@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CD97_HUMAN: (2016-01-09 )
MGGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVHSQTLSRFFDKVQDLGRDSKTSSAEVTIQNVIKLVDELMEAPGDVEALAPPVRHLIATQLLSNLEDIMRILAKSLPKGPFTYISPSNTELTLMIQERGDKNVTMGQSSARMKLNWAVAAGAEDPGPAVAGILSIQNMTTLLANASLNLHSKKQAELEEIYESSIRGVQLRRLSAVNSIFLSHNNTKELNSPILFAFSHLESSDGEAGRDPPAKDVMPGPRQELLCAFWKSDSDRGGHWATEGCQVLGSKNGSTTCQCSHLSSFAILMAHYDVEDWKLTLITRVGLALSLFCLLLCILTFLLVRPIQGSRTTIHLHLCICLFVGSTIFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLSTRWLCLIGYGVPLLIVGVSAAIYSKGYGRPRYCWLDFEQGFLWSFLGPVTFIILCNAVIFVTTVWKLTQKFSEINPDMKKLKKARALTITAIAQLFLLGCTWVFGLFIFDDRSLVLTYVFTILNCLQGAFLYLLHCLLNKKVREEYRKWACLVAGGSKYSEFTSTTSGTGHNQTRALRASESGI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.....-..140-.......150.......160.......170.---......180.....-..190.......200---........-.210....-----...220.......----230.......240.......250.---......260.......270.......280...----------....290.......300.......310....--...320.......330.......340.......350.......360.......370.-..-----....380.......390.---......400.......410.......420.......430....--...440.......450.......460.......470.......480.......490.......-500.......510....--...520.......530.......540.......550---.........560.......570.......580.......-590.......600.........610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGG
R
V
F
L
A
F
C
V
W
L
TLPGAETQDSR
G
C
A
RWCPQNSSCVNA
T
A
C
RCNP
G
F
S
S
F
S
E
I
ITTPT
E
T
C
D
D
I
N
ECATPSKVSCGKF
S
D
CWNTEGS
Y
D
C
V
CSPGYEPVSGAKTFKNESEN
T
C
Q
D
V
D
E
C
Q
QN
P
R
L
C
K
S
Y
G
T
C
V
N
T
L
-
G
S
Y
T
C
-QCLPGFKFIPEDP
K
V
C
T
D
V
N
E
CTSGQNPCHS---S
T
H
C
LNNVG
S
Y
Q
C
R
-CRPGWQPIPGSPN-----GPNN
T
V
C
E
-
D
V
D
E
CSSG-----QHQCDSS
T
V
C
F
NT----VGS
Y
S
C
RCRPGWKPRHGIPNNQKD---TVCEDMTFSTWTPPPGV
H
S
Q
T
L
S
R
F
F
D
K
V
Q
D
L----------GRDSKTSSAE
V
T
I
Q
N
V
I
K
L
V
D
E
L
M
EAPGD
V
E
--
A
L
A
P
P
V
R
H
L
I
A
T
Q
L
L
S
N
L
E
D
I
M
R
I
L
A
K
SLPKGP
F
T
Y
ISPSN
T
E
L
T
L
M
I
QERGDKNVT-MG-----QSS
A
R
M
K
L
N
W
A
V
AAGAED---PG
P
A
V
A
G
I
L
S
I
Q
N
M
T
T
L
L
ANASLNLH
S
K
K
Q
A
E
L
E
E
I
Y
E
SSIR
G
--
V
Q
L
R
R
L
S
A
V
N
S
I
F
LSHNNTKELNS
P
I
L
F
A
F
SHLESSDGEAGRDP
P
A
KDVMPG
P
R
Q
E
L
L
C
A
F
WK-SDSDRGGHW
A
T
E
G
C
Q
VL--GSKNGS
T
T
C
Q
C
S
H
L
S
S
F
A
I
L
M
AHYDVED
W
K
L
T
L
I
-----
T
R
V
G
L
A
L
S
L
F
C
L
L
L
C
I
L
T
F
L
L
VRPIQGS
R
T
T
I
H
L
H
L
C
I
C
-
L
F
VGS
T
I
F
L
A
G--IENEGG
Q
V
G
L
R
C
R
L
V
A
G
L
L
H
Y
C
F
L
A
A
F
C
W
MSLE
G
L
E
L
Y
F
L
V
V
R
V
FQGQGL
S
T
R
W
L
C
L
IGYG
V
P
L
L
I
V
G
V
S
A
A
I
Y
SKGYGRP
R
Y
C
W
L
DFEQ
G
F
L
W
S
F
L
G
P
V
T
F
I
I
L
CN
A
V
I
F
V
T
T
V
W
K
L
T
Q
K
F
S
EINP
D
M
K
K
L
K
K
ARA
L
T
I
T
A
I
A
Q
L
F
L
L
G
C
T
W
V
F
G
L
F
I
FDD
R
S
L
V
L
T
Y
V
F
T
I
L
N
C
L
Q
G
A
F
L
Y
L
L
H
C
L
L
N
K
K
V
R
E
E
Y
R
K
W
A
C
L
VAGGSKY
S
E
F
TSTTSGTGHNQ
T
R
A
LRASESGI
83
Fugue
65.16
17%
-50
- C4 -
4DLQ
16
A:
[18-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
L
F
-
C
E
P
--
R
E
V
R
R
V
Q
W
-----
P
A
T
Q
Q
G
M
L
-
V
E
R
P
C
P
K
G
T
R
G
I
A
S
F
Q
C
L
P
A
L
G
L
W
N
P
----
R
G
P
D
L
S
N
C
T
S
P
W
V
N
Q
V
A
Q
K
I
K
S
G
E
N
A
A
N
I
A
S
E
L
A
R
H
T
R
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
D
I
L
D
A
Q
L
Q
A
L
RN
K
M
H
K
R
E
R
T
C
K
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
P
E
A
L
E
S
W
K
D
M
N
A
T
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
Q
N
V
V
L
E
V
T
V
L
S
T
E
G
Q
V
Q
E
-
L
V
F
PQEY
A
S
E
S
S
I
Q
L
S
A
N
T
I
K
Q
N
S
R
---
N
G
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
A
T
V
K
L
A
G
E
A
G
T
G
G
P
G
G
A
S
------
L
V
V
N
S
Q
V
I
A
A
S
I
N
K
E
S
S
R
V
F
L
M
D
P
V
I
F
T
V
A
H
L
E
A
K
N
----------------
H
F
N
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Y
W
S
T
Q
G
C
R
L
V
--
E
S
N
K
T
H
T
T
C
A
C
S
H
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.00
85%
-29
- C7 -
2BO2
3
AGRE2_HUMAN
A:
[4-128]
------------------------
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
L
S
K
V
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
R
P
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.46
85%
-24
- C7 -
2BOX
4
AGRE2_HUMAN
A:
[3-128]
-----------------------
R
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
----
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
--
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
60.13
84%
-25
- C7 -
2BOU
5
AGRE2_HUMAN
A:
[3-129]
-----------------------
R
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
----
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
R
P
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
59.82
85%
-23
- C7 -
2BOU
5
AGRE2_HUMAN
A:
[3-128]
-----------------------
R
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
----
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
R
P
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
59.35
85%
-23
- C7 -
2BO2
2
AGRE2_HUMAN
B:
[4-128]
------------------------
G
C
A
R
W
C
P
Q
D
S
S
C
V
N
A
T
A
C
R
C
N
P
G
F
S
S
F
S
E
I
I
T
T
P
M
E
T
C
D
D
I
N
E
C
A
T
L
S
--
S
C
G
K
F
S
D
C
W
N
T
E
G
S
Y
D
C
V
C
S
P
G
Y
E
P
V
S
G
A
K
T
F
K
N
E
S
E
N
T
C
Q
D
V
D
E
C
S
S
G
Q
H
Q
C
D
S
S
T
V
C
F
N
T
V
-
G
S
Y
S
C
-
R
C
R
P
G
W
K
P
R
H
G
I
P
N
N
Q
K
D
T
V
C
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Fugue
53.38
16%
-92
- C2 -
4CZB
1
NAH1_METJA
A:
[1-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
S
L
V
A
K
I
A
E
K
L
K
-----
I
P
D
I
P
L
L
L
L
L
G
L
I
I
G
P
F
L
QII
P
S
D
S
A
M
E
I
F
E
Y
A
G
P
I
G
L
I
F
I
L
L
G
G
A
F
T
M
R
I
S
L
L
K
R
V
I
K
T
V
V
R
L
D
T
I
T
F
L
I
T
L
L
I
S
G
F
I
F
N
M
V
L
N
L
P
Y
T
S
P
V
G
Y
L
F
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
R
T
N
P
E
V
A
I
T
L
E
A
E
S
-
I
F
N
D
P
L
G
I
V
S
T
S
V
I
L
G
L
F
G
L
F
S
S
S
N
P
L
I
D
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
A
K
I
Y
E
K
I
I
I
H
CDFH
E
Y
V
A
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
D
L
L
P
S
I
C
G
Y
G
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
D
DI
D
Y
K
Y
I
V
S
F
C
D
D
L
S
L
L
A
R
V
F
I
F
V
F
L
G
A
C
--
I
K
L
S
M
L
E
N
Y
F
I
P
G
L
L
V
A
L
G
S
I
F
-----------
L
A
R
P
L
G
V
F
L
G
L
I
G
S
K
H
--------
S
F
K
E
K
L
Y
F
A
L
E
G
P
R
G
V
V
P
A
A
L
A
V
T
V
G
I
E
I
L
K
--------
N
A
D
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
-----------------------------------------------------------
23
PsiBlast_CBE
53.19
37%
-38
- C7 -
4XLW
2
NOTC1_RAT
E:
[3-109]
---------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
G
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
52.72
37%
-44
- C7 -
4XLW
1
G:
[3-109]
---------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
G
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
52.60
37%
-29
- C7 -
4XL1
8
D:
[2-110]
-------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
51.08
37%
-41
- C7 -
4XLW
7
NOTC1_RAT
A:
[3-109]
---------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
50.38
37%
-28
- C7 -
4XL1
9
NOTC1_RAT
A:
[4-110]
---------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
50.04
37%
-37
- C7 -
4XLW
14
NOTC1_RAT
C:
[3-109]
---------------------------------------------------------------------------------------------------------------------
D
E
C
A
L
G
A
N
P
C
E
H
A
G
K
C
L
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
I
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
---------------
Y
C
E
I
N
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
V
D
K
----
I
N
E
F
L
C
Q
C
P
K
G
F
S
G
H
L
C
Q
S
G
R
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
49.92
37%
-27
- C7 -
2VJ3
6
A:
[3-112]
------------------------------------------------------------------------------------------------------------------
Q
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
N
---------------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
49.69
37%
-25
- C7 -
4CUF
4
A:
[4-112]
-------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
S
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
N
---------------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
48.96
37%
-23
- C7 -
4D0F
4
A:
[3-112]
------------------------------------------------------------------------------------------------------------------
Q
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
A
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
N
---------------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
---
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
48.03
37%
-25
- C7 -
4CUD
5
?
A:
[4-112]
-------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
N
---------------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
---
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
47.86
37%
-27
- C7 -
4D0E
5
A:
[4-112]
-------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
T
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
N
---------------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
---
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
47.76
37%
-22
- C7 -
4CUE
3
?
A:
[4-112]
-------------------------------------------------------------------------------------------------------------------
D
V
D
E
C
S
L
G
A
N
P
C
E
H
A
G
K
C
I
N
T
L
-
G
S
F
E
C
-
Q
C
L
Q
G
Y
T
----
G
P
R
C
E
I
D
V
N
E
C
V
S
--
N
P
C
Q
N
---
D
A
V
C
L
D
Q
I
G
E
F
Q
C
I
-
C
M
P
G
Y
E
G
V
H
C
E
V
N
---------------
T
D
E
C
A
S
S
-------
P
C
L
H
N
G
R
C
L
D
K
----
I
N
E
F
Q
C
E
C
P
T
G
F
T
G
H
L
C
Q
V
D
L
H
H
I
---
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
46.59
27%
-38
- C7 -
1YO8
3
A:
[4-141]
---------------------------------------------------------------------------------------------------------------------
D
G
C
L
S
N
--
P
C
F
P
G
A
Q
C
S
S
F
P
D
G
S
W
S
C
G
F
C
P
V
G
F
L
G
---
N
G
T
H
C
E
D
L
D
E
C
A
L
V
P
D
I
C
F
S
TSK
V
P
R
C
V
N
T
Q
P
G
F
H
C
L
P
C
P
P
R
Y
R
G
N
Q
P
V
G
V
G
L
E
A
A
K
T
E
K
Q
V
C
E
-
P
E
N
P
C
K
D
K
-----
T
H
N
C
H
K
H
A
E
C
I
Y
L
GHFS
D
P
M
Y
K
C
E
C
Q
T
G
Y
A
G
D
G
L
I
C
G
E
D
S
D
---
L
D
G
W
P
N
L
N
L
V
C
A
T
N
A
T
Y
H
C
I
K
D
N
C
P
H
L
P
N
S
G
Q
----------
E
D
F
D
K
D
G
I
G
D
A
C
D
D
D
D
D
N
D
G
V
T
D
E
K
D
N
C
Q
L
L
--
F
N
P
R
Q
A
D
Y
D
K
D
E
V
G
D
R
C
D
N
C
P
Y
V
H
N
P
A
Q
I
D
T
D
N
N
G
E
G
D
A
C
S
V
D
I
D
G
D
D
V
F
N
E
R
D
N
C
P
-
Y
V
-----
Y
N
T
D
Q
R
D
T
D
G
D
G
V
G
D
H
C
D
---
N
C
P
L
V
H
N
P
D
Q
T
D
V
D
N
D
L
V
G
D
Q
C
D
N
N
E
D
I
D
D
D
G
H
Q
N
N
Q
D
N
C
P
Y
I
--
S
N
A
N
Q
A
D
H
D
R
D
G
Q
G
D
A
C
D
P
D
D
D
N
D
G
V
P
D
D
R
D
N
C
R
L
V
F
N
P
D
Q
E
D
L
D
G
D
G
R
G
D
I
C
K
D
D
F
D
N
D
N
I
P
-
D
I
D
D
V
C
P
E
N
N
A
I
S
E
T
D
F
--
R
N
F
Q
M
V
P
L
D
P
K
G
T
T
Q
I
D
P
N
W
V
I
R
H
Q
G
K
E
L
V
Q
T
A
N
-----
S
D
P
G
I
A
V
G
F
D
E
F
G
S
V
D
F
S
G
T
F
Y
V
N
T
D
R
D
D
D
Y
A
G
F
V
F
G
Y
Q
-
S
S
S
R
F
Y
V
V
M
W
K
--
Q
V
T
Q
T
Y
W
E
D
Q
P
T
R
A
Y
G
Y
S
G
V
S
L
K
V
V
N
S
T
T
G
T
G
E
H
L
R
N
A
L
W
H
T
G
N
T
P
G
Q
V
R
T
L
W
H
D
P
R
N
I
G
W
K
D
Y
T
A
Y
R
W
H
L
T
H
R
P
K
T
G
Y
I
R
V
L
V
H
E
G
K
Q
V
M
A
D
S
G
P
I
Y
D
Q
T
Y
A
G
G
R
L
G
L
F
V
F
S
Q
E
M
V
Y
F
S
D
L
K
Y
E
C
R
D
-----------------------------------------------------------------------------------------------------------