@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
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Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
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Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
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Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CELR1_HUMAN: (2016-01-09 )
MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRAPRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVRLRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRCDNPFAEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPELFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQIQRSEGGTAQLLRRLEGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESSVSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRRENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSYASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKPRLKVETKVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLTLTEQTLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVRTGSAQADGSDSEKP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.....-.-.-290.......300.......310.......320.......330.......340.......350.......360.......370.......380.---.---.....390...-----.-----...400.....-..-410.-..-.....420.......430......-..440.......450.......460.----......470...--.....480......-.490.--....--....500----.----......----510--.--------........520.....---..530.......-------540.-----.--.--.--.....550.......560.......----570.......580.........590.---..---.---...600.......610.......620.......630..--------.....-640.-..-....----.650---.........660...--.---...670.......680.......690-..--......700.......710....-----.----.----.720...---.-.---.----.----730...----.--..--.740....-..-..750...---....760....--.---------.------.-----770.......780.......790....-...800.......810.......820........-.830--.......----.840.......850..-.-----..----..860.......---870...-....880.......890.......-900.......910.......920...-.-...930...-....940......---.950........960----........970.......980.......990.......1000......1010......1020......1030.......1040-..-......1050......1060......1070......-1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460........1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590-.......1600......-1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760........1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780......2790......2800......2810......2820......2830......2840......2850......2860......2870......2880......2890......2900......2910......2920......2930......2940......2950......2960......2970......2980......2990......3000......3010.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPPPP
P
V
L
P
V
L
L
L
L
A
A
A
A
ALPAMGLRAAAWEPRVPGG
T
R
A
F
A
LRPGC
T
Y
AVGAACTPRA
P
R
E
L
L
DVGRDGRLAGRRRVSGAGR
P
L
P
L
Q
V
R
L
V
ARSA
P
T
A
L
S
R
R
L
R
A
RTHLPGCG
A
R
A
R
L
CGT
G
A
R
L
C
G
ALCFPVPGG
C
A
A
A
QHSALAAPTTLPACRCPPRPRPRCPGR
P
I
C
LPPGG
S
V
R
L
R
L
L
C
A
L
R
R
AA
G
A
V
R
V
G
L
A
L
E
AATAGTPSASPSPSPPLPPNLPEARAG
P
A
R
R
ARRGTSGRGSLKFPMPN
Y
Q
V
A
L
F
ENEPA
G
T
L
I
L
Q
L
H
A
H
Y
T
IEG
E
E
E
R
V
S
Y
Y
M
E
G
L
-F-D-ERSR
G
Y
F
R
IDSATGAVST
D
S
V
LDRETKE
T
H
V
L
R
V
K
A
VDYSTPPRSA
T
T
Y
I
T
V
L
V
KDTNDHSPVF
E
Q
S
E
Y
R
E
R
V
R
E
N
L
EVG
Y
E
V
L
T
I
R
ASDRDSP---I---NA
N
L
R
Y
R
V
LGG-----
A
-----
W
D
V
F
Q
LNESSG-V
V
-
S
T
-
R
-
A
V-L
D
R
E
EAA
E
Y
Q
L
L
V
EAND-QGRNPG-PLS
A
T
A
T
V
Y
I
E
V
EDENDNYPQFSEQ
N
----
Y
V
V
QVPE-DVGL--
N
T
A
V
L
R
V
Q
ATDRDQ-GQ--N--
A
A
I
H
--
Y
S
I
LSGN----V----
A
G
Q
F
Y
L
----
H
----
S
--------
L
S
G
I
L
D
V
INPL
D
F
E
D
V
---
Q
K
Y
S
L
S
I
K
AQDG-------G--R-----P--
P
--
L
--INSS
G
V
V
S
V
Q
V
L
DVNDNE
P
I
F
VSSP----F
Q
A
T
V
LENVPL--G
Y
P
V
V
H
I
Q
A
VDAD---SG---E---N
A
R
L
H
Y
R
L
VDT
A
S
T
FLGGGSAGPKNPAPTPDF
P
F
Q
I
HN--------SS
G
W
I
-
T
V
-
C
-
A
E-L
D
R
E
----
E
V
-----
E
H
Y
SFG
V
E
AVDHGSP--P---MSSS
T
S
V
S
I
T
V
L
DVNDNDP
V
F
TQP
T
--
Y
E
--
L
R
LNEDAAVG
S
S
V
L
T
L
Q
ARDRDA-----N----
S
----
V
I
T
Y
Q
LT---G-G---N----T----R
N
R
F
A
L----S--SQ--RG-G
G
L
I
T
-
L
A
-LPLDYKQE---
Q
Q
Y
V
L
A
V
TASD--G---------T------R-----S
H
T
A
H
V
L
I
N
VTDANTHRPVFQSS
H
Y
T
V
-SVSEDRPVG
T
S
I
A
T
L
SANDEDTGE--N
A
R
I
T
Y
V
I-QDP---VP
Q
F
R
ID----PDS
G
T
M
Y
T
M
M
E
LDYEN-
Q
-----
V
A
----
Y
T
L
T
I
M
A
QDNGI---PQKSDT-
T
T
L
E
I
L
I
L
DANDNA
P
Q
F
L
W
D
F
YQG-SIFEDAPPST
S
I
L
Q
V
SATDRDSGPN
G
-
R
-
L
L
Y
T
F
QGGD-DGDG
D
F
Y
I
EPTS
G
---
V
I
R
-
T
Q
R
RLDREN-
V
----
A
V
Y
N
L
W
A
L
A
VDRGSPTPL
S
A
S
V
E
I
Q
V
T
I
L
DINDNAPMFEKD
E
L
E
L
F
V
EENNP
V
G
S
V
V
A
K
I
RANDPDEGPNA-
Q
I
M
Y
Q
I
V
EG---
D
M
-
R
H
F
F
Q
LDLLN
G
D
L
R
A
M
V
E
L
D
F
E
V
R
R
E
Y
V
L
V
V
QATSA-PL
V
S
R
A
T
V
H
I
L
L
V
DQNDNPPVL
P
D
F
Q
I
L
F
N
N
YVTNKSNSFPTG
V
I
G
CIPAHDPDVSDSL
N
Y
T
F
VQGN
E
L
R
L
L
L
LDPATG
E
L
Q
L
SRDLDNNR
P
L
E
A
L
M
E
V
S
VSDG
I
H
S
V
T
A
F
C
T
L
R
V
T
I
I
TDDMLT
N
S
I
T
V
R
LENM
S
Q
E
K
F
L
S
P
L
L
A
L
F
V
E
G
V
A
A
V
L
STTKD
D
V
F
V
F
NVQNDTDVSS
N
I
L
N
V
T
F
S
A
LLPGGVRGQFF
P
S
E
D
L
Q
E
Q
I
Y
LNR
T
L
L
T
TISTQRVLPFDDNIC
L
R
E
P
C
E
N
Y
M
K
C
V
S
V
L
RFDSSAPFLSS
T
T
V
L
F
R
PIHPING
L
R
C
RCPPGFTGDYCE
T
E
I
D
L
C
YSDPCGANGRCRSREGG
Y
T
C
E
C
F
E
DFTGE
H
C
E
VDARSGRCANGVCKNG
G
T
C
V
N
L
L
IGG
F
H
CVCPPGEYERP
Y
C
E
VTTRSFPP
Q
S
F
V
T
F
R
G
L
R
Q
--
R
F
H
F
T
I
S
L
T
F
A
TQERN
G
L
L
L
YNGRFNEKH
D
F
I
A
L
E
I
VD
E
Q
V
Q
L
T
FSAGE
T
T
T
T
VAPKVPSGVSDG
R
W
H
S
V
Q
V
Q
Y
YNKPNIGHLGLPHGPSG
E
K
M
A
V
V
T
VDDCDTT
M
A
V
R
FGKDIGNYSCAAQGTQTGSKKSL--DLTG
P
L
LLGGVPNLPED-FPVH
N
R
Q
F
V
G
C
M
R
NLSVDGKNV
D
M
A
G
F
IANNGTR
E
G
C
A
A
R
RNFCDGRRCQNG
G
T
C
V
NRW
N
M
Y
L
CEC
P
L
RFGGK
N
C
E
QAMPHPQLFSGE
S
V
V
S
WSD
L
N
I
I
I
S
V
P
W
Y
L
G
L
M
F
RTRKED
S
V
L
M
E
ATSGGP
T
S
F
R
L
Q
I
L
N
N
Y
L
Q
F
E
VSHGP
S
D
V
E
--
S
V
M
L
SGLRVTDGE
W
H
H
L
L
I
E
LKNVK
E
D
S
E
M
K
H
L
V
T
M
T
L
DYGMDQNKADIGGMLPG
L
T
V
R
S
V
V
VGGASE
D
K
V
S
V
R
R
G
F
R
G
C
M
Q
G
VRMGGTPT
N
V
A
T
L
NMN
N
A
L
K
V
R
VKDGCDVDDPCTSSPCPPNS
R
C
H
D
A
W
EDYS
C
V
CDKG
Y
L
G
I
N
C
VDACHLN
P
C
E
NM
G
A
C
VRSPGSPQ
G
Y
V
CECGPSHYGPYCENKLDLPCPRGWWGNPVCGP
C
H
C
AVSKGFDPDCNKTNG
Q
C
Q
C
K
E
N
Y
Y
K
L
L
AQDTCLPCDCFPHGSHS
R
T
CDMATGQCACKPGVI
G
R
Q
CNRCDN
P
F
A
E
V
T
T
L
G
C
E
V
I
YNG
C
P
K
A
F
EAGIWWPQTKFGQPAAVPCPKGSV
G
N
A
V
R
HCSGEKGWLP
P
E
LFN
C
T
T
I
S
F
V
D
L
R
A
M
N
E
K
LSRNETQV
D
G
A
R
A
L
Q
L
V
R
A
L
R
S
A
T
QHT
G
T
LFG
N
D
V
R
T
A
Y
Q
L
L
G
H
V
L
Q
H
E
S
W
QQGFDLAATQDA
D
F
H
E
D
V
I
HSGS
A
L
LA
P
A
T
R
A
A
W
E
Q
I
Q
RSEG
G
T
A
Q
L
L
R
R
L
E
G
Y
F
S
N
V
A
R
N
V
R
R
T
YLR
P
F
V
I
V
T
A
N
M
I
L
A
V
D
I
FDKFNFTGARVPR
F
D
T
I
H
E
E
F
P
R
E
L
E
S
SVSF
P
A
D
FFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREA
P
I
S
R
RRRHPD
D
A
G
Q
F
A
V
A
L
V
I
I
Y
R
T
L
G
Q
L
L
P
E
RYDP
D
R
RSLRLPHRPIINTP
M
V
S
T
L
VYSEGAPLPRPLER
P
V
L
V
E
F
A
L
L
E
V
EERTK
P
V
C
V
F
WNH
S
L
A
VGGTGGWSA
R
G
C
E
L
L
SRNR
T
H
V
A
C
QCSHTA
S
F
A
V
L
M
D
ISRRENG
E
V
L
P
L
K
I
V
T
Y
A
A
V
S
L
S
L
A
A
L
L
V
A
F
V
L
L
S
L
V
R
M
L
R
S
N
L
H
S
I
H
K
H
L
A
V
A
L
F
L
S
Q
L
V
F
V
I
GINQTEN
P
F
L
C
T
V
V
A
I
L
L
H
Y
I
Y
M
S
T
F
A
W
T
L
V
E
S
L
H
V
Y
R
M
L
T
E
V
RNIDTG
P
M
R
F
Y
Y
V
V
GW
G
I
P
A
I
V
T
G
L
AVGLDPQGYGNP
D
F
C
W
L
SLQ
D
T
L
I
W
SFAGP
I
G
A
V
I
I
I
N
T
V
T
S
V
L
S
A
K
V
S
CQRKHHYY
G
K
K
G
I
V
S
L
L
R
T
A
F
L
L
L
L
L
I
S
A
T
W
L
L
G
L
L
A
VNR
D
A
L
S
F
H
Y
L
F
A
I
F
SGLQ
G
P
F
V
L
L
F
H
C
VL
N
Q
E
V
R
K
H
L
K
G
VLGG
R
K
L
H
LEDSAT
T
R
A
T
L
L
T
RSLNCNTTFGD
G
P
D
M
L
R
T
DLGE
S
T
A
S
L
D
S
I
V
R
D
E
G
I
Q
K
LGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSL
D
E
QSSSYASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGD
A
V
ANHVPAGWPDQSLAESDSEDPSGK
P
R
L
K
V
E
T
K
V
S
V
E
L
H
REEQGSHRGEYPPDQESGGAARLASSQ
P
P
E
Q
R
K
G
I
LKNKVTYPPPLT
L
T
E
Q
T
L
K
G
R
L
R
E
K
L
A
D
CEQSPTSSRTSSLGSGGP
D
C
A
I
T
VKSPGREP
G
R
D
HLN
G
V
A
M
N
V
RTGSAQADGSDSEKP
138
HHSearch
89.45
28%
-49
- C10 -
3Q2V
22
CADH1_MOUSE
A:
[7-536]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
C
P
E
-
N
E
K
---
G
E
F
P
K
N
L
V
Q
I
K
S
N
R
-
D
K
--
E
--
T
K
V
F
--
Y
S
I
T
G
Q
G
ADKP
P
----
V
G
V
F
I
I
----
E
----
R
--------
E
T
G
W
L
K
V
T
Q
P
L
D
R
E
A
I
---
A
K
Y
I
L
Y
S
H
A
V
S
S
-------
N
--
G
-----
E
--
A
--
V
---
E
D
P
M
E
I
V
I
T
V
T
D
Q
N
D
N
R
P
E
F
T
Q
E
V
----
F
E
G
S
V
A
E
G
A
V
P
--
G
T
S
V
M
K
V
S
A
T
D
A
D
---
D
D
---
V
NTY
N
A
A
I
A
Y
T
I
V
S
Q
D
P
-------------
E
L
P
H
K
N
M
F
T
V
N
R
--------
D
T
G
V
I
-
S
V
L
T
-
S
G
-
L
D
R
E
----
S
Y
-----
P
T
Y
T
L
V
V
Q
A
A
D
L
Q
G
E
--
G
---
L
S
T
T
A
K
A
V
I
T
V
K
D
I
N
D
N
A
P
V
F
N
P
S
T
--
Y
Q
--
G
Q
V
P
E
N
E
-
V
N
A
R
I
A
T
L
K
V
T
D
D
D
A
-----
P
NTPA
W
----
K
A
V
Y
T
V
V
---
N
-
D
---
P
---------
D
Q
Q
F
V
V
V
T
--
D
--
P
T
--
T
N
-
D
G
I
L
K
-
T
A
-
K
G
L
D
F
E
A
K
---
Q
Q
Y
I
L
H
V
R
V
E
N
--
E
---------
E
PFEGS
L
V
-----
P
S
T
A
T
V
T
V
D
V
V
D
V
N
E
-
A
P
I
F
M
P
A
E
R
R
V
-
E
V
P
E
D
F
G
V
G
Q
E
I
T
S
Y
T
A
R
E
P
D
T
F
M
--
D
Q
K
I
T
Y
R
I
-
W
R
D
T--
A
N
W
L
E
I
N
----
P
E
T
G
A
I
F
T
R
A
E
M
D
R
E
D
-
A
EHVKN
S
T
----
Y
V
A
L
I
I
A
T
D
D
G
S
---
P
I
A
T
G
T
-
G
T
L
L
L
V
L
L
D
V
N
D
N
A
P
I
P
E
P
R
N
M
Q
F
--
C
Q
R
N
P
-
Q
---
P
H
I
I
T
I
L
D
P
D
L
P
P
N
T
S
P
-
F
T
A
E
L
T
H
G
A
---
S
V
N
W
T
I
E
Y
N
D
A
AQE
S
L
I
-
L
Q
-
P
R
K
D
---------
E
Y
K
I
H
L
K
L
A
D
N
Q
N
---
K
D
Q
V
T
T
L
D
V
H
V
C
D
C
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
84.02
30%
-51
- C10 -
3Q2W
26
CADH2_MOUSE
A:
[5-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
I
N
L
P
E
-
N
S
R
---
G
P
F
P
Q
E
L
V
R
I
R
S
D
R
-
D
K
--
N
--
L
S
L
R
--
Y
S
V
T
G
P
G
ADQP
P
----
T
G
I
F
I
I
----
N
----
P
--------
I
S
G
Q
L
S
V
T
K
P
L
D
R
E
L
I
---
A
R
F
H
L
R
A
H
A
V
D
I
-------
N
--
G
-----
N
--
Q
--
V
--
E
-
N
P
I
D
I
V
I
N
V
I
D
M
N
D
N
R
P
E
F
L
H
Q
V
----
W
N
G
S
V
P
E
G
S
K
P
--
G
T
Y
V
M
T
V
T
A
I
D
A
D
---
D
P
NA-
L
---
N
G
M
L
R
Y
R
I
L
S
Q
A
P
-------------
S
T
P
S
P
N
M
F
T
I
N
N
--------
E
T
G
D
I
I
T
V
-
A
-
A
G
-
L
D
R
E
----
K
V
-----
Q
Q
Y
T
L
I
I
Q
A
T
D
M
E
G
N
--
P
TY
G
L
S
N
T
A
T
A
V
I
T
V
T
D
V
N
D
N
P
P
E
F
T
A
M
T
--
F
Y
--
G
E
V
P
E
N
R
-
V
D
V
I
V
A
N
L
T
V
T
D
K
D
Q
-----
P
----
H
TPAW
N
A
A
Y
R
I
S
---
G
-
G
---
D
----
P
----
T
G
R
F
A
I
L
T
DP
N
--
S
N
--
D
---
G
L
V
T
-
V
V
-
K
P
I
D
F
E
T
N
---
R
M
F
V
L
T
V
A
A
E
N
--
Q
V
P
L
A
KGIQH
P
------
P
-----
Q
S
T
A
T
V
S
V
T
V
I
D
V
N
E
N
-
P
Y
F
A
P
N
P
K
I
I
-
R
Q
E
E
G
L
H
A
G
T
M
L
T
T
L
T
A
Q
D
P
D
R
Y
M
--
Q
Q
N
I
R
Y
T
K
-
L
S
D
P--
A
N
W
L
K
I
D
----
P
V
N
G
Q
I
T
T
I
A
V
L
D
R
E
S
-
P
NVKN-
N
I
----
Y
N
A
T
F
L
A
S
D
N
G
I
---
P
P
M
S
G
T
-
G
T
L
Q
I
Y
L
L
D
I
N
D
N
A
P
Q
V
L
P
Q
E
A
---
E
T
C
E
T
P
E
P
N
S
--
I
N
I
T
A
L
D
Y
D
I
D
P
N
A
-
G
P
F
A
F
D
L
P
L
S
P
V
T
I
K
R
N
W
T
I
N
R
L
N
G
---
D
F
A
Q
L
N
L
K
I
K
F
-
E
-
A
----
G
I
Y
E
V
P
I
I
I
T
D
S
G
N
P
P
-
K
S
N
I
S
I
L
R
V
K
V
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
83.25
29%
-42
- C10 -
3Q2W
26
CADH2_MOUSE
A:
[5-542]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
I
N
L
P
E
N
S
R
-
G
P
F
P
Q
E
L
V
R
I
R
S
D
R
D
K
N
L
S
L
R
Y
S
V
T
G
P
-
G
A
D
-
Q
P
P
T
G
I
F
I
I
N
P
I
S
G
Q
L
S
V
T
K
P
L
D
R
E
L
I
A
R
F
H
L
R
A
H
A
V
D
I
N
G
N
Q
V
E
N
P
I
D
I
V
I
N
V
I
D
M
N
D
N
R
P
E
F
L
H
Q
V
W
N
G
S
V
P
E
G
S
K
P
G
T
Y
V
M
T
V
T
A
I
D
A
D
D
P
NA-
L
---
N
G
M
L
R
Y
R
I
L
S
Q
-----
A
PSTPS
P
N
M
F
T
I
N
N
E
T
G
-
D
I
I
T
V
-
A
-
A
G
-
L
D
R
E
K
V
Q
Q
Y
T
L
I
I
Q
A
T
D
-
M
E
G
N
P
T
Y
G
L
S
N
T
A
T
A
V
I
T
V
T
D
V
N
D
N
P
P
E
F
T
A
M
T
----
F
Y
G
E
V
P
E
-
N
R
-
V
--
D
V
I
V
A
N
L
T
V
T
D
K
D
Q
-
P
H
--
T
PA
W
N
A
A
--
Y
R
I
S
G
G
D
----
P
----
T
G
R
F
A
I
L
T
DP
N
----
S
--------
N
D
G
L
V
T
V
V
K
P
I
D
F
E
T
N
---
R
M
F
V
L
T
V
A
A
E
N
Q
-------
V
--
P
L
A
KGI
Q
--
H
--
P
--
P
Q
S
T
A
T
V
S
V
T
V
I
D
V
N
E
N
-
P
Y
F
A
P
N
P
----
K
I
I
R
Q
E
E
G
L
H
A
--
G
T
M
L
T
T
L
T
A
Q
D
P
D
---
R
Y
---
M
---
Q
Q
N
I
R
Y
T
K
L
S
D
------------------
P
A
N
W
L
K
I
D
P
--------
V
N
G
Q
I
-
T
T
-
I
-
A
V
-
L
D
R
E
----
S
P
NVKN-
N
I
Y
N
A
T
F
L
A
S
D
N
G
I
P
--
P
---
M
S
G
T
G
T
L
Q
I
Y
L
L
D
I
N
D
N
A
P
Q
V
L
P
Q
E
--
A
----
E
T
C
E
T
P
E
P
N
S
--
I
N
I
T
A
L
D
Y
D
I
-----
D
----
P
NA
G
-
P
F
A
F
D
L
P
---
L
-
S
---
P
V
T
--
I
----
K
R
N
W
T
I
----
N
--
R
L
--
N
---
G
D
F
A
Q
L
N
-
L
K
I
K
F
-
E
A
---
G
I
Y
E
V
P
I
I
I
T
D
--
S
---------
G
NP
P
---
K
-----
S
N
I
S
I
L
R
V
K
V
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
80.67
29%
-34
- C10 -
1L3W
26
CADHF_XENLA
A:
[7-543]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
V
S
E
N
E
R
G
P
F
P
K
R
L
V
Q
I
K
S
N
K
D
R
F
---
N
K
V
Y
Y
S
I
T
G
Q
-
G
A
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
N
IDS
L
---
N
G
V
L
S
Y
S
I
L
K
Q
-----
D
PEEPI
P
N
L
F
T
I
N
R
E
T
G
-
V
I
-
S
L
-
I
G
T
G
-
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
-
L
E
G
A
---
G
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
-
N
E
-
I
--
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
-
P
G
TP
A
--
W
Q
A
V
--
Y
K
I
R
V
-
N
----
E
----
G
G
F
F
N
I
----
T
T
D
PE
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
-------
E
--
P
-----
F
--
S
V
P
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
F
I
G
N
D
------------------
P
A
R
W
L
T
V
N
K
--------
D
N
G
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
----
S
E
YVKN-
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
--
F
T
--
M
--
C
D
Q
-
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
-----
N
---------
T
Y
P
Y
K
V
S
---
L
-
S
HGS
D
----
L
----
T
W
K
A
E
L
----
D
--
S
K
------
G
T
S
M
-
L
L
-
S
P
T
Q
Q
L
K
K
---
G
D
Y
S
I
Y
V
L
L
S
D
--
A
Q--------
N
------
N
-----
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
80.50
25%
-53
- C10 -
1L3W
26
CADHF_XENLA
A:
[7-543]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
----
I
K
V
S
E
N
E
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
N
K
D
R
------------
F
N
K
V
Y
Y
S
I
T
G
Q
G
-------------
A
D
N
P
P
Q
G
V
F
R
I
E
W
--------
E
T
G
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
----
E
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
--
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
--
F
R
--
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
NIDSL
N
----
G
----
V
L
S
Y
S
I
L
---
K
-
Q
---
D
----
P
EEPI
P
N
L
F
T
I
----
N
--
R
E
--
T
---
G
V
I
S
-
L
I
G
T
G
L
D
R
E
K
F
---
P
E
Y
T
L
T
V
Q
A
T
D
--
L
---------
E
GA
G
---
L
-----
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
-
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
TP
A
W
Q
A
V
Y
K
I
-
R
V
N
E--
G
G
F
F
N
I
T
T
D
PE
S
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
-
R
-----
K
Q
----
Y
V
L
Q
I
T
V
E
N
A
E
P
FS
V
P
L
P
T
S
T
-
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
I
Q
-
K
-
L
S
Y
F
I
G
N
D
---
P
A
R
W
L
T
V
N
K
D
N
G
---
I
V
T
-
G
N
G
N
L
D
R
E
S
-
E
YVKN
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
-
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
F
T
M
--
C
D
Q
-
N
P
E
P
Q
V
--
L
T
I
S
D
A
D
I
P
P
N
--
T
Y
P
Y
K
V
S
L
S
HGS
D
L
-
T
W
K
A
E
L
D
S
-
K
G
T
S
M
L
L
S
P
T
Q
Q
L
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
79.37
23%
-52
- C10 -
1Q55
15
?
A:
[156-692]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWVI
P
P
I
K
V
S
E
N
E
R
G
PF
P
K
R
L
V
Q
I
K
S
N
K
D
---------
R
---
F
N
K
V
Y
Y
S
I
T
G
Q
G
-------------
A
D
N
P
P
Q
G
V
F
R
I
E
W
--------
E
T
G
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
----
E
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
--
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
--
F
R
--
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
NIDSL
N
----
G
----
V
L
S
Y
S
I
L
---
K
-
Q
---
D
PEEP
I
----
P
N
L
F
T
I
----
N
--
R
E
--
T
---
G
V
I
S
-
L
I
G
T
G
L
D
R
E
K
F
---
P
E
Y
T
L
T
V
Q
A
T
D
--
L
---------
E
GA
G
---
L
-----
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
-
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
TP
A
W
Q
A
V
Y
K
I
-
R
V
N
E--
G
G
F
F
N
I
T
T
D
PE
S
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
-
R
-----
K
Q
----
Y
V
L
Q
I
T
V
E
N
A
E
P
FS
V
P
L
P
T
S
T
-
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
I
Q
-
K
-
L
S
Y
F
I
G
N
D
---
P
A
R
W
L
T
V
N
K
D
N
G
---
I
V
T
-
G
N
G
N
L
D
R
E
S
-
E
YVKN
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
-
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
F
T
--
M
C
D
Q
N
P
E
P
---
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
P
Y
K
V
S
L
S
H
G
---
S
D
L
T
W
K
A
E
L
D
S
-
K
G
T
S
M
L
L
S
P
T
Q
Q
L
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Fugue
76.83
25%
-35
- C10 -
1L3W
26
CADHF_XENLA
A:
[7-546]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
----
I
K
V
S
E
N
E
-
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
---
N
K
-
D
R
--
F
--
N
K
V
Y
--
Y
S
I
T
G
Q
G
----
A
DNPP
Q
G
V
F
R
I
----
E
----
W
--------
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
---
D
K
Y
V
L
S
S
H
A
V
S
E
-------
N
--
G
-----
S
--
P
--
V
---
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
----
F
R
G
S
V
R
E
G
V
Q
P
--
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNI
D
S
---
L
---
N
G
V
L
S
Y
S
I
L
K
Q
-------------
D
P
E
E
P
I
P
N
L
F
T
I
N
R
--------
E
T
G
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
----
K
F
-----
P
E
Y
T
L
T
V
Q
A
T
D
L
E
G
A
--
G
---
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
--
Y
T
--
A
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
-----
P
----
G
----
T
P
A
W
Q
A
V
Y
K
I
R
-
V
---
N
----
E
----
G
G
F
F
N
I
----
T
T
D
P
E
--
S
N
-
Q
G
I
L
T
-
T
A
-
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
--
A
EPFS
V
P
---
L
------
P
-----
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
--
I
Q
K
L
S
Y
F
I
G
N
D
P
---
A
R
W
L
T
V
N
----
K
D
N
G
I
V
T
G
N
G
N
L
D
R
E
S
-
E
-----
Y
V
KNN
T
Y
T
V
I
M
L
V
T
D
D
G
V
---
S
V
G
T
G
T
-
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
-----
S
P
-
R
V
F
T
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
-
Y
-
P
Y
K
V
S
L
S
H
G
-
S
D
L
T
W
K
A
E
L
D
S
K
G
---
T
S
M
-
L
L
S
P
T
Q
Q
L
K
-
K
----
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
---
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
76.57
28%
-43
* C8 *
3UBH
6
A:
[8-418]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
P
T
K
R
I
E
F
T
E
A
D
---
G
D
---
T
---
E
G
K
S
V
F
Q
L
E
K
E
-----------------
T
D
K
E
T
F
K
I
R
D
DNPW
V
T
V
E
T
N
G
A
V
-
R
V
-
K
-
K
K
-
W
D
Y
E
----
E
L
GPE--
K
T
I
D
F
W
V
I
I
T
N
--
H
N
--
A
G
I
K
Y
T
D
N
Q
R
V
I
I
L
V
K
D
V
N
D
E
P
P
Y
F
I
N
R
P
LP
M
Q
--
A
V
V
Q
L
N
A
P
P
N
T
P
V
F
T
L
Q
A
R
D
P
D
T
-----
D
----
H
----
N
I
H
Y
F
I
V
---
R
-
D
---
R
----
T
----
G
G
R
F
E
V
----
D
--
E
R
--
S
---
G
V
V
R
-
T
R
-
G
T
D
L
F
Q
L
D
---
M
E
Y
V
L
Y
V
K
A
E
D
--
Q
---------
N
------
G
KVRRF
Q
S
T
P
E
E
R
L
S
I
V
G
-
G
K
R
A
P
Q
F
Y
M
P
S
Y
E
A
-
E
I
P
E
N
Q
K
K
D
S
D
I
I
S
I
K
A
K
S
F
A
-----
D
R
E
I
R
Y
T
L
-
K
A
Q
GQG
A
G
T
F
N
I
G
----
P
T
S
G
I
V
K
L
A
K
E
L
D
F
E
D
-
L
RQP--
H
V
----
Y
S
L
I
V
T
A
T
E
D
S
G
----
G
F
S
T
S
-
V
D
L
T
I
R
V
T
D
V
N
D
N
A
P
K
F
E
L
P
D
Y
Q
A
H
N
V
D
E
D
I
P
L
G
T
S
I
L
R
V
K
A
M
D
S
D
S
G
S
N
A
-
E
-
I
E
Y
L
V
S
D
------
D
H
F
A
V
D
S
-
N
G
---
I
I
V
-
N
N
K
Q
L
D
A
D
N
N
N
----
A
Y
Y
E
F
I
V
T
A
K
D
K
G
E
P
P
-
K
S
G
V
A
T
V
R
V
Y
T
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
76.55
24%
-46
* C10 *
1Q55
15
?
A:
[156-691]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWVI
P
P
I
K
V
S
E
-
N
E
R
G
PF
P
K
R
L
V
Q
I
K
S
N
K
D
R
------
F
--
N
K
V
Y
--
Y
S
I
T
G
Q
G
----
A
DNPP
Q
G
V
F
R
I
----
E
----
W
--------
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
---
D
K
Y
V
L
S
S
H
A
V
S
E
-------
N
--
G
-----
S
--
P
--
V
---
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
----
F
R
G
S
V
R
E
G
V
Q
P
--
G
T
Q
V
M
A
V
S
A
T
D
E
D
---
D
N
IDS
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
-------------
P
E
E
P
I
P
N
L
F
T
I
N
R
--------
E
T
G
V
I
-
S
L
-
I
G
T
G
-
L
D
R
E
----
K
F
-----
P
E
Y
T
L
T
V
Q
A
T
D
L
E
G
A
--
G
---
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
--
Y
T
--
A
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
-----
P
----
G
TPAW
Q
A
V
Y
K
I
R
---
V
-----
N
----
E
----
G
G
F
F
N
I
----
T
--
T
D
PE
S
N
-
Q
G
I
L
T
-
T
A
-
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
--
A
---------
E
PFS
V
P
L
P
-----
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
--
I
Q
K
L
S
Y
F
I
-
G
N
D
P--
A
R
W
L
T
V
N
----
K
D
N
G
I
V
T
G
N
G
N
L
D
R
E
S
-
E
YVKN-
N
T
----
Y
T
V
I
M
L
V
T
D
D
G
V
---
S
V
G
T
G
T
-
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
F
---
T
M
C
D
Q
N
P
E
P
---
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
P
-
Y
K
V
S
L
S
H
G
S
-
D
L
T
W
K
A
E
L
D
S
-
K
G
---
T
S
M
-
L
L
S
P
T
Q
Q
L
K
-
K
----
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
---
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
76.43
27%
-38
- C10 -
3Q2V
22
CADH1_MOUSE
A:
[7-536]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
C
P
E
N
E
K
-
G
E
F
P
K
N
L
V
Q
I
K
S
N
R
D
K
E
T
K
V
F
Y
S
I
T
G
Q
-
G
-
A
D
K
P
P
V
G
V
F
I
I
E
R
E
T
G
W
L
K
V
T
Q
P
L
D
R
E
A
I
A
K
Y
I
L
Y
S
H
A
V
S
S
N
G
E
A
V
E
D
P
M
E
I
V
I
T
V
T
D
Q
N
D
N
R
P
E
F
T
Q
E
V
F
E
G
S
V
A
E
G
A
V
P
G
T
S
V
M
K
V
S
A
T
D
A
D
D
D
---
V
NTY
N
A
A
I
A
Y
T
I
V
S
Q
-----
D
PELPH
K
N
M
F
T
V
N
R
D
T
G
-
V
I
-
S
V
L
T
-
S
G
-
L
D
R
E
S
Y
P
T
Y
T
L
V
V
Q
A
A
D
-
L
Q
G
E
---
G
L
S
T
T
A
K
A
V
I
T
V
K
D
I
N
D
N
A
P
V
F
N
P
S
T
----
Y
Q
G
Q
V
P
E
-
N
E
-
V
--
N
A
R
I
A
T
L
K
V
T
D
D
D
A
-
P
N
TP
A
--
W
K
A
V
--
Y
T
V
V
N
D
-----
P
----
D
Q
Q
F
V
V
V
T
DP
T
----
T
--------
N
D
G
I
L
K
T
A
K
G
L
D
F
E
A
K
---
Q
Q
Y
I
L
H
V
R
V
E
N
E
-------
E
--
P
-----
F
EG
S
--
L
--
V
P
S
T
A
T
V
T
V
D
V
V
D
V
N
E
-
A
P
I
F
M
P
A
E
----
R
R
V
E
V
P
E
D
F
G
V
--
G
Q
E
I
T
S
Y
T
A
R
E
P
D
---
T
F
---
M
---
D
Q
K
I
T
Y
R
I
W
R
D
------------------
T
A
N
W
L
E
I
N
P
--------
E
T
G
A
I
-
F
T
-
R
-
A
E
-
M
D
R
E
----
D
A
EHVKN
S
T
Y
V
A
L
I
I
A
T
D
D
G
S
P
--
I
---
A
T
G
T
G
T
L
L
L
V
L
L
D
V
N
D
N
A
P
I
P
E
P
R
N
--
M
Q
--
F
C
-
Q
R
N
-
P
Q
P
---
H
I
I
T
I
L
D
P
D
L
-----
P
PN--
T
S---
P
F
T
A
E
L
T
---
H
-
G
---
A
---------
S
V
N
W
T
I
----
E
--
Y
N
--
D
A
A
Q
E
S
L
I
-
L
--
Q
P
R
K
D
-------
E
Y
K
I
H
L
K
L
A
D
--
N
---------
Q
N-----
K
-----
D
Q
V
T
T
L
D
V
H
V
C
D
C
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.55
30%
-34
- C9 -
1L3W
25
CADHF_XENLA
A:
[10-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
K
V
S
E
N
E
R
G
P
F
P
K
R
L
V
Q
I
K
S
N
---
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
N
---
I
DSL
N
G
V
L
S
Y
S
I
L
K
Q
DPEEP
I
-----
P
N
L
F
T
I
N
R
E
T
G
-
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
L
E
G
A
G
----
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
N
E
I
G
F
----
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
--
V
Y
K
I
R
V
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
-------
E
PF
S
-----
V
--
P
--
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
--------
F
I
G
N
D
----------
P
A
R
W
L
T
V
N
K
--------
D
N
G
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
N
-----
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
--
F
T
--
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
------
L
-----
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.13
28%
-32
- C9 -
1Q5B
14
?
A:
[156-594]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
V
S
E
N
E
R
G
P
F
P
K
R
L
V
Q
I
K
S
N
---
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
N
---
I
DSL
N
G
V
L
S
Y
S
I
L
K
Q
DPEEP
I
-----
P
N
L
F
T
I
N
R
E
T
G
-
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
L
E
G
A
G
----
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
-
N
-
E
I
--
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
--
V
Y
K
I
R
V
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
-------
E
PF
S
-----
V
--
P
--
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
--------
F
I
G
N
D
----------
P
A
R
W
L
T
V
N
K
--------
D
N
G
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
N
-----
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
--
F
T
--
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
------
L
-----
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.13
28%
-32
- C9 -
1Q5A
14
?
A:
[156-594]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
V
S
E
N
E
R
G
P
F
P
K
R
L
V
Q
I
K
S
N
---
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
N
---
I
DSL
N
G
V
L
S
Y
S
I
L
K
Q
DPEEP
I
-----
P
N
L
F
T
I
N
R
E
T
G
-
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
L
E
G
A
G
----
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
-
N
-
E
I
--
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
--
V
Y
K
I
R
V
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
-------
E
PF
S
-----
V
--
P
--
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
--------
F
I
G
N
D
----------
P
A
R
W
L
T
V
N
K
--------
D
N
G
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
N
-----
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
--
F
T
--
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
------
L
-----
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.07
28%
-32
- C9 -
1Q5C
14
?
A:
[156-594]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
V
S
E
N
E
R
G
P
F
P
K
R
L
V
Q
I
K
S
N
---
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
N
---
I
DSL
N
G
V
L
S
Y
S
I
L
K
Q
DPEEP
I
-----
P
N
L
F
T
I
N
R
E
T
G
-
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
L
E
G
A
G
----
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
-
N
-
E
I
--
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
--
V
Y
K
I
R
V
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
-------
E
PF
S
-----
V
--
P
--
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
--------
F
I
G
N
D
----------
P
A
R
W
L
T
V
N
K
--------
D
N
G
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
N
-----
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
--
F
T
--
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
------
L
-----
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.54
28%
-32
- C9 -
1Q55
14
?
A:
[156-594]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
V
S
E
N
E
R
G
P
F
P
K
R
L
V
Q
I
K
S
N
---
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
N
---
I
DSL
N
G
V
L
S
Y
S
I
L
K
Q
DPEEP
I
-----
P
N
L
F
T
I
N
R
E
T
G
-
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
L
E
G
A
G
----
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
-
N
-
E
I
--
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
--
V
Y
K
I
R
V
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
-------
E
PF
S
-----
V
--
P
--
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
--------
F
I
G
N
D
----------
P
A
R
W
L
T
V
N
K
--------
D
N
G
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
N
-----
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
--
F
T
--
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
------
L
-----
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
69.93
27%
-39
- C8 -
3UBH
6
A:
[8-418]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
P
T
K
R
I
E
F
T
E
A
D
G
-
D
T
--
E
--
G
K
S
V
--
F
Q
L
E
K
E
T
----
D
----
K
E
T
F
K
I
----
R
----
D
DNPW
V
T
V
E
T
N
G
A
V
R
V
K
K
K
W
D
Y
E
E
L
GPE
K
T
I
D
F
W
V
I
I
T
N
-----------
H
-----
N
--
A
--
G
I
K
Y
T
D
N
Q
R
V
I
I
L
V
K
D
V
N
D
E
P
P
Y
F
I
N
R
P
LP--
M
Q
A
V
V
Q
L
N
A
P
P
--
N
T
P
V
F
T
L
Q
A
R
D
P
D
---
T
D
---
H
-----
N
I
H
Y
F
I
V
R
D
-----------------
R
T
G
G
R
F
E
V
D
E
--------
R
S
G
V
V
-
R
T
-
R
-
G
T
-
D
L
F
Q
----
L
D
-----
M
E
Y
V
L
Y
V
K
A
E
D
Q
N
G
K
VR
R
---
F
Q
S
T
P
E
E
R
L
S
I
V
G
-
G
K
R
A
P
Q
F
Y
M
P
S
--
Y
E
--
A
E
I
P
E
N
Q
K
K
D
S
D
I
I
S
I
K
A
K
S
F
A
------
D
----
R
----
E
I
R
Y
T
L
K
---
A
Q
G
---
Q
----
G
----
A
G
T
F
N
I
----
G
--
P
T
--
S
---
G
I
V
K
-
L
A
-
K
E
L
D
F
E
D
L
RQP
H
V
Y
S
L
I
V
T
A
T
E
DS
G
---------
G
------
F
-----
S
T
S
V
D
L
T
I
R
V
T
D
V
N
D
N
A
P
K
F
E
L
P
D
Y
Q
A
H
N
V
D
E
D
I
P
L
G
T
S
I
L
R
V
K
A
M
D
S
D
S
G
S
--
N
A
E
I
E
Y
L
V
-
S
D
-----
D
H
F
A
V
D
----
S
-
N
G
I
I
V
N
N
K
Q
L
D
A
D
N
N
N
-----
A
Y
----
Y
E
F
I
V
T
A
K
D
K
G
E
---
P
P
K
S
G
V
-
A
T
V
R
V
Y
T
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
68.30
31%
-26
- C9 -
3Q2W
25
CADH2_MOUSE
A:
[44-444]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
Q
P
P
T
G
I
F
I
I
N
P
I
S
G
Q
L
S
V
T
K
P
L
D
R
E
L
I
A
R
F
H
L
R
A
H
A
V
D
I
N
G
N
Q
V
E
N
P
I
D
I
V
I
N
V
I
D
M
N
D
N
R
P
E
F
L
H
Q
V
W
N
G
S
V
P
E
G
S
K
P
G
T
Y
V
M
T
V
T
A
I
D
A
D
D
P
NA-
L
---
N
G
M
L
R
Y
R
I
L
S
Q
-----
A
PSTPS
P
N
M
F
T
I
N
N
E
T
G
D
I
I
-
T
V
-
A
-
A
G
-
L
D
R
E
K
V
Q
Q
Y
T
L
I
I
Q
A
T
D
-
M
E
G
N
P
T
Y
G
L
S
N
T
A
T
A
V
I
T
V
T
D
V
N
D
N
P
P
E
F
T
A
M
T
----
F
Y
G
E
V
P
E
-
N
-
R
V
--
D
V
I
V
A
N
L
T
V
T
D
K
D
Q
-
P
H
--
T
--
P
A
W
N
A
A
Y
R
I
S
G
G
D
----
P
----
T
G
R
F
A
I
L
T
DP
N
----
S
--------
N
D
G
L
V
T
V
V
K
P
I
D
F
E
T
N
---
R
M
F
V
L
T
V
A
A
E
N
Q
V
P
L
A
KGI
Q
--
H
-----
P
--
P
------
Q
S
T
A
T
V
S
V
T
V
I
D
V
N
E
N
-
P
Y
F
A
P
N
P
----
K
I
I
R
Q
E
E
G
L
H
A
--
G
T
M
L
T
T
L
T
A
Q
D
P
D
---
R
Y
---
M
---
Q
Q
N
I
R
Y
T
K
L
S
D
P
A
N
W
L
------------------
K
I
D
P
--------
V
N
G
Q
I
-
T
T
-
I
-
A
V
-
L
D
R
E
SPNV
K
N
-----
N
I
Y
N
A
T
F
L
A
S
D
N
G
I
P
--
P
---
M
S
G
T
G
T
L
Q
I
Y
L
L
D
I
N
D
N
A
P
Q
V
L
P
Q
E
--
A
E
--
T
C
E
T
P
E
P
N
S
I
N
I
T
A
L
D
Y
D
I
D
P
N
A
-----
G
----
P
----
F
A
F
D
L
P
L
---
S
-
P
---
V
----
T
----
I
K
R
N
W
T
----
I
--
N
R
--
L
N
-
G
D
F
A
Q
-
L
N
-
L
K
I
K
F
E
A
G
---
I
Y
E
V
P
I
I
I
T
D
S
--
G
---------
N
------
P
-----
P
K
S
N
I
S
I
L
R
V
K
V
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
65.45
19%
-75
- C- -
2WJS
5
A:
[206-561]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
F
D
G
E
G
Y
A
L
V
S
R
P
I
R
WY
P
N
I
S
T
V
M
F
K
F
R
T
F
S
S
S
A
L
L
M
Y
L
A
T
R
-
D
L
K
D
F
M
S
V
E
L
S
D
G
H
V
K
V
S
Y
D
L
G
S
G
M
T
S
V
V
--
S
N
Q
N
H
N
D
G
K
W
K
A
F
T
L
S
R
I
Q
K
Q
----------------
A
N
I
S
I
V
D
I
D
S
N
Q
E
E
N
-------
V
A
T
S
----
S
S
G
N
N
F
G
L
DL
K
A
D
D
K
I
Y
F
G
G
L
P
T
L
R
N
L
R
P
E
V
N
V
K
K
Y
S
G
C
L
K
D
I
E
I
S
R
T
P
Y
N
I
L
S
S
P
D
Y
V
G
V
T
K
G
C
S
L
E
N
--------------------------------------
V
Y
T
V
S
F
P
K
P
G
F
V
E
L
A
A
V
--
S
I
D
V
G
T
E
I
N
L
S
F
S
T
R
N
E
S
G
I
I
L
L
G
S
---
Q
A
Y
Y
A
I
F
L
N
K
G
R
L
E
V
H
L
S
S
----
M
R
K
I
V
I
K
P
E
P
N
R
F
H
D
G
R
E
H
S
V
H
V
E
R
T
R
G
--------
I
F
T
V
Q
I
D
E
D
R
R
H
M
Q
N
L
T
E
--
E
Q
P
I
E
V
K
K
L
F
V
G
G
A
P
P
----
N
I
P
A
F
Q
G
C
V
W
N
L
V
I
N
S
I
P
M
D
F
A
Q
P
I
---
A
F
K
N
A
D
I
G
R
C
T
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.01
34%
4
- C9 -
2WCP
9
CAD23_MOUSE
A:
[7-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
F
T
N
H
F
--
F
D
T
Y
L
L
I
S
E
D
T
P
V
G
S
S
V
T
Q
L
L
A
R
D
M
D
------
N
----
D
----
P
L
V
F
G
V
S
---
G
-
E
---
E
----
A
----
S
R
F
F
A
V
--------
E
--
P
D
-
T
G
V
V
W
-
L
R
-
Q
P
L
D
R
E
T
K
---
S
E
F
T
V
E
F
S
V
S
D
--
H
---------
Q
------
G
-----
V
I
T
R
K
V
N
I
Q
V
G
D
V
N
D
N
A
P
T
F
H
N
Q
P
Y
S
V
-
R
I
P
E
N
T
P
V
G
T
P
I
F
I
V
N
A
T
D
P
D
L
G
A
--
G
G
S
V
L
Y
S
F
-
Q
P
P
---
S
P
F
F
A
I
D
----
S
A
R
G
I
V
T
V
I
Q
E
L
D
Y
E
V
-
T
-----
Q
A
----
Y
Q
L
T
V
N
A
T
D
Q
D
K
---
T
R
P
L
S
T
L
A
N
L
A
I
I
I
T
D
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
64.75
34%
-1
- C9 -
2WD0
5
CAD23_MOUSE
C:
[7-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
F
T
N
H
F
--
F
D
TY
L
L
I
S
E
D
T
P
V
G
S
S
V
T
Q
L
L
A
R
D
M
D
------
N
----
D
----
P
L
V
F
G
V
S
---
G
-
E
---
E
----
A
----
S
R
F
F
A
V
--------
E
--
P
D
-
T
G
V
V
W
-
L
R
-
Q
P
L
D
R
E
T
K
---
S
E
F
T
V
E
F
S
V
S
D
--
H
---------
Q
------
G
-----
V
I
T
R
K
V
N
I
Q
V
G
G
V
N
D
N
A
P
T
F
H
N
Q
P
Y
S
V
-
R
I
P
E
N
T
P
V
G
T
P
I
F
I
V
N
A
T
D
P
D
L
G
A
--
G
G
S
V
L
Y
S
F
-
Q
P
P
---
S
P
F
F
A
I
D
----
S
A
R
G
I
V
T
V
I
Q
E
L
D
Y
E
V
-
T
-----
Q
A
----
Y
Q
L
T
V
N
A
T
D
Q
D
K
---
T
R
P
L
S
T
L
A
N
L
A
I
I
I
T
D
L
E
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------