-------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
-----------
6
HHSearch
60.10
10%
-135
- C4 -
2Z73
5
OPSD_TODPA
A:
[35-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
-----
F
--
S
L
V
N
G
F
P
L
---
M
T
I
S
C
F
L
-----
K
---
K
W
I
F
G
F
A
A
-----
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
---
S
------
H
--
R
R
A
--------
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
-
G
A
Y
T
L
E
--------------
G
V
L
C
N
C
S
F
--
D
Y
---
I
SRD
S
T
T
R
S
N
I
L
C
----------
M
F
I
L
G
F
F
G
---------
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
-
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
-
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
-----
L
A
Q
FGPLEW---------
V
-------
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
-----------
18
HHSearch
58.30
12%
-130
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[42-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
-----
F
--
A
L
T
L
P
I
W
A
---
A
-----
S
K
V
---
N
---
G
W
I
F
G
T
F
L
-----
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
---
L
---
T
------
Q
K
R
H
L
V
--------
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
-
Q
A
Y
H
P
N
--------------
N
S
S
P
V
C
Y
E
--
V
L
GN-
D
TAKWRMVLRI-
L
----------
P
H
T
F
G
F
I
V
---------
P
L
F
V
M
L
F
C
Y
G
F
T
----
L
R
T
L
-
F
K
A
H
-----------------
M
G
Q
K
H
R
A
-
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
-----
A
D
T
L
M
RTQVIQE
S
C
E
R
R
N
N
-------
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------
16
HHSearch
57.06
9%
-131
- C4 -
2KS9
1
NK1R_HUMAN
A:
[36-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
-----
M
--
A
A
F
N
T
V
V
N
---
F
-----
T
Y
A
V
H
-
N
---
E
W
Y
Y
G
L
F
Y
-----
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
---
R
---
L
S-----
A
--
T
A
T
--------
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
--
T
E
T
M
--------------
P
S
R
V
V
C
M
I
--
E
W
PEH
P
NKIY
E
K
V
Y
H
I
-
C
----------
V
T
V
L
I
Y
F
L
---------
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
-
I
P
G
D
S
S
DR---------
Y
H
E
Q
V
S
A
K
R
K
V
-
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
-----
L
P
Y
I
N-------------
P
DLYLKKF
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
-----------
27
Fugue
53.04
16%
-30
- C3 -
1IQ4
-
RL5_GEOSE
A:
[1-179]
--------------------------------
M
N
R
L
K
E
K
Y
L
N
--
E
V
V
P
A
L
M
S
K
-
F
N
Y
K
S
---
I
M
Q
V
P
K
I
E
K
I
V
I
N
M
G
V
G
D
------
A
V
Q
N
P
K
A
L
D
S
A
V
E
E
L
T
L
I
A
G
Q
R
P
V
V
T
R
A
K
--
K
S
I
A
G
F
R
L
RQGMPI
G
A
K
V
T
L
R
G
E
R
M
Y
E
F
L
D
K
L
I
S
-
V
S
L
P
-
R
A
R
D
F
R
-----
G
V
S
K
K
S
F
D
G
R
G
-
N
Y
T
L
G
I
K
E
Q
L
I
F
P
E
I
D
Y
D
K
V
N
K
V
R
G
-
M
D
I
V
I
V
T
T
AN
T
D
E
E
A
R
E
L
L
A
L
L
GMP
F
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
52.24
9%
-134
- C4 -
1U19
14
OPSD_BOVIN
A:
[46-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-----
M
--
V
F
G
G
F
T
T
T
---
L
-----
Y
T
S
L
H
-
G
---
Y
F
V
F
G
P
T
G
-----
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
---
F
R
F
-
G
------
E
--
N
H
A
--------
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
I
P
E
--------------
G
M
Q
C
S
C
G
I
--
D
Y
---
Y
TPHEETN
N
E
--
S
F
V
I
Y
------
M
F
V
V
H
F
I
I
---------
P
L
I
V
I
F
F
C
Y
G
Q
L
V
----
F
T
V
-
K
E
A
A
A
Q
QQE--------
S
A
T
T
Q
K
A
E
K
E
V
-
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
GSD--------------
F
-------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
-----------
8
HHSearch
52.17
12%
-117
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[64-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
-----
A
--
G
V
A
Y
T
A
N
L
---
L
-----
L
-----
S
GAT
T
Y
K
L
T
P
A
Q
-----
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
------
N
--
F
R
L
--------
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
-
I
-----------------
S
A
L
S
S
C
S
T
--
V
L
---
P
LYH
K
H
Y
I
----
L
----------
F
C
T
T
V
F
T
L
---------
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
-
I
F
E
M
L
R
-----------
I
D
E
G
L
R
L
K
I
Y
K
-
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
-----
K
-----------------
S
-------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
-----------
3
PsiBlast_PDB
50.44
28%
-105
- C4 -
4L6R
-
GLR_HUMAN
A:
[160-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
H
A
N
L
F
A
S
F
V
L
K
A
S
S
V
L
--
V
I
D
G
L
L
R
T
-------------------
L
S
D
G
A
V
A
G
-----
C
R
V
A
A
V
F
M
Q
Y
G
I
V
A
N
Y
C
W
L
L
V
E
G
L
Y
L
H
N
L
L
G
L
A
T
L
P
---
E
---
R
------
S
--
F
F
S
--------
L
Y
L
G
I
-
G
W
G
A
P
M
L
F
V
V
P
W
A
V
V
K
------
C
L
F
E
N
V
Q
C
W
---
T
S
N
D
N
M
G
F
W
W
I
L-
R
F
---
P
-----------
V
----------
F
L
A
I
L
I
N
F
---------
F
I
F
V
R
I
V
Q
L
L
V
A
K
L
R
A
R
Q
M
H
-
H
T
D
Y
K
F
-----------
R
L
A
K
S
T
L
T
L
I
P
-
L
L
G
V
H
E
V
V
F
A
F
V
T
D
E
H
A
Q
G
T
L
R
S
-----
A
-----------------
K
-------
L
F
F
D
L
F
L
S
S
F
Q
G
L
L
V
A
V
L
Y
C
F
L
N
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
-----------
1
PsiBlast_PDB
50.17
31%
-60
- C5 -
4DLO
-
AGRB3_HUMAN
A:
[311-370]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
A
H
L
A
N
--
G
T
L
N
P
Y
---
C
V
L
---
W
D
D
S
---
E
S
L
G
T
W
S
T
Q
------------
G
C
K
T
V
L
T
D
A
S
H
T
K
C
L
C
D
R
L
S
T
F
A
I
L
A
Q
Q
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.35
24%
-70
- C4 -
4K5Y
4
CRFR1_HUMAN (first)
A:
[289-419]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
W
G
V
P
-------------------
F
P
I
I
V
A
W
A
I
G
K
L
Y
Y
D
N
E
K
C
W
A
GK
R
P
---
G
-----------
V
----------
Y
T
D
Y
I
Y
Q
G
---------
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
A
S
-----------
T
T
S
E
T
I
Q
A
R
K
A
-
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
--E----
V
-----------------
S
-------
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
-------------------------------
28
Fugue
44.27
14%
-38
- C2 -
2BM5
-
?
A:
[4-186]
-------------------------------------------
M
Q
Q
W
V
D
C
E
F
T
-
G
R
D
F
R
D
E
D
L
S
R
L
H
T
E
R
A
M
F
S
E
C
D
F
S
G
V
N
L
AE
S
Q
H
R
G
S
A
F
R
N
C
T
F
E
-
R
T
T
L
W
H
S
T
F
A
Q
C
S
M
L
G
S
V
F
V
A
C
R
L
R
----------
P
L
T
L
D
D
V
D
F
T
L
A
V
L
G
G
N
D
L
R
G
L
N
L
T
G
C
R
-
L
R
E
T
S
L
V
D
T
D
L
R
K
C
V
L
R
G
A
D
L
S
G
A
R
T
T
G
A
R
L
D
D
A
D
L
R
G
A
--
T
V
D
P
V
L
W
R
T
--
A
S
L
V
G
A
R
V
D
------
V
D
Q
A
V
A
F
A
A
A
H
G
L
C
L
A
------------
G
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
42.78
9%
-113
- C4 -
2RH1
5
ADRB2_HUMAN (first)
A:
[45-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
-----
M
--
G
L
A
V
V
P
F
G
---
A
A
H
I
--
L
M
----
K
---
M
W
T
F
G
N
F
W
-----
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
SLL
T
------
K
--
N
K
A
--------
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
--
A
S
---
S
-----------
I
----------
V
S
F
Y
V
P
L
V
---------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
-
E
M
L
R
I
D
-----------
E
G
L
R
L
K
I
Y
K
D
T
-
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
-----
E
-----------------
L
-------
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
-----------
17
HHSearch
41.48
8%
-103
- C4 -
3PBL
1
DRD3_HUMAN (first)
A:
[44-178]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
-----
V
--
A
T
L
V
M
P
W
V
---
V
-----
Y
L
E
V
T
G
G
---
V
W
N
F
S
R
I
C
-----
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
---
Q
---
H
G
T
G
Q
SS
C
--
R
R
V
--------
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
G
D
P
T
V
C
S
I
S
N
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
--
G
V
---
T
-----------
V
----------
L
V
Y
A
R
I
Y
V
---------
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
G
L
-
R
L
K
I
Y
K
-----------
D
T
E
G
Y
Y
T
I
G
I
G
-
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
-----
T
-----------------
N
-------
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
-----------
21
HHSearch
41.32
10%
-95
* C5 *
3G5B
2
A:
[20-146]
-----------------------------------------------------------------------------------------------------------------------------------------
G
T
G
V
S
L
L
V
P
N
G
A
I
P
-
Q
G
K
-----
F
Y
D
-
L
Y
L
R
I
N
K
T
E
S
T
L
P
L
S
-
E
G
S
Q
T
V
L
S
P
S
V
T
C
G
P
T
G
---
L
L
L
C
R
P
V
V
L
T
V
P
H
C
--
A
E
V
I
A
G
D
W
I
F
Q
L
---
K
T
-
Q
A
---
H
Q
G
H
W
E
E
V
VTLDEETLNTPC
Y
C
Q
---
L
E
A
K
S
C
H
I
L
L
D
Q
L
G
T
Y
V
F
T
G
E
S
Y
S
R
S
A
V
K
R
L
Q
L
A
I
F
A
P
A
L
C
T
S
L
E
Y
S
L
R
V
Y
C
L
E
D
T
P
A
A
L
K
E
V
L
E
L
E
R
T
L
G
G
Y
L
V
E
E
P
K
P
-----
L
--
L
F
K
D
S
Y
H
N
---
L
-----
R
-----
L
---
S
L
H
D
I
P
H
A
-----
H
W
R
S
K
L
L
A
K
Y
Q
E
I
P
F
Y
H
V
W
N
G
S
Q
K
A
L
H
C
T
F
T
L
E
R
H
S
---
L
---
A
------
S
--
T
E
F
--------
T
C
K
V
C
V
R
Q
V
E
G
E
G
Q
I
F
Q
L
H
T
T
L
T
T
Q
L
G
P
Y
A
F
K
I
P
L
S
I
R
Q
K
I
C
N
S
L
D
A
P
N
S
R
--
G
N
---
D
-----------
W
----------
R
L
L
A
Q
K
L
S
---------
M
D
R
Y
L
N
Y
F
A
T
K
A
S
P
T
G
V
I
L
D
-
L
W
E
A
R
Q
-----------
Q
D
D
G
D
L
N
S
L
A
S
-
A
L
E
E
M
G
K
S
E
M
L
V
A
M
T
T
D
------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
40.43
32%
7
- C5 -
4DLQ
9
A:
[324-381]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
D
P
V
I
F
T
V
A
H
L
--
E
A
K
N
H
F
N
A
N
C
S
F
---
W
N
Y
S
E
R
S
M
-
L
G
Y
W
S
T
Q
------------
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
40.26
10%
-97
- C4 -
3RZE
2
ENLYS_BPT4 (first)
A:
[12-142]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
-----
V
--
G
A
V
V
M
P
M
N
I
L
Y
L
L
----
M
-----
S
---
K
W
S
L
G
R
P
L
-----
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
---
L
KYR
T
------
K
--
T
R
A
--------
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
H
R
R
E
D
K
C
E
T
D
F
Y
D
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
--
T
L
---
L
-----------
M
----------
L
W
F
Y
A
K
I
Y
---------
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
-
L
K
I
Y
K
D
-----------
T
E
G
Y
Y
T
I
G
I
G
H
-
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
-----
N
-----------------
G
-------
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
-----------
10
HHSearch
39.85
10%
-109
- C4 -
3UON
2
ACM2_HUMAN (first)
A:
[28-160]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
-----
I
--
G
V
F
S
M
N
L
Y
---
T
L
Y
T
V
-
I
-----
G
---
Y
W
P
L
G
P
V
V
-----
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
---
P
VKR
T
------
T
--
K
M
A
--------
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
S
N
A
A
V
T
F
G
T
A
--
I
A
---
A
-----------
F
----------
Y
L
P
V
I
I
M
T
---------
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
-
R
I
D
E
G
L
-----------
R
L
K
I
Y
K
D
T
E
G
Y
-
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
-----
K
-----------------
A
-------
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
-----------
14
HHSearch
39.50
8%
-108
- C4 -
3EML
8
ENLYS_BPT4
A:
[26-155]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
-----
V
--
G
V
L
A
I
P
F
A
---
I
-----
T
-----
I
ST-
G
F
C
A
A
C
H
G
-----
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
---
N
G
L
V
T
------
G
--
T
R
A
--------
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
--
F
N
---
F
-----------
F
----------
A
C
V
L
V
P
L
L
---------
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
-
E
M
L
R
I
D
-----------
E
G
L
R
L
K
I
Y
K
D
T
-
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
-----
E
-----------------
L
-------
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
-----------