@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CCKAR_HUMAN: (2016-01-09 )
MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ
Atome Classification :
(20 SA)
.--...--.....10........20........30........40........50.......---.60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170......--.180.......190.........200---..-..---.....210.......220.......230.....--..240........250...---..-.-----------.---260----------------.-------------------------------.-----.------.---------.------..--..270------.------------.-.------------------.-----.------------------------------------..------------------------------.-----.-------------------------------280------------------------------.------------.---..---.----------.--.--------------------.------------.---------290-------.---.-----------------..-----.---------....300......--.310.......---320.......330.......340------.......350....------------------------..--.360.......370.......380.......390........400.......410.......420......--------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M--D
V
V
--
D
S
L
L
VNGSNITPPCELGLEN
E
T
L
F
C
LDQPRPS
K
E
W
Q
P
A
V
Q
I
L
L
Y
S
L
I
F
L
L
S
V
LG---N
T
L
V
I
T
V
L
IRNKR
M
R
T
V
T
N
I
F
L
L
S
L
A
V
S
D
L
M
L
C
L
F
C
M
P
F
N
L
I
P
N
L
L
K
D
F
IFGS
A
V
C
K
T
T
T
Y
F
MG
T
S
V
S
V
S
T
F
N
L
V
A
I
S
L
E
R
Y
G
A
I
C
K
P
L
Q
S
R
V
W
QTKS
H
A
L
K
V
I
A
A
T
W
C
L
S
F
T
IMTPYP
I
--
Y
SNLVPFTKNNN--
Q
T
A
N
M
C
R
F
LL-----
P
N
-
D
V
---
M
Q
Q
S
W
H
T
F
L
L
L
I
L
F
L
I
P
G
I
V
M
M
V
A
Y
G
L
I
S
L
E
L
Y--QGI-KFEASQKKSAKERKP---ST-T-----------S---S------------------G-------------------------------K-----Y------E---------D------SD--G
C
Y
--------
L
------------Q-K------------------T-----R------------------------------------PP------------------------------R-----
K
-------------------------------
L
--------------------------------
E
------------
L
---
R
Q
---L----------S--T--------------------G------------S---------S---------
S
---
R
-----------------
A
N
-----R---------IRSNS
S
A
A
N
L
M
A
K
--
K
R
V
I
R
M
L
I
V
I
V
---
V
L
F
F
L
C
W
M
P
IFSANAWRAYDTA
S
------
A
ERRLSGTP
I
S
F
I
L
------------------------
L
L
--
S
Y
T
S
S
C
V
N
P
I
I
Y
C
F
MNK
R
F
R
L
G
F
M
A
TFPCCPNP-GPPGARGEVGEEEEGGTTGAS
L
S
R
F
SYSHMSASVPPQ--------------------------------------------------------------------
36
HHSearch
93.71
23%
-128
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
----------------------------------------------
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
-------------
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
--
R
Q
L
-
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
YYTIGIGHLLT
K
---
S
------------------
P
S
L
N
----------------------------
A
A
K
S
E
L
D
------
K
---------
A
------
I
G
--
R
N
T
NGVIT
K
D
E
A
------------
E
-
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
-----
K
------------------------------------
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
-----
R
-------------------------------
M
--------------------------------
L
------------
Q
---
Q
K
---
R
W
D
E
A
A
V
N
L
A
K
S
--
R
--------------------
W
------------
Y
---------
N
---------
Q
---
T
-----------------
P
N
-----
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
--
H
K
A
L
K
T
L
G
I
I
M
---
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
----------
I
R
K
E
V
Y
I
L
L
N
------------------------
W
I
--
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------
37
HHSearch
92.80
24%
-119
- C2 -
3EML
13
ENLYS_BPT4
A:
[20-472]
-------------------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
--
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
N
N
C
G
Q
---------
S
Q
G
C
G
E
G
Q
VACLF
E
D
-
V
V
---
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
--
R
Q
L
-
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
---
I
Y
-
K
-----------
D
---
T
EGYYTIGIGHLL------
T
-------------------------------
K
-----
S
------
P
S
L
-------
N
------
A
A
--
K
S
E
--------
L
D
K
A
I
GRNTNGVI
T
K
D
E
A
E
K
L
F
N
-----------
Q
-----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
------------------------------
T
G
V
A
G
F
T
-------------------------------
N
--------------------------------
S
------------
L
---
R
M
L
Q
Q
K
----------
R
W
D
E
--------------------
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
---------
P
---------
N
---
R
A
K
---------------
R
V
I
T
T
F
R
T
---------
G
T
W
D
A
Y
R
S
T
L
Q
K
E
--
V
H
A
A
K
S
L
A
I
I
V
---
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
------
S
--
H
A
P
L
W
L
M
Y
L
A
I
------------------------
V
L
--
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-
Q
--------------------------------------------------------------------------------------------------------
38
HHSearch
90.48
20%
-110
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-496]
----------------------------------------
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
---
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
L
P
F
W
A
V
D
A
V
-
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
--
F
A
N
V
S
E
-----
A
--
D
D
R
Y
I
C
D
R
F
Y
-----
P
N
-
D
L
---
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
--
H
S
G
-
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
---
K
I
-
Y
-----------
K
D
TE
G
------------------
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTN
G
-----
V
IT----
K
---------
D
E
-----
A
E
--
K
L
F
--------
N
------------
Q
-
D
------------------
V
D
----
A
A
V
R
G
I
L
R
N----------------------------
A
K
LK
P
V
--------------------------
Y
-----
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
--------------------------------
Q
------------
Q
---
K
R
---
W
----------
D
--
E
--------------------
A
------------
A
---------
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
----------
F
R
-----
T
---------
G
T
W
D
A
Y
G
S
K
G
H
Q
K
--
R
K
A
L
K
T
T
V
I
L
I
---
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
------------------------
A
L
--
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
-
E
V
L
F
Q
----------------------------------------------------------------------------------------------------
35
HHSearch
89.82
21%
-132
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[12-443]
------------------------------------------------
V
V
V
L
S
T
I
C
L
V
T
V
G
L
---
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
--
W
N
H
-----------
R
R
E
D
K
C
E
T
D
F
-----
Y
D
-
V
------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
--
Q
H
C
-
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
---
I
Y
-
K
-----------
D
---
T
EG
Y
Y
T
I
G
IGHLLTKSPS
L
N
-------------------------------
A
-----
A
------
K
S
E
L
D
K
A
I
GR
N
TNGVIT
K
D
--
E
A
E
--------
K
------------
L
-
F
N
-----------------
Q
-----
D
------------------------------------
V
D
A
A
V
---------------------------
R
-----
G
-------------------------------
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
------------
A
G
F
T
N
S
---
L
----------
R
--
M
--------------------
L
------------
Q
---------
Q
---------
K
---
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
-----
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
N
R
E
--
R
K
A
A
K
Q
L
G
F
I
M
---
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
------
C
----
N
E
H
L
H
M
F
T
I
------------------------
W
L
--
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------------------------------------------------------------------------
34
HHSearch
88.56
23%
-112
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[26-457]
-----------------------------------------------
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
--
F
W
Q
F
I
V
G
V
--
R
T
--
V
E
D
G
E
C
Y
I
Q
F
-----
F
S
-------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
--
S
R
I
-
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
---
I
Y
-
K
-----------
D
---
T
EG
Y
Y
T
I
GIGHLLTK----
S
-------------------------------
P
-----
S
L
N
A
A
K
S
E
L
D
K
------
A
I
GRNTN
G
V
IT
K
D
E
--------
A
------------
E
-
K
------------------
L
F
N
Q
D
V
D
------------------------------------
A
A
------------------------------
V
-----
R
-------------------------------
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
-----
Q
MG
E
T
G
V
A
G
F
T
N
S
L
---
R
M
---
L
----------
Q
--
Q
--------------------
K
------------
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
---
A
-----------------
K
R
V
I
T
T
F
R
---------
T
G
T
W
D
A
Y
P
P
P
S
R
E
--
K
K
V
T
R
T
I
L
A
I
L
---
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
------
I
----
P
N
T
V
W
T
I
G
Y
------------------------
W
L
--
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------------------------------------------------
56
Fugue
88.27
25%
-106
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
--
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
------
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G-
W
S
R
Y
I
P
E
G
M
Q
C
S
--
C
G
I
D
Y
--
Y
T
P
-----
H
E
-
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
--
E
A
A
-
A
S
A
T
T
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---------
G
S
D
F
G
P
I
F
M
T
I
P
A
------------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
-
S
T
T
-------
V
S
K
T
E
T
S
---------------
Q
V
A
P
A
--------------------------------------------------------------------
60
Fugue
87.01
20%
-87
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-
P
I
--
Q
M
H
W
Y
R
A
T
H
Q
E
A
--
I
N
C
Y
A
E
E
T
C
C
-----
D
F
-
F
T
----
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
--
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
---
Y
K
-
D
-----------
T
---
E
------------------
G
-------------------------------
Y
-----
Y
------
T
---------
I
------
G
I
--
G
H
L
--------
L
------------
T
-
K
------------------
S
-----
P
------------------------------------
S
L
------------------------------
N
-----
A
-------------------------------
A
--------------------------------
K
------------
S
---
E
L
---
D
----------
K
--
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
------------
V
---------
D
---------
A
---
A
-----------------
V
R
-----
G
---------
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
---
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
------
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC
L
K
--
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
-
L
P
F
F
I
V
N
I
V
H
V
I
Q
-
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
CL--------------------------------------------------------------
3
PsiBlast_PDB
86.17
25%
-112
- C- -
3C9L
13
OPSD_BOVIN
A:
[32-332]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
VG
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------------
K
E
A
A
A
Q
Q
Q
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D
F
G
----
P
I
F
M
T
I
P
A
----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---
D
D
E
-----------------------------------------------------------------------------------------------------
42
HHSearch
85.49
29%
-141
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
----------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
--
Y
S
T
T
E
T
-----
M
--
P
S
R
V
V
C
M
I
E
W
-----
P
E
-
H
P
NKI
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
--
A
S
E
-
I
P
G
D
S
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
Q
V
S
A
K
--
R
K
V
V
K
M
M
I
V
V
V
---
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
L
------
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
------------------------
W
L
--
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
-
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
--------------------------------------------------------------------
5
PsiBlast_PDB
85.36
25%
-134
- C2 -
3PQR
10
OPSD_BOVIN
A:
[32-326]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
V
G
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------------
K
E
A
A
A
Q
Q
Q
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D
F
G
----
P
I
F
M
T
I
P
A
----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------
55
Fugue
85.18
25%
-93
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
--
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
------
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G-
W
S
R
Y
I
P
E
G
M
Q
C
S
--
C
G
I
D
Y
--
Y
T
P
-----
H
E
-
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------
E
A
-----
A
---------
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
---------
G
S
D
F
G
P
I
F
M
T
I
P
A
------------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
-
L
----------
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
------
Q
V
A
P
A
--------------------------------------------------------------------
7
PsiBlast_PDB
84.79
25%
-133
- C2 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[32-326]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
V
G
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------------
K
E
A
A
A
Q
Q
Q
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D
F
G
----
P
I
F
M
T
I
P
A
----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.31
25%
-134
- C2 -
3DQB
7
GNAT1_BOVIN (first)
A:
[32-326]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
VG
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------------
K
E
A
A
A
Q
Q
Q
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D
F
G
----
P
I
F
M
T
I
P
A
----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
84.22
25%
-129
- C2 -
2I37
1
OPSD_BOVIN
A:
[32-329]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
VG
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----------------------
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D
F
G
----
P
I
F
M
T
I
P
A
----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
---
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
--------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.08
25%
-132
- C2 -
2I36
2
OPSD_BOVIN
A:
[32-326]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
VG
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------------
K
E
A
A
A
Q
Q
Q
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D
F
G
----
P
I
F
M
T
I
P
A
----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.90
25%
-111
- C- -
2I35
4
OPSD_BOVIN
A:
[32-332]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
VG
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------------
K
E
A
A
A
Q
Q
Q
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D
F
G
----
P
I
F
M
T
I
P
A
----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---
D
D
E
-----------------------------------------------------------------------------------------------------
62
Fugue
83.71
18%
-67
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
--------------------
P
C
F
-------------
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
---
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
-
L
P
F
-
W
A
V
D
A
V
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
-------
I
P
D
F
I
F
A
N
V
S
E
A
--
D
D
R
Y
I
C
D
R
F
Y
-----
P
N
-
D
L
---
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
HS
G
S
N
-
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
---
Y
K
-
D
-----------
T
---
E
------------------
G
-------------------------------
Y
-----
Y
------
T
---------
I
------
G
I
--
G
H
L
--------
L
------------
T
-
K
------------------
S
------------------------------------------
P
S
------------------------------
L
-----
N
-------------------------------
A
--------------------------------
A
------------
K
---
S
E
---
L
----------
D
--
K
--------------------
A
------------
I
---------
G
---------
R
---
N
-----------------
T
N
-----
G
---------
V
I
T
K
D
E
A
E
K
L
F
N
Q
--
D
V
D
A
A
V
R
G
I
L
R
NAK
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
------
G
E
T
G
V
A
G
F
T
N
S
L
R
M
------------------------
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
-
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
6
PsiBlast_PDB
83.55
25%
-133
- C2 -
3PXO
5
OPSD_BOVIN
A:
[32-326]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
VG
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------------
K
E
A
A
A
Q
Q
Q
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D
F
G
----
P
I
F
M
T
I
P
A
----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.22
25%
-132
- C2 -
3CAP
7
OPSD_BOVIN
A:
[32-326]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
V
G
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------------
K
E
A
A
A
Q
Q
Q
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------
S
D
F
G
----
P
I
F
M
T
I
P
A
----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
82.99
25%
-119
- C- -
3C9M
1
OPSD_BOVIN
A:
[32-327]
---------------------------------------
A
E
P
W
Q
F
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-
P
L
V
G
W
S
R
Y
I
P
---
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-------------
K
E
A
A
A
Q
Q
Q
E
---
S
A
-
T
-----------
T
----------------------------------------------------------------------------------------------------------------
Q
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
--
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
C
W
L
P
Y
----
A
G
V
A
F
Y
I
F
T
------
H
Q
G
S
C
F
G
-
P
I
F
M
T
I
PA----------------------
F
F
--
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
----------------------------------------------------------------------------------------------------------