@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CASR_HUMAN: (2016-01-09 )
MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHQPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
Atome Classification :
(24 SA)
.........10........20........30........40........50........60--...-.-.-....70........80........90........100.......110...--....120.......130.......-140........150.......160.......170.......180.......190.......200.......210.......220.......230.-......240.......250..---..-.-..-260.........270.......280.......290........-300........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430....--..-.440.......450.......-460.-.-......470-----.----.--...------.--...480.......490.......500.......510......---.520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
F
Y
S
C
C
W
V
L
L
A
L
T
WHTSAYGP
D
Q
R
AQKKG
D
I
I
L
G
G
L
F
P
I
HFGVAAK
D
Q
D
L
KSRPES
V
E
C
---
I
R
Y-N-F-
R
G
F
R
W
L
Q
A
M
I
F
A
I
E
E
INSSPALLPNLTL
G
Y
R
I
F
D
T
C
N
T
V
S
K
A
L
E
A
T
L
S
F
V
--
A
QNKIDSL
N
L
D
E
FC
N
C
S
E
HIPS
T
I
-
A
-
V
VGATGS
G
V
S
T
A
V
A
N
L
L
G
L
F
YIPQVSYAS
S
S
R
LLSN
K
N
Q
F
K
S
F
L
R
TIPND
E
H
Q
A
T
A
M
A
D
I
I
E
Y
F
RWN
W
V
G
T
I
AADDDYGR
P
G
I
E
K
F
R
E
E
A
E
ER-
D
I
C
I
D
F
S
E
L
I
S
QYS
D
E
E
E
I
Q
H
---
V
V
-
E
-
V
I
-Q--NST
A
K
V
I
V
V
FSSGP
D
L
E
P
L
I
K
E
I
V
RRNIT
G
K
-
I
W
L
A
SEAW-AS-SS
L
I
A
M
P
Q
Y
F
H
VVGGT
I
G
F
A
L
KAGQIP
G
F
R
E
F
L
K
K
VHP
R
K
S
V
H
N
G
F
A
K
E
F
W
E
E
T
F
N
C
H
LQEGAKGPL
P
V
D
T
F
L
RGHEESGDRFSNSST
A
F
R
PLCTGDENISSVETP
Y
I
D
Y
T
H
L
R
I
S
Y
N
V
Y
L
A
V
Y
S
I
A
H
A
L
Q
D
I
Y
T
--CL-PGRGLFTNGSCA
D
I
K
K
V
E
A
W
Q
-
V
-
L
K
-
H
-
L
R
HLNFT-------N----N--MGE------
Q
--
V
T
F
D
E
C
G
D
L
VGN
Y
S
I
I
N
W
H
LSPEDG
S
I
V
F
K
EV
G
Y
Y
N
V
Y
AKKG---
E
R
L
F
INEE
K
I
L
WSGFSREVPFSNC
S
R
D
C
L
A
GTRKGIIEGEP
T
C
C
F
E
CVECPDGEYSDET
D
A
S
A
C
NKCPDDFWSNEN
H
T
S
C
I
A
K
E
I
E
FLSWTEP
F
G
I
A
L
T
L
F
A
V
L
G
I
F
L
T
A
F
V
L
G
V
F
I
KFRNT
P
I
V
K
ATNR
E
L
S
Y
L
L
L
F
S
L
L
C
C
FSSS
L
F
F
IGEPQ
D
W
T
C
R
LRQPAF
G
I
S
F
V
L
C
I
S
C
I
LVKTN
R
V
L
L
V
F
EAKIPT
S
F
H
R
K
W
WG
L
N
L
Q
F
L
L
V
F
L
C
T
F
M
Q
I
V
I
C
V
I
W
LYTAPPSSYRNQELED
E
I
I
F
I
T
CHEG
S
L
M
A
L
G
F
L
I
G
Y
T
C
L
L
A
A
I
C
F
F
F
A
F
K
SRKLPENFNE
A
K
F
I
T
F
S
M
L
I
F
F
I
V
W
I
S
F
I
P
A
Y
A
S
T
Y
G
K
F
V
S
A
V
E
V
I
A
I
L
A
A
S
F
G
L
L
A
C
I
F
FN
K
I
Y
I
I
L
F
KPSRN
T
I
E
E
V
R
C
S
T
A
A
H
A
F
K
V
A
A
R
A
T
L
R
RSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQ
P
E
R
Q
KQQQPLA
L
T
Q
Q
E
QQQQPLTL
P
Q
Q
Q
R
SQQQPRCK
Q
K
V
I
FGS
G
T
V
T
F
S
L
SFDEP
Q
K
N
A
M
AHRNSTHQNSLEAQKSSDTLTRHQPL
L
P
LQCGETDL
D
L
T
V
QETGLQGPVGGDQRPEVE
D
P
E
ELS
P
A
L
V
VSSSQ
S
F
V
I
SGGGS
T
V
T
E
N
VVNS
57
Fugue
93.61
35%
-89
- C2 -
2E4U
2
GRM3_RAT
A:
[6-543]
----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
----------
T
G
T
E
E
C
---
G
R
I
-
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
--
R
A
S
L
I
P
--------------
L
L
I
A
-
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
-
R
-
E
L
L
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
-
G
A
-
Q
E
S
I
-
V
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
-------------------------------
Q
V
C
D
K
H
L
A
I
D
S
S
-----
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
---
Q
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
-
E
Y
L
L
K
I
Q
F
T
-------
A
----
P
--
F
N
P
NKGADS
I
--
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
--
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
---------
E
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
-
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
90.43
33%
-89
- C2 -
2E4U
2
GRM3_RAT
A:
[7-543]
-----------------------
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
----------
G
T
E
E
C
---
G
R
I
N
E
-
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
--
R
A
S
L
--------------
I
P
L
L
I
A
-
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
-
R
-
E
L
-
L
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
-
S
F
-
T
W
V
A
S
D
G
W
-
G
A
-
Q
E
S
I
V
-
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
-------------------------------
Q
V
C
D
K
H
L
A
I
D
S
S
--
N
Y
---
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
T
---
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
Y
K
E
-
Y
-
L
L
K
I
Q
F
T
APFNPNK
G
----
A
--
D
S
I
---------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
--
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
---------
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
-
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
--
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.92
32%
-90
- C2 -
2E4W
2
GRM3_RAT
A:
[12-543]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
K
-----------
R
N
H
--------------
R
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
-
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.82
32%
-88
- C2 -
2E4Y
2
GRM3_RAT
A:
[12-543]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
K
-----------
R
N
H
--------------
R
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
-
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.78
32%
-87
- C2 -
2E4V
2
GRM3_RAT
A:
[12-543]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
RA
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
K
-----------
R
N
H
--------------
R
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
-
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
89.21
32%
-88
- C2 -
2E4U
2
GRM3_RAT
B:
[12-543]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
-------------------------------
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
-
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
89.10
32%
-86
- C2 -
2E4V
2
GRM3_RAT
B:
[12-543]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
K
-----------
R
N
H
--------------
R
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
-
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.94
32%
-90
- C2 -
2E4U
2
GRM3_RAT
A:
[12-543]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
RA
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
-------------------------------
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
-
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
88.91
32%
-89
- C2 -
2E4W
2
GRM3_RAT
B:
[12-543]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
K
-----------
R
N
H
--------------
R
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
-
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
88.76
32%
-88
- C2 -
2E4X
2
GRM3_RAT
B:
[12-543]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
K
-----------
R
N
H
--------------
R
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
-
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.43
32%
-86
- C2 -
2E4X
2
GRM3_RAT
A:
[12-543]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
RA
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
K
-----------
R
N
H
--------------
R
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
-
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
85.64
35%
-92
* C2 *
3SM9
8
GRM3_HUMAN
A:
[7-475]
------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-----------
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
--
R
A
S
-----------------
L
L
I
A
-
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
Y
D
S
---
V
I
-
R
-
E
L
-
L
Q
-
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
-
S
F
-
T
W
V
A
S
D
G
W
-
G
A
-
Q
E
S
I
I
-
K
G
S
E
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
----------------------------
H
R
R
V
C
D
K
H
L
A
I
D
S
-----
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
N
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
L
Y
-
K
D
-
Y
-
L
L
K
I
N
F
T
-------
A
----
P
FN
D
S
I
---------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
--
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
---------
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.52
30%
-99
- C2 -
5CNJ
2
?
A:
[31-490]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
V
H
---------
Q
K
G
G
P
-
A
E
D
C
---
G
P
V
-
N
E
H
-
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
--------
R
A
S
L
----------
P
T
A
I
T
G
-
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
A
R
-
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
G
---
V
V
-
R
A
L
L
-
Q
--
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
-
F
-
T
W
V
A
S
D
G
W
-
G
A
L
E
S
V
V
A
G
S
E
--
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
-------------------------------
S
F
R
Q
R
D
C
A
A
H
S
L
R
A
V
--
P
F
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
--
A
L
C
P
N
----
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
-
D
F
V
L
N
V
K
F
D
APFRP--
A
----
D
--
T
H
N
------
E
--
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
-
L
R
A
G
S
G
R
Y
R
Y
Q
K
V
G
Y
W
------
A
---
E
G
L
T
L
D
T
S
L
I
P
W
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.23
33%
-92
- C2 -
3SM9
8
GRM3_HUMAN
A:
[11-475]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
-
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
--------------------
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
I
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
--------------
H
--------------
R
R
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
C
P
N
----
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
APFN------------
D
S
------
I
--
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
-----------
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
HWA
E
T
L
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
84.41
32%
-87
- C2 -
2E4Y
1
GRM3_RAT
B:
[12-484]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
RA
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
V
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
H
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
K
-----------
R
N
H
--------------
R
Q
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
-
C
P
Q
---
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
Y
-
L
L
K
I
Q
F
T
-------
A
PFNP
N
--
K
G
A
------
D
SI
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
--
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
------
A
---
E
T
L
S
L
D
V
D
S
I
H
W
S
R
N
S
--
V
P
T
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.68
33%
-87
- C2 -
5CNK
4
?
B:
[38-501]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
RA
S
L
-------------------
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
I
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--------------------------------
R
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
C
P
N
----
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
APFNP----------
A
D
S
------
I
--
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
-----------
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
HWA
E
T
L
S
L
D
V
N
S
I
H
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.33
33%
-83
- C2 -
5CNK
5
?
A:
[38-502]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
I
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
-------------------------------
R
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
C
P
N
----
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
APFNP-----------
D
S
------
I
--
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
-----------
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
HWA
E
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
83.30
33%
-85
- C2 -
5CNK
3
?
C:
[38-502]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
RA
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
I
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
-------------------------------
R
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
C
P
N
----
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
APN----
K
----
D
--
A
D
S
------
I
--
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
-----------
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
HWA
E
T
L
S
L
D
V
N
S
I
H
W
S
S
V
P
T
S
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.13
33%
-85
- C2 -
4XAR
9
GRM3_HUMAN
A:
[38-502]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-------------------
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
I
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
--------------------------------
R
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
C
P
N
----
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
AP----------
D
--
A
D
S
------
I
--
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
-----------
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
V
P
T
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
82.94
29%
-81
- C2 -
1EWK
5
GRM1_RAT
A:
[4-480]
----------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
--------
I
R
-
E
-
Q
-
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
--
R
K
-------------------
P
I
A
-
G
-
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
-
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
---
L
L
-
R
-
K
L
-
R
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
L
I
G
S
D
G
W
-
A
D
-
R
D
E
V
I
-
E
G
Y
E
V
E
A
N
G
G
I
T
I
K
L
Q
S
P
E
V
R
S
F
D
D
Y
F
L
K
L
R
L
D
T
N
T
R
N
P
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
---------------------
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
------
N
Y
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
--
A
L
-
C
P
G
---
H
V
G
L
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
-
F
-
L
I
K
S
S
F
V
-------
G
----
V
--
S
G
E
------
E
--
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
-
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
---
D
D
Y
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.92
33%
-94
- C2 -
5CNM
5
?
A:
[38-497]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
I
N
----------
E
K
G
T
G
T
E
E
C
---
G
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-----------------
I
P
L
L
I
-
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
-
N
I
S
I
A
T
A
E
K
V
G
---
I
R
K
S
Y
D
S
---
V
I
R
E
-
L
L
-
Q
--
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
W
V
A
S
D
G
W
G
A
Q
-
E
S
I
I
K
G
S
E
--
H
V
A
Y
G
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
--------------
H
--------------
R
R
V
C
--
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
--
T
L
C
P
N
----
T
T
K
L
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
D
Y
-
L
L
K
I
N
F
T
APFNPN-
K
----
D
--
A
D
S
------
I
--
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
-----------
F
Q
------
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
82.88
30%
-94
- C2 -
5CNI
5
?
A:
[31-489]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
V
H
---------
Q
K
G
G
P
-
A
E
D
C
---
G
P
V
-
N
E
H
-
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
--------
R
A
S
------------
T
A
I
T
G
-
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
A
R
-
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
G
---
V
V
-
R
A
L
L
-
Q
--
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
-
F
-
T
W
V
A
S
D
G
W
-
G
A
L
E
E
V
V
A
G
S
E
--
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
-------------------------------
S
F
R
-
R
D
C
A
A
H
S
L
R
A
V
--
P
F
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
--
A
L
C
P
N
----
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
-
D
F
V
L
N
V
K
F
D
APFRP--
A
----
D
--
T
H
N
------
E
--
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
-
L
R
A
G
--
R
Y
R
Y
Q
K
V
G
Y
W
------
A
---
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.82
30%
-96
- C2 -
4XAS
1
GRM2_HUMAN
A:
[31-489]
----------------------------
E
G
D
L
V
L
G
G
L
F
P
V
H
---------
Q
K
G
G
P
-
A
E
D
C
---
G
P
V
-
N
E
H
-
R
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
--------
R
A
S
------------
T
A
I
T
G
-
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
A
R
-
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
G
---
V
V
-
R
A
L
L
-
Q
--
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
-
F
-
T
W
V
A
S
D
G
W
-
G
A
L
E
E
V
V
A
G
S
E
--
G
A
A
E
G
A
I
T
I
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
N
N
S
R
N
P
W
F
R
E
F
W
E
Q
R
F
R
C
-------------------------------
S
F
R
Q
R
D
C
A
A
H
S
L
R
A
V
--
P
F
E
Q
E
S
K
I
M
F
V
V
N
---
A
V
Y
A
M
A
H
A
L
H
N
M
H
R
--
A
L
C
P
N
----
T
T
R
L
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
-
D
F
V
L
N
V
K
F
D
APFRP--
A
----
D
--
T
H
N
------
E
--
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
F
T
Y
-
L
R
A
G
-
G
R
Y
R
Y
Q
K
V
G
Y
W
------
A
---
E
G
L
T
L
D
T
S
L
I
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.50
31%
-97
- C2 -
2E4Z
1
GRM7_RAT
A:
[14-479]
----------------------------
E
G
D
V
T
L
G
G
L
F
P
V
H
----------
A
K
G
P
S
G
V
P
C
GDI
K
R
E
-
N
----
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
T
F
V
---
Q
A
L
I
Q
K
------------
P
E
K
V
V
-
G
-
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
Q
S
V
R
I
P
------
T
I
D
F
D
R
I
I
K
-
Q
-
L
L
-
D
--
T
P
N
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
Q
V
G
H
F
L
W
V
G
S
D
S
W
-
G
--
S
K
I
N
P
L
H
Q
H
E
D
I
A
E
G
A
I
T
I
Q
P
K
R
A
T
V
E
G
F
D
A
Y
F
T
S
R
T
L
E
N
N
R
R
N
V
W
F
A
E
Y
W
E
E
N
F
N
C
K
----------------------------------
K
C
T
G
Q
E
R
I
G
K
-
D
S
N
Y
E
Q
E
G
K
V
Q
F
---
V
I
D
A
V
Y
A
M
A
H
A
L
H
H
M
N
K
D
L
C
---
Y
R
G
V
-----
C
P
E
M
E
Q
A
G
G
K
K
-
L
-
L
K
-
Y
-
I
R
H
V
N
F
N
-------
G
----
S
--
A
G
T
------
P
--
V
M
F
N
K
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
Q
T
T
N
T
T
N
P
-------
G
Y
R
L
I
G
Q
W
T
---
D
E
L
Q
L
N
I
E
D
M
Q
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------