@TOME V2.3
(Nov 2016)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
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Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CELR2_HUMAN: (2016-01-09 )
MRSPATGVPLPTPPPPLLLLLLLLLPPPLLGDQVGPCRSLGSRGRGSSGACAPMGWLCPSSASNLWLYTSRCRDAGTELTGHLVPHHDGLRVWCPESEAHIPLPPAPEGCPWSCRLLGIGGHLSPQGKLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGERSPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTGEHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFITFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSVCTRKPSAPHGYTCECPPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCDNPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRGWLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQLALLLRNATQHTAGYFGSDVKVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSALLDTANKRHWELIQQTEGGTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNFAGAKLPRYEALRGEQPPDLETTVILPESVFRETPPVVRPAGPGEAQEPEELARRQRRHPELSQGEAVASVIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTLLRILRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLYILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLALLSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLACSRKPSPDPALTTKSTLTSSYNCPSPYADGRLYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGLGDPGSLFLEGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQGWDSLLGPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEERLRENGDALSREGSLGPLPGSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGPPPRPPPRQSLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.-.-.-....230.......240.......250.......260........270.......280.......290.......300.......310.....---..---320-.........330..-..-...340.......-350.-..-.....360.......370.....-..380.......390.......400.----......410..--.....420......-.430.--........440---.----.----......----450--.--------........460.....---..470.......480.-----.--..--.....490.......500......--.----510.......520.........530.---..---.---...540......----.----550----.....--------..560.-..-.-..-..570---.------.-----......580..-....--.---590.......600.......610..---.--.....620.......630.......-----640--.----.----......---.-650-.----.----......----.--660.--..-.....-.670.......---.680.......--690-------.---------.-----.---......700.......710.......-720.......730.......740-...--......750...---...-..760---..----......770.....----.-----.----780-.......-..790---....--...800.......810.......820-.......830.......840..---....-.-850......-.860..--.....870--...-..-...880.-.-----.....890.......900.........910.......920.......930.......940.......950..-.....960.---..-....970.----......--980.--......990.......1000--------........1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780......2790......2800......2810......2820......2830......2840......2850......2860......2870......2880......2890......2900......2910......2920
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRSPATGVPLPTP
P
P
P
L
L
L
L
L
L
L
LLPPPLLGDQVG
P
C
R
S
LGSRGRGSSGACAP
M
G
W
LCPSSAS
N
L
W
L
Y
T
S
R
CRDAGTELT
G
H
LVPHHD
G
L
R
V
WCPESEAHIPLPPAPEGC
P
W
S
C
R
L
L
G
IGGHLSPQGKLTLPEEHPCLKAP
R
L
R
CQSCKLAQAPGLRAGERS
P
E
E
S
LGGRRKRNVNTAPQFQPPSY
Q
A
TVPENQPAGTPV
A
S
L
RAIDPDEGEAG
R
L
E
Y
T
M
D
A
L
-
F
-D-SRS
N
Q
F
F
S
LDPVTGAVT
T
A
E
E
L
D
R
ETKS
T
H
V
F
R
V
TA-QDHGMPRRS
A
L
A
T
L
T
I
L
V
TDTNDHDPV
F
E
Q
Q
E
Y
K
E
S
L
R
E
N
L
E
VG
Y
E
V
L
T
V
R
ATDGD---AP---P---
N
A
N
I
L
Y
R
L
LEGSGG-SP-S
E
V
F
E
IDPRS
G
V
I
-RT-R-GP-V
D
R
E
EV
E
S
Y
Q
L
T
V
E
ASDQGRDPG-PRS
T
T
A
A
V
F
L
S
V
EDDNDNAPQFSE
K
R
----
Y
V
V
Q
V
REDVTP--GA
P
V
L
R
V
TASDRDK-GS--
N
--
A
V
V
H
Y
S
I
MSG----N----A----R
G
Q
F
Y
L
----D----A--------QTGA
L
D
VVSPLDYETT---
K
E
Y
T
L
R
V
R
AQDGG--R-----P--PL--SNVS
G
L
V
T
V
Q
V
L
DINDNA
P
I
F
V
ST--P----F
Q
A
T
V
L
E
SVP
L
--
G
Y
L
V
L
H
V
Q
A
IDAD---AG---D---N
A
R
L
E
Y
R
L
AGVG----H----DF
P
----
F
T
INN--------GT
G
-
W
I
-
S
V
-
A
-
A
E-L
D
R
E
----E------V-----
D
F
Y
SFGVEARD-HGTP--
A
---
L
TAS
A
S
V
S
V
T
V
L
D
VNDNNPTF-TQP---
E
--
Y
T
V
R
LNEDAAVG
T
S
V
V
T
V
S
AVDRDA-----
H
----
S
----
V
----
I
T
Y
Q
IT---S-G---N----T----R
N
R
F
S
I
----T--S--Q--SG-G
G
L
V
S
-
L
A
-LPLD
Y
K
L
E
---
R
Q
Y
V
L
A
V
TASD--G---------T---------R-----Q---D
T
A
Q
I
V
V
N
VTDANTHRPVFQSS
H
Y
T
V
-NVNEDRPA
G
T
T
V
V
L
I
SATDED---TGE--N
A
R
I
T
Y
F
-MEDS---I
P
Q
-
F
R
I
D----AD----TG
A
V
T
T
Q
A
ELDYED----Q-----
V
----
S
---
Y
T
L
A
I
T
A-RDNGI---PQKS--D
T
T
Y
L
E
I
L
V
NDVNDN
A
P
Q
F
L
R
D
SYQG-SVYEDVPP
F
T
S
V
L
Q
I
SATDRDS---GLN
G
-
R
-
V
F
Y
T
F
QGGD-DGDG
D
F
--
I
V
EST
S
G
---
I
V
R
-
T
L
-
R
R
L
D
R
E
N
-
V
-----
A
Q
Y
V
L
R
A
Y
A
VDKGMPP--ART
P
M
E
V
T
V
T
V
L
DVNDNPPVFEQDE
F
D
V
F
VEENSP
I
G
L
A
V
A
R
V
TATDPDEGTN
A
-
Q
I
M
Y
Q
IVEG---NI-
P
E
V
F
Q
L
D
I----FSG
E
L
T
--
A
L
V
D--LDYEDRP
E
Y
V
L
V
I
QATSA----------P
L
V
S
R
A
T
V
H
V
R
L
L
DRNDNP
P
V
L
G
N
F
E
I
L
F
NNYVTNRSSSFPGGAIGRVPAHDPDISDS
L
T
Y
S
FERG
N
E
L
S
L
V
L
L
NASTG
E
L
K
L
S
R
ALDNNR
P
L
E
A
I
M
S
V
L
V
SD
G
V
H
S
V
T
A
Q
C
A
L
R
V
T
I
I
TDEMLT
H
S
I
T
L
R
L
EDM
S
P
E
R
F
L
S
P
L
L
G
L
F
I
Q
A
V
A
A
T
LATPPD
H
V
V
V
F
N
V
QRDTDAPG
G
H
I
L
N
V
S
L
S
VGQPPGPGGGPPFL
P
S
E
D
L
Q
E
R
L
Y
L
N
R
S
L
L
T
A
I
S
AQRVLPFDDNIC
L
R
E
P
C
E
N
Y
M
R
C
V
S
V
L
RFDSSAPFIASS
S
V
L
F
R
PIHPVGG
L
R
C
RCPPGFTGD
Y
C
E
T
E
V
D
L
CYSRPCGPHGRCRSREG
G
Y
T
C
L
CRDGYTGE
H
C
E
V
SARSGRCTPGVCKNG
G
T
C
V
N
L
L
V
G
G
F
KCDCPSGDFEKP
Y
C
Q
V
TTRSFPAH
S
F
I
T
F
R
G
L
R
Q
R
F
H
F
T
L
A
L
S
F
ATKERD
G
L
L
L
YNGRFNEKH
D
F
V
A
L
E
V
I
Q
E
Q
V
Q
L
T
F
SAGEST
T
T
VSPFVPGGVSDG
Q
W
H
T
V
Q
L
K
YYNKPLLGQTGLPQGPSE
Q
K
V
A
V
V
T
VDGCDT
G
V
A
L
R
F
G
S
V
LGNYSCAAQGTQGGSKKSLDLTG
P
L
LLGGVPDLPES
F
P
V
R
M
R
Q
F
V
G
C
M
R
NLQVDSRHI
D
M
A
D
F
IANNGTVPGCPAKKNVCDSNTCHNG
G
T
CVNQWDAFSCECPLGFG
G
K
S
C
A
Q
E
MA
N
P
Q
H
F
L
G
S
S
L
V
A
WHGLSLPISQP
W
Y
L
S
L
M
F
RTRQAD
G
V
L
L
Q
A
I
TRGR
S
T
I
T
L
Q
LRE
G
H
V
M
L
S
V
EGTGLQAS
S
L
R
LEPGRANDGDW
H
H
A
Q
L
A
LGASGGPG
H
A
I
L
S
FDYGQQRAEGNLGP
R
L
H
G
L
H
LS
N
I
T
VGGIPGPA
G
G
V
A
R
G
F
R
G
C
LQGVRVSDTPEGVNSLDPSHGESINVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQ
S
V
CTRKPSAPHGYTCECPPNYLGP
Y
C
ETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCNKTSG
E
C
HCKENHYRPPGS
P
T
C
L
L
CDCYPTGSLSRVCDPEDGQCPCKPGVIGR
Q
C
DRCDN
P
F
A
E
VTTNG
C
E
V
N
Y
DSC
P
R
A
I
E
AGIWWPRTRFGLPAAAPCPKGS
F
G
T
A
V
R
H
C
D
E
HRGWLPPNLFNCTSI
T
F
S
E
L
K
G
F
A
E
R
L
Q
RNESGLDSG
R
S
Q
Q
L
A
L
L
L
R
NA
T
Q
HTAGYFGS
D
V
K
V
A
Y
Q
L
A
T
R
L
L
AHESTQRGFGLSATQD
V
H
F
T
E
N
L
L
R
V
G
S
A
L
L
D
TAN
K
R
H
W
E
L
I
Q
QTEG
G
T
A
W
L
L
Q
H
Y
E
A
Y
A
S
A
L
A
Q
N
M
R
H
TYLS
P
F
T
I
VTP
N
I
V
I
S
V
V
R
LDKGNFAGAKLP
R
Y
E
ALRGEQPPDL
E
T
T
V
IL
P
E
S
V
FRETPPVVRPAGPGEAQ
E
P
E
E
L
A
R
R
Q
RRHPELSQ
G
E
A
V
A
S
V
I
I
Y
R
T
L
A
G
LLPHNYDPDKRSLRVPKRPIINT
P
V
V
S
I
S
VH
D
D
E
E
L
L
P
R
ALDK
P
V
T
V
Q
F
R
L
LETEERTK
P
I
C
V
F
WN
H
S
I
L
V
SGTGGWSAR
G
C
E
V
V
F
RNE
S
H
V
S
C
QCNHM
T
S
F
A
V
L
M
D
V
SRRENG
E
I
L
P
L
K
T
L
T
Y
V
A
L
G
V
T
L
A
A
L
L
L
T
F
F
F
L
T
L
L
R
I
L
RSNQH
G
I
R
R
N
L
T
A
A
L
G
L
A
Q
L
V
F
L
LGINQADL
P
F
A
C
T
V
I
A
I
L
L
H
F
L
Y
L
C
T
F
S
W
A
L
L
E
A
L
H
L
Y
R
A
L
T
E
V
RDVNTG
P
M
R
F
Y
Y
M
LGWG
V
P
A
F
I
T
G
L
AVGLDPEGYGNP
D
F
C
W
L
S
I
Y
D
T
L
I
W
SFA
G
P
V
A
F
A
V
S
M
S
V
F
L
Y
I
L
A
A
R
A
S
C
A
A
Q
RQGFEKKGPVSGL
Q
P
S
F
A
V
L
L
L
L
S
A
T
W
L
L
A
L
L
SVNS
D
T
L
L
F
H
Y
L
F
A
T
C
NCIQ
G
P
F
I
F
L
S
Y
V
V
L
S
K
E
V
R
K
A
L
K
L
A
CSRKPSPDPALTTKSTLTSSYNCPSPYADG
R
L
YQPYGDSAGSLHSTSRSGKSQP
S
Y
I
P
F
L
L
REESALNPGQGPPGLGDPG
S
L
F
L
EGQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSE
E
E
E
E
E
E
E
E
EAAFPGEQ
G
W
D
S
LLGPGAERLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGA
P
E
E
R
L
R
ENGDALSREGSLGPLPGSSAQ
P
H
K
G
I
L
K
K
KCLPT
I
S
E
K
S
S
L
L
RL
P
L
E
QCTGSSRGSSASEGSRGGPPPRPP
P
R
Q
S
L
Q
E
Q
LNGVM
P
I
A
M
S
I
KAGTVDEDSSGS
E
F
L
F
F
NFLH
197
HHSearch
86.93
30%
-52
- C9 -
3Q2W
26
CADH2_MOUSE
A:
[5-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
I
N
L
P
E
N
S
R
---
G
P
F
P
Q
E
L
V
R
I
R
S
D
R
-
D
K
--
N
--
L
S
L
R
Y
S
V
T
G
P
----
G
ADQP
P
----
T
G
I
F
I
I
----
N
----
P
--------
I
S
G
Q
L
S
V
T
K
P
L
D
R
E
L
I
---
A
R
F
H
L
R
A
H
A
V
D
I
N
--
G
-----
N
--
Q
V
---
E
N
P
I
D
I
V
I
N
V
I
D
M
N
D
N
R
P
E
F
L
H
Q
--
V
----
W
N
G
S
V
P
E
G
S
K
P
--
G
T
Y
V
M
T
V
T
A
I
D
A
D
---
D
P
NA-
L
---
N
G
M
L
R
Y
R
I
L
S
Q
A
PSTP
S
----
P
N
M
----
F
T
I
N
N
--------
E
T
G
-
D
I
I
T
V
-
A
-
A
G
-
L
D
R
E
----
K
------
V
-----
Q
Q
Y
T
L
I
I
Q
A
T
D
-
M
E
G
N
--
P
TY
G
L
S
N
T
A
T
A
V
I
T
V
T
D
V
N
D
N
P
P
E
F
-
T
A
M
---
T
--
F
Y
G
E
V
P
E
N
R
-
V
D
V
I
V
A
N
L
T
V
T
D
K
D
Q
-----
P
----
H
TPAW
N
----
A
A
Y
R
I
S
---
G
-
G
---
D
----
P
----
T
G
R
F
A
I
L
T
DP
N
--
S
--
N
--
D
---
G
L
V
T
-
V
V
-
K
P
I
D
F
E
T
N
---
R
M
F
V
L
T
V
A
A
E
N
--
Q
V
P
L
A
KGIQH
P
---------
P
-----
Q
---
S
T
A
T
V
S
V
T
V
I
D
V
N
E
N
-
P
Y
F
A
P
N
P
K
I
I
-
R
Q
E
E
G
L
H
A
G
T
M
L
T
T
L
T
A
Q
D
P
D
---
R
Y
M
--
Q
Q
N
I
R
Y
T
-
K
L
S
D
P--
A
N
W
-
L
K
I
D
----
P
V
----
N
G
Q
I
T
T
I
A
V
L
D
R
E
S
----
P
NVKN-
N
----
I
---
Y
N
A
T
F
L
A
-
S
D
N
G
I
---
P
P
M
S
--
G
T
G
T
L
Q
I
Y
L
L
D
I
N
D
N
A
P
Q
V
L
P
Q
E
A
---
E
T
C
E
T
P
E
P
N
--
S
I
N
I
T
A
L
D
Y
D
I
---
D
P
N
A
-
G
P
F
A
F
D
L
P
L
S
P
V
T
I
K
R
N
W
--
T
I
N
R
L
N
G
---
D
F
A
Q
L
N
-
L
K
I
K
F
-
E
-
A
-----
G
I
Y
E
V
P
I
I
I
T
D
S
G
N
P
P
--
K
S
N
I
S
I
L
R
V
K
V
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
HHSearch
83.62
26%
-33
- C9 -
1L3W
26
CADHF_XENLA
A:
[7-543]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
V
S
E
N
E
R
G
P
F
P
K
R
L
V
Q
I
K
S
N
K
D
R
F
---
N
K
V
Y
Y
S
I
T
G
Q
-
G
A
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
-
V
S
E
N
G
S
P
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
---
D
N
IDS
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
P
E
E
P
I
-
P
N
L
F
T
I
N
R
E
T
G
V
I
-
S
L
-
I
G
T
G
-
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
L
E
G
A
---
G
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
N
E
-
I
--
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
-
P
G
TP
A
--
W
Q
A
V
Y
K
I
R
V
-----
N
----
E
----
G
G
F
F
N
I
----
T
T
D
PE
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
E
--
P
-----
F
S
V
P
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
--
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
F
I
G
N
D
-----
P
----
A
R
W
----
L
T
V
N
K
--------
D
N
G
-
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
----
S
------
E
YVKN-
N
T
Y
T
V
I
M
L
V
T
D
-
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
-
S
P
R
---
V
--
F
T
M
--
C
D
Q
-
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
----------
N
----
T
----
Y
P
Y
K
V
S
---
L
-
S
HGS
D
----
L
----
T
W
K
A
E
L
----
D
--
S
--
K
------
G
T
S
M
-
L
L
-
S
P
T
Q
Q
L
K
K
---
G
D
Y
S
I
Y
V
L
L
S
D
--
A
Q--------
N
---------
N
-----
P
---
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
HHSearch
83.58
27%
-48
- C9 -
1L3W
26
CADHF_XENLA
A:
[7-543]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
--
P
----
I
K
V
S
E
N
E
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
N
K
D
R
------------
F
N
K
V
Y
Y
S
I
T
G
Q
G
ADNP
P
----
Q
G
V
----
F
R
I
E
W
--------
E
T
G
-
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
----
E
------
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
-
E
N
G
S
--
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
-
T
Q
D
---
V
--
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
NIDSL
N
----
G
----
V
----
L
S
Y
S
I
L
---
K
-
Q
---
D
----
P
EEPI
P
N
L
F
T
I
----
N
--
R
--
E
--
T
---
G
V
I
S
-
L
I
G
T
G
L
D
R
E
K
F
---
P
E
Y
T
L
T
V
Q
A
T
D
--
L
---------
E
GA
G
------
L
-----
S
---
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
-
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
---
M
P
G
TP
A
W
Q
A
V
Y
K
-
I
R
V
N
E--
G
G
F
-
F
N
I
T
T
D
PE
S
N
----
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
----
R
-----
K
----
Q
---
Y
V
L
Q
I
T
V
-
E
N
A
E
P
FS
V
P
L
P
T
--
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
---
Q
Q
I
Q
-
K
-
L
S
Y
F
I
G
N
D
---
P
A
R
W
L
--
T
V
N
K
D
N
G
---
I
V
T
-
G
N
-
G
N
L
D
R
E
S
-
E
YVKN-
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
--
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
F
T
M
--
C
D
Q
-
N
P
E
P
Q
V
--
L
T
I
S
D
A
D
I
P
P
N
--
T
Y
P
Y
K
V
S
L
S
HGS
D
L
-
T
W
K
A
E
L
D
S
----
K
-
G
T
S
M
--
L
L
S
P
--
T
Q
Q
L
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q---------
N
N
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
HHSearch
81.87
25%
-47
- C9 -
1Q55
15
?
A:
[156-691]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWVI
P
P
I
K
V
S
E
N
E
R
G
PF
P
K
R
L
V
Q
I
K
S
N
K
D
---------
R
---
F
N
K
V
Y
Y
S
I
T
G
Q
G
----
A
DNPP
Q
G
V
----
F
R
I
E
W
--------
E
T
G
-
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
----
E
------
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
-
E
N
G
S
--
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
-
T
Q
D
---
V
--
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
NIDSL
N
----
G
----
V
----
L
S
Y
S
I
L
---
K
-
Q
---
D
PEEP
I
----
P
N
L
F
T
I
----
N
--
R
--
E
--
T
---
G
V
I
S
-
L
I
G
T
G
L
D
R
E
K
F
---
P
E
Y
T
L
T
V
Q
A
T
D
--
L
---------
E
GA
G
------
L
-----
S
---
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
-
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
---
M
P
G
TP
A
W
Q
A
V
Y
K
-
I
R
V
N
E--
G
G
F
-
F
N
I
T
T
D
PE
S
N
----
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
----
R
-----
K
----
Q
---
Y
V
L
Q
I
T
V
-
E
N
A
E
P
FS
V
P
L
P
T
--
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
---
Q
Q
I
Q
-
K
-
L
S
Y
F
I
G
N
D
---
P
A
R
W
L
--
T
V
N
K
D
N
G
---
I
V
T
-
G
N
-
G
N
L
D
R
E
S
-
E
YVKN-
N
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
--
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
F
T
--
M
C
D
Q
N
P
E
P
---
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
P
Y
K
V
S
L
S
H
G
---
S
D
L
T
W
K
A
E
L
D
S
-----
K
G
T
S
M
--
L
L
S
P
--
T
Q
Q
L
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q---------
N
N
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
HHSearch
80.42
27%
-50
* C9 *
1Q55
15
?
A:
[156-691]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWVI
P
P
I
K
V
S
E
N
E
R
G
PF
P
K
R
L
V
Q
I
K
S
N
K
D
R
------
F
--
N
K
V
Y
Y
S
I
T
G
Q
----
G
----
A
DNPP
Q
G
V
F
R
I
----
E
----
W
--------
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
---
D
K
Y
V
L
S
S
H
A
V
S
E
N
--
G
-----
S
--
P
V
---
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
--
V
----
F
R
G
S
V
R
E
G
V
Q
P
--
G
T
Q
V
M
A
V
S
A
T
D
E
D
---
D
N
IDS
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
PEEP
I
----
P
N
L
----
F
T
I
N
R
--------
E
T
G
-
V
I
-
S
L
-
I
G
T
G
-
L
D
R
E
----
K
------
F
-----
P
E
Y
T
L
T
V
Q
A
T
D
-
L
E
G
A
--
G
---
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
-
D
P
K
---
T
--
Y
T
A
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
-----
P
GTPA
W
----
Q
----
A
V
Y
K
I
R
---
V
-
N
--------
E
----
G
G
F
F
N
I
----
T
--
T
--
D
PE
S
N
-
Q
G
I
L
T
-
T
A
-
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
--
A
---------
E
PFS
V
P
L
---
P
-----
T
---
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
Q
--
I
Q
K
L
S
Y
F
-
I
G
N
D
P--
A
R
W
-
L
T
V
N
----
K
D
----
N
G
I
V
T
G
N
G
N
L
D
R
E
S
----
E
YVKN-
N
----
T
---
Y
T
V
I
M
L
V
-
T
D
D
G
V
---
S
V
G
T
--
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
F
---
T
M
C
D
Q
N
P
E
P
---
Q
V
L
T
I
S
D
A
D
I
---
P
P
N
T
---
Y
P
Y
K
V
S
L
S
H
-
G
S
D
L
T
W
K
A
E
L
D
S
-
K
G
---
T
S
M
-
L
L
-
S
P
T
Q
Q
L
K
-
K
-----
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
----
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
HHSearch
79.98
28%
-50
- C9 -
3Q2V
22
CADH1_MOUSE
A:
[7-536]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
C
P
E
N
E
K
---
G
E
F
P
K
N
L
V
Q
I
K
S
N
R
-
D
K
--
E
--
T
K
V
F
Y
S
I
T
G
Q
----
G
ADKP
P
----
V
G
V
F
I
I
----
E
----
R
--------
E
T
G
W
L
K
V
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P
L
D
R
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A
I
---
A
K
Y
I
L
Y
S
H
A
V
S
S
N
--
G
-----
E
--
A
V
---
E
D
P
M
E
I
V
I
T
V
T
D
Q
N
D
N
R
P
E
F
T
Q
E
--
V
----
F
E
G
S
V
A
E
G
A
V
P
--
G
T
S
V
M
K
V
S
A
T
D
A
D
---
D
D
---
V
NTY
N
A
A
I
A
Y
T
I
V
S
Q
D
PELP
H
----
K
N
M
----
F
T
V
N
R
--------
D
T
G
-
V
I
-
S
V
L
T
-
S
G
-
L
D
R
E
----
S
------
Y
-----
P
T
Y
T
L
V
V
Q
A
A
D
-
L
Q
G
E
--
G
---
L
S
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A
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V
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V
K
D
I
N
D
N
A
P
V
F
-
N
P
S
---
T
--
Y
Q
G
Q
V
P
E
N
E
-
V
N
A
R
I
A
T
L
K
V
T
D
D
D
A
-----
P
NTPA
W
----
K
----
A
V
Y
T
V
V
---
N
-
D
---
P
---------
D
Q
Q
F
V
V
V
T
--
D
--
P
--
T
--
T
N
-
D
G
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L
K
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A
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K
G
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---
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Q
Y
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L
H
V
R
V
E
N
--
E
---------
E
PFEGS
L
---
V
-----
P
---
S
T
A
T
V
T
V
D
V
V
D
V
N
E
-
A
P
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F
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R
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-
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--
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N
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L
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N
----
P
E
----
T
G
A
I
F
T
R
A
E
M
D
R
E
D
----
A
EHVKN
S
----
T
---
Y
V
A
L
I
I
A
-
T
D
D
G
S
---
P
I
A
T
--
G
T
G
T
L
L
L
V
L
L
D
V
N
D
N
A
P
I
P
E
P
R
N
M
Q
F
-
C
-
Q
R
N
P
-
Q
---
P
H
I
I
T
I
L
D
P
D
L
---
P
P
N
T
S
P
-
F
T
A
E
L
T
H
G
A
---
S
V
N
W
--
T
I
E
Y
N
D
A
AQE
S
L
I
-
L
Q
--
P
R
K
D
----------
E
Y
K
I
H
L
K
L
A
D
N
Q
N
----
K
D
Q
V
T
T
L
D
V
H
V
C
D
C
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
HHSearch
79.52
26%
-42
- C9 -
3Q2V
22
CADH1_MOUSE
A:
[6-536]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
C
P
E
N
E
K
-
G
E
F
P
K
N
L
V
Q
I
K
S
N
R
D
K
E
T
K
V
F
Y
S
I
T
G
Q
-
G
-
A
D
K
P
P
V
G
V
F
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I
E
R
E
T
G
W
L
K
V
T
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L
D
R
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A
I
A
K
Y
I
L
Y
S
H
A
-
V
S
S
N
G
E
A
V
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D
P
M
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I
V
I
T
V
T
D
Q
N
D
N
R
P
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F
T
Q
E
V
F
E
G
S
V
A
E
G
A
V
P
G
T
S
V
M
K
V
S
A
T
D
A
D
---
D
D
---
V
NTY
N
A
A
I
A
Y
T
I
V
S
Q
D
P
E
L
P
H
-
K
N
M
F
T
V
N
R
D
T
G
V
I
-
S
V
L
T
-
S
G
-
L
D
R
E
S
Y
P
T
Y
T
L
V
V
Q
A
A
D
L
Q
G
E
---
G
L
S
T
T
A
K
A
V
I
T
V
K
D
I
N
D
N
A
P
V
F
N
P
S
T
----
Y
Q
G
Q
V
P
E
N
E
-
V
--
N
A
R
I
A
T
L
K
V
T
D
D
D
A
-
P
N
TP
A
--
W
K
A
V
Y
T
V
V
N
D
---------
P
----
D
Q
Q
F
V
V
V
T
DP
T
----
T
--------
N
D
G
I
L
K
T
A
K
G
L
D
F
E
A
K
---
Q
Q
Y
I
L
H
V
R
V
E
N
E
E
--
P
-----
F
EG
S
L
--
V
P
S
T
A
T
V
T
V
D
V
V
D
V
N
E
-
A
P
I
F
M
P
A
--
E
----
R
R
V
E
V
P
E
D
F
G
V
--
G
Q
E
I
T
S
Y
T
A
R
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---
T
F
---
M
---
D
Q
K
I
T
Y
R
I
W
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-----
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----
A
N
W
----
L
E
I
N
P
--------
E
T
G
-
A
I
-
F
T
-
R
-
A
E
-
M
D
R
E
----
D
------
A
EHVKN
S
T
Y
V
A
L
I
I
A
T
D
-
D
G
S
P
--
I
---
A
T
G
T
G
T
L
L
L
V
L
L
D
V
N
D
N
A
P
I
P
-
E
P
R
---
N
--
M
Q
F
C
Q
-
R
N
P
-
Q
P
---
H
I
I
T
I
L
D
P
D
L
-----
P
PNT-
S
----
P
----
F
T
A
E
L
T
---
H
-
G
---
A
---------
S
V
N
W
T
I
----
E
--
Y
--
N
--
D
A
A
Q
E
S
L
I
-
L
--
Q
P
R
K
D
-------
E
Y
K
I
H
L
K
L
A
D
--
N
---------
Q
N--------
K
-----
D
---
Q
V
T
T
L
D
V
H
V
C
D
C
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.00
34%
-45
- C4 -
3Q2W
25
CADH2_MOUSE
A:
[26-447]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
D
K
-----
N
--
L
S
L
R
Y
S
V
T
G
P
----
G
----
A
DQPP
T
G
I
F
I
I
----
N
----
P
--------
I
S
G
Q
L
S
V
T
K
P
L
D
R
E
L
I
---
A
R
F
H
L
R
A
H
A
V
D
I
N
--
G
-----
N
--
Q
V
--
E
N
P
I
D
I
V
-
I
N
V
I
D
M
N
D
N
R
P
E
F
L
H
Q
--
V
----
W
N
G
S
V
P
E
G
S
K
P
--
G
T
Y
V
M
T
V
T
A
I
D
A
D
---
D
P
---
N
AL-
N
G
M
L
R
Y
R
I
L
S
Q
A
----
P
----
S
T
P
SPNM
F
T
I
N
N
--------
E
T
G
D
I
I
-
T
V
-
A
-
A
G
-
L
D
R
E
----
K
------
V
-----
Q
Q
Y
T
L
I
I
Q
A
T
D
M
E
G
N
P
TY
G
---
L
S
N
T
A
T
A
V
I
T
V
T
D
V
N
D
N
P
P
E
F
-
T
A
M
---
T
--
F
Y
G
E
V
P
E
N
-
R
V
D
V
I
V
A
N
L
T
V
T
D
K
D
Q
-----
P
----
H
----
T
PAW
N
A
A
Y
R
I
S
---
G
-
G
---
D
----
P
----
T
G
R
F
A
I
----
L
--
T
DP
N
--
S
N
-
D
G
L
V
T
-
V
V
-
K
P
I
D
F
E
T
N
---
R
M
F
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L
T
V
A
A
E
N
--
Q
---------
V
P
L
A
KGIQHP
P
-----
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---
S
T
A
T
V
S
V
T
V
I
D
V
N
E
N
-
P
Y
F
A
P
N
P
K
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-
R
Q
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E
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L
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A
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L
T
T
L
T
A
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D
---
R
Y
M
--
Q
Q
N
I
R
Y
T
K
L
S
D
P
---
A
N
W
-
L
K
I
D
----
P
V
----
N
G
Q
I
T
T
I
A
V
L
D
R
E
S
PNVK
N
-----
N
----
I
---
Y
N
A
T
F
L
A
-
S
D
N
G
I
---
P
P
M
S
--
G
T
G
T
L
Q
I
Y
L
L
D
I
N
D
N
A
P
Q
V
L
P
Q
E
A
E
T
-
C
E
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P
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P
N
S
I
N
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A
L
D
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D
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D
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A
---
G
P
F
A
-
F
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L
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L
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P
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T
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-
K
R
N
W
T
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--
N
R
L
N
G
D
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---
A
Q
L
-
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L
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K
I
K
F
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A
G
-
I
-----
Y
E
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P
I
I
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T
D
S
G
N
P
P
K
S
--
N
I
S
I
L
R
V
K
V
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Fugue
73.62
26%
-40
- C9 -
1L3W
26
CADHF_XENLA
A:
[7-546]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
----
I
K
V
S
E
N
E
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
---
N
K
-
D
R
--
F
--
N
K
V
Y
Y
S
I
T
G
Q
GADN
P
----
P
----
Q
G
V
F
R
I
----
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----
W
--------
E
T
G
W
M
L
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L
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R
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---
D
K
Y
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L
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S
H
A
V
S
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N
--
G
-----
S
--
P
V
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E
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P
M
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I
N
V
I
D
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N
D
N
R
P
K
F
T
Q
D
--
V
----
F
R
G
S
V
R
E
G
V
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P
--
G
T
Q
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M
A
V
S
A
T
D
E
D
DNI
D
S
---
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
----
P
----
E
E
P
IPNL
F
T
I
N
R
--------
E
T
G
-
V
I
-
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L
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I
-
G
T
G
L
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----
K
------
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-----
P
E
Y
T
L
T
V
Q
A
T
D
-
L
E
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A
--
G
---
L
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E
G
K
A
I
I
Q
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A
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D
N
A
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---
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Y
T
A
L
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I
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L
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D
L
D
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-----
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----
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----
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----
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A
W
Q
A
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Y
K
I
R
-
V
---
N
----
E
----
G
G
F
F
N
I
----
T
T
D
P
--
E
--
S
N
-
Q
G
I
L
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-
T
A
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K
G
L
D
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E
L
R
---
K
Q
Y
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L
Q
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E
N
--
A
EPFS
V
P
---
L
---------
P
-----
T
---
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
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G
E
K
I
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S
L
V
A
Q
D
P
D
---
K
Q
Q
--
I
Q
K
L
S
Y
F
-
I
G
N
D
---
P
A
R
W
L
T
V
N
----
K
D
----
N
G
I
V
T
G
N
G
N
L
D
R
E
S
----
E
-----
Y
VKNN
T
---
Y
T
V
I
M
L
V
-
T
D
D
G
V
---
S
V
G
T
--
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
F
T
M
-
C
-----
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
---
P
P
N
T
-
Y
-
P
Y
K
V
S
L
S
H
G
-
S
D
L
T
W
K
--
A
E
L
D
S
K
G
---
T
S
M
-
L
L
-
S
P
T
Q
Q
L
K
-
K
-----
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
--
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.16
28%
-31
- C4 -
1Q5C
14
?
A:
[156-594]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
-------
V
S
E
N
E
R
G
P
F
P
-
K
R
L
V
Q
I
K
S
N
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
-
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNI
D
S
---
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
P
E
-
E
P
I
P
N
L
F
T
I
N
R
E
T
G
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
--
L
E
G
A
-
G
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
N
E
I
---
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
V
Y
K
I
R
V
----
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
E
PF
S
-----
V
--
P
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
--
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
---
F
I
G
----
N
----
D
P
A
RW--
L
T
V
N
K
--------
D
N
G
-
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
------
N
-----
N
T
Y
T
V
I
M
L
V
T
D
-
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
-
S
P
R
---
V
--
F
T
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
----
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
--
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
---------
L
-----
T
---
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.80
28%
-31
- C4 -
1Q5B
14
?
A:
[156-594]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
-------
V
S
E
N
E
R
G
P
F
P
-
K
R
L
V
Q
I
K
S
N
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
-
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNI
D
S
---
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
P
E
-
E
P
I
P
N
L
F
T
I
N
R
E
T
G
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
--
L
E
G
A
-
G
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
N
E
I
---
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
V
Y
K
I
R
V
----
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
E
PF
S
-----
V
--
P
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
--
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
---
F
I
G
----
N
----
D
P
A
RW--
L
T
V
N
K
--------
D
N
G
-
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
------
N
-----
N
T
Y
T
V
I
M
L
V
T
D
-
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
-
S
P
R
---
V
--
F
T
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
----
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
--
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
---------
L
-----
T
---
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.80
28%
-31
- C4 -
1Q5A
14
?
A:
[156-594]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
-------
V
S
E
N
E
R
G
P
F
P
-
K
R
L
V
Q
I
K
S
N
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
-
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNI
D
S
---
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
P
E
-
E
P
I
P
N
L
F
T
I
N
R
E
T
G
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
--
L
E
G
A
-
G
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
N
E
I
---
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
V
Y
K
I
R
V
----
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
E
PF
S
-----
V
--
P
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
--
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
---
F
I
G
----
N
----
D
P
A
RW--
L
T
V
N
K
--------
D
N
G
-
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
------
N
-----
N
T
Y
T
V
I
M
L
V
T
D
-
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
-
S
P
R
---
V
--
F
T
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
----
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
--
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
---------
L
-----
T
---
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.41
28%
-31
- C4 -
1Q55
14
?
A:
[156-594]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
-------
V
S
E
N
E
R
G
P
F
P
-
K
R
L
V
Q
I
K
S
N
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
-
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNI
D
S
---
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
P
E
-
E
P
I
P
N
L
F
T
I
N
R
E
T
G
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
--
L
E
G
A
-
G
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
N
E
I
---
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
V
Y
K
I
R
V
----
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
E
PF
S
-----
V
--
P
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
--
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
---
F
I
G
----
N
----
D
P
A
RW--
L
T
V
N
K
--------
D
N
G
-
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
------
N
-----
N
T
Y
T
V
I
M
L
V
T
D
-
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
-
S
P
R
---
V
--
F
T
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
----
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
--
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
---------
L
-----
T
---
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
70.93
25%
-29
- C4 -
3Q2V
21
CADH1_MOUSE
A:
[24-524]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
S
N
---
R
D
---
K
---
E
T
K
V
F
Y
S
I
T
G
Q
G
----
A
----
D
K
P
PVGV
F
I
I
E
R
--------
E
T
G
-
W
L
-
K
V
-
T
-
Q
P
-
L
D
R
E
----
A
------
I
-----
A
K
Y
I
L
Y
S
H
A
V
S
-
S
N
G
E
--
A
---
V
E
D
P
M
E
I
V
I
T
V
T
D
Q
N
D
N
R
P
E
F
-
T
Q
E
---
V
--
F
E
G
S
V
A
E
G
A
V
P
G
T
S
V
M
K
V
S
A
T
D
A
D
D
DVNTY
N
----
A
----
A
----
I
A
Y
T
I
V
---
S
-
Q
---
D
----
P
ELPH
K
N
M
F
T
V
----
N
--
R
--
D
--
T
--
G
V
I
S
V
-
L
T
-
S
G
L
D
R
E
S
Y
---
P
T
Y
T
L
V
V
Q
A
A
D
--
L
---------
Q
---------
G
-----
E
G
L
S
T
T
A
K
A
V
I
T
V
K
D
I
N
D
N
A
P
V
F
N
P
S
T
Y
Q
G
-
Q
V
P
E
N
E
-
V
N
A
R
I
A
T
L
K
V
T
D
D
D
APN
T
P
A
--
W
K
A
V
Y
T
V
-
V
N
D
P
---
D
Q
Q
-
F
V
V
V
----
T
D
PTTN
D
G
I
L
K
T
A
K
G
L
D
F
E
A
----
K
-----
Q
----
Q
---
Y
I
L
H
V
R
V
-
E
N
E
E
P
---
F
E
G
S
L
V
P
S
T
A
T
V
T
V
D
V
V
D
V
N
E
A
P
I
F
M
P
A
E
R
R
V
-
E
V
P
E
D
F
G
V
G
Q
E
I
T
S
Y
T
A
R
E
P
D
T
---
F
M
D
Q
-
K
-
I
--
T
Y
R
I
W
R
-
D
T
A
N
W
L
--
E
I
N
P
E
T
G
---
A
I
F
-
T
R
-
A
E
M
D
R
E
D
-
A
EHVKN
S
T
Y
V
A
L
I
I
A
T
D
D
G
S
P
I
--
A
T
G
T
G
T
L
L
L
V
L
L
D
V
N
D
N
A
P
I
P
E
P
R
N
M
Q
-
F
C
Q
R
N
P
Q
P
H
I
----
I
T
I
L
D
P
D
L
P
P
N
T
-
S
---------------------
P
----
F
T
A
E
L
T
HG
A
S
V
N
W
T
I
E
Y
N
D
A
A
Q
E
S
L
I
L
Q
P
R
K
D
--------------
E
Y
K
I
H
L
K
L
A
D
N
Q
N
K
D
Q
V
T
T
L
D
V
H
V
C
D
C
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
HHSearch
70.59
30%
-43
* C7 *
3UBH
6
A:
[7-418]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
V
R
P
T
K
R
I
E
F
T
E
A
D
---
G
D
---
T
---
E
G
K
S
V
F
Q
L
E
K
E
T
----
D
----
K
E
T
----
F
K
I
R
D
DNPW
V
T
V
E
T
N
G
-
A
V
-
R
V
-
K
-
K
K
-
W
D
Y
E
----
E
------
L
GPE--
K
T
I
D
F
W
V
I
I
T
N
---
H
N
--
A
G
I
K
Y
T
D
N
Q
R
V
I
I
L
V
K
D
V
N
D
E
P
P
Y
F
-
I
N
R
---
P
LP
M
Q
A
V
V
Q
L
N
A
P
P
N
T
P
V
F
T
L
Q
A
R
D
P
D
T
-----
D
----
H
----
N
----
I
H
Y
F
I
V
---
R
-
D
---
R
----
T
----
G
G
R
F
E
V
----
D
--
E
--
R
--
S
---
G
V
V
R
-
T
R
-
G
T
D
L
F
Q
L
D
---
M
E
Y
V
L
Y
V
K
A
E
D
--
Q
---------
N
---------
G
KVRRF
Q
---
S
T
P
E
E
R
L
S
I
V
G
-
G
K
R
A
P
Q
F
Y
M
P
S
Y
E
A
-
E
I
P
E
N
Q
K
K
D
S
D
I
I
S
I
K
A
K
S
F
A
--------
D
R
E
I
R
Y
T
-
L
K
A
Q
GQG
A
G
T
-
F
N
I
G
----
P
T
----
S
G
I
V
K
L
A
K
E
L
D
F
E
D
----
L
RQP--
H
----
V
---
Y
S
L
I
V
T
A
-
T
E
D
S
G
----
G
F
S
--
T
S
V
D
L
T
I
R
V
T
D
V
N
D
N
A
P
K
F
E
L
P
D
Y
Q
A
H
N
V
D
E
D
I
P
L
G
T
S
I
L
R
V
K
A
M
D
S
D
S
---
G
S
N
A
-
E
-
I
E
Y
L
V
S
D
------
D
H
F
--
A
V
D
S
-
N
G
---
I
I
V
-
N
N
-
K
Q
L
D
A
D
N
N
N
-----
A
Y
Y
E
F
I
V
T
A
K
D
K
G
E
P
P
--
K
S
G
V
A
T
V
R
V
Y
T
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
HHSearch
69.55
25%
-40
- C9 -
3Q2W
26
CADH2_MOUSE
A:
[4-542]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
N
L
P
E
N
S
R
-
G
P
F
P
Q
E
L
V
R
I
R
S
D
R
D
K
N
L
S
L
R
Y
S
V
T
G
P
-
G
-
A
D
Q
P
P
T
G
I
F
I
I
N
P
I
S
G
Q
L
S
V
T
K
P
L
D
R
E
L
I
A
R
F
H
L
R
A
H
A
-
V
D
I
N
G
N
Q
V
E
N
P
I
D
I
V
I
N
V
I
D
M
N
D
N
R
P
E
F
L
H
Q
V
W
N
G
S
V
P
E
G
S
K
P
G
T
Y
V
M
T
V
T
A
I
D
A
D
---
D
P
NA-
L
---
N
G
M
L
R
Y
R
I
L
S
Q
A
P
S
T
P
S
-
P
N
M
F
T
I
N
N
E
T
G
D
I
I
T
V
-
A
-
A
G
-
L
D
R
E
K
V
Q
Q
Y
T
L
I
I
Q
A
T
D
M
E
G
N
P
T
Y
G
L
S
N
T
A
T
A
V
I
T
V
T
D
V
N
D
N
P
P
E
F
T
A
M
T
----
F
Y
G
E
V
P
E
N
R
-
V
--
D
V
I
V
A
N
L
T
V
T
D
K
D
Q
-
P
H
--
T
PA
W
N
A
A
Y
R
I
S
G
G
----
D
----
P
----
T
G
R
F
A
I
L
T
DP
N
----
S
--------
N
D
G
L
V
T
V
V
K
P
I
D
F
E
T
N
---
R
M
F
V
L
T
V
A
A
E
N
Q
V
--
P
L
A
KGI
Q
--
H
P
--
P
Q
S
T
A
T
V
S
V
T
V
I
D
V
N
E
N
-
P
Y
F
A
P
N
--
P
----
K
I
I
R
Q
E
E
G
L
H
A
--
G
T
M
L
T
T
L
T
A
Q
D
P
D
---
R
Y
---
M
---
Q
Q
N
I
R
Y
T
K
L
S
D
-----
P
----
A
N
W
----
L
K
I
D
P
--------
V
N
G
-
Q
I
-
T
T
-
I
-
A
V
-
L
D
R
E
----
S
------
P
NVKN-
N
I
Y
N
A
T
F
L
A
S
D
-
N
G
I
P
--
P
---
M
S
G
T
G
T
L
Q
I
Y
L
L
D
I
N
D
N
A
P
Q
V
-
L
P
Q
---
E
--
A
--
E
T
C
E
T
P
E
P
N
S
--
I
N
I
T
A
L
D
Y
D
I
-----
D
PNA-
G
----
P
----
F
A
F
D
L
P
---
L
-
S
---
P
V
T
--
I
----
K
R
N
W
T
I
----
N
--
R
--
L
--
N
---
G
D
F
A
Q
L
N
-
L
K
I
K
F
-
E
A
---
G
I
Y
E
V
P
I
I
I
T
D
--
S
---------
G
NP
P
------
K
-----
S
---
N
I
S
I
L
R
V
K
V
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.96
30%
-25
- C4 -
1L3W
25
CADHF_XENLA
A:
[57-444]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
-
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNI
D
S
---
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
P
E
-
E
P
I
P
N
L
F
T
I
N
R
E
T
G
V
I
-
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
--
L
E
G
A
-
G
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
N
E
I
---
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
--
A
W
Q
A
V
Y
K
I
R
V
----
N
----
E
----
G
G
F
F
N
I
T
T
D
P
E
----
S
--------
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
---
K
Q
Y
V
L
Q
I
T
V
E
N
A
E
PF
S
-----
V
--
P
L
--
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
--
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
F
---
I
G
----
N
----
D
P
A
RW--
L
T
V
N
K
--------
D
N
G
-
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
SEYV
K
------
N
-----
N
T
Y
T
V
I
M
L
V
T
D
-
D
G
V
S
--
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
-
S
P
R
---
V
--
F
T
M
C
D
Q
N
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
-----
P
----
Y
----
K
----
V
S
L
S
H
G
---
S
-
D
---
L
----
T
----
W
K
A
E
L
D
----
S
--
K
--
G
--
T
S
-
M
L
L
S
P
-
T
Q
-
Q
L
K
K
G
D
Y
S
---
I
Y
V
L
L
S
D
A
Q
N
N
--
P
---------
Q
---------
L
-----
T
---
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.77
30%
-27
- C7 -
3UBH
6
A:
[45-405]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
P
----
W
V
T
V
E
--------
T
N
G
-
A
V
-
R
V
-
K
-
K
K
-
W
D
Y
E
----
E
LGPEKT
I
-----
D
F
W
V
I
I
T
N
--
H
-
N
A
G
I
--
K
---
Y
T
D
N
Q
R
V
I
I
L
V
K
D
V
N
D
E
P
P
Y
F
I
N
R
P
LP
M
Q
--
A
V
V
Q
L
N
--
A
P
P
N
T
P
V
F
T
L
Q
A
R
D
P
D
T
-----
D
----
H
----
N
----
I
H
Y
F
I
V
---
R
-
D
---
R
----
T
----
G
G
R
F
E
V
----
D
--
E
--
R
--
S
G
---
V
V
R
-
T
R
-
G
T
D
L
F
Q
L
D
---
M
E
Y
V
L
Y
V
K
A
E
D
--
Q
---------
N
---------
G
KVRRF
Q
---
S
T
P
E
E
R
L
S
I
V
-
G
G
K
R
A
P
Q
F
Y
M
P
S
Y
E
A
-
E
I
P
E
N
Q
K
K
D
S
D
I
I
S
I
K
A
K
S
F
A
---
D
R
E
--
I
R
Y
T
L
K
A
-
Q
G
Q
G
---
A
G
T
-
F
N
I
G
----
P
T
----
S
G
I
V
K
L
A
K
E
L
D
F
E
D
----
L
-----
R
----
Q
PH
V
Y
S
L
I
V
T
A
T
E
D
S
G
-----
G
F
S
--
T
S
V
D
L
T
I
R
V
T
D
V
N
D
N
A
P
K
F
E
L
P
D
Y
Q
A
H
N
V
D
E
D
I
P
L
G
T
S
I
L
R
V
K
A
M
D
S
D
S
---
G
S
N
A
-
E
-
I
E
Y
L
V
S
------
D
D
H
F
--
A
V
D
S
-
N
G
---
I
I
V
-
N
N
-
K
Q
L
D
A
D
N
-
N
N----
A
Y
Y
E
F
I
V
T
A
K
D
K
G
E
P
P
--
K
S
G
V
A
T
V
R
V
Y
T
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
HHSearch
64.09
25%
-39
- C7 -
3UBH
6
A:
[8-418]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
P
T
K
R
I
E
F
T
E
A
D
G
-
D
T
--
E
--
G
K
S
V
F
Q
L
E
K
E
----
T
----
D
----
K
E
T
F
K
I
----
R
----
D
DNPW
V
T
V
E
T
N
G
A
V
R
V
K
K
K
W
D
Y
E
E
L
GPE
K
T
I
D
F
W
V
I
I
T
N
----
H
-----
N
--
A
G
I
K
Y
T
D
N
Q
R
V
I
I
L
V
K
D
V
N
D
E
P
P
Y
F
I
N
R
PL
P
----
M
Q
A
V
V
Q
L
N
A
P
P
--
N
T
P
V
F
T
L
Q
A
R
D
P
D
---
T
D
---
H
-----
N
I
H
Y
F
I
V
R
D
R
----
T
----
G
G
R
----
F
E
V
D
E
--------
R
S
G
-
V
V
-
R
T
-
R
-
G
T
-
D
L
F
Q
----
L
------
D
-----
M
E
Y
V
L
Y
V
K
A
E
D
-
Q
N
G
K
--
V
RR-
F
Q
S
T
P
E
E
R
L
S
I
V
G
-
G
K
R
A
P
Q
F
-
Y
M
P
---
S
--
Y
E
A
E
I
P
E
N
Q
K
K
D
S
D
I
I
S
I
K
A
K
S
F
A
------
D
----
R
----
E
----
I
R
Y
T
L
K
---
A
Q
G
---
Q
----
G
----
A
G
T
F
N
I
----
G
--
P
--
T
--
S
---
G
I
V
K
-
L
A
-
K
E
L
D
F
E
D
L
RQP
H
V
Y
S
L
I
V
T
A
T
E
DS
G
---------
G
---------
F
-----
S
---
T
S
V
D
L
T
I
R
V
T
D
V
N
D
N
A
P
K
F
E
L
P
D
Y
Q
A
H
N
V
D
E
D
I
P
L
G
T
S
I
L
R
V
K
A
M
D
S
D
---
S
G
S
--
N
A
E
I
E
Y
L
-
V
S
D
-----
D
H
-
F
A
V
D
----
S
-----
N
G
I
I
V
N
N
K
Q
L
D
A
D
N
N---
N
-----
A
----
Y
---
Y
E
F
I
V
T
A
-
K
D
K
G
E
---
P
P
K
S
--
G
V
A
T
V
R
V
Y
T
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
HHSearch
63.15
32%
-31
- C9 -
2A62
6
CADH8_MOUSE
A:
[8-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
V
L
E
E
F
S
G
P
E
P
I
L
V
G
R
L
H
T
D
L
D
---
P
G
---
S
K
K
I
K
Y
I
-
L
S
G
D
GA-
G
T
I
-
F
Q
I
N
----
D
I
----
T
G
D
I
H
A
I
K
R
L
D
R
E
E
----
K
-----
A
----
E
---
Y
T
L
T
A
Q
A
-
V
D
F
E
T
N--
K
P
L
E
--
P
P
S
E
F
I
I
K
V
Q
D
I
N
D
N
A
P
E
F
L
N
G
P
Y
H
A
-
T
V
P
E
M
S
I
L
G
T
S
V
T
N
V
T
A
T
D
A
D
D
PVY
G
N
S
A
-
K
-
L
V
Y
S
I
L
E
G
----
Q
P
Y
F
--
S
I
E
P
E
T
A
---
I
I
K
-
T
A
L
P
N
M
D
R
E
A
-
K
-----
E
E
Y
L
V
V
I
Q
A
K
D
M
G
G
H
S
G
G
L
S
G
T
T
T
L
T
V
T
L
T
D
V
N
D
N
P
P
K
F
A
Q
S
L
Y
H
F
S
V
P
E
D
V
V
L
G
T
A
I
G
R
V
K
A
N
D
Q
D
I
G
E
N
A
-
Q
S
S
Y
D
I
I
------
G
-
T
A
L
F
E
I
T
S
D
AQA
Q
D
G
V
I
R
--
L
R
K
P
--
L
D
F
E
T
K
K
S
Y
T
L
K
V
E
A
A
N
I
HIDPRFSSRG
P
F
K
D
T
A
T
V
K
I
V
V
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------