@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AGRG7_HUMAN: (2016-01-09 )
MASCRAWNLRVLVAVVCGLLTGIILGLGIWRIVIRIQRGKSTSSSSTPTEFCRNGGTWENGRCICTEEWKGLRCTIANFCENSTYMGFTFARIPVGRYGPSLQTCGKDTPNAGNPMAVRLCSLSLYGEIELQKVTIGNCNENLETLEKQVKDVTAPLNNISSEVQILTSDANKLTAENITSATRVVGQIFNTSRNASPEAKKVAIVTVSQLLDASEDAFQRVAATANDDALTTLIEQMETYSLSLGNQSVVEPNIAIQSANFSSENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLNPDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFKKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEASKVLMLLSSIGRRKSLPSVTRPRLRVKMYNFLRSLPTLHERFRLLETSPSTEEITLSESDNAKESI
Atome Classification :
(20 SA)
.........10........20........30........40........50--........60........70........80......-..90......-..100.--......110-.---.......120.......130.-......140.......150.......160.......170.......180.......190.......---200.......210.......220.......230.......240.......250.....-..260.......270.......280.......290.......300.......310.......320.......330---------------.......340.......350.......360.......370.......380.......390----.......400.......410.......420.......430.......440.......450.......460.......470.......480.....-..490.......500.......510.......520.......530.......540.......550.......560--.------.--......570......-.580.--......590.......600.----......610...------.------...620.......630-.........640.......650.-..-..----------.-------------------------------------------------------------------------------------------------------------------------------------------------------.660.......670.......680.......690...--------.--------------...700.......710.......720.......730.......740.......750.......760.......770.......780.......790.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASCRAW
N
L
R
V
L
V
A
V
V
C
G
L
L
T
G
I
I
L
G
L
G
I
W
R
I
V
I
R
I
QRGKSTSSSS
T
P
T
E
F
--CRNGGTWEN
G
R
C
I
C
T
E
EWKG
L
R
C
T
I
A
N
FCENS
T
Y
M
G
-
F
T
F
A
RIPVGR-YGP
S
L
Q
--TCGKDTPN--A---GNP
M
A
V
R
L
C
S
L
S
L
Y
G
E
I
E
L
Q
K
-
V
T
IGNCNE
N
L
E
T
L
E
K
Q
V
K
D
V
T
A
P
L
N
NISS
E
V
Q
I
L
TSDANK
L
T
A
E
N
I
T
S
A
T
R
V
V
G
Q
I
F
NTSRNASPE---A
K
K
V
A
I
V
T
V
S
Q
L
LDA
S
E
D
A
F
Q
R
V
AATAN
D
D
A
L
T
T
L
I
E
Q
M
E
T
Y
S
LSLGNQSVVEP
N
I
A
I
-
Q
SANFSSENAVGPS
N
V
R
F
S
V
QKGASSSLVSS
S
T
F
I
H
TNVDGLNP
D
A
Q
T
E
L
Q
V
L
L
N
M
TKNYTK
T
C
G
F
V
V
Y
QND
K
L
F---------------QSKTFTAK
S
D
F
S
Q
K
I
I
SSKTDENEQDQSAS
V
D
M
V
FSPKYNQK
E
F
Q
L
Y
S
Y
A
C
V
Y
W
NLSAKD----WDTYGCQKDKGTD
G
F
L
R
C
R
CNHTT
N
F
A
V
L
M
T
F
K
K
DYQYP
K
S
L
D
I
L
SNVGC
A
L
S
V
T
G
L
A
L
T
V
I
F
Q
I
V
T
R
K
V
RKT
S
V
T
W
V
L
V
N
L
C
I
S
M
L
I
F
N
L
L
F
V
F-GIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIP
N
P
M
C
T
A
I
A
A
L
L
H
Y
F
L
L
V
T
F
TWNA
L
S
A
A
Q
L
Y
Y
L
L
I
R
TMKP---L------
P
--
R
H
F
I
L
F
I
S
L
I
GW
G
V
P
-
A
I
V
V
A
--
I
T
V
G
V
I
Y
SQNGNNP
Q
W
E
L
D
Y----RQE
K
I
C
W
L
A
IPE------P------NGVIKS
P
L
L
W
S
F
I
V
---
P
V
T
I
I
L
I
SN
V
V
M
F
I
T
I
S
I
K
V
L
W
K-NN-QN----------L-------------------------------------------------------------------------------------------------------------------------------------------------------T
S
T
K
K
V
S
S
M
K
K
I
V
S
T
L
S
V
A
V
V
F
G
I
T
W
I
L
A
Y
L
M
LVNDD--------
S
--------------
I
R
I
V
F
S
Y
I
F
C
L
FNTTQ
G
L
Q
I
F
I
L
Y
T
V
R
T
K
V
F
Q
S
E
A
S
K
V
L
M
L
L
S
S
IGRRKSLPSVTRPR
L
R
V
K
M
Y
N
F
L
R
S
L
P
T
L
H
E
R
F
R
L
LETSPST
E
E
I
T
LSESDNAKESI
40
HHSearch
70.51
17%
-105
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[41-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
-
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
P
I
-
W
A
A
S
K
V
-----------------------
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
---
L
------
T
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
-
M
N
L
S
L
--
P
F
F
L
F
R
-
Q
A
Y
H
-----
P
--
N
----
N
S
S
P
V
C
Y
E
V
L
G
N
------
D
TAKWR-
M
V
L
R
I
L
P
H
T
F
G
F
I
V
---
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
-----
F
K
-
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
--------
L
M
RTQVIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
----------------------------------------------------------
15
PsiBlast_PDB
68.48
21%
-107
- C1 -
4L6R
1
GLR_HUMAN
A:
[208-394]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
R
V
A
A
V
F
M
Q
Y
G
I
V
A
N
Y
C
W
L
L
V
E
G
L
Y
L
H
N
L
L
G
L
A
T
L
P
---
E
------
R
--
S
F
F
S
L
Y
L
G
-
I
G
W
G
A
P
-
M
L
F
V
V
PW
A
V
V
K
C
L
F
E
----
N
V
Q
--------------
C
W
T
S
N
D
N
------
M
------
G
------
F
W
W
I
L
R
F
---
P
V
F
L
A
I
L
I
N
F
F
I
F
V
R
I
V
Q
L
L
V
A
K
L
R
A
-
R
Q
----------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
T
D
Y
K
F
R
L
A
K
--
S
T
L
T
L
I
P
L
L
G
V
H
E
V
V
--
F
A
F
V
T
D
E
HAQ
G
----
T
--------------
L
R
S
A
K
L
F
F
D
L
F
L
S
S
F
Q
G
L
L
V
A
V
L
Y
C
F
L
N
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
------------------------------------------------
35
HHSearch
67.41
11%
-118
- C1 -
2KS9
1
NK1R_HUMAN
A:
[35-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
-
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
-
V
N
F
T
Y
A
V
---------------------
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
---
R
------
L
S-
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
-
L
L
L
A
F
--
P
Q
G
Y
Y
S
--
T
T
E
-------
T
M
----
P
S
R
V
V
C
M
I
E
W
P
E
HPNKIY
E
------
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
---
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-
W
A
S
E
I
P
-
G
D
S
S
D
----------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
NPDLYLK
K
--------------
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
------------------
51
Fugue
65.65
14%
-13
- C1 -
4DLQ
16
A:
[18-381]
---------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
V
R
R
-
V
Q
W
P
A
T
Q
Q
G
---
M
L
V
E
R
--
P
C
----
P
K
--
G
---
T
R
G
I
A
S
F
Q
C
L
P
A
-
L
G
L
W
N
P
R
G
-
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
R
--
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
RN
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
M
N
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
P
Q
E
Y
A
S
E
--
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
LSTENATVKLA
G
E
A
G
T
G
G
P
G
G
A
S
L
V
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
R
V
F
L
M
D
P
V
I
F
T
V
A
H
L
E
A
K
-
N
H
F
N
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
64.95
11%
-111
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[65-495]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
-
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
T
A
-
N
L
L
L
S
G
A
----------------------
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
--------------
N
--
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
-
L
I
L
G
G
--
L
P
I
M
G
-
W
N
C
----------
I
----
S
A
L
S
S
C
S
T
V
L
P
L
------
Y
------
H
K
H
Y
I
L
F
C
T
T
V
F
T
L
---
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
-
R
T
R
N
I
F
-
E
M
-
L
R
----------
I
DEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA
Y
A
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
CKVKT--
C
--------------
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
----------------------------------------------------------
37
HHSearch
64.88
13%
-110
- C1 -
1U19
14
OPSD_BOVIN
A:
[43-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
-
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
-
T
T
L
Y
T
S
L
---------------------
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
------
G
--
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
--
P
P
L
V
G
-
W
S
R
Y
I
P
-------
E
----
G
M
Q
C
S
C
G
I
D
Y
Y
T
------
P
HEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-
K
E
A
A
A
Q
-
Q
---
Q
----------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS---
D
--------------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------
28
HHSearch
64.48
11%
-116
- C1 -
2Z73
5
OPSD_TODPA
A:
[35-336]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
-
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
-
P
L
M
T
I
S
-------------------
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
------
S
--
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
-
V
L
W
A
I
--
G
P
I
F
G
W
-
G
A
Y
T
-------
L
E
----
G
V
L
C
N
C
S
F
D
Y
I
S
------
R
D
S
T
T
--
R
S
N
I
L
C
M
F
I
L
G
F
F
G
---
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-
S
N
H
E
K
E
-
M
A
-
A
M
A
K
RLNAKE
L
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
FGPLE---
W
--------------
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
----------------------------------
34
HHSearch
52.65
14%
-113
- C1 -
2RH1
6
ADRB2_HUMAN (first)
A:
[43-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
-
F
G
A
A
H
I
--------------------
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
---
Q
SLL---
T
--
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
-
G
L
T
S
F
--
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
-
E
A
I
N
C
Y
----
A
-
E
E
T
C
C
D
F
F
T
-------
N
------
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
---
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
-
E
M
-
L
R
----------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
--------
D
--------------
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
29
HHSearch
51.95
13%
-131
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[50-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
-
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
L
P
F
-
W
A
V
D
A
V
----------------------
A
-
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
------
K
--
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
-
L
L
L
T
I
--
P
D
F
I
F
A
N
V
S
E
---------
A
----
D
D
R
Y
I
C
D
R
F
Y
P
N
------
D
L
W
V
---
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
---
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
-
S
H
S
G
S
N
-
I
F
-
E
M
----------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
--------
E
--------------
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
17
PsiBlast_PDB
51.81
25%
1
- C3 -
1SB3
2
HCRA_THAAR
A:
[429-557]
---------------------------------------------------------------------------------------------
G
K
L
P
K
G
R
G
L
G
I
A
L
S
H
F
V
S
G
T
S
T
P
K
HW
T
---
G
E
P
H
A
T
V
N
L
K
L
D
F
D
G
G
I
T
L
L
--
T
G
A
A
D
I
G
Q
G
S
N
T
M
A
S
Q
V
--
A
A
E
V
L
G
V
R
L
S
R
I
R
V
I
S
A
D
S
A
L
T
P
K
D
N
G
S
Y
S
S
R
V
T
F
M
V
G
N
A
S
I
S
A
A
E
E
---
L
K
G
V
L
V
K
A
A
A
K
K
L
D
A
R
E
E
D
I
E
V
I
D
E
M
F
M
V
S
G
S
Q
D
P
G
L
S
F
Q
E
V
V
K
A
A
M
V
D
S
G
T
I
T
V
K
G
T
-
Y
T
C
P
T
E
F
Q
G
D
K
K
I
R
G
S
A
I
G
A
T
M
G
F
C
Y
A
A
Q
V
V
E
A
S
V
D
E
I
T
G
K
V
T
A
H
K
V
W
V
A
V
D
V
G
K
A
L
N
P
L
A
V
E
G
Q
T
Q
G
G
V
W
M
G
M
G
---------------
Q
A
L
S
E
E
T
V
Y
D
N
G
R
M
V
H
G
N
I
L
D
Y
R
V
P
T
I
V
E
S
P
D
I
E
V
I
I
V
E
S
M
D
P
N
G
P
F
G
A
K
E
A
S
E
G
M
L
A
G
F
----
L
P
A
I
H
E
A
V
Y
E
A
V
G
V
R
A
T
D
F
P
L
S
P
D
R
I
T
E
L
L
D
A
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
51.76
11%
-122
- C1 -
3UON
2
ACM2_HUMAN (first)
A:
[27-213]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
-
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
-
L
Y
T
L
Y
T
--------------------
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
---
P
VKR---
T
--
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
-
F
I
L
W
A
--
P
A
I
L
F
-
W
Q
F
I
V
-----
G
V
R
T
----
V
E
D
G
E
C
Y
I
Q
F
F
S
------
N
------
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
---
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
-
E
M
-
L
R
----------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
--------
D
--------------
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
16
PsiBlast_PDB
51.33
25%
8
* C3 *
1RM6
2
HCRA_THAAR
A:
[429-557]
---------------------------------------------------------------------------------------------
G
K
L
P
K
G
R
G
L
G
I
A
L
S
H
F
V
S
G
T
S
T
P
K
HW
T
---
G
E
P
H
A
T
V
N
L
K
L
D
F
D
G
G
I
T
L
L
--
T
G
A
A
D
I
G
Q
G
S
N
T
M
A
S
Q
V
--
A
A
E
V
L
G
V
R
L
S
R
I
R
V
I
S
A
D
S
A
L
T
P
K
D
N
G
S
Y
S
S
R
V
T
F
M
V
G
N
A
S
I
S
A
A
E
E
---
L
K
G
V
L
V
K
A
A
A
K
K
L
D
A
R
E
E
D
I
E
V
I
D
E
M
F
M
V
S
G
S
Q
D
P
G
L
S
F
Q
E
V
V
K
A
A
M
V
D
S
G
T
I
T
V
K
G
T
-
Y
T
C
P
T
E
F
Q
G
D
K
K
I
R
G
S
A
I
G
A
T
M
G
F
C
Y
A
A
Q
V
V
E
A
S
V
D
E
I
T
G
K
V
T
A
H
K
V
W
V
A
V
D
V
G
K
A
L
N
P
L
A
V
E
G
Q
T
Q
G
G
V
W
M
G
M
G
---------------
Q
A
L
S
E
E
T
V
Y
D
N
G
R
M
V
H
G
N
I
L
D
Y
R
V
P
T
I
V
E
S
P
D
I
E
V
I
I
V
E
S
M
D
P
N
G
P
F
G
A
K
E
A
S
E
G
M
L
A
G
F
----
L
P
A
I
H
E
A
V
Y
E
A
V
G
V
R
A
T
D
F
P
L
S
P
D
R
I
T
E
L
L
D
A
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
50.81
12%
-131
- C1 -
3RZE
2
ENLYS_BPT4 (first)
A:
[11-198]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
-
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
-
M
N
I
L
Y
L
-------------------
L
-
M
S
K
-
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
LKY
R
------
T
--
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
-
F
L
W
V
I
--
P
I
L
G
W
--
N
H
---------------
R
R
E
D
K
C
E
T
D
F
Y
D
------
V
------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
---
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
-
E
M
-
L
R
----------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
--------
D
--------------
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
1
PsiBlast_PDB
50.04
26%
-60
- C1 -
4K5Y
4
CRFR1_HUMAN (first)
A:
[289-412]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
W
G
V
P
F
P
I
I
V
A
--
W
A
I
G
K
L
Y
------------
Y
----
D
N
E
K
-
C
W
A
G
--------------------
K
R
P
G
V
Y
T
D
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
-
V
R
I
L
M
T
-
K
L
-
R
A
----------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
----
E
--------
V
--------------
S
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
------------------------------------------------------------------------
38
HHSearch
47.43
11%
-125
- C1 -
3PBL
1
DRD3_HUMAN (first)
A:
[42-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
-
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
-
W
V
V
Y
L
E
-------------------
V
-
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
---
Q
H
G
T
G
Q
S
S
--
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
-
F
A
V
S
C
--
P
L
L
F
-
G
F
N
T
----------
T
----
G
D
P
T
V
C
S
I
S
N
P
D
---------------
F
V
I
Y
S
S
V
V
S
F
Y
L
---
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
-
I
F
-
E
M
----------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
--------
E
--------------
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
36
HHSearch
43.81
13%
-99
- C1 -
3EML
8
ENLYS_BPT4
A:
[25-219]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
-
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-----------------------
G
-
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
---
N
G
L
V
---
T
--
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
-
F
A
I
G
L
--
T
P
M
L
G
-
W
N
N
C
G
Q
-------
S
QGCG
E
G
Q
V
A
C
L
F
E
D
V
V
------
P
M
-----
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
---
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
-
E
M
-
L
R
----------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
--------
D
--------------
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
2
PsiBlast_PDB
42.63
30%
93
* C5 *
4Z19
2
FABH_YERPE
A:
[246-305]
-------
N
L
R
I
I
S
A
------
T
A
K
K
L
G
M
G
M
D
K
V
V
I
T
L
D
R
H
G
N
T
S
A
A
S
V
P
S
A
F
D
E
A
V
R
D
G
R
I
Q
R
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
42.06
30%
92
- C5 -
4YLT
-
FABH_YERPE
A:
[246-305]
-------
N
L
R
I
I
S
A
------
T
A
K
K
L
G
M
G
M
D
K
V
V
I
T
L
D
R
H
G
N
T
S
A
A
S
V
P
S
A
F
D
E
A
V
R
D
G
R
I
Q
R
G
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
41.39
14%
45
- C2 -
1U34
-
CRFR2_MOUSE
A:
[57-120]
------------------------------------------------------------------------------
Y
T
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
Q
S
A
P
G
A
-
L
V
--
E
R
--
P
C
P
E
Y
F
N
G
--
I
KYN
T
T
R
N
A
Y
R
E
C
L
E
N
----
G
T
W
A
S
R
V
N
Y
S
H
C
E
P
I
L
D
D
K
Q
R
K
Y
D
L
H
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
40.52
24%
83
- C3 -
3KWV
-
LEF_BACAN
C:
[126-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
V
L
V
I
-
Q
S
S
E
D
Y
V
E
N
T
E
K
A
L
N
V
Y
Y
E
I
G
K
I
L
S
R
D
I
L
S
K
----------
I
N
Q
P
Y
Q
K
F
L
D
V
-
L
N
T
I
K
N
A
S
D
S
D
G
-----
Q
D
L
L
F
---------------
T
N
Q
L
K
E
H
P
T
D
F
S
V
E
F
L
E
Q
N
S
N
E
V
Q
E
V
F
A
K
A
F
A
Y
Y
I
E
P
Q
H
-
R
D
V
L
Q
L
Y
A
P
E
A
F
N
Y
M
D
K
F
N
E
----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------