@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AGRL2_HUMAN: (2016-01-09 )
MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTYKYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEATWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIISTTSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWPQTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAPSAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFEKMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHHKELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRDSPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70....--.--...80........90........100.......110.......120.......130-----.......140.......150.......160..--.....170.......180.-------.-.....190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730....---...740-.........750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVSSG
C
R
M
R
S
L
W
F
I
I
V
I
S
FLPNTEGFSRAA
L
P
F
G
L
V
R
R
E
LSCEG
Y
S
I
D
L
RCPGS
D
V
I
M
I
ESANYGRTDDKICDAD--P--FQMENTDCYL
P
D
A
F
K
I
M
T
Q
RCNNR
T
Q
C
I
V
V
TGSDVFPDPCPG
T
Y
K
Y
L
E
V
Q
Y
E
C
V
P
Y
-----
I
F
VCP
G
T
L
K
A
IVDSPCI
Y
E
A
E
QKAGAWCK
D
P
L
--
Q
AA
D
K
I
Y
F
M
PWTPYRT
D
T
L
-------
I
-
E
Y
A
S
L
E
D
F
QNSRQT
T
T
YKLPNRVDG
T
G
F
V
V
YD
G
A
V
F
FNKERTR
N
I
V
K
F
D
L
R
TRIKSG
E
A
I
I
N
YANYHDTSPYRWGGK
T
D
I
D
L
A
VDEN
G
L
W
V
I
Y
A
TEQNN
G
M
I
V
I
S
QLN
P
Y
T
L
R
F
E
A
T
W
E
T
V
Y
DKRAASN
A
F
M
I
C
G
V
L
Y
V
V
R
S
V
Y
QDNESETGKN
S
I
D
Y
I
YNTRLNRG
E
Y
VDVPFPNQ
Y
Q
Y
I
A
A
V
DYNPRD
N
Q
L
Y
V
WNN
N
F
I
L
R
Y
S
L
EFGPPDPAQV
P
T
T
A
V
T
IT
S
S
A
E
L
F
K
T
I
I
STTSTTSQKGPMS
T
T
VAGSQEGSKGTKPPPAVSTTKIPPITNIFP
L
P
E
R
F
C
E
A
L
DSKGIKWPQTQRGMMVERPCPKGTRGT
A
S
Y
L
C
M
I
STGTWNPKGP
D
L
S
N
C
T
S
H
W
V
N
Q
L
A
Q
K
I
RSGE
N
A
A
S
L
A
N
E
L
A
K
HTKG
P
V
F
AG
D
V
S
S
S
V
R
L
M
E
Q
L
V
D
I
L
D
A
Q
L
Q
ELKPSEKDSAGR
S
Y
N
K
L
Q
K
R
E
K
T
C
R
A
Y
L
K
A
I
V
D
T
V
D
N
LL
R
P
E
A
L
E
S
W
K
HMNSSE
Q
A
H
T
A
T
M
L
L
D
T
L
EEGA
F
V
L
A
D
NLLEPTRVSMPTE
N
I
V
L
E
V
A
V
LSTEGQIQDFKFPLGIKGAG
S
S
I
Q
L
S
A
N
TVKQNSRN
G
L
A
K
L
V
F
I
I
Y
R
S
L
G
Q
F
LSTEN
A
T
I
K
L---
G
A
D
F---IGRN
S
T
I
A
V
N
S
H
V
I
S
V
S
INKES
S
R
V
Y
LTDP
V
L
F
TLPHIDPDNYFNANCSFWNYSE
R
T
M
M
G
Y
WSTQG
C
K
L
VDTNKT
R
T
T
C
A
C
S
H
L
T
N
F
A
I
L
M
AHREI
A
Y
KD
G
V
H
E
L
L
L
T
V
I
T
W
V
G
I
V
I
S
L
V
C
L
A
I
C
I
F
T
F
C
F
F
R
GLQSD
R
N
T
I
H
K
N
L
C
I
N
L
F
I
A
E
F
I
F
L
IGIDKT
K
Y
A
I
A
C
P
I
F
A
G
L
L
H
F
F
F
L
A
A
F
A
W
M
C
L
E
G
V
Q
L
Y
L
M
L
V
E
V
F
E
S
EYSR
K
K
Y
Y
Y
V
A
G
YL
F
P
A
T
V
V
G
V
S
A
A
I
DYKSYGTE
K
A
C
W
L
H
VD
N
Y
F
I
W
S
F
I
G
P
V
T
F
I
I
L
L
N
I
I
F
L
V
I
T
L
C
K
M
V
KHSNTLKP
D
S
S
R
L
E
N
I
K
S
W
V
L
G
A
F
A
L
L
C
L
L
G
L
TWS
F
G
L
L
F
INE
E
T
I
V
M
A
Y
L
F
T
I
F
N
A
F
Q
G
V
F
I
F
I
F
H
C
A
L
Q
K
K
V
R
K
E
Y
G
K
C
F
R
HSYCCGGLPTESPHSSVKASTTRTSARYSSG
T
Q
S
R
I
R
R
M
W
N
D
T
V
RKQSESSFISGDINSTSTLNQGMTG
N
Y
L
LTNPLLRPHGTNN
P
Y
N
T
L
L
A
E
T
VVCNAPSAPVFNSPGHSLNNARDTSAM
D
T
LPLNGNFNNSYSLHKGDYND
S
V
Q
V
V
DCGLSL
N
D
T
A
F
E
K
M
I
I
S
E
L
V
H
N
NLRGSSKT
H
N
L
E
L
T
L
PVKPVIGGSSSED
D
A
I
VA
D
A
S
S
LMHSDNPG
L
E
L
H
H
K
ELEAPLI
P
Q
R
T
H
S
L
L
YQ
P
Q
K
K
VKSEG
T
D
S
Y
V
S
Q
L
T
A
E
A
E
D
HLQSPNR
D
S
L
YTSMPNLRDSPYPESSP
D
M
E
EDLSPSRRSENE
D
I
Y
YKSMPNLGAG
H
Q
L
Q
M
C
Y
Q
ISRGNSD
G
Y
I
I
P
INKEGCIPEGDVREGQ
M
Q
L
VTSL
1
PsiBlast_PDB
96.45
75%
-98
- C1 -
5AFB
5
LPHN3_MOUSE
A:
[1-347]
----------------------------------
V
V
R
R
E
L
S
C
E
S
Y
P
I
E
L
R
C
P
G
T
D
V
I
M
I
E
S
A
N
Y
G
R
T
D
D
K
I
C
D
S
D
---------
N
I
R
C
Y
L
P
D
A
Y
K
I
M
S
Q
R
C
N
N
R
T
Q
C
A
V
V
A
G
P
D
V
F
P
D
P
C
P
G
T
Y
K
Y
L
E
V
Q
Y
E
C
V
P
Y
KVEQK
V
F
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
C
K
D
P
L
--
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
T
D
T
L
-------
T
-
E
Y
S
S
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
E
N
G
L
W
V
I
Y
A
T
E
Q
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
I
L
Y
V
V
K
S
-----------
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
V
K
Y
S
L
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
88.19
67%
-87
- C1 -
4DLQ
16
A:
[18-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
V
R
R
V
Q
W
P
A
T
Q
Q
G
M
L
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
L
P
A
L
G
L
W
N
P
R
G
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
R
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
R
-----------
N
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
M
N
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
P
Q
E
-
Y
A
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
A
T
V
K
L
---
A
G
E
A
G
T
G
G
P
G
G
A
S
L
V
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
R
V
F
L
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
H
F
N
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.41
65%
-86
- C1 -
4DLQ
16
A:
[18-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
V
R
R
V
Q
W
P
A
T
Q
Q
G
M
L
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
L
P
A
L
G
L
W
N
P
R
G
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
R
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
R
-----------
N
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
M
N
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
L
V
F
P
Q
E
Y
-
A
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
A
T
V
K
L
A
G
E
A
G
T
G
---
G
P
G
G
A
S
L
V
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
R
V
F
L
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
H
F
N
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
82.33
78%
-76
- C1 -
5CMN
1
?
E:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
C
K
D
P
L
--
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
T
D
T
L
-------
T
-
E
Y
S
S
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
E
N
G
L
W
V
I
Y
A
T
E
Q
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
I
L
Y
V
V
K
S
-----------
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
V
K
Y
S
L
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.92
76%
-76
- C1 -
5CMN
1
?
E:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
C
K
D
P
L
--
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
T
D
T
L
-------
T
-
E
Y
S
S
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
E
N
G
L
W
V
I
Y
A
T
E
Q
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
I
L
Y
V
V
K
S
-----------
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
V
K
Y
S
L
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.81
75%
-74
- C1 -
4RMK
1
?
A:
[20-282]
---------------------------------------------------------------------------------------------------------------------------------------------
V
F
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
C
K
D
P
L
--
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
T
D
T
L
-------
T
-
E
Y
S
S
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
E
N
G
L
W
V
I
Y
A
T
E
Q
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
I
L
Y
V
V
K
S
V
Y
E
-------
G
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
V
K
Y
S
L
D
F
G
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
80.76
76%
-76
- C1 -
5CMN
1
?
H:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
C
K
D
P
L
--
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
T
D
T
L
-------
T
-
E
Y
S
S
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
E
N
G
L
W
V
I
Y
A
T
E
Q
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
I
L
Y
V
V
K
S
-----------
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
V
K
Y
S
L
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.92
75%
-73
- C1 -
4YEB
1
?
A:
[20-288]
---------------------------------------------------------------------------------------------------------------------------------------------
V
F
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
C
K
D
P
L
--
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
T
D
T
L
-------
T
-
E
Y
S
S
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
E
N
G
L
W
V
I
Y
A
T
E
Q
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
I
L
Y
V
V
K
S
V
Y
E
D
--
N
E
A
T
G
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
V
K
Y
S
L
D
F
G
P
L
D
S
R
S
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
79.79
76%
-72
- C1 -
5CMN
1
?
G:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
C
K
D
P
L
--
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
T
D
T
L
-------
T
-
E
Y
S
S
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
E
N
G
L
W
V
I
Y
A
T
E
Q
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
I
L
Y
V
V
K
S
-----------
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
V
K
Y
S
L
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.77
76%
-75
- C1 -
5CMN
1
?
F:
[3-260]
-----------------------------------------------------------------------------------------------------------------------------------------------
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
C
K
D
P
L
--
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
T
D
T
L
-------
T
-
E
Y
S
S
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
E
N
G
L
W
V
I
Y
A
T
E
Q
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
I
L
Y
V
V
K
S
-----------
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
V
K
Y
S
L
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.72
75%
-82
- C1 -
4RML
2
?
A:
[20-282]
---------------------------------------------------------------------------------------------------------------------------------------------
V
F
L
C
P
G
L
L
K
G
V
Y
Q
S
E
H
L
F
E
S
D
H
Q
S
G
A
W
C
K
D
P
L
--
Q
A
S
D
K
I
Y
Y
M
P
W
T
P
Y
R
T
D
T
L
-------
T
-
E
Y
S
S
K
D
D
F
I
A
G
R
P
T
T
T
Y
K
L
P
H
R
V
D
G
T
G
F
V
V
Y
D
G
A
L
F
F
N
K
E
R
T
R
N
I
V
K
F
D
L
R
T
R
I
K
S
G
E
A
I
I
A
N
A
N
Y
H
D
T
S
P
Y
R
W
G
G
K
S
D
I
D
L
A
V
D
E
N
G
L
W
V
I
Y
A
T
E
Q
N
N
G
K
I
V
I
S
Q
L
N
P
Y
T
L
R
I
E
G
T
W
D
T
A
Y
D
K
R
S
A
S
N
A
F
M
I
C
G
I
L
Y
V
V
K
S
V
---------
G
N
K
I
D
Y
I
Y
N
T
D
Q
S
K
D
S
L
V
D
V
P
F
P
N
S
Y
Q
Y
I
A
A
V
D
Y
N
P
R
D
N
L
L
Y
V
W
N
N
Y
H
V
V
K
Y
S
L
D
F
G
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.98
39%
-70
- C1 -
4XAT
4
?
A:
[11-257]
--------------------------------------------------------------------------------------------------------------------------------------------------
G
K
L
T
G
I
S
D
P
V
T
V
K
T
S
G
S
R
F
G
S
W
M
T
D
P
L
AP
E
G
D
N
R
V
W
Y
M
D
--
G
Y
H
N
N
R
F
-------
V
R
E
Y
K
S
M
V
D
F
M
N
T
D
N
F
T
S
H
R
L
P
H
P
W
S
G
T
G
Q
V
V
Y
N
G
S
I
Y
F
N
K
F
Q
S
H
I
I
I
R
F
D
L
K
T
E
T
I
L
K
T
R
S
L
D
Y
A
G
Y
N
N
M
Y
H
Y
A
W
G
G
H
S
D
I
D
L
M
V
D
E
S
G
L
W
A
V
Y
A
T
N
Q
N
A
G
N
I
V
V
S
R
L
D
P
V
S
L
Q
T
L
Q
T
W
N
T
S
Y
P
K
R
S
A
G
E
A
F
I
I
C
G
T
L
Y
V
T
N
G
Y
-------
S
G
G
T
K
V
H
Y
A
Y
Q
T
N
A
S
T
Y
E
Y
I
D
I
P
F
Q
N
K
Y
S
H
I
S
M
L
D
Y
N
P
K
D
R
A
L
Y
A
W
N
N
G
H
Q
I
L
Y
N
V
T
L
F
H
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
64.18
36%
-44
- C1 -
4WXS
7
MYOC_HUMAN
A:
[39-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
G
V
W
M
R
D
P
K
--
P
T
Y
P
---
Y
T
Q
E
T
T
W
R
I
D
T
V
GTDVR
Q
V
F
-
E
Y
D
L
I
S
Q
F
M
Q
G
Y
P
S
K
V
H
I
L
P
R
P
L
E
S
T
G
A
V
V
Y
S
G
S
L
Y
F
Q
G
A
E
S
R
T
V
I
R
Y
E
L
N
T
E
T
V
K
A
E
K
E
I
P
G
A
G
Y
H
G
Q
F
P
Y
S
W
G
G
Y
T
D
I
D
L
A
V
D
E
A
G
L
W
V
I
Y
S
T
D
D
A
K
G
A
I
V
L
S
K
L
N
P
E
N
L
E
L
E
Q
T
W
E
T
N
I
R
K
Q
S
V
A
N
A
F
I
I
C
G
T
L
Y
T
V
S
S
Y
------
T
S
A
D
A
T
V
N
F
A
Y
D
T
G
T
G
I
S
K
T
L
T
I
P
F
K
N
R
Y
K
Y
S
S
M
I
D
Y
N
P
L
E
K
K
L
F
A
W
D
N
L
N
M
V
T
Y
D
I
K
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.39
36%
-46
- C1 -
4WXQ
9
MYOC_HUMAN
A:
[39-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
G
V
W
M
R
D
P
K
--
P
T
Y
P
---
Y
T
Q
E
T
T
W
R
I
D
T
V
GTDVR
Q
V
F
-
E
Y
D
L
I
S
Q
F
M
Q
G
Y
P
S
K
V
H
I
L
P
R
P
L
E
S
T
G
A
V
V
Y
S
G
S
L
Y
F
Q
G
A
E
S
R
T
V
I
R
Y
E
L
N
T
E
T
V
K
A
E
K
E
I
P
G
A
G
Y
H
G
Q
F
P
Y
S
W
G
G
Y
T
D
I
D
L
A
V
D
E
A
G
L
W
V
I
Y
S
T
D
E
A
K
G
A
I
V
L
S
K
L
N
P
E
N
L
E
L
E
Q
T
W
E
T
N
I
R
K
Q
S
V
A
N
A
F
I
I
C
G
T
L
Y
T
V
S
S
Y
------
T
S
A
D
A
T
V
N
F
A
Y
D
T
G
T
G
I
S
K
T
L
T
I
P
F
K
N
R
Y
K
Y
S
S
M
I
D
Y
N
P
L
E
K
K
L
F
A
W
D
N
L
N
M
V
T
Y
D
I
K
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.18
24%
-58
- C1 -
4XAV
7
?
A:
[23-264]
----------------------------------------------------------------------------------------------------------------------------------------------------
I
T
S
I
G
N
P
A
Q
V
L
K
V
R
E
T
F
G
T
W
M
R
E
S
A
--
N
K
S
D
D
R
I
W
V
--
T
E
H
F
S
G
I
M
-------
V
K
E
F
K
D
L
P
A
L
L
N
S
S
F
T
L
L
H
-
L
P
H
Y
F
H
G
C
G
H
A
V
Y
N
N
S
L
Y
Y
H
K
G
G
S
N
T
I
V
R
F
E
F
G
K
E
T
P
Q
T
L
K
L
E
N
-
A
L
Y
F
D
R
K
Y
L
F
A
N
S
K
T
Y
F
N
I
A
V
D
E
K
G
I
W
I
I
Y
A
S
S
V
D
G
S
S
I
L
V
A
Q
L
D
E
R
T
F
S
V
T
Q
H
I
N
T
T
Y
P
K
S
K
A
G
N
A
F
I
A
R
G
I
L
Y
V
---------
T
D
T
K
D
T
R
V
T
F
A
F
D
L
L
G
G
K
Q
I
N
A
N
F
D
F
R
M
S
Q
S
V
L
A
M
L
S
Y
N
M
R
D
Q
H
L
Y
S
W
E
D
G
H
L
M
L
Y
P
V
Q
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
47.41
86%
-18
- C1 -
2JX9
1
LPHN1_MOUSE
A:
[1-103]
-----------------------------
G
L
P
F
G
L
M
R
R
E
L
A
C
E
G
Y
P
I
E
L
R
C
P
G
S
D
V
I
M
V
E
N
A
N
Y
G
R
T
D
D
K
I
C
D
A
D
--
P
--
F
Q
M
E
N
V
Q
C
Y
L
P
D
A
F
K
I
M
S
Q
R
C
N
N
R
T
Q
C
V
V
V
A
G
S
D
A
F
P
D
P
C
P
G
T
Y
K
Y
L
E
V
Q
Y
D
C
V
P
Y
-----
K
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
46.08
86%
-11
- C1 -
2JXA
2
LPHN1_MOUSE
A:
[1-103]
-----------------------------
G
L
P
F
G
L
M
R
R
E
L
A
C
E
G
Y
P
I
E
L
R
C
P
G
S
D
V
I
M
V
E
N
A
N
Y
G
R
T
D
D
K
I
C
D
A
D
--
P
--
F
Q
M
E
N
V
Q
C
Y
L
P
D
A
F
K
I
M
S
Q
R
C
N
N
R
T
Q
C
V
V
V
A
G
S
D
A
F
P
D
P
C
P
G
T
Y
K
Y
L
E
V
Q
Y
D
C
V
P
Y
-----
K
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
45.21
83%
-9
* C1 *
2JXA
2
LPHN1_MOUSE
A:
[1-106]
-----------------------------
G
L
P
F
G
L
M
R
R
E
L
A
C
E
G
Y
P
I
E
L
R
C
P
G
S
D
V
I
M
V
E
N
A
N
Y
G
R
T
D
D
K
I
C
D
A
D
--
P
--
F
Q
M
E
N
V
Q
C
Y
L
P
D
A
F
K
I
M
S
Q
R
C
N
N
R
T
Q
C
V
V
V
A
G
S
D
A
F
P
D
P
C
P
G
T
Y
K
Y
L
E
V
Q
Y
D
C
V
P
Y
-----
K
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
44.64
41%
19
- C1 -
2ZX2
1
CSL3_ONCKE
A:
[101-195]
------------------------------------
I
S
S
I
I
C
E
G
S
D
S
Q
L
L
C
D
R
G
E
-
I
R
I
Q
R
A
N
Y
G
R
R
Q
H
D
V
C
S
I
G
--
R
PH
Q
Q
L
K
N
T
N
C
L
S
Q
S
T
T
S
K
M
A
E
R
C
D
G
K
R
Q
C
I
V
K
V
S
N
S
V
F
G
D
P
C
V
G
T
Y
K
Y
L
D
V
A
Y
T
C
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
44.23
39%
4
- C1 -
2ZX1
2
CSL3_ONCKE
A:
[4-95]
---------------------------------------
I
T
C
E
G
S
D
A
L
L
Q
C
D
G
A
K
-
I
H
I
K
R
A
N
Y
G
R
R
Q
H
D
V
C
S
I
G
RP
D
--
N
Q
L
T
D
T
N
C
L
S
Q
S
S
T
S
K
M
A
E
R
C
G
G
K
S
E
C
I
V
P
A
S
N
F
V
F
G
D
P
C
V
G
T
Y
K
Y
L
D
T
K
Y
S
C
V
Q
Q
-----
Q
E
T
I
S
S
I
I
C
E
G
S
D
S
Q
L
L
C
D
R
G
E
I
R
I
Q
R
A
N
Y
G
R
--
R
Q
H
D
V
C
S
I
G
R
P
H
Q
Q
L
K
N
T
N
-------
C
-
L
S
Q
S
T
T
S
K
M
A
E
R
C
D
G
K
R
Q
C
I
V
K
V
S
N
S
V
F
G
D
P
C
V
G
T
Y
K
Y
L
D
V
A
Y
T
C
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------