@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CALRL_HUMAN: (2016-01-09 )
MEKKCTLNFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
Atome Classification :
(20 SA)
---------------------------------------.........10.-----...-------....20........30.-----------------.......------40........--50........60..--......70--------...--.....80........90--........-100.......110.----......120.......130-----....---...140.......150...-----------....160.......170.......180...--..---..190..------.-.....200..-------------.....210-------........220.......230........240......----.--250.......260.......270...-..----..280....-----------------.-------.-----------.------290---------......--.300..-.....310...-----....320----------........330.......340.......350..----.-.-.----.-----.360----...-......370..-------------.....380-----.......-.390.......400.......410.......420......--.430.......440.......450.---------......460------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------MEKK
C
T
L
N
F
L
V
L
-----
L
P
F
-------
F
M
I
L
V
T
A
E
LEESPED
S
I
-----------------
Q
LGVTRN------
K
I
M
T
A
Q
Y
E
C
Y
--
Q
K
I
M
Q
D
P
I
Q
Q
AE
G
V
--
Y
CNRTWDG--------
W
L
C
--WNDVAAGT
E
S
M
QL
C
P
D
Y
--
F
QDFD
P
S
E
-
K
V
T
K
I
C
DQDGNWFR----HPASNRTW
T
N
Y
T
Q
CNV
N
T
H
-----
E
K
V
K
---
T
A
L
N
L
F
Y
L
T
IIGH
G
L
S
I
A
S
-----------
L
L
I
S
L
G
I
F
F
Y
F
KSL
S
C
Q
R
I
T
LH
K
N
L
F
F
S
F
V
--
C
N
---
S
V
V
T
-
I
I
------
H
-
L
T
A
VANN
Q
A
L
-------------
V
ATNPV
S
--------
C
K
V
S
Q
F
I
H
L
Y
LMG
C
N
Y
F
W
M
-
L
C
E
G
I
Y
L
H
T
L
I
V
V
A
V
F
AE----K--
Q
H
L
M
W
Y
Y
F
LGWG
F
P
L
I
P
A
C
I
H
A
I
A
R
S-LY----YND
N
C
W
ISS-----------------D-------
T
-----------
H
------
L
L
Y
---------
I
IHG
P
I
--
C
A
A
L
L
V
-
N
L
F
F
L
L
N
I
V
R
V
-----
L
I
T
K
L
-
K
----------
V
T
HQAES
N
L
Y
M
K
A
V
R
A
T
L
I
L
V
P
LLG
I
E
F
V
L
I
PW----R-P-E----G-----
K
I
------
A
E
E
-
V
Y
D
Y
I
M
H
I
L
M
H
-------------
F
Q
G
L
L
V
S
------
T
I
F
C
F
FN-
G
E
V
Q
A
I
L
R
RNW
N
Q
Y
K
I
Q
FGNSFS
N
S
E
A
L
RSA
S
Y
T
V
S
TISD--GPGYSHDCPSEHLNGK
S
I
H
D
I
E
N
V
L---------LKPENLYN-------------------------------------------------
5
PsiBlast_PDB
77.77
32%
-163
- C2 -
4L6R
1
GLR_HUMAN
A:
[152-393]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
H
C
T
R
N
A
I
H
A
N
L
F
A
S
F
V
L
K
A
S
---
S
V
L
V
-
I
D
------
G
-
L
L
R
T
--------------------------LSDGAVA
G
C
R
V
A
A
V
F
M
Q
Y
G
I
V
A
N
Y
C
W
L
-
L
V
E
G
L
Y
L
H
N
L
L
G
L
A
T
L
P
E
----
R
--
S
F
F
S
L
Y
L
G
I
G
W
G
A
P
M
L
F
V
V
P
W
A
V
V
K
C
-
L
F
----
E
N
V
Q
C
W
T
S
N
-----------------
D
-------
N
M----------
G
------
F
W
W
---------
I
L
R
F
P
V
--
F
L
A
I
L
I
-
N
F
F
I
F
V
R
I
V
Q
L
-----
L
V
A
K
L
-
R
----------
A
R
Q
M
H
H
T
D
Y
K
F
R
L
A
K
S
T
L
T
L
I
P
L
L
G
V
H
E
V
V
F
A
F
VTDE
H
-
A
-
Q
----
G
-----
T
L
R
S
----
A
K
L
-
F
F
D
L
---
F
L
S
S
-------------
F
Q
G
L
L
V
A
------
V
L
Y
C
F
L
N
-
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
75.21
40%
-137
- C2 -
4K5Y
2
CRFR1_HUMAN
C:
[289-422]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
L
-
Y
Y
----
D
N
E
K
C
W
A
G
K
RP---------------
G
-------
V
-----------
Y
------
T
D
Y
---------
I
Y
Q
G
P
M
--
A
L
V
L
L
I
-
N
F
I
F
L
F
N
I
V
R
I
-----
L
M
T
K
L
-
R
----------
A
S
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
----
N
-
P
G
E
----
D
-----
E
V
------
S
R
V
-
V
F
I
Y
F
N
A
F
L
E
S
-------------
F
Q
G
F
F
V
S
------
V
F
A
C
F
L
N
--------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.60
97%
-34
- C3 -
3N7P
6
CALRL_HUMAN
A:
[11-110]
-------------------------------------------------------------------------------
E
D
S
I
-----------------
Q
L
G
V
T
R
N
------
K
I
M
T
A
Q
Y
E
C
Y
--
Q
K
I
M
Q
D
P
I
Q
Q
A
E
G
V
--
Y
C
N
R
T
W
D
G
--------
W
L
C
--
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
--
F
Q
D
F
D
P
S
E
-
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
----
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.47
100%
-46
- C3 -
3N7R
1
CALRL_HUMAN
A:
[14-110]
----------------------------------------------------------------------------------
I
-----------------
Q
L
G
V
T
R
N
------
K
I
M
T
A
Q
Y
E
C
Y
--
Q
K
I
M
Q
D
P
------
V
--
Y
C
N
R
T
W
D
G
--------
W
L
C
--
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
--
F
Q
D
F
D
P
S
E
-
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
----
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.42
100%
-42
- C3 -
3N7S
2
CALRL_HUMAN
B:
[14-112]
----------------------------------------------------------------------------------
I
-----------------
Q
L
G
V
T
R
N
------
K
I
M
T
A
Q
Y
E
C
Y
--
Q
K
I
M
Q
D
----
A
E
G
V
--
Y
C
N
R
T
W
D
G
--------
W
L
C
--
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
--
F
Q
D
F
D
P
S
E
-
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
----
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
V
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.23
100%
-50
- C3 -
3N7S
1
CALRL_HUMAN
A:
[14-110]
----------------------------------------------------------------------------------
I
-----------------
Q
L
G
V
T
R
N
------
K
I
M
T
A
Q
Y
E
C
Y
--
Q
K
I
M
Q
D
P
I
---
E
G
V
--
Y
C
N
R
T
W
D
G
--------
W
L
C
--
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
--
F
Q
D
F
D
P
S
E
-
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
----
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.73
100%
-47
- C3 -
3N7R
1
CALRL_HUMAN
B:
[16-111]
-----------------------------------------------------------------------------------------------------
L
G
V
T
R
N
------
K
I
M
T
A
Q
Y
E
C
Y
--
Q
K
I
M
Q
D
----
A
E
G
V
--
Y
C
N
R
T
W
D
G
--------
W
L
C
--
W
N
D
V
A
A
G
T
E
S
M
Q
L
C
P
D
Y
--
F
Q
D
F
D
P
S
E
-
K
V
T
K
I
C
D
Q
D
G
N
W
F
R
----
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
70.14
16%
-109
- C2 -
4S3Q
7
?
A:
[2-691]
ES
K
R
L
D
N
A
A
L
A
A
GISP
N
Y
I
N
AHG
K
P
Q
S
I
S
A
E
T
K
R
R
L
L
D
A
M
H
Q
T
P
V
P
N
V
M
V
Y
T
S
G
K
K
M
P
M
V
V
E
G
S
G
E
Y
S
W
L
L
T
T
E
E
G
T
Q
Y
K
G
H
V
T
GG
K
A
F
N
L
P
TKLPE
G
Y
H
T
L
T
L
T
Q
D
D
Q
R
A
H
C
R
V
I
V
A
P
K
R
C
Y
EP
Q
A
L
L
N
K
Q
K
L
W
G
A
C
V
QL
Y
T
L
R
S
E
K
N
--------
W
G
I
GD
F
G
D
L
K
A
M
L
V
D
V
A
K
R
G
G
S
--
F
I
G
L
N
P
I
H
-
A
L
Y
P
A
N
P
E
S
A
S
P
Y
------
S
P
S
S
R
R
W
L
N
V
I
Y
I
D
V
N
A
V
-----
E
D
F
H
L
S
E
E
A
Q
A
W
W
Q
L
P
T
T
Q
Q
T
L
Q
Q
A
R
D
ADWVD
Y
S
T
V
T
A
L
K
M
T
A
L
R
M
A
W
K
G
F
A
-
Q
R
D
D
E
Q
M
A
A
F
R
Q
F
V
--
A
E
Q
G
D
S
L
F
W
-
Q
A
------
A
-
F
D
A
L
H
A
Q
Q
V
K
E
DEMRWGWPAWP
E
M
Y
Q
N
V
D
S
--------
P
E
V
R
Q
F
C
E
E
H
R
D
D
V
D
F
Y
L
W
-
L
Q
W
L
A
Y
S
Q
F
A
A
C
W
E
I
S
Q
G
----
Y
--
E
-
M
P
I
G
L
Y
R
D
L
A
V
G
V
A
E
G
G
A
E
T
W
C
D
R
-
E
L
----
Y
C
L
K
A
S
V
G
A
P
PDILGPLGQNWG
L
P
P
M
D
-------
P
-----------
H
------
I
I
T
A
R
AY
E
P
F
I
E
L
L
R
A
N
M
QN
C
G
A
L
R
I
D
H
V
M
S
M
L
R
L
W
W
I
PYGET
A
D
Q
G
A
-
Y
----------
V
H
Y
P
V
D
D
L
L
S
I
L
A
L
E
S
K
R
H
R
C
M
V
I
G
E
D
L
G
T
V
P
V
----
E
-
I
-
V
----
G
-----
K
L
------
R
S
S
G
V
Y
S
Y
K
V
L
Y
F
E
N
DHEKTFRAPKAYP
E
Q
S
M
A
V
A
ATHDLP
T
L
R
G
Y
W
E
C
G
D
L
T
L
G
K
T
L
G
L
Y
P
D
E
V
V
L
R
G
L
Y
Q
D
R
E
L
A
K
Q
G
L
L
D
A
L
H
K
Y
G
CL
P
K
R
A
G
H
K
A
S
L
M
S
M
T
P
T
L
N
R
G
L
Q
R
Y
I
A
D
SNSA
L
L
G
L
Q
P
E
D
W
L
D
MAEPVNIPGTSYQYKNWRRKLSAT
L
E
S
M
F
A
D
D
G
V
N
K
L
L
K
D
L
D
R
R
R
R
S
AH
61
Fugue
69.99
21%
-110
- C2 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
-----------------------------------H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
-----
L
V
A
-------
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
C
L
-----------------
R
N
I
I
H
A
N
L
I
A
A
F
-
I
L
R
N
A
T
W
F
V
V
--
Q
L
T
M
S
P
E
V
H
Q
S
N
V
G
--
W
C
R
L
V
T
A
A
Y
N
Y
F
H
V
T
N
F
F
W
--
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
T
N
I
--
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
IGIG
H
L
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
I
GRNS
N
G
V
I
---
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
-----------
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
S
A
L
I
N
M
V
F
Q
M
G
--
E
T
---
G
V
A
G
-
F
T
------
N
S
L
R
M
L
Q
Q
K
R
W
D
-------------
E
A
A
V
N
L
A
--------
K
S
-----
R
W
Y
N
Q
T
P
N
R
A
K
R
-
V
I
A
T
F
R
T
G
T
W
----
D
A
Y
D
----
R
--
L
R
A
W
M
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
L
-
Y
Y
----
D
N
E
K
C
W
A
G
K
-----------------
R
PG-----
V
-----------
Y
------
T
D
Y
---------
I
Y
Q
G
P
M
--
A
L
V
L
L
I
-
N
F
I
F
L
F
N
I
V
R
I
-----
L
M
T
K
L
-
R
----------
A
S
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
---------
V
----
N
-----
E
V
------
S
R
V
-
V
F
I
Y
F
N
A
F
L
E
S
-------------
F
Q
G
F
F
V
S
------
V
F
A
C
F
L
N
-
S
------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
65.21
14%
-144
* C2 *
2Z73
5
OPSD_TODPA
A:
[34-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
-----------
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
--
T
F
---
S
L
V
N
G
F
P
------
L
-
M
T
I
S
C
F
-
L
K
K
-------------
W
I
F
G
F
A
A
--------
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
-
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
--
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
-
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
-----------------
I
-------
S
RD
S
T
T
R
S
N
I
L
C
M
------
F
I
L
---------
G
F
F
G
P
I
--
L
I
I
F
F
C
-
Y
F
N
I
V
M
S
V
S
N
H
-----
E
K
E
M
A
-
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
----
V
A
L
-
L
----
A
Q
FGPL
E
W
------
V
T
P
-
Y
A
A
Q
L
P
V
M
F
A
K
-------------
A
S
A
I
H
N
P
------
M
I
Y
S
V
S
H
-
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
----------------------------------------------------------------------------------------------
67
Fugue
59.96
19%
-104
- C1 -
4KBL
6
ARI1_HUMAN
A:
[101-554]
---------------------------------------------
Y
R
Y
E
V
L
-----
T
A
E
-------
Q
I
L
Q
H
M
V
E
C
I
R
E
V
N
E
V
I
-----------------
Q
N
P
A
T
I
T
------
R
I
L
L
S
H
F
N
-------------------------
W
D
K
--------
E
K
L
--
M
E
R
Y
F
D
G
N
M
P
C
Q
I
C
-----
Y
L
N
Y
P
N
S
Y
-
F
T
G
L
E
C
G
-----------
H
K
F
C
M
Q
C
W
S
E
Y
L
T
T
K
I
M
E
E
-----
G
M
G
Q
---
T
------
I
S
C
P
A
H
G
C
D
I
--------------
L
V
D
D
N
T
V
M
R
L
I
T
D
S
K
V
K
L
K
Y
Q
H
L
I
T
N
S
F
V
E
-
C
N
---
R
L
L
K
-
W
C
PAPDCH
H
-
V
V
K
V
Q
Y
P
D
A
-----------------
K
P
V
R
--------
C
K
C
G
R
Q
F
C
---
F
N
C
G
E
N
W
H
D
P
V
K
C
K
W
L
K
K
W
I
K
K
C
I
A
A
N
----
T
--
K
E
C
P
K
C
H
V
---
T
I
E
K
D
G
G
C
N
H
M
V
C
R
---------
N
Q
N
C
---------------------
K
-------
A
-----------
E
------
F
C
W
---------
V
C
L
G
P
W
----
E
P
H
G
-
S
A
W
Y
N
C
N
R
Y
N
R
-----
S
R
A
A
L
-
Q
-----------
R
Y
L
F
Y
C
N
R
Y
M
N
H
M
Q
S
L
R
F
E
H
K
L
Y
A
Q
V
K
Q
K
M
E
W
------
I
-
E
----
V
-----
Q
F
------
L
K
K
-
A
V
D
V
L
C
Q
C
R
----------------
A
T
L
M
Y
T
------
Y
V
F
A
F
Y
L
-
K
K
---------
N
N
Q
S
I
I
F
E
N
---
N
Q
A
D
L
E
N
A
T
E
V
L
S
G
Y
L
E
---
R
D
I
S
Q
D
-
S
L
Q
D
I
K
Q
K
V
Q
D
K
Y
R
Y
C
E
---------
S
R
R
R
V
L
L
Q
H
V
H
E
G
YEKDLW--------------------------------------
63
Fugue
59.52
12%
-88
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
-----
F
S
N
-------
K
T
G
V
V
R
-----
S
P
F
E
A
P
-----------------
Q
Y
Y
L
A
E
P
------
W
Q
F
S
M
L
A
A
Y
M
--
F
L
L
I
M
L
G
F
P
I
N
F
L
T
--
L
Y
V
T
V
Q
-------------------------------------------------------------------------------
H
-----
K
K
L
R
---
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
---
G
E
I
A
-
L
W
------
S
-
L
V
V
L
A
I
E
R
Y
V
-------------
V
V
C
K
P
M
S
---------
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
-
M
A
L
A
C
A
A
P
P
L
-----------------------
V
G
W
S
-
R
Y
I
P
E
G
M
Q
C
S
C
G
I
-
D
Y
----
Y
T
P
H
E
E
T
N
N
-----------------
E
-------
S
-----------
F
------
V
I
Y
---------
M
F
V
V
H
F
--
I
I
P
L
I
V
-
I
F
F
C
Y
G
Q
L
V
F
T
-----
V
K
E
A
A
-
A
----------
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
----
A
-
G
-
V
----
A
-----
F
Y
------
I
F
T
-
H
Q
G
S
D
F
G
P
I
F
M
-------------
T
I
P
A
F
F
A
------
K
T
S
A
V
Y
N
-
P
V
I
Y
I
M
M
-----------------
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
--
N
P
L
G
D
D
E
------
A
S
T
T
V
S
K
T
E
T
S
Q
---------
V
A
P
A
-----------------------------------------------------
53
HHSearch
57.34
11%
-139
- C2 -
2KS9
1
NK1R_HUMAN
A:
[36-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
-----------
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
--
S
M
---
A
A
F
N
-
T
V
------
V
-
N
F
T
Y
A
V
H
N
-
E
-------------
W
Y
Y
G
L
F
Y
--------
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
-
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
----
L
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
-
T
E
TMP-
S
R
V
V
C
M
I
E
W
PEH--------------
P
-------
N
KIY
E
K
------
V
Y
H
I
C
V
-
T
V
L
---------
I
Y
F
L
P
L
--
L
V
I
G
Y
A
-
Y
T
V
V
G
I
T
L
W
A
S
-----
E
I
P
G
D
S
S
----------
D
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
----
F
F
L
-
L
----
P
Y
I
---
N
P
DLYLKK
F
I
Q
-
Q
V
Y
L
A
I
M
W
L
A
M
-------------
S
S
T
M
Y
N
P
------
I
I
Y
C
C
L
N
-
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
--
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
----------------------------------------------------------------------------
25
PsiBlast_CBE
51.89
40%
8
- C3 -
3C4M
2
B:
[451-516]
-----------------------------------------------------------------------------------------------------------------------------------------
G
R
--
P
C
L
P
E
W
D
H
--------
I
L
C
--
W
P
L
G
A
P
G
E
V
V
A
V
P
C
P
D
Y
--
I
Y
D
F
N
H
K
G
-
H
A
Y
R
R
C
D
R
N
G
S
W
E
L
----
V
P
G
H
N
R
T
W
A
N
Y
S
E
C
V
K
F
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.58
40%
-136
- C2 -
4K5Y
4
CRFR1_HUMAN (first)
A:
[289-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
L
-
Y
Y
----
D
N
E
K
C
W
A
G
K
RP---------------
G
-------
V
-----------
Y
------
T
D
Y
---------
I
Y
Q
G
P
M
--
A
L
V
L
L
I
-
N
F
I
F
L
F
N
I
V
R
I
-----
L
M
T
K
L
-
R
----------
A
S
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
----
N
--------------
E
V
------
S
R
V
-
V
F
I
Y
F
N
A
F
L
E
S
-------------
F
Q
G
F
F
V
S
------
V
F
A
C
F
L
N
-
S
------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
51.56
40%
9
- C3 -
3H3G
1
A:
[451-516]
-----------------------------------------------------------------------------------------------------------------------------------------
G
R
--
P
C
L
P
E
W
D
H
--------
I
L
C
--
W
P
L
G
A
P
G
E
V
V
A
V
P
C
P
D
Y
--
I
Y
D
F
N
H
K
G
-
H
A
Y
R
R
C
D
R
N
G
S
W
E
L
----
V
P
G
H
N
R
T
W
A
N
Y
S
E
C
V
K
F
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
51.51
40%
-148
- C2 -
4K5Y
7
CRFR1_HUMAN (first)
B:
[289-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
L
-
Y
Y
----
D
N
E
K
C
W
A
G
K
R------------------------------------
Y
------
T
D
Y
---------
I
Y
Q
G
P
M
--
A
L
V
L
L
I
-
N
F
I
F
L
F
N
I
V
R
I
-----
L
M
T
K
L
-
R
----------
A
S
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
---------------------------------
V
F
I
Y
F
N
A
F
L
E
S
-------------
F
Q
G
F
F
V
S
------
V
F
A
C
F
L
N
-
S
------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
50.63
10%
-137
- C2 -
1U19
14
OPSD_BOVIN
A:
[43-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-----------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--
F
M
---
V
F
G
G
-
F
T
------
T
-
T
L
Y
T
S
L
H
G
-
Y
-------------
F
V
F
G
P
T
G
--------
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
-
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
-
E
--
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G-
M
Q
C
S
C
G
I
D
Y
-----------------
Y
TPHEETN
N
-----------
E
S
F
V
I
Y
M
F
V
V
---------
H
F
I
I
P
L
--
I
V
I
F
F
C
-
Y
G
Q
L
V
F
T
V
-
K
E
-----
A
A
A
-
Q
-
Q
----------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
---
A
-
F
-
Y
I
F
T
H
Q
G----
S
D
------
F
G
P
-
I
F
M
T
I
P
A
F
F
A
K
-------------
T
S
A
V
Y
N
P
------
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------------------------------------------------------------------
10
PsiBlast_PDB
49.56
27%
-8
- C3 -
3C5T
2
GLP1R_HUMAN
A:
[6-103]
---------------------------------------------------------------------------------
T
V
-----------------
S
L
W
E
T
V
Q
------
K
W
R
E
Y
R
R
Q
C
Q
--
R
S
L
T
E
D
P
-
P
P
A
T
D
L
--
F
C
N
R
T
F
D
E
--------
Y
A
C
--
W
P
D
G
E
P
G
S
F
V
N
V
S
C
P
W
Y
LP
W
A
S
S
V
P
Q
G
-
H
V
Y
R
F
C
T
A
E
G
L
W
L
Q
----
K
D
N
S
S
L
P
W
R
D
L
S
E
C
E
E
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
49.37
27%
-2
- C3 -
3C59
1
GLP1R_HUMAN
A:
[6-103]
---------------------------------------------------------------------------------
T
V
-----------------
S
L
W
E
T
V
Q
------
K
W
R
E
Y
R
R
Q
C
Q
--
R
S
L
T
E
D
P
-
P
P
A
T
D
L
--
F
C
N
R
T
F
D
E
--------
Y
A
C
--
W
P
D
G
E
P
G
S
F
V
N
V
S
C
P
W
Y
LP
W
A
S
S
V
P
Q
G
-
H
V
Y
R
F
C
T
A
E
G
L
W
L
Q
----
K
D
N
S
S
L
P
W
R
D
L
S
E
C
E
E
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------