@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : C5AR1_HUMAN: (2016-01-09 )
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
Atome Classification :
(20 SA)
.........10........20........30........40..---......50-....---.....60.-..-.-.-..-..70........80.......--.90.....-...100.......110.......120.......130.......140.....---.-.150.......160.......170-.......180..--.--..--...190--....-...200-.......210........220-------...---..---------.-------.230.------------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------...------.-----240------.-........250.......260.-----....-.------.----270----.-----.......280.......290.......300.......310---........320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLR
V
P
D
I
L
A
L
V
I
---
F
A
V
V
F
L
V
--
G
V
LG---N
A
L
V
V
W
-
V
-
T
A-F-E-AK-
R
T
I
N
A
I
W
F
L
N
L
A
V
A
D
F
L
S
C
L
A
--
L
P
I
L
F
T
S
I
-
V
Q
HHHWPFGG
A
A
C
S
I
L
P
S
L
I
L
L
N
M
Y
A
S
I
L
L
L
A
TISA
D
R
F
L
L
V
F
KP
I
W
CQNF---R-G
A
G
L
A
W
I
A
C
A
V
A
W
G
L
A
L
L
L
T
I
P
S
F
-
L
Y
R
V
V
R
E
E-YFP--
P
--
K
V
--
L
CGVDY--S
H
D
K
-
R
R
E
R
A
V
-
A
I
V
R
L
V
L
G
-
F
L
W
P
L
L
T
L
T
I
C
Y
-------
T
F
I
---
L
L
---------
R
-------
T
W
S
R
R------------------------------------------------------------------------------------------------------------------------------------------------------------------A--------------------------------------------------------------------------------------------------------------------------------------------------------------------T-------------------------------------------------RST------
K
-----
T
--------
L
-
K
V
V
V
A
V
V
A
S
F
F
I
F
W
L
P
Y
Q
V
T
G
I
-----
M
M
S
F
-L------E----PS-----S-----
P
T
F
L
L
L
K
K
L
D
S
L
C
V
S
F
A
Y
I
N
C
C
I
N
P
I
I
Y
V
V
AGQG
F
Q
G
R
L
----
R
K
S
L
P
S
L
L
R
N
VL
T
E
E
S
V
V
R
E
S
K
S
F
T
R
S
T
V
D
T
M
A
Q
K
TQAV
26
HHSearch
88.66
27%
-162
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-497]
----------------------------------
F
N
K
I
F
L
P
T
I
---
Y
S
I
I
F
L
T
--
G
I
V
G
---
N
G
L
V
I
L
-
V
-
M
G
-
Y
-
Q
K
K
L
-
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
-
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
-
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
-
I
F
A
N
V
S
E
--
A
D
D
--
R
--
Y
I
--
C
D
R
F
Y
P
--
N
D
L
---
W
V
V
V
F
-
Q
F
Q
H
I
M
V
G
-
L
I
L
P
G
I
V
I
L
S
C
Y
-------
C
I
I
---
I
S
---------
K
-------
L
S
H
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
-------------------------------------------------
Q
K
R
------
K
-----
A
--------
L
-
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
-----
I
D
S
F
-
I
------
L
----
L
E
I
I
K
Q
G
C
-----
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
----
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
------------------------
7
PsiBlast_PDB
88.56
26%
-162
- C1 -
4N6H
23
C562_ECOLX (first)
A:
[111-407]
---------------------
L
G
S
P
G
A
R
S
A
S
S
L
A
L
A
-
I
A
I
T
A
L
---
Y
S
A
V
C
A
V
--
G
L
L
G
---
N
V
L
V
M
F
G
I
-
V
R
-
Y
-
T
-
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
-
L
M
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
-
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
-
V
M
A
V
T
R
P
R
---
D
--
G
--
A
V
--
V
C
M
L
Q
F
P
-
S
P
S
W
-
Y
W
D
T
V
T
-
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
---
R
L
---------
L
-------
S
G
S
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------
R
S
L
------
R
-----
R
--------
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
-----
V
W
T
L
-
V
------
D
----
I
D
-----
R
-----
R
D
P
L
V
V
A
A
L
-
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
----
R
Q
L
C
R
K
P
C
G
------------------------------
1
PsiBlast_PDB
87.96
28%
-166
- C1 -
5C1M
7
?
A:
[8-293]
---------------------------
Q
T
G
S
P
S
M
V
T
A
I
T
I
M
A
L
---
Y
S
I
V
C
V
V
--
G
L
F
G
---
N
F
L
V
M
Y
-
V
-
I
V
R
Y
-
T
-
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
--
F
Q
S
V
N
Y
L
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
-
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
-
F
--
M
A
T
T
K
-
Y
R
Q
--
G
--
S
I
--
D
C
T
L
T
F
--
S
H
P
T
W
Y
W
E
N
L
L
-
K
I
C
V
F
I
F
A
-
F
I
M
P
V
L
I
I
T
V
C
Y
-------
G
L
M
---
I
L
---------
R
-------
L
K
S
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------
S
G
S
------
K
-----
E
K
D
R
N
L
R
R
I
T
-
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
-----
I
K
A
L
-
I
------
T
----
I
P
-----
E
-----
T
T
F
Q
T
V
S
W
--
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
-------------------------------------------
9
PsiBlast_PDB
87.17
26%
-163
- C1 -
4RWD
6
C562_ECOLX (first)
A:
[128-404]
------------------------------------------
L
---
Y
S
A
V
C
A
V
--
G
L
L
G
---
N
V
L
V
M
F
G
I
-
V
R
-
Y
-
T
-
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
-
L
M
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
-
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
-
V
M
A
V
T
R
P
R
---
D
--
G
--
A
V
--
V
C
M
L
Q
F
P
-
S
P
S
W
-
Y
W
D
T
V
T
-
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
---
R
L
---------
L
-------
S
G
S
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------
R
S
L
------
R
-----
R
--------
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
-----
V
W
T
L
-
V
------
D
----
I
D
-----
R
-----
R
D
P
L
V
V
A
A
L
-
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
----
R
Q
L
C
-----------------------------------
11
PsiBlast_PDB
86.41
20%
-169
- C1 -
4MBS
8
CCR5_HUMAN (first)
A:
[21-366]
----------------------------
P
C
Q
K
I
N
V
K
Q
I
A
A
R
L
L
P
P
L
Y
S
L
V
F
I
F
--
G
F
V
G
---
N
M
L
V
I
L
-
I
L
I
N
-
Y
-
K
-
R
L
-
K
S
M
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
T
--
V
P
--
F
W
A
H
-
Y
A
A
A
Q
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
---
R
-
T
V
T
F
G
V
V
T
S
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
-
I
F
T
R
S
Q
K
E
-
G
L
H
--
Y
--
T
C
--
S
S
H
F
P
Y
--
S
Q
Y
Q
-
F
W
K
N
F
Q
-
T
L
K
I
V
I
L
G
-
L
V
L
P
L
L
V
M
V
I
C
Y
-------
S
G
I
L
K
T
L
L
---------
R
-------
M
K
K
Y
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
VCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
E
E
EK
K
R
H
------
R
-----
D
--------
V
-
R
L
I
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
N
I
V
L
L
-----
L
N
T
F
-
Q
------
E
FFGL
N
N
-----
C
-----
S
S
S
N
R
L
D
Q
A
M
Q
V
T
E
T
L
G
M
T
H
C
C
I
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
F
Q
--------------------------------------
24
HHSearch
86.09
24%
-166
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------
F
I
V
L
V
---
A
G
S
L
S
L
V
--
T
I
I
G
---
N
I
L
V
M
V
-
S
-
I
K
-
V
N
R
-
H
L
-
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
--
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
-
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
R
T
V
E
--
D
--
G
E
--
C
Y
I
Q
F
F
--------
S
N
A
A
V
-
T
F
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
-------
W
H
I
---
S
R
---------
A
-------
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------
R
E
K
------
K
-----
V
--------
T
-
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
-----
I
N
T
F
-
C
------
A
----
P
C
-----
I
----------
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
----
K
H
L
L
M
----------------------------------
33
HHSearch
85.84
23%
-158
- C1 -
2Z73
5
OPSD_TODPA
A:
[34-335]
------------------------------------
Y
Y
S
L
G
I
F
---
I
G
I
C
G
I
I
--
G
C
G
G
---
N
G
I
V
I
Y
-
L
-
F
T
-
K
T
K
-
S
L
-
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
-
S
-
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
-
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
-
L
-
E
G
V
--
L
--
C
N
--
C
S
F
D
Y
I
--
S
R
D
--
S
T
T
R
S
N
-
I
L
C
M
F
I
L
G
-
F
F
G
P
I
L
I
I
F
F
C
Y
-------
F
N
I
---
V
M
---------
S
-------
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------
A
E
M
------
R
-----
L
--------
A
-
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
-----
L
A
Q
F
-
G
------
P
----
L
E
-----
W
---------
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
----
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-------
42
Fugue
85.81
22%
-124
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
--
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
---
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
-
V
-
T
V
Q
H
-
K
-
K
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
--
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-
V
G
W
---
S
R
-
Y
I
P
E
G
M
--
Q
C
--
S
C
G
I
D
Y
YT
P
H
E
E
-
T
N
N
E
S
F
-
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
-------
G
Q
L
---
V
F
---------
T
-------
V
K
E
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------
A
T
T
------
Q
K
A
E
K
E
V
--------
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-----
Y
I
F
T
--------
H
----
Q
G
-----
S
-----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
---
Y
N
P
V
I
Y
I
M
M
----------------
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--
4
PsiBlast_PDB
85.24
28%
-165
- C1 -
4EA3
3
C562_ECOLX (first)
A:
[131-405]
------------------------------------------
L
---
Y
L
A
V
C
V
G
--
G
L
L
G
---
N
C
L
V
M
Y
-
V
-
I
L
-
R
-
H
-
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
--
L
P
F
Q
G
T
D
I
-
L
-
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
-----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
-
I
M
G
S
A
Q
V
E
-
D
E
E
--
I
--
E
C
--
L
V
E
I
P
T
--
P
Q
D
Y
-
W
G
P
-
V
F
-
A
I
C
I
F
L
F
S
-
F
I
V
P
V
L
V
I
S
V
C
Y
-------
S
L
M
---
I
R
---------
R
L
RGVRLL
S
G
S
R
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------
R
N
L
------
R
-----
R
--------
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
-----
A
Q
G
L
G
V
------
Q
----
P
S
-----
S
-----
E
T
A
V
A
I
L
R
---
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
----
R
--------------------------------------
35
HHSearch
84.71
25%
-171
* C1 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------
Y
A
L
S
---
Y
C
A
L
I
L
A
--
I
V
F
G
---
N
G
L
V
C
M
-
A
-
V
L
-
K
E
R
-
A
L
-
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V-
M
P
W
V
V
Y
L
E
-
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
-
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
-----
G
D
--
P
--
T
V
--
C
S
I
S
N
-----------
P
D
F
-
V
I
Y
S
S
V
V
S
-
F
Y
L
P
F
G
V
T
V
L
V
Y
-------
A
R
I
---
Y
V
---------
V
-------
L
K
Q
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
-------------------------------------------------
R
E
K
------
K
-----
A
--------
T
-
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
-----
L
N
T
H
-
C
------
Q
----
T
C
-----
H
---------
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
----
L
K
I
L
S
C
---------------------------------
8
PsiBlast_PDB
83.94
26%
-165
- C1 -
4RWA
2
C562_ECOLX (first)
A:
[128-404]
------------------------------------------
L
---
Y
S
A
V
C
A
V
--
G
L
L
G
---
N
V
L
V
M
F
G
I
-
V
R
-
Y
-
T
-
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
-
L
M
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
-
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
-
V
M
A
V
T
R
P
R
---
D
--
G
--
A
V
--
V
C
M
L
Q
F
P-
S
P
S
W
-
Y
W
D
T
V
T
-
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
LL----------------------------
G
S
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------
R
S
L
------
R
-----
R
--------
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
-----
V
W
T
L
-
V
------
D
----
I
D
-----
R
-----
R
D
P
L
V
V
A
A
L
-
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
----
R
Q
L
C
-----------------------------------
25
HHSearch
83.75
21%
-148
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[12-443]
----------------------------------------
V
V
V
---
L
S
T
I
C
L
V
--
T
V
G
L
---
N
L
L
V
L
Y
-
A
-
V
R
-
S
-
E
R
K
L
-
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
--
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
-
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-
G
W
N
H
------
R
R
--
E
--
D
K
--
C
E
T
D
F
Y
--
D
------
V
T
W
F
-
K
V
M
T
A
I
I
N
-
F
Y
L
P
T
L
L
M
L
W
F
Y
-------
A
K
I
---
Y
K
---------
A
-------
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------
R
E
R
------
K
-----
A
--------
A
-
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
-----
V
I
A
F
-
C
------
K
----
N
C
-----
C
----------
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
----
K
R
I
L
H
I
---------------------------------
23
HHSearch
82.08
22%
-156
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
--------------------------------------
G
M
G
I
V
---
M
S
L
I
V
L
A
--
I
V
F
G
---
N
V
L
V
I
T
-
A
-
I
A
-
K
F
E
-
R
L
-
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V-
V
P
F
G
A
A
-
H
-
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
-
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--
H
Q
E
--
A
--
I
N
--
C
Y
A
E
E
T
--
C
C
D
F
-
F
T
N
Q
A
Y
-
A
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
-------
S
R
V
---
F
Q
---------
E
-------
A
K
R
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
-------------------------------------------------
K
E
H
------
K
-----
A
--------
L
-
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
-----
V
H
V
I
-
Q
------
D
----
N
L
-----
I
----------
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
----
Q
E
L
L
C
L
---------------------------------
19
PsiBlast_PDB
80.68
25%
-157
- C1 -
2X72
7
GNAT1_BOVIN (first)
A:
[45-327]
-----------------------------------------------
A
Y
M
F
L
L
--
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
-
T
V
-
Q
-
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
---
H
G
Y
F
V
F
G
P
T
G
C
N
L
Q
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
---
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
----
V
G
W
S
R
-
Y
I
P
--
E
GM
Q
C
--
S
C
G
I
D
Y
YT
P
H
E
E
-
T
N
N
E
S
F
-
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
----
V
F
T
---
V
K
---------
E
-------
A
A
A
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
-----
V
--------
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-----
Y
I
F
T
-
H
------
Q
----
G
S
C
F
---
G
-----
P
I
F
M
T
I
P
A
F
------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
----
V
T
T
L
C
C
G
K
N
------------------------------
18
PsiBlast_PDB
80.29
25%
-159
- C1 -
4BEY
5
OPSD_BOVIN
A:
[45-327]
-----------------------------------------------
A
Y
M
F
L
L
--
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
-
T
V
-
Q
-
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
D
F
T
T
T
L
Y
T
S
L
---
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
---
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
----
V
G
W
S
R
-
Y
I
P
--
E
GM
Q
C
--
S
C
G
I
D
Y
YT
P
H
E
E
-
T
N
N
E
S
F
-
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
----
V
F
T
---
V
K
---------
E
-------
A
A
A
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
-----
V
--------
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-----
Y
I
F
T
-
H
------
Q
----
G
S
C
F
---
G
-----
P
I
F
M
T
I
P
A
F
------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
----
V
T
T
L
C
C
G
K
N
------------------------------
43
Fugue
80.23
22%
-114
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
--
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
---
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
-
V
-
T
V
-
Q
-
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
--
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-
V
G
W
---
S
R
-
Y
I
P
E
G
M
--
Q
C
--
S
C
G
I
D
Y
YT
P
H
E
E
-
T
N
N
E
S
F
-
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
-------
G
Q
L
---
V
F
TVKEAAAQQ
Q
-------
E
S
A
T
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------
A
E
K
------
E
-----
V
--------
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-----
Y
I
F
T
-
H
------
Q
----
G
S
-----
D
-----
F
G
----
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
----
V
T
T
L
-
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------
27
HHSearch
79.94
29%
-142
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[41-322]
--------------------------------------
V
V
I
I
A
---
Y
A
L
V
F
L
L
--
S
L
L
G
---
N
S
L
V
M
L
-
V
-
I
L
-
Y
S
R
-
V
G
-
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
---
K
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
-
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
-
L
F
R
Q
A
Y
H
P
-
N
N
S
--
S
--
P
V
--
C
Y
E
V
L
G
--
N
D
T
A
-
K
W
R
M
V
L
-
R
I
L
P
H
T
F
G
-
F
I
V
P
L
F
V
M
L
F
C
Y
-------
G
F
T
---
L
R
---------
T
-------
L
F
K
A
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------
Q
K
H
------
R
-----
A
--------
M
-
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
-----
A
D
T
L
-
M
------
R
----
T
Q
-----
V
IQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
----
L
K
I
L
A
M
H
G
-------------------------------
3
PsiBlast_PDB
79.52
25%
-162
- C1 -
4XT3
2
US28_HCMVA
A:
[34-316]
-----------------------------
T
D
V
L
N
Q
S
K
P
V
T
L
F
L
---
Y
G
V
V
F
L
F
--
G
S
I
G
---
N
F
L
V
I
F
-
T
-
I
T
-
W
-
R
-
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
--
L
P
L
W
M
Q
Y
L
-
L
D
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
----
M
R
Y
---
R
-
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
-
M
V
V
T
K
K
D
N
-
Q
------------
C
M
T
D
Y
--
D
Y
L
E
-
V
S
Y
P
I
I
-
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
-------
Y
R
I
---
S
R
---------
I
-------
V
A
V
S
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------
H
K
G
------
R
-----
I
--------
V
-
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
K
W
-
I
------
S
----
S
S
-----
C
-----
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
----
H
C
L
L
A
E
---------------------------------
17
PsiBlast_PDB
79.28
25%
-161
- C1 -
4BEZ
4
OPSD_BOVIN
A:
[45-327]
-----------------------------------------------
A
Y
M
F
L
L
--
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
-
T
V
-
Q
-
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
D
F
T
T
T
L
Y
T
S
L
---
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
---
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
----
V
G
W
S
R
-
Y
I
P
--
E
GM
Q
C
--
S
C
G
I
D
Y
YT
P
H
E
E
-
T
N
N
E
S
F
-
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
----
V
F
T
---
V
K
---------
E
-------
A
A
A
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
-----
V
--------
T
-
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-----
Y
I
F
T
-
H
------
Q
----
G
S
C
F
---
G
-----
P
I
F
M
T
I
P
A
F
------
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
----
V
T
T
L
C
C
G
K
N
------------------------------
5
PsiBlast_PDB
78.46
31%
-137
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[43-320]
----------------------------------------
I
I
A
---
Y
A
L
V
F
L
L
--
S
L
L
G
---
N
S
L
V
M
L
-
V
-
I
L
-
Y
S
R
-
V
G
-
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
-
V
N
G
--
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
-
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
-
L
F
R
---
Q
A
-
Y
H
P
--
N
--
N
S
SP
V
C
Y
E
V
L
--
G
N
D
T
-
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
-
F
I
V
P
L
F
V
M
L
F
C
Y
-------
G
F
T
---
L
R
---------
T
-------
L
F
K
A
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------
Q
K
H
------
R
-----
A
--------
M
-
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
-----
A
D
T
L
-
M
RTQVIQ
E
----
S
C
-----
E
-----
R
R
N
N
I
G
R
A
L
D
A
T
E
I
-
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
----
L
K
I
L
A
M
H
G
-------------------------------