@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CALCR_HUMAN: (2016-01-09 )
MQFSGEKISGQRDLQKSKMRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRKLTTIFPLNWKYRKALSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.-.......80........90........100.......110.......120--.......130.......140.......150--........160.......170.......180......-.-190.......200.......-210.......220.....--..230......-.240....-...250--------.......260.-......270.......280.......----290.---...-....-.300.......310......----.----320..---.....---.-------.--330---------.----........340.......350.......360.----------..--.....370.......380.......390....----.----.----.--400---------.-----...-.------....410.......420.......430.......440.......450.......460.......470.......480.......490.......500......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQFSGEKISG
Q
R
D
L
Q
K
S
K
M
R
F
T
F
T
S
R
C
L
A
L
F
L
L
LNHPTPILPAFSNQTYPTIEPK
P
F
L
Y
V
VGR
K
K
M
M
D
A
Q
Y
K
-
C
Y
D
R
M
Q
QLPAYQGEGPYCNRTWD
G
W
L
C
WDDTPA
G
V
L
S
Y
QFCPDYFPDFD
P
--
S
E
K
V
T
K
Y
C
D
EKG
V
W
F
KHPENNRTWS
N
Y
T
M
---CNAF
T
P
E
K
LKN
A
Y
V
L
Y
Y
L
A
I
VGH
S
L
S
I
F
T
L
V
I
S
L
G
I
F
-
V
-
F
F
R
K
L
T
T
IFPLN
W
K
Y
R
K
A
L
S-LGC
Q
R
V
T
LH
K
N
M
F
L
T
Y
I
L
--
N
S
M
I
I
I
I
H
L
V
E
-VVPNG
E
L
V
-RRDPV
S
--------
C
K
I
L
H
F
F
H
Q
Y
M
-
M
A
C
N
Y
F
W
M
L
C
E
G
I
Y
L
H
T
L
I
V
V
AVFTE----K--
Q
---
R
L
R
-
W
Y
Y
L
-
L
GWGFPL
V
P
T
T
I
H
A
I
T
R
A
V
Y
----F----N--D
N
---
C
W
L
S
V
---
E
-------
T
--
H
-----------
L
----
L
Y
I
IH
G
P
V
M
A
A
L
V
V
N
F
F
F
L
L
N
I
V
R
V
L
V
T
K
M
-
R
----------
E
T
--
H
E
A
E
S
H
M
Y
L
K
A
V
K
A
T
M
I
L
V
P
LLG
I
Q
F
V
V
F
P
WR----P----S----N--
K
-----------
M
-----
L
G
K
-
I
------
Y
D
Y
V
M
H
S
L
I
H
F
Q
G
F
F
V
A
T
I
Y
C
F
CNN
E
V
Q
T
T
V
K
R
Q
W
A
Q
F
K
I
Q
WNQRWGRRPSNRS
A
R
A
AAAAAEAGD
I
P
I
Y
I
CHQEPRNEPANNQGEESA
E
I
I
P
L
N
I
I
EQESSA
57
Fugue
71.71
21%
-98
- C3 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
-------------
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
C
---
L
R
N
I
I
H
A
N
L
I
A
A
F
I
L
R
N
A
T
W
F
-
V
V
Q
L
T
M
S
P
E
V
H
Q
S
N
V
G
W
C
R
L
V
T
A
A
Y
N
Y
F
H
V
T
N
F
F
W
M
F
G
E
G
C
-
Y
L
H
T
A
I
V
L
--
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
--
Y
T
I
GIG
H
L
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
I
G
R
N
S
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
-
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
S
A
L
I
N
M
V
F
Q
M
G
E
--
T
G
V
A
G
F
T
N
S
L
R
-
M
L
Q
Q
K
-----
R
W
D
E
A
--------
A
V
N
L
A
K
S
R
W
Y
N
-
Q
T
P
N
R
A
K
R
V
I
A
T
F
R
T
G
T
W
----
D
A
Y
D
----
R
--
L
---
R
A
W
-
M
F
I
C
-
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
L
Y
Y
----
D
----
N
--
E
K
---
C
W
A
G
K
---
R
PG-----
V
--
Y
-----------
T
----
D
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
-
R
----------
A
S
--
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
-----------
V
----
N
--
E
-----------
V
-----
S
R
V
-
V
------
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
------------------------------------------------------------------------------
25
PsiBlast_CBE
69.53
38%
-118
- C3 -
4K5Y
2
CRFR1_HUMAN
C:
[279-422]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
R
L
R
A
W
M
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
L
Y
Y
----
D
----
N
--
E
K
---
C
W
A
G
K
---
R
PG-----
V
--
Y
-----------
T
----
D
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
-
R
----------
A
S
--
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
----
P
----
G
----
E
--
D
-----------
E
-----
V
S
R
V
V
------
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
-------------------------------------------------------------------------------
60
Fugue
68.04
20%
-95
- C1 -
4R33
5
?
A:
[35-418]
G
D
F
V
L
P
E
L
E
D
V
R
A
E
A
A
-----
T
V
D
T
R
A
V
L
A
L
A
E
G
E
E
P
A
E
S
R
A
A
V
A
L
A
L
W
E
D
R
S
-------
I
G
T
A
E
L
Q
A
A
A
E
A
R
C
G
A
R
R
P
R
L
H
T
-----------------------------
F
V
P
L
Y
T
T
N
Y
C
D
--
S
E
--
C
K
M
C
S
M
R
K
------------
G
N
H
R
L
---
D
R
K
F
S
G
----
R
K
E
I
T
E
Q
L
E
I
L
Y
H
H
E
G
V
R
G
V
G
F
L
T
G
E
Y
-
E
D
K
H
T
R
L
A
S
A
F
R
I
G
W
A
I
R
T
A
L
D
-
L
G
F
E
R
V
Y
F
N
--------
I
--
G
S
M
----
E
Q
D
E
-
I
D
V
L
G
E
W
I
G
R
E
D
P
V
T
--------
M
C
V
--
F
Q
E
S
Y
D
-
R
E
T
Y
R
R
F
M
G
K
T
S
V
G
-----
V
P
K
A
D
F
D
----
R
--
R
---
V
V
S
-
F
D
R
W
-
L
D
A
G
Y
R
Y
V
N
P
G
V
-----
L
V
G
----
L
----
H
--
D
D
------
L
S
---
A
-------
E
--
L
-----------
V
----
S
L
V
A
H
G
D
H
L
R
S
R
G
A
T
A
D
L
S
V
P
R
M
R
P
A
M
-
K
S
-
R
----------
D
T
--
T
R
V
G
D
D
D
Y
L
R
L
M
S
V
V
A
F
T
C
P
---
E
Q
R
L
V
L
T
T
R
----
E
----
P
----
Q
--
E
-----------
F
-----
Q
D
V
-
A
------
L
G
L
A
--
G
V
I
S
P
G
S
P
D
V
A
P
Y
----
R
A
G
C
E
A
R
N
D
E
K
S
S
Q
F
L
V
---------
A
D
L
R
R
P
R
H
I
L
G
R
I
E
A
S
G
T
P
V
D
--------
H
F
V
N
P
A
G
E
A
S
R
--------------
22
PsiBlast_CBE
67.46
64%
-32
- C4 -
4RWG
1
CALRL_HUMAN (first)
B:
[479-587]
------------------------------------------------------------
V
T
R
N
K
I
M
T
A
Q
Y
E
-
C
Y
Q
K
I
M
Q
D
P
I
Q
Q
A
E
G
V
Y
C
N
R
T
W
D
G
W
L
C
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
P
--
S
E
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
---
C
N
V
N
T
H
E
K
V
K
T
A
L
N
L
F
Y
L
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.39
31%
-154
- C3 -
4L6R
1
GLR_HUMAN
A:
[153-393]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
C
T
R
N
A
I
H
A
N
L
F
A
S
F
V
L
K
A
S
S
V
L
V
I
D
G
L
L
R
-
T
--------------LSDGAVA
G
C
R
V
A
A
V
F
M
Q
Y
G
-
I
V
A
N
Y
C
W
L
L
V
E
G
L
Y
L
H
N
L
L
G
L
A
T
L
P
E
----
R
--
S
---
F
F
S
-
L
Y
L
G
-
I
G
W
G
A
P
M
L
F
V
V
P
W
A
V
V
K
C
L
F
----
E
----
N
--
V
Q
---
C
W
T
S
N
---
D
-------
N
M-
G
-----------
F
----
W
W
I
L
R
F
P
V
F
L
A
I
L
I
N
F
F
I
F
V
R
I
V
Q
L
L
V
A
K
L
-
R
----------
A
R
--
Q
M
H
H
T
D
Y
K
F
R
L
A
K
S
T
L
T
L
I
P
L
L
G
V
H
E
V
V
F
A
F
V
----
T
----
D
----
E
--
H
-----------
A
-----
Q
G
T
-
L
R
S
A
K
L
F
F
D
L
F
L
S
S
---
F
Q
G
L
L
V
A
V
L
Y
C
F
L
N
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
------------------------------------------------------
2
PsiBlast_PDB
65.89
64%
-33
- C4 -
4RWF
2
A:
[477-570]
------------------------------------------------------------
V
T
R
N
K
I
M
T
A
Q
Y
E
-
C
Y
Q
K
I
M
Q
D
P
I
Q
Q
A
E
G
V
Y
C
N
R
T
W
D
G
W
L
C
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
P
--
S
E
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
---
C
N
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
65.41
64%
-23
- C4 -
4RWG
-
CALRL_HUMAN (first)
A:
[479-573]
------------------------------------------------------------
V
T
R
N
K
I
M
T
A
Q
Y
E
-
C
Y
Q
K
I
M
Q
D
P
I
Q
Q
A
E
G
V
Y
C
N
R
T
W
D
G
W
L
C
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
P
--
S
E
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
---
C
N
V
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.65
64%
-27
- C4 -
3N7P
5
CALRL_HUMAN
A:
[18-110]
------------------------------------------------------------
V
T
R
N
K
I
M
T
A
Q
Y
E
-
C
Y
Q
K
I
M
Q
D
P
I
Q
Q
A
E
G
V
Y
C
N
R
T
W
D
G
W
L
C
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
P
--
S
E
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
---
C
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
62.99
65%
-33
- C4 -
3N7R
1
CALRL_HUMAN
B:
[18-111]
------------------------------------------------------------
V
T
R
N
K
I
M
T
A
Q
Y
E
-
C
Y
Q
K
I
M
Q
D
----
A
E
G
V
Y
C
N
R
T
W
D
G
W
L
C
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
P
--
S
E
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
---
C
N
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.07
65%
-32
- C4 -
3N7S
1
CALRL_HUMAN
A:
[18-110]
------------------------------------------------------------
V
T
R
N
K
I
M
T
A
Q
Y
E
-
C
Y
Q
K
I
M
Q
D
P
I
---
E
G
V
Y
C
N
R
T
W
D
G
W
L
C
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
P
--
S
E
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
---
C
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
61.78
65%
-30
- C4 -
3N7S
2
CALRL_HUMAN
B:
[18-112]
------------------------------------------------------------
V
T
R
N
K
I
M
T
A
Q
Y
E
-
C
Y
Q
K
I
M
Q
D
----
A
E
G
V
Y
C
N
R
T
W
D
G
W
L
C
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
P
--
S
E
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
---
C
N
V
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.47
65%
-39
- C4 -
3N7R
1
CALRL_HUMAN
A:
[18-110]
------------------------------------------------------------
V
T
R
N
K
I
M
T
A
Q
Y
E
-
C
Y
Q
K
I
M
Q
D
P
------
V
Y
C
N
R
T
W
D
G
W
L
C
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
P
--
S
E
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
---
C
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
56.38
13%
-87
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
--
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
V
Q
H
K
K
L
-----------------------------------------------------------------------------------
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
-
L
-
H
G
Y
-----
F
V
F
G
-------
P
-
T
G
C
N
L
E
G
F
------
F
A
T
L
--
G
G
E
I
A
L
W
S
L
V
V
-
L
A
I
E
R
Y
V
V
-
V
C
K
P
M
S
---------
N
F
R
F
G
E
N
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
----------------------------
V
G
W
S
-
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
----
Y
----
T
--
P
H
---
E
E
T
N
N
---
E
-------
S
--
F
-----------
V
----
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
-
A
----------
Q
Q
--
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
----
G
----
V
----
A
--
F
-----------
Y
-----
I
F
T
-
H
------
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
---------------------------
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
------
S
Q
V
A
P
A
36
HHSearch
53.30
11%
-148
- C3 -
2Z73
5
OPSD_TODPA
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
-
T
-
K
T
K
----------------
S
-
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
--
F
S
L
V
N
G
F
P
L
M
T
-
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
--------
C
K
V
Y
G
F
I
G
G
I
F
-
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
--
R
---
R
A
F
-
I
M
I
I
-
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
----
L
--
C
N
---
C
S
F
D
Y
---
I
-------
S
--
R
D
S
T
T
R
S
N
I
L
C
M
F
----
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
-
A
M
A
K
RLNAKE
L
R
K
--
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
----
A
----
L
L
A
Q
F
G
PL
E
-----------
W
-----
V
T
P
-
Y
------
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
----------------------------------------
63
Fugue
52.36
10%
-70
- C2 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
---------
G
T
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
-
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
-
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
S
G
Q
C
--
E
V
P
L
V
R
T
D
N
P
K
S
W
Y
------
E
D
V
E
G
C
G
I
Q
---
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
-
A
-
D
W
R
N
S
-----
N
R
Y
P
A
V
I
L
F
Y
-
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
D
--
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
-
S
N
E
T
L
S
--------
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
Y
Q
----
P
--
G
---
K
T
S
-
Y
F
H
L
-
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
----
G
----
D
--
S
V
SG
I
C
F
V
G
Y
---
K
-------
N
-------------------
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
-
F
----------
S
I
--
K
S
N
H
P
G
L
-
L
S
E
K
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
----
G
----
F
----
V
--
L
-----------
I
-----
T
F
S
-
C
------
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
-----------------------------------
49
HHSearch
50.70
11%
-138
- C3 -
2KS9
1
NK1R_HUMAN
A:
[37-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
-
L
-
A
H
K
----------------
R
-
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
--
M
A
A
F
N
T
V
V
N
F
T
-
Y
A
-
V
H
N
E
W
-
Y
Y
G
L
F
Y
--------
C
K
F
H
N
F
F
P
I
A
A
-
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
----
L
S
A
T
---
A
T
K
-
V
V
I
C
-
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
----
T
MPS-
R
--
V
V
---
C
M
I
E
W
PEH
P
-------
N
--
K
IY
E
K
V
Y
H
I
C
V
-
T
----
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
----------
D
R
--
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
----
F
----
L
L
P
Y
I
N
--
P
-----------
D
LYLKK
F
I
Q
-
Q
------
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
------------------------
32
HHSearch
48.82
21%
-5
* C4 *
2QKH
1
GIPR_HUMAN
A:
[26-119]
-------------------------------------------------------
G
Q
T
A
G
E
L
Y
Q
R
W
E
R
Y
R
R
E
-
C
Q
E
T
L
A
A
A
E
--
P
P
S
G
L
A
C
N
G
S
F
D
M
Y
V
C
W
D
Y
A
A
P
N
A
T
A
R
A
S
C
P
W
Y
L
P
W
H
H
H
VA
A
G
F
V
L
R
Q
C
G
S
D
G
Q
W
G
-------
L
W
R
D
H
T
Q
---
C
E
N
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
47.90
38%
-123
- C3 -
4K5Y
7
CRFR1_HUMAN (first)
B:
[279-423]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
R
L
R
A
W
M
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
L
Y
Y
----
D
----
N
--
E
K
---
C
W
A
G
K
---
R
----------
Y
-----------
T
----
D
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
-
R
----------
A
S
--
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
------------------------------------------
V
------
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
------------------------------------------------------------------------------
51
HHSearch
47.57
14%
-127
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[42-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
-
L
-
Y
S
R
----------------
V
-
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
--
F
A
L
T
L
P
I
W
-
A
A
-
S
--
K
V
N
G
W
-
I
F
G
T
F
L
--------
C
K
V
V
S
L
L
K
E
V
N
-
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
----
T
--
Q
K
R
H
L
V
K
-
F
V
C
L
-
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
----
H
PNNS
S
--
P
V
---
C
Y
E
V
L
GN-
D
-------
T
AK
W
RMVLRILP---
H
----
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
----
L
R
T
L
F
K
A
--------------------
H
M
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
----
L
L
A
D
T
L
----
M
--
R
TQVIQE
S
C
E
R
R
N
-----
N
I
G
-
R
------
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
----------------------------------------------------------------
46
HHSearch
46.74
9%
-127
- C3 -
1U19
14
OPSD_BOVIN
A:
[45-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
-
V
-
Q
H
K
----------------
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
F
T
T
T
L
Y
-
T
S
-
L
H
G
Y
F
-
V
F
G
P
T
G
--------
C
N
L
E
G
F
F
A
T
L
G
-
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
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M
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F
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-
E
--
N
---
H
A
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-
M
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-
F
T
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M
A
L
A
C
A
A
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P
L
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W
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R
Y
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--
E
----
G
MQ
C
S
---
C
G
I
D
Y
---
Y
TPHEETN
N
E
S
F
-----------
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
----
T
V
K
E
A
A
-
A
----------
Q
Q
QE
S
A
T
T
Q
K
A
E
K
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T
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M
V
I
I
M
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I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
----
T
H
---
Q
G-
S
-----------
D
-----
F
G
P
-
I
------
F
M
T
I
P
A
F
F
A
K
T
S
A
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Y
N
P
V
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Y
I
M
M
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K
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R
N
C
M
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T
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C
C
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N
P
L
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D
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A
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S
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A
P
A
-----------------------------------------