@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BAI1_HUMAN: (2016-01-09 )
MRGQAAAPGPVWILAPLLLLLLLLGRRARAAAGADAGPGPEPCATLVQGKFFGYFSAAAVFPANASRCSWTLRNPDPRRYTLYMKVAKAPVPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDPSAPLAFLQASKQFLQMRRQQPPQHDGLRPRAGPPGPTDDFSVEYLVVGNRNPSRAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGEAGGPAAGPLAPRGDVCLRDAVAGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQILSNLLAEENRDKWEEAQLAGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASGATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNTTVLNSKVISVTVKPPPRSLRTPLEIEFAHMYNGTTNQTCILWDETDVPSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPSVTLIVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWSSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPEASLPARSPPSRQPPSGGPPEAPPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHPGPSTGPSTKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLNRKLQHAAEKDKEVLGPDSKPEKQQTPNKRPWESLRKAHGTPTWVKKELEPLQPSPLELRSVEWERSGATIPLVGQDIIDLQTEV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280......-.290..-.....300-.......310........320.......330.......340.......350.......360.......370.----...---...380.-..-----....-----390--.--.......400....---------------...410.......420......----.430.......--440--........--.450.....-.-.-460........470.......------480..--.--..-..490......--.500.......510...-.-...520.......530..------.--....--540.-..-.---....550-..--......560-.........570........580.......590........600.......610.......620......--.630--.......640.......650.......660.......670.......680.......690....--...700......-------------.710.......720.......730.........740.......750---......-.760..---.....770.......780-.-.......790.......800.......810.......820.......830.......----------------840....----------------...850.......860--.--......870...-....880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000-------.-----......1010......1020......1030......1040....-----.---.1050-.........1060......1070..-.-...1080....---..-----------1090-------.........1100......1110......1120----------......1130......1140......1150......1160-------------.---.---.......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRGQAAAPG
P
V
W
I
L
A
P
L
L
L
L
L
L
L
LGRRARAAAGADAGP
G
P
E
P
C
A
T
L
VQGK
F
F
G
Y
F
S
A
A
AVFPANAS
R
C
S
W
TLRNPDP
R
R
Y
T
L
Y
M
K
VAKAPVPCSGPG
R
V
R
T
Y
Q
F
D
S
F
L
E
S
T
R
T
YL
G
V
E
S
F
D
E
V
L
R
LCDPSA
P
L
A
F
L
Q
A
S
K
Q
F
L
Q
M
R
RQQPPQHDGLRPRAGPPGPTDD
F
S
V
E
Y
L
V
V
GNRNP
S
R
A
A
C
Q
M
L
C
R
W
L
D
A
C
LAGSRSSHPCGIMQT
P
C
A
C
LGGEAGGPAAGPLAPRG
D
V
C
L
R
D
AVAGG
P
E
N
C
L
T
S
L
T
QDRGGHGATGG
W
K
L
W
S
L
W
G
E
C
T
R
DCGGGLQTRTRTC-LPAPGV-EGGGC
E
G
V
-
L
E
E
G
R
Q
C
N
R
-
E
ACGPAGRTS
S
R
S
Q
S
L
R
S
T
D
A
R
R
R
E
E
L
G
D
E
L
Q
Q
FGFPAPQTGDPAAEEWS
P
W
S
V
C
S
S
T
CGEG----WQ
T
---
R
T
R
F
C
VS-SS-----YSTQ-----CS---G--P
L
R
E
Q
R
LCNNSAVC---------------PVHGAWDEWS
P
W
S
L
C
S
S
T
CGRG----FRDRTRTCRPP--Q----FGGNPCEG--PEKQ
T
K
F
C
N
-
I
-
A
-L-CPGRAVDGNWNEWSSW
S
A
C
------
S
A
S
C
S
--Q--
G
R
-
Q
Q
R
T
RECNGPS--YGGAECQ
G
H
W
V
E
T
R
D
C
F
-
L
-
Q
QCPVDGK
W
Q
A
WASWG
S
C
------
S
--
V
T
CG--AG-
S
-
Q
R
-
R
---
E
R
VCSG--PF--FGGAACQ---G
P
Q
D
E
Y
R
Q
CG-TQRCP
E
P
H
EICDEDNF
G
A
V
I
W
-
K
ETPAG
E
V
A
A
V
RCPRNAT
G
L
I
L
R
RCELDEEGIAYWEP--P
T
Y
I
--
R
C
V
S
ID
Y
R
N
I
Q
M
M
T
R
E
H
L
A
K
A
QRGLPG
E
G
V
S
E
V
I
Q
T
L
V
E
ISQDGTSYS
G
D
L
L
S
T
I
D
V
L
R
N
M
T
E
I
--
F
R
R
AYYSPT
P
G
D
-------------
V
Q
N
F
V
Q
I
L
S
N
L
L
A
EENR
D
K
W
E
E
--AQLAGP
N
A
K
E
L
F
R
L
V
E
D
F
V
D
V
I
---
G
F
R
M
K
D
-
L
R
D
A
Y
Q
---
V
T
D
N
L
V
L
S
I
HKLPASG-A-T-DISFPMKGWRATGDWAKVPEDR
V
T
V
S
K
S
V
F
STGLTEADEA
S
V
F
V
V
G
T
V
L
Y
R
N
L
G
S
F
L
----------------
A
LQRN
T
T
----------------
V
L
N
S
K
V
I
S
V
T
VKPPPR--S--LRT
P
L
E
I
E
F
A
H
M
-YNGTTN
Q
T
C
I
L
WDETDVPSSSAPPQLGPWSWRG
C
R
TV
P
L
D
A
L
R
T
R
C
L
C
D
R
L
S
T
F
A
I
L
A
Q
LSADANMEKATLP
S
V
T
L
I
V
GC
G
V
S
S
L
T
L
L
M
L
V
I
I
Y
V
S
V
W
R
Y
I
RSER
S
V
I
L
I
N
F
C
L
S
I
ISSN
A
L
I
L
I
GQ--------T-----QTR
N
K
V
V
C
T
L
V
A
A
F
L
H
F
F
F
L
S
S
F
C
W
V
L
T
E
A
W
Q
S
Y
M
A
V
T
G
H
L
R
N
R
-----
L
---
I
R
----
K
R
F
L
C
LGW
G
L
P
A
L
V
V
A
ISVGFTKAK-G-Y
S
T
M
N
Y
C
W
L
S
L---EG-----------
G
----------
L
L
Y
A
FVG
P
A
A
A
V
V
L
V
N
M
V
I
G
I
L
V
F
N
K
L
VSKDGI----------
T
D
K
K
L
K
E
R
A
G
A
S
L
W
S
S
C
V
V
L
P
L
L
A
L
T
W
M
S
A
V
L
A
VT
D
R
----------------
R
---
S
---
A
L
F
Q
I
L
F
A
V
F
D
SL
E
G
F
V
I
V
M
V
H
C
I
L
R
R
E
V
Q
D
A
V
K
C
R
V
V
DRQEEGNGDSGGSFQN
G
H
A
Q
L
M
T
D
F
E
K
D
V
D
L
A
C
R
S
V
L
N
K
D
I
A
A
CR
T
A
T
I
T
GTLKRPSLP
E
E
E
K
L
K
L
AHAKGPPTNFNSLPAN
V
S
K
L
H
LHGSPRYPGGPLPDFPNH
S
L
T
L
KRDKAPKSSFVG
D
G
D
I
F
K
K
L
D
S
E
L
S
R
A
Q
E
KALDT
S
Y
V
I
L
PTATATLRPKPKEEP
K
Y
S
I
H
IDQMPQ
T
R
L
I
H
L
STAPEASLPARSPPSRQPPSGGPPEAPPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHPGPSTGPSTKNE
N
V
A
T
L
S
V
S
S
L
E
R
R
K
S
R
YAEL
D
F
E
K
I
M
H
T
R
K
R
H
Q
D
M
F
Q
D
L
N
R
K
L
Q
H
A
A
E
K
D
K
E
VLGPDSKPEKQQTPNKR
P
W
E
S
L
R
K
AHGT
P
T
W
V
K
K
ELEPLQPSPL
E
L
R
S
V
E
WERSGATIPLVGQD
I
I
DLQTEV
21
PsiBlast_CBE
85.27
51%
-78
- C2 -
4DLO
6
B:
[7-370]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
S
-
E
Q
R
C
P
A
P
Y
E
I
C
P
E
D
Y
L
M
S
M
V
W
-
K
R
T
P
A
G
D
L
A
F
N
Q
C
P
L
N
A
T
G
T
T
S
R
R
C
S
L
S
L
H
G
V
A
F
W
E
Q
--
P
S
F
A
--
R
C
I
S
N
E
Y
R
H
L
Q
H
S
I
K
E
H
L
A
-------
G
D
G
M
S
Q
V
T
K
T
L
L
D
L
T
Q
R
K
N
F
Y
A
G
D
L
L
M
S
V
E
I
L
R
N
V
T
D
T
--
F
K
R
A
S
Y
I
P
A
S
D
G
-------------
V
Q
N
F
F
Q
I
V
S
N
L
L
D
E
E
N
K
E
K
W
E
D
--
A
Q
Q
I
Y
P
G
S
I
E
L
M
Q
V
I
E
D
F
I
H
I
V
---
G
M
G
M
M
D
-
F
Q
N
S
Y
L
---
M
T
G
N
V
V
A
S
I
Q
K
L
P
A
A
S
-
V
L
T
-
D
I
N
F
P
M
K
G
R
K
G
M
V
D
W
A
R
N
S
E
D
R
V
V
I
P
K
S
I
F
T
---------
S
V
F
V
L
G
A
V
L
Y
K
N
L
D
L
I
L
----------------
P
T
L
R
N
Y
T
----------------
V
I
N
S
K
I
I
V
V
T
I
R
P
E
P
--------
S
F
L
E
I
E
L
A
H
L
-
A
N
G
T
L
N
P
Y
C
V
L
W
D
D
-----------
L
G
T
W
S
T
Q
G
C
K
T
V
L
T
D
A
S
H
T
K
C
L
C
D
R
L
S
T
F
A
I
L
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
68.38
23%
-76
- C2 -
4DLQ
16
A:
[18-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
C
E
P
R
E
V
R
R
V
Q
W
-
P
A
T
Q
Q
G
M
L
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
-
L
P
A
L
G
L
W
N
P
R
G
--
P
D
L
S
--
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
----------
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
R
G
-
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
--
L
D
A
Q
L
Q
A
L
R
N
K
M
H
K
R
E
R
T
C
K
D
Y
---
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
MN
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
---
A
D
N
V
R
E
-
P
A
R
F
L
A
---
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
-
Q
-
E
L
V
F
P
Q
E
Y
---------
A
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
----
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
STENATVKLA
G
E
A
G
T
G
G
P
G
G
A
S
L
----------------
V
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
RV
F
--
L
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
H
F
N
A
N
C
S
F
W
N
Y
S
E
------
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
65.81
36%
63
- C- -
1W0R
-
PROP_HUMAN
A:
[50-382]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
R
W
S
L
W
S
T
W
A
P
C
S
V
T
C
S
E
G
S
Q
L
R
Y
R
R
C
-
V
G
W
N
G
Q
C
S
G
K
V
A
P
G
T
L
E
W
Q
L
Q
A
C
E
D
-
Q
Q
C
C
P
------------------------------------
E
M
G
G
W
S
G
W
G
P
W
E
P
C
S
V
T
C
S
K
G
----
T
R
T
---
R
R
R
A
C
N
H
-
P
A
PK---
C
G
G
H
-----
C
P
---
G
--
Q
A
Q
E
S
E
A
C
D
T
Q
Q
V
C
---------------
P
T
H
G
A
W
A
T
W
G
P
W
T
P
C
S
A
S
C
H
G
G
P
H
E
P
K
E
T
R
S
R
K
C
S
A
P
--
E
P
S
Q
K
P
P
G
K
P
C
P
G
--
L
A
Y
E
Q
R
R
C
T
G
L
-
P
-
P
-
C
P
---
V
A
G
G
W
G
P
W
G
P
V
S
P
C
------
P
V
T
C
G
--
L
--
G
Q
-
T
M
E
Q
R
T
C
N
H
P
V
PQ
H
G
G
P
F
C
A
G
D
A
T
R
T
H
I
C
N
-
T
A
V
P
C
P
V
D
G
E
W
D
S
W
G
E
W
S
P
C
I
R
RNMK
S
--
I
S
C
Q
E
I
P
G
-
Q
-
Q
S
-
R
---
G
R
T
C
R
G
--
R
K
--
F
D
G
H
R
C
A
---
G
Q
Q
Q
D
I
R
H
C
Y
S
I
Q
H
C
P
L
K
---
G
--------
S
W
S
E
W
S
T
W
G
-
L
C
M
P
P
C
G
P
N
P
T
R
A
R
Q
R
L
C
T
P
L
L
P
K
Y
P
P
T
V
S
--
M
V
E
G
--
Q
G
E
K
N
V
T
F
W
G
R
P
L
P
R
C
E
E
L
Q
G
Q
K
L
V
V
E
E
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.46
21%
-73
- C2 -
4DLQ
16
A:
[20-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
L
F
C
E
P
R
E
V
R
R
V
Q
W
-
P
A
T
Q
Q
G
M
L
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
L
---
P
A
L
G
L
W
N
P
RG
P
D
L
S
--
N
C
T
S
P
W
V
N
Q
V
----------
A
Q
K
I
K
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
R
-
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
--
L
D
A
Q
L
Q
A
L
R
---N
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
--
M
-----
N
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
-
Q
-
V
Q
E
L
V
F
P
Q
E
---------
Y
A
S
E
S
S
I
Q
L
S
----
A
N
T
I
K
Q
N
S
R
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
----------------
S
T
E
N
A
T
V
KLA
G
E
A
G
T
GGPGGASL
V
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
--
R
VF
L
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
H
F
N
A
N
C
S
F
W
N
Y
S
E
------
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
T
C
A
C
S
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
63.44
40%
68
- C- -
1W0R
-
PROP_HUMAN
A:
[106-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
P
E
M
G
G
W
S
G
W
G
P
W
E
P
C
S
V
T
C
S
K
G
T
R
T
R
R
R
A
C
-
N
H
P
A
P
K
-
C
G
G
H
C
P
G
Q
-
A
Q
E
S
E
A
C
D
T
Q
Q
V
C
P
-------------------------------------
T
H
G
A
W
A
T
W
G
P
W
T
P
C
S
A
S
C
H
G
G
P
H
E
P
K
E
T
---
R
S
R
K
C
S
A
-
P
E
P
S
Q
K
P
P
G
K
P
-----
C
P
---
G
--
L
A
Y
E
Q
R
R
C
T
G
L
P
P
C
---------------
P
V
A
G
G
W
G
P
W
G
P
V
S
P
C
P
V
T
C
G
L
G
----
Q
T
M
E
Q
R
T
C
N
H
P
VP
Q
----
H
G
G
P
F
C
A
G
--
D
A
T
R
T
H
I
C
N
-
T
-
A
V
P
-
C
P
---
V
D
G
E
W
D
S
W
G
E
W
S
P
C
I
R
RNMK
S
I
S
C
Q
E
I
P
--
G
Q
-
Q
S
R
G
R
T
C
R
G
R
K
--
F
D
G
H
R
C
A
G
Q
Q
Q
D
I
R
H
C
Y
S
I
-
Q
H
C
P
L
K
G
S
W
S
E
W
S
T
W
G
L
C
------
M
--
P
P
C
G
--
P
N
P
T
-
R
A
-
R
---
Q
R
L
C
T
P
--
L
L
--
P
K
Y
P
P
T
V
---
S
M
V
E
G
Q
G
E
K
N
-
V
T
F
W
G
R
P
L
P
R
C
E
E
L
Q
G
Q
K
L
V
V
-
E
E
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
50.20
14%
-124
- C2 -
2KS9
1
NK1R_HUMAN
A:
[40-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
-
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
H
N-
E
-----
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
-----
L
S
A
T
A
T
----
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
-
T
-
M
P
S
R
V
V
C
M
I
E
W
PEH
P
N
-----------
K
IY
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D---------
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
NP------------
D
LYL
K
KFI
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
47.90
44%
94
- C3 -
1LSL
2
A:
[3-113]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
S
P
SP
Q
----
M
N
G
K
P
C
E
G
--
E
A
R
E
T
K
A
C
K
-
K
-
D
-
A
-
C
P
---
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
--
G
V
-
Q
K
R
S
R
L
C
N
N
P
T
PQ
F
G
G
K
D
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
D
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
47.23
48%
103
- C3 -
1LSL
2
A:
[3-109]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
S
P
SP
Q
----
M
N
G
K
P
C
E
G
--
E
A
R
E
T
K
A
C
K
-
K
-
D
-
A
-
C
P
---
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
--
G
V
-
Q
K
R
S
R
L
C
N
N
P
T
PQ
F
G
G
K
D
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
D
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
46.14
44%
92
- C3 -
3R6B
8
A:
[12-123]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
S
P
SP
Q
----
M
N
G
K
P
C
E
G
--
E
A
R
E
T
K
A
C
K
-
K
-
D
-
A
-
C
P
---
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
--
G
V
-
Q
K
R
S
R
L
C
N
N
P
T
PQ
F
G
G
K
D
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
D
C
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
45.99
40%
88
- C3 -
3R6B
8
A:
[9-123]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
D
G
G
W
S
H
W
S
P
W
S
S
C
S
V
T
C
G
D
G
----
V
I
T
R
I
R
L
C
N
S
P
--
S
PQ--
M
N
G
K
P
C
E
G
--
E
A
R
E
T
K
A
C
K
-
K
-
D
-
A
-
C
P
---
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
V
T
C
G
--
G
--
G
V
-
Q
K
R
S
R
L
C
N
N
P
T
PQ
F
G
G
K
D
C
V
G
D
V
T
E
N
Q
I
C
N
-
K
-
Q
D
C
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
45.37
10%
-109
* C2 *
2Z73
5
OPSD_TODPA
A:
[38-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
-
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
-----
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
---
R
A
----
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
-
T
L
E
G
V
L
C
N
C
S
F
D
Y
---
I
S
RD
S
T
T
R
S
N
I
L
C
M
----------
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
FGPLEW---------
V
---
T
---
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
45.04
45%
109
- C3 -
1LSL
2
A:
[1-113]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
G
G
W
S
H
W
S
P
W
S
S
C
------
S
V
T
C
G
--
D
--
G
V
-
I
T
R
I
R
L
C
N
S
P
S
PQ
M
N
G
K
P
C
E
G
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
--
V
T
C
G
--
G
G
-
V
-
Q
K
-
R
---
S
R
L
C
N
N
PT
P
Q
--
F
G
G
K
D
C
V
---
G
D
V
T
E
N
Q
I
C
N
-
K
Q
D
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
45.00
46%
86
- C3 -
3R6B
8
A:
[10-123]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
G
G
W
S
H
W
S
P
W
S
S
C
------
S
V
T
C
G
--
D
--
G
V
-
I
T
R
I
R
L
C
N
S
P
S
PQ
M
N
G
K
P
C
E
G
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
--
V
T
C
G
--
G
G
-
V
-
Q
K
-
R
---
S
R
L
C
N
N
--
P
T
PQ
F
G
G
K
D
C
V
---
G
D
V
T
E
N
Q
I
C
N
-
K
Q
D
C
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
44.95
45%
108
- C3 -
1LSL
2
A:
[3-112]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
W
S
H
W
S
P
W
S
S
C
------
S
V
T
C
G
--
D
--
G
V
-
I
T
R
I
R
L
C
N
S
P
S
PQ
M
N
G
K
P
C
E
G
E
A
R
E
T
K
A
C
K
-
K
-
D
A
C
P
I
N
G
G
W
G
P
W
S
P
W
D
I
C
------
S
--
V
T
C
G
--
G
G
-
V
-
Q
K
-
R
---
S
R
L
C
N
N
--
P
T
PQ
F
G
G
K
D
C
V
---
G
D
V
T
E
N
Q
I
C
N
-
K
Q
D
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
42.79
19%
1
- C3 -
3GHM
3
ATS13_HUMAN
A:
[15-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
P
G
L
Y
Y
S
A
N
E
Q
C
R
V
A
F
G
P
K
----
A
V
A
CMC
Q
A
L
S
C
H
T
D
P
L
-----
D
Q
S
S
-----
C
S
R
L
L
V
--
P
L
L
D
G
T
E
C
G
V
E
K
W
C
S
KG
R
C
R
S
LVELTPIA
A
V
H
G
R
W
S
S
W
G
P
R
S
P
C
S
R
S
C
G
G
G
----
V
V
T
R
R
R
Q
C
N
N
P
--
R
PA--
F
G
G
R
A
C
V
G
--
A
D
L
Q
A
E
M
C
N
-
T
-
Q
-
A
-
C
E
K
-----
T
Q
L
E
F
M
S
Q
Q
C
A
------
R
T
D
G
Q
--
P
--
L
S
-
F
Y
H
W
G
A
A
V
P
H
S
--
Q
G
D
A
L
C
R
-------------
H
M
C
R
A
I
G
E
S
F
I
M
K
R
G
D
S
F
------
L
DG
T
R
C
M
--
P
S
-
G
-
P
R
-
E
DG
T
L
S
L
C
V
L
--
G
S
--
C
R
T
F
G
C
D
GRM
D
S
Q
Q
V
W
D
R
C
Q
-
V
--
C
G
G
D
N
S
T
C
S
P
--
R
K
G
S
F
T
-
A
G
R
A
R
E
Y
V
T
F
L
T
V
T
P
N
L
T
S
V
Y
I
A
N
H
R
P
L
F
T
H
L
A
V
R
I
G
--
G
R
Y
V
VA
G
K
M
S
I
S
P
N
T
T
Y
P
S
L
L
E
D
G
R
V
E
Y
R
V
A
L
T
E
D
R
L
P
R
L
E
E
I
R
I
W
G
P
L
Q
E
D
A
D
I
Q
V
Y
R
R
Y
G
E
E
Y
G
N
L
T
R
PD
I
T
F
T
Y
F
Q
P
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
42.20
34%
-
- C3 -
1W0S
-
PROP_HUMAN
A:
[110-381]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
W
S
G
W
G
P
W
E
P
C
S
V
T
C
S
K
G
T
R
T
R
R
R
A
C
N
H
P
A
P
K
C
--
G
G
H
C
P
G
Q
-
A
Q
E
S
E
A
C
D
--------------
T
Q
Q
V
C
P
T
H
G
-----------------------
A
W
A
T
W
G
P
W
T
P
C
S
A
S
C
H
G
G
P
H
E
P
K
E
T
---
R
S
R
K
C
S
A
-
P
E
-----
P
S
Q
K
PPGKP
C
P
---
G
--
L
A
Y
E
Q
R
R
C
T
G
L
P
P
C
---------------
P
V
A
G
G
W
G
P
W
G
P
V
S
P
C
P
V
T
C
G
L
G
----
Q
T
M
E
Q
R
T
C
N
H
P
VP
Q
----
H
G
G
P
F
C
A
G
--
D
A
T
R
T
H
I
C
N
-
T
-
A
-
V
P
C
P
---
V
D
G
E
W
D
S
W
G
E
W
S
P
C
I
R
RNMK
S
I
S
C
Q
--
E
I
P
G
Q
-
Q
S
R
G
R
T
C
R
G
R
K
--
F
D
G
H
R
C
A
G
Q
Q
Q
D
I
R
H
C
Y
S
I
-
Q
H
C
P
L
K
G
S
W
S
E
W
S
T
W
G
L
C
------
M
--
P
P
C
G
--
P
N
-
P
-
T
R
A
R
---
Q
R
L
C
T
P
--
L
L
--
P
K
Y
P
P
T
V
---
S
M
V
E
G
Q
G
E
K
N
-
V
T
F
W
G
R
P
L
P
R
C
E
E
L
Q
G
Q
K
L
V
V
-
E
E
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
41.79
34%
-
- C3 -
1W0R
-
PROP_HUMAN
A:
[110-381]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
W
S
G
W
G
P
W
E
P
C
S
V
T
C
S
K
G
T
R
T
R
R
R
A
C
N
H
P
A
P
K
C
--
G
G
H
C
P
G
Q
-
A
Q
E
S
E
A
C
D
--------------
T
Q
Q
V
C
P
T
H
G
-----------------------
A
W
A
T
W
G
P
W
T
P
C
S
A
S
C
H
G
G
P
H
E
P
K
E
T
---
R
S
R
K
C
S
A
-
P
E
-----
P
S
Q
K
PPGKP
C
P
---
G
--
L
A
Y
E
Q
R
R
C
T
G
L
P
P
C
---------------
P
V
A
G
G
W
G
P
W
G
P
V
S
P
C
P
V
T
C
G
L
G
----
Q
T
M
E
Q
R
T
C
N
H
P
VP
Q
----
H
G
G
P
F
C
A
G
--
D
A
T
R
T
H
I
C
N
-
T
-
A
-
V
P
C
P
---
V
D
G
E
W
D
S
W
G
E
W
S
P
C
I
R
RNMK
S
I
S
C
Q
--
E
I
P
G
Q
-
Q
S
R
G
R
T
C
R
G
R
K
--
F
D
G
H
R
C
A
G
Q
Q
Q
D
I
R
H
C
Y
S
I
-
Q
H
C
P
L
K
G
S
W
S
E
W
S
T
W
G
L
C
------
M
--
P
P
C
G
--
P
N
-
P
-
T
R
A
R
---
Q
R
L
C
T
P
--
L
L
--
P
K
Y
P
P
T
V
---
S
M
V
E
G
Q
G
E
K
N
-
V
T
F
W
G
R
P
L
P
R
C
E
E
L
Q
G
Q
K
L
V
V
-
E
E
K
R
P
C
L
H
V
P
A
C
K
D
P
E
E
E
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
41.71
14%
-101
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[46-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
-
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
P
I
W
A
--------
A
S
K
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
-----
T
---
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
P
-
N
N
S
S
P
V
C
Y
E
V
L
GN-
D
T
-----------
A
KWRMVLRILP
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
----
T
L
R
T
L
F
K
A
H
M
-----------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
RTQVIQE
S
C
E
R
R
N
N
---
I
---
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
40.83
32%
4
- C3 -
3T5O
4
CO6_HUMAN
A:
[2-159]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
C
D
H
Y
A
W
T
Q
W
T
S
C
S
K
T
C
N
S
G
----
T
Q
S
---
R
H
R
Q
I
V
V
-
D
K
Y
Y
---
Q
E
N
F
-----
C
E
---
Q
IC
S
K
Q
E
T
R
E
C
N
-
W
Q
R
C
---------------
P
I
N
C
L
L
G
D
F
G
P
W
S
D
C
D
P
-
C
I
-
E
----
K
Q
S
K
V
R
S
V
L
R
P
--
S
Q---
F
G
G
Q
P
C
T
A
--
P
L
V
A
F
Q
P
C
I
-
P
S
K
-
L
-
C
K
-----------
I
E
E
A
D
C
KN----
K
F
R
C
D
--
S
--
G
R
C
I
A
R
K
L
E
C
N
G
E
------
N
D
C
G
-
D
N
S
D
E
R
D
C
G
-
R
-
T
K
A
V
C
T
R
K
Y
N
P
I
P
S
V
Q
L
M
------
G
--
N
G
F
H
--
F
L
-
A
-
G
E
-
P
---
R
G
E
V
L
D
--
N
S
--
F
T
G
G
I
C
K
---
T
V
K
S
S
R
T
S
N
P
-
Y
R
V
P
A
N
L
E
N
V
G
F
E
V
Q
T
A
E
D
D
L
-
K
T
D
F
Y
K
D
L
T
S
L
G
H
V
P
I
F
Y
S
S
K
R
S
E
N
I
N
H
N
S
A
F
K
Q
A
I
Q
--
A
S
H
K
--
K
D
S
S
F
I
R
I
H
K
V
M
K
V
L
N
F
T
T
K
A
K
D
L
H
L
S
D
V
F
L
K
A
L
N
H
L
P
L
E
Y
N
S
A
L
Y
S
R
I
F
D
D
F
G
T
H
Y
F
T
S
G
S
L
G
--
G
V
Y
D
L
L
Y
Q
F
S
S
E
-------------
E
L
K
N
S
G
L
T
E
E
E
A
K
H
C
V
R
I
E
T
K
K
--
R
V
L
F
A
K
K
T
K
V
E
H
R
C
T
T
N
K
L
S
E
K
---
H
E
G
S
F
I
-
Q
G
A
E
K
S
---
I
S
L
I
R
G
G
R
S
E
Y
G
A
A
L
A
-
W
-
E
-
K
G
S
S
G
L
E
E
K
T
F
S
E
W
L
E
S
V
K
E
N
P
A
V
I
D
F
E
L
A
P
I
V
D
L
V
R
N
I
P
C
A
V
T
K
R
N
N
L
R
K
A
L
Q
E
Y
A
----------------
A
K
F
D
P
C
Q
----------------
C
A
P
C
P
N
N
G
R
P
T
L
S
G
T
E
--
C
--
L
C
V
C
Q
S
G
T
Y
G
E
N
-
C
E
K
Q
S
P
D
Y
K
S
N
A
V
D
G
Q
W
G
C
W
S
S
W
S
T
C
D
A
T
Y
K
R
S
R
T
R
E
C
N
N
P
A
P
Q
R
G
G
K
R
C
E
G
E
K
R
Q
E
E
D
C
T
P
C
I
N
D
D
E
E
D
S
G
C
P
Q
P
V
P
P
E
N
G
F
I
R
N
E
K
Q
L
Y
L
V
G
E
D
V
E
I
S
C
L
T
G
F
E
T
V
G
Y
Q
Y
F
R
C
L
P
D
G
T
W
R
Q
G
D
V
E
--------
C
-----
Q
R
T
E
C
I
K
P
V
V
Q
E
V
L
T
I
T
P
F
Q
R
L
Y
R
I
G
E
S
I
E
L
T
C
P
K
G
F
V
V
A
G
P
S
R
-----
Y
---
T
C
----
Q
G
N
S
W
T
P
P
I
S
N
S
L
T
C
E
K
D
T
G
H
C
Q
L
G
-
Q
-
K
Q
S
G
S
E
C
I
C
M
S
---
P
E
-----------
E
----------
D
C
S
H
H
S
E
D
L
C
V
F
D
T
D
S
N
D
Y
F
T
S
P
A
C
K
F
L
A
E
K
C
L
----------
N
N
Q
Q
L
H
F
L
H
I
G
S
C
Q
D
G
R
Q
L
E
W
G
L
E
R
T
R
L
S
S
N
S
T
K
K
E
S
----------------
C
---
G
---
Y
D
T
C
Y
D
W
E
K
C
S
A
S
T
S
K
C
V
C
L
L
P
P
Q
C
F
K
G
G
N
Q
L
Y
C
V
K
M
G
S
S
T
S
E
K
T
L
N
I
C
E
V
G
T
I
R
C
A
N
R
K
M
E
I
L
H
P
G
K
C
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
40.59
28%
-11
- C3 -
3T5O
4
CO6_HUMAN
A:
[2-158]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
C
D
H
Y
A
W
T
Q
W
T
S
C
S
K
T
C
N
S
G
----
T
Q
S
R
H
R
Q
I
V
V
D
K
-
Y
----
Y
Q
E
N
F
C
E
Q
IC
S
K
Q
E
T
R
E
C
N
-
W
-
Q
-
R
-
C
P
---
I
N
C
L
L
G
D
F
G
P
W
S
D
C
------
D
P
-
C
I
-----
E
K
-
Q
S
K
V
R
S
V
L
R
P
S
Q-
F
G
G
Q
P
C
T
A
P
L
V
A
F
Q
P
C
I
-
P
S
K
L
C
K
I
--------
E
E
A
D
C
KN----
K
--
F
R
C
D
--
S
G
-
R
C
I
A
-
R
---
K
L
E
C
N
G
--
E
------
N
D
C
G
----
D
N
S
D
E
R
D
C
G
-
R
T
K
A
V
C
T
R
K
Y
N
P
I
P
S
V
Q
L
M
G
N
-
G
F
H
F
L
A
G
E
P
R
G
E
V
L
D
N
S
F
T
G
G
I
C
K
T
V
K
S
S
R
T
S
N
P
Y
R
V
--
P
A
N
L
--
E
N
V
G
F
E
V
Q
T
A
E
D
D
L
K
T
D
F
Y
K
D
L
T
S
L
G
H
V
P
I
F
Y
S
S
K
R
S
E
N
I
N
H
N
S
A
F
K
Q
A
I
Q
A
S
H
K
K
D
S
S
F
I
R
I
H
--
K
V
M
K
V
L
N
F
T
T
K
A
-------------
K
D
L
H
L
S
D
V
F
L
K
A
L
N
H
L
P
L
E
Y
N
S
--
A
L
Y
S
R
I
F
D
D
F
G
T
H
Y
F
T
S
G
S
L
G
G
---
V
Y
D
L
L
Y
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----------------
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----------------
S
---
N
---
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A
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