@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CCR10_HUMAN: (2016-01-09 )
MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
Atome Classification :
(20 SA)
.........10........20........30........40....-....50...-------.....60........70........80........90..-......100.--.--.--....110.......120.......130.......140......-.150--........160.......170.......180...---..-.-..-190.....--..----------200...-....210...--....220.......230----.....----------------------------------------------------..------------------------------------------------.------------.--------------------------------------------------------------------------------------------------------------------------------------------------------------------240----------------------------------------.--.......250.....-------------..260---........270........280..----.....290.......300.-----......--------310......----------.320.......330.......340.......350......-.360------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGTEAT
E
Q
VSWGHYSGDEEDAYSAE
P
L
P
E
L
C
Y
K
A
D
V
Q
A
F
S
R
A
FQP-SV
S
L
T
V
A
A
L-------GLAGN
G
L
V
L
A
T
H
L
A
A
R
R
AARS
P
T
S
A
H
L
L
Q
L
A
L
A
D
L
L
L
A
L
-
T
L
P
F
A
AAGAL--Q--G--WSLG
S
A
T
C
R
T
I
S
G
L
Y
SA
S
F
H
A
G
F
L
F
L
A
C
ISAD
R
Y
V
A
I
A
R
ALPA-GPR---PSTP
G
R
A
H
L
V
S
V
I
V
W
L
L
S
L
L
L
A
L
P
A
L
L
FS-QDG
Q
---
R
E
-
G
-
Q
R-
R
C
R
L
IFPE--G
L
----------
T
Q
T
V
K
G
-
A
S
A
V
A
Q
V
A
L
G
--FAL
P
L
G
V
M
V
A
C
Y
A
L
L
------
G
R
T
L
L
----------------------------------------------------AA------------------------------------------------R------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
-----------------------------------------
R
--
R
R
A
L
R
V
V
V
A
L
V
A
A
F
V
-------------
V
L
QL----
P
Y
S
L
A
L
L
LD-
T
A
D
L
L
A
A
R
ERSCPA----SKRK
D
V
A
L
L
VTSG
L
A
L
A
R
C-----G
L
N
P
V
L
--------
Y
A
F
L
G
L
R
F
R
----------
Q
D
L
R
R
L
LRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSL-SWDN------------------------------------------------------------------------------------------------------
23
HHSearch
90.18
23%
-118
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
----------------------------------------
V
V
F
I
V
-
L
V
A
G
S
L
S
L
V
-------
T
I
I
G
N
I
L
V
M
V
S
I
K
V
-
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
-
G
--
Y
--
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
--
P
V
---
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
-
Q
F
I
V
GVR
T
V
-
E
-
D
G
-
E
C
Y
I
Q
F
F
S
--
N
----------------
A
-
A
V
T
F
G
T
A
I
A
A
--
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
------
S
R
A
S
K
----------------------------------------------------
S
R
------------------------------------------------
I
------------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP--
S
R
-----------------------------------------
E
--
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
-------------
I
T
W
A
----
P
Y
N
V
M
V
L
I
N
-
T
F
C
A
------
P
--------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
-----
T
I
N
P
A
C
--------
Y
A
L
C
N
A
T
F
K
----------
K
T
F
K
H
L
L
M
-------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
89.47
30%
-107
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-498]
-----------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
-
T
I
Y
S
I
I
F
L
T
-------
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
-
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
L
P
F
W
A
V
D
A
V
--
A
--
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
--
Q
R
---
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
-
N
V
S
E
---
A
D
-
D
-
R
Y
-
I
C
D
R
F
Y
P
N
--
D
L
-------------
W
V
V
-
V
F
Q
F
Q
H
I
M
V
G
--
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
------
I
S
K
L
S
----------------------------------------------------
H
S
------------------------------------------------
G
------------
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
-----------------------------------------
K
--
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
-------------
A
C
W
L
----
P
Y
Y
I
G
I
S
I
D
-
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
----
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
-----
C
L
N
P
I
L
--------
Y
A
F
L
G
A
K
F
K
----------
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
---------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.43
29%
-120
- C3 -
4MBS
8
CCR5_HUMAN (first)
A:
[21-361]
-------------------------
P
----
C
Q
K
I
N
V
K
Q
I
A
A
R
L
L
P
-
P
L
Y
S
L
V
F
I
F
-------
G
F
V
G
N
M
L
V
I
L
I
L
I
N
Y
K
R
L
-
K
S
M
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
-
T
V
P
F
W
A
H
Y
A
A
--
A
--
Q
--
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
R
---
T
V
T
F
G
V
--
V
T
S
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
I
F
T
-
R
-
S
Q
---
K
E
-
G
L
H
Y
-
T
C
S
S
H
F
P
Y
--
S
Q
----------
Y
Q
F
W
K
N
-
F
Q
T
L
K
I
V
I
L
G
--
L
V
L
P
L
L
V
M
V
I
C
Y
S
G
I
------
L
K
T
L
L
----------------------------------------------------
R
M
------------------------------------------------
K
K
Y
T
C
TVCG
Y
I
Y
-
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
DGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
E
E
EK
K
R
--
H
R
D
V
R
L
I
F
T
I
M
I
V
Y
F
-------------
L
F
W
A
----
P
Y
N
I
V
L
L
L
N
-
T
F
Q
E
F
F
G
L
-
N
N
C
S
S
----
S
N
R
L
D
Q
A
M
Q
V
T
E
T
L
G
M
T
H
C
-----
C
I
N
P
I
I
--------
Y
A
F
V
G
E
E
F
R
----------
N
Y
L
L
V
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
88.37
27%
-126
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------
Y
A
-
L
S
Y
C
A
L
I
L
A
-------
I
V
F
G
N
G
L
V
C
M
A
V
L
K
-
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
--
V
--
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
--
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
-
N
T
T
-----
G
-
D
-
P
T
-
V
C
S
I
S
N
P
----------------------
D
F
V
I
Y
S
S
V
V
S
--
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
------
Y
V
V
L
K
----------------------------------------------------
Q
R
------------------------------------------------
R
------------
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
-----------------------------------------
E
--
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
-------------
V
C
W
L
----
P
F
F
L
T
H
V
L
N
-
T
H
C
Q
------
T
C
-------
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
-----
A
L
N
P
V
I
--------
Y
T
T
F
N
I
E
F
R
----------
K
A
F
L
K
I
L
S
C
------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
86.85
27%
-112
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
---------------------------
S
F
K
C
-
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
-
A
V
Y
I
L
V
F
I
I
-------
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
-
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
L
P
A
L
I
F
Y
Y
F
--
N
--
K
TD
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
--
P
K
-
S
L
G
---
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
-
G
T
G
V
---
R
K
N
K
-
T
I
-
T
C
Y
D
T
T
S
D
--
E
Y
----------
L
R
S
Y
F
I
-
Y
S
M
C
T
T
V
A
M
---
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
------
V
R
A
L
I
----------------------------------------------------
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
E
------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
-----------------------------------------
R
--
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
-------------
V
S
Y
I
----
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
----
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
-----
C
V
N
P
I
L
--------
Y
F
L
A
G
D
T
F
R
----------
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.10
24%
-113
- C3 -
4XNW
2
RUBR_CLOPA
A:
[48-382]
--------------------------------------
F
Q
F
Y
Y
L
P
-
A
V
Y
I
L
V
F
I
I
-------
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
-
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
L
P
A
L
I
F
Y
Y
F
--
N
KT
D
--
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
-
L
G
R
---
L
K
K
K
N
-
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
-
G
T
G
V
---
R
K
-
N
-
K
T
I
T
C
Y
D
T
T
S
D
--
E
Y
----------
L
R
S
Y
F
I
-
Y
S
M
C
T
T
V
A
M
---
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
------
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
------------------------------------------------
E
------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
-----------------------------------------
R
--
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
-------------
V
S
Y
I
----
P
F
H
---
V
M
K
-
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
-----
C
V
N
P
I
L
--------
Y
F
L
A
G
D
T
F
R
----------
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.11
24%
-113
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[48-382]
--------------------------------------
F
Q
F
Y
Y
L
P
-
A
V
Y
I
L
V
F
I
I
-------
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
-
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
L
P
A
L
I
F
Y
Y
F
--
N
KT
D
--
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
-
L
G
R
---
L
K
K
K
N
-
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
-
G
T
G
V
---
R
K
-
N
-
K
T
I
T
C
Y
D
T
T
S
D
--
E
Y
----------
L
R
S
Y
F
I
-
Y
S
M
C
T
T
V
A
M
---
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
------
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
----
E
V
------------------------------------------------
E
------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
-----------------------------------------
R
--
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
-------------
V
S
Y
I
----
P
F
H
---
V
M
K
-
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
-----
C
V
N
P
I
L
--------
Y
F
L
A
G
D
T
F
R
----------
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.81
30%
-113
- C3 -
4XT3
2
US28_HCMVA
A:
[26-314]
-----------------------
E
D
A
T
P
--
C
V
F
T
D
V
L
N
Q
S
K
P
V
T
L
-
F
L
Y
G
V
V
F
L
F
-------
G
S
I
G
N
F
L
V
I
F
T
-
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
L
P
L
W
M
Q
Y
L
L
--
D
--
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
------
R
---
Y
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
--
F
M
-
V
V
T
K
---
K
D
-
N
-
Q
C
-
M
T
D
Y
D
Y
L
E
--
V
S
----------
Y
P
I
I
L
N
-
V
----
E
L
M
L
G
A
-
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
------
S
R
I
V
A
----------------------------------------------------
V
S
------------------------------------------------
Q
------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
-----------------------------------------
K
--
G
R
I
V
R
V
L
I
A
V
V
L
V
F
I
-------------
I
F
W
L
----
P
Y
H
L
T
L
F
V
D
-
T
L
K
L
L
K
W
I
S
S
S
C
E
F
----
E
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
-----
C
L
N
P
L
L
--------
Y
V
F
V
G
T
K
F
R
----------
Q
E
L
H
C
L
L
A
E
------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.17
30%
-116
- C3 -
4XT1
15
US28_HCMVA
A:
[23-314]
--------------------
D
Y
D
E
D
A
T
P
--
C
V
F
T
D
V
L
N
Q
S
K
P
V
T
L
-
F
L
Y
G
V
V
F
L
F
-------
G
S
I
G
N
F
L
V
I
F
T
-
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
-
T
L
P
L
W
M
Q
Y
L
L
--
D
---------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
------
R
---
Y
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
--
F
M
-
V
V
T
K
---
K
D
-
N
-
Q
C
-
M
T
D
Y
D
Y
L
E
--
V
S
----------
Y
P
I
I
L
N
-
V
----
E
L
M
L
G
A
-
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
------
S
R
I
V
A
----------------------------------------------------
V
S
------------------------------------------------
Q
------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
-----------------------------------------
K
--
G
R
I
V
R
V
L
I
A
V
V
L
V
F
I
-------------
I
F
W
L
----
P
Y
H
L
T
L
F
V
D
-
T
L
K
L
L
K
W
I
S
S
S
C
E
F
----
E
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
-----
C
L
N
P
L
L
--------
Y
V
F
V
G
T
K
F
R
----------
Q
E
L
H
C
L
L
A
E
F
R
----------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.61
27%
-129
- C3 -
4N6H
21
OPRD_HUMAN
A:
[135-410]
---------------------------------------------------
V
C
A
V
-------
G
L
L
G
N
V
L
V
M
-
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
K
Y
L
M
-
E
--
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
-
L
D
F
----
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
-
V
T
R
P
---
R
D
-
G
-
A
V
-
V
C
M
L
Q
F
P
S
--
P
-----------
S
W
Y
W
D
T
-
V
T
K
I
C
V
F
L
F
A
--
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
------
L
L
R
L
R
----------------------------------------------------
S
V
------------------------------------------------
R
LLSG--------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
-----------------------------------------
K
--
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
-------------
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
-
T
---
L
V
D
I
D
R
R
D
P
L
----
V
V
---
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
-----
S
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
----------
R
C
F
R
Q
L
C
R
K
P
C
G
---------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
82.33
21%
-120
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
----------------------------------------
V
V
G
M
G
-
I
V
M
S
L
I
V
L
A
-------
I
V
F
G
N
V
L
V
I
T
A
I
A
K
-
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
--
M
--
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
--
Q
S
---
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
---
H
Q
-
E
-
A
I
-
N
C
Y
A
E
E
T
C
--
C
D
-----------
F
F
T
N
Q
-
A
Y
A
I
A
S
S
I
V
S
--
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
------
F
Q
E
A
K
----------------------------------------------------
R
Q
------------------------------------------------
L
------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
-----------------------------------------
E
--
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
-------------
L
C
W
L
----
P
F
F
I
V
N
I
V
H
-
V
I
Q
D
------
N
--------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
-----
G
F
N
P
L
I
--------
Y
C
-
R
S
P
D
F
R
----------
I
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
82.11
27%
-133
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[121-405]
--------------------------------------------
P
L
G
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
L
P
F
Q
G
T
D
I
L
--
L
--
G
F-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
------------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
G
-
S
A
Q
V
---
E
D
-
E
-
E
I
-
E
C
L
V
E
I
P
T
--------------
P
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
--
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
------
I
R
R
L
R
----------------------------------------------------
G
V
------------------------------------------------
R
LLSG--------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
-----------------------------------------
K
--
D
R
N
L
R
R
I
T
R
L
V
L
V
V
V
-------------
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
----
A
Q
G
L
G
V
Q
----
P
S
----
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
-----
C
L
N
P
I
L
--------
Y
A
F
L
D
E
N
F
K
----------
A
C
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.57
27%
-127
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[132-406]
---------------------------------------------------
V
C
A
V
-------
G
L
L
G
N
V
L
V
M
-
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
K
Y
L
M
-
E
--
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
-
L
D
F
----
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
-
V
T
R
P
---
R
D
-
G
-
A
V
-
V
C
M
L
Q
F
P
S
--
P
-----------
S
W
Y
W
D
T
-
V
T
K
I
C
V
F
L
F
A
--
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
------
L
L
----------------------------------------------------------------------------------------------------------G-----------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
-----------------------------------------
K
--
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
-------------
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
-
T
---
L
V
D
I
D
R
R
D
P
L
----
V
V
---
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
-----
S
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
----------
R
C
F
R
Q
L
C
--------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
81.09
27%
-127
- C3 -
4RWD
6
C562_ECOLX (first)
A:
[132-406]
---------------------------------------------------
V
C
A
V
-------
G
L
L
G
N
V
L
V
M
-
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
K
Y
L
M
-
E
--
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
-
L
D
F
----
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
-
V
T
R
P
---
R
D
-
G
-
A
V
-
V
C
M
L
Q
F
P
S
--
P
-----------
S
W
Y
W
D
T
-
V
T
K
I
C
V
F
L
F
A
--
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
------
L
L
R
L
R
----------------------------------------------------
S
V
------------------------------------------------
R
LLSG--------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
-----------------------------------------
K
--
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
-------------
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
-
T
---
L
V
D
I
D
R
R
D
P
L
----
V
V
---
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
-----
S
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
----------
R
C
F
R
Q
L
C
--------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
80.21
22%
-123
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
------------------------------------------
P
L
V
-
V
V
L
S
T
I
C
L
V
-------
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
-
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
-
S
--
K
--
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
--
L
K
---
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
-
H
-------
R
-
R
-
E
D
-
K
C
E
T
D
F
Y
D
--
V
----------------
T
-
W
F
K
V
M
T
A
I
I
N
--
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
------
Y
K
A
V
R
----------------------------------------------------
Q
H
------------------------------------------------
C
------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
R
-----------------------------------------
E
--
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
-------------
L
C
W
I
----
P
Y
F
I
F
F
M
V
I
-
A
F
C
K
------
N
C
--------
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
-----
T
L
N
P
L
I
--------
Y
P
L
C
N
E
N
F
K
----------
K
T
F
K
R
I
L
H
I
------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
79.90
20%
-90
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
---
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
-
E
P
W
Q
F
S
M
L
A
-
A
Y
M
F
L
L
I
M
L
-------
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
G
F
T
T
T
L
Y
T
S
--
L
H
G
Y
--
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
--
P
M
-
S
N
F
---
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-------------
G
-
W
S
-
R
---
Y
I
P
E
--
G
M
QC
S
C
G
I
DYYT
P
H
E
E
T
N
-
N
E
S
F
V
I
Y
M
F
V
VH
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
------
V
F
T
V
K
----------------------------------------------------
E
A
AASAT-------------------------------------------
T
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
-----------------------------------------
E
--
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
-------------
I
C
W
L
----
P
Y
A
G
V
A
F
Y
I
-
F
T
H
---------
Q
G
----
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
-----
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
----------
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.66
27%
-126
- C3 -
5C1M
7
?
A:
[27-294]
---------------------------------------------------
V
C
V
V
-------
G
L
F
G
N
F
L
V
M
Y
V
-
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
V
N
Y
L
--
M
--
G
T-
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
-
L
D
F
----
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
A
-
T
T
K
Y
---
R
Q
-
G
-
S
I
-
D
C
T
L
T
F
S
H
--
P
-----------
T
W
Y
W
E
N
-
L
L
K
I
C
V
F
I
F
A
--
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
K
S
V
R
M
L
S
----------------------------------------------------
G
S
------------------------------------------------
K
------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
-----------------------------------------
R
N
L
R
R
I
T
R
M
V
L
V
V
V
A
V
F
I
-------------
V
C
W
T
----
P
I
H
I
Y
V
I
I
K
-
A
L
I
T
I
-------
P
E
----
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
-----
C
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
----------
R
C
F
------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
77.33
25%
-81
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-----------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
-
T
I
Y
S
I
I
F
L
T
-------
G
I
V
G
N
G
L
V
I
L
V
-
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
L
P
F
W
A
V
D
A
V
--
A
--
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
--
Q
R
---
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
-
N
V
S
E
---
A
D
-
D
-
R
Y
-
I
C
D
R
F
Y
P
---------------
N
D
L
W
V
V
-
V
F
Q
F
Q
H
I
M
V
G
--
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
-------
I
S
K
L
----------------------------------------------------
S
H
------------------------------------------------
S
------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
-----------------------------------------
I
--
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGH
L
L
T
K
----
S
P
S
L
N
A
A
K
S
-
E
L
D
K
A
I
G
R
N
T
N
G
V
I
----
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NA
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
YGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
26
HHSearch
76.87
23%
-109
- C3 -
2KS9
1
NK1R_HUMAN
A:
[31-327]
---------------------------------------
Q
I
V
L
W
A
-
A
A
Y
T
V
I
V
V
T
-------
S
V
V
G
N
V
V
V
M
W
I
I
L
A
-
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
H
-
N
--
E
--
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
--
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
T
---
M
P
-
S
-
R
V
-
V
C
M
I
E
W
P
E
--
H
P
----------
N
K
I
Y
E
K
-
V
Y
H
I
C
V
T
V
L
I
--
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
------
G
I
T
L
W
----------------------------------------------------
A
S
------------------------------------------------
E
IPGDSSDRYH
E
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
-----------------------------------------
K
--
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
-------------
I
C
W
L
----
P
F
H
I
F
F
L
L
P
-
Y
I
N
P
------
D
L
Y
L
----
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
-----
M
Y
N
P
I
I
--------
Y
C
C
L
N
D
R
F
R
----------
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
-
L
E
T
T
------------------------------------------------------------------------------------------------------
32
HHSearch
75.82
21%
-106
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-472]
----------------------------------------
S
S
V
Y
I
-
T
V
E
L
A
I
A
V
L
-------
A
I
L
G
N
V
L
V
C
W
A
V
W
L
-
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-----
G
--
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
--
N
G
---
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
-
N
N
C
G
---
Q
----
S
Q
-
G
C
G
E
G
Q
V
A
CL
F
E
----------
D
V
V
P
M
N
-
Y
M
V
Y
F
N
F
F
A
C
--
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
------
F
L
A
A
R
----------------------------------------------------
R
Q
------------------------------------------------
L
------------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
K
-----------------------------------------
E
--
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
-------------
L
C
W
L
----
P
L
H
I
I
N
C
F
T
-
F
F
C
P
------
D
C
------
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
-----
V
V
N
P
F
I
--------
Y
A
Y
R
I
R
E
F
R
----------
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------------------------------------------------------------------------------------------------