@TOME V2.3
(Nov 2016)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
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Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
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Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
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Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CELR3_HUMAN: (2016-01-09 )
MMARRPPWRGLGGRSTPILLLLLLSLFPLSQEELGGGGHQGWDPGLAATTGPRAHIGGGALALCPESSGVREDGGPGLGVREPIFVGLRGRRQSARNSRGPPEQPNEELGIEHGVQPLGSRERETGQGPGSVLYWRPEVSSCGRTGPLQRGSLSPGALSSGVPGSGNSSPLPSDFLIRHHGPKPVSSQRNAGTGSRKRVGTARCCGELWATGSKGQGERATTSGAERTAPRRNCLPGASGSGPELDSAPRTARTAPASGSAPRESRTAPEPAPKRMRSRGLFRCRFLPQRPGPRPPGLPARPEARKVTSANRARFRRAANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFLEGVAAVLATPAEDVFIFNIQNDTDVGGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLYVRRAALAARSLLDVLPFDDNVCLREPCENYMKCVSVLRFDSSAPFLASASTLFRPIQPIAGLRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEEAPQGLVGCIQGVWLGSTPSGSPALLPPSHRVNAEPGCVVTNACASGPCPPHADCRDLWQTFSCTCQPGYYGPGCVDACLLNPCQNQGSCRHLPGAPHGYTCDCVGGYFGHHCEHRMDQQCPRGWWGSPTCGPCNCDVHKGFDPNCNKTNGQCHCKEFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRPGALGRQCNSCDSPFAEVTASGCRVLYDACPKSLRSGVWWPQTKFGVLATVPCPRGALGAAVRLCDEAQGWLEPDLFNCTSPAFRELSLLLDGLELNKTALDTMEAKKLAQRLREVTGHTDHYFSQDVRVTARLLAHLLAFESHQQGFGLTATQDAHFNENLLWAGSALLAPETGDLWAALGQRAPGGSPGSAGLVRHLEEYAATLARNMELTYLNPMGLVTPNIMLSIDRMEHPSSPRGARRYPRYHSNLFRGQDAWDPHTHVLLPSQSPRPSPSEVLPTSSSIENSTTSSVVPPPAPPEPEPGISIIILLVYRTLGGLLPAQFQAERRGARLPQNPVMNSPVVSVAVFHGRNFLRGILESPISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSRTGTFGVLMDASPRERLEGDLELLAVFTHVVVAVSVAALVLTAAILLSLRSLKSNVRGIHANVAAALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQVEPRNVDRGAMRFYHALGWGVPAVLLGLAVGLDPEGYGNPDFCWISVHEPLIWSFAGPVVLVIVMNGTMFLLAARTSCSTGQREAKKTSALTLRSSFLLLLLVSASWLFGLLAVNHSILAFHYLHAGLCGLQGLAVLLLFCVLNADARAAWMPACLGRKAAPEEARPAPGLGPGAYNNTALFEESGLIRITLGASTVSSVSSARSGRTQDQDSQRGRSYLRDNVLVRHGSAADHTDHSLQAHAGPTDLDVAMFHRDAGADSDSDSDLSLEEERSLSIPSSESEDNGRTRGRFQRPLCRAAQSERLLTHPKDVDGNDLLSYWPALGECEAAPCALQTWGSERRLGLDTSKDAANNNQPDPALTSGDETSLGRAQRQRKGILKNRLQYPLVPQTRGAPELSWCRAATLGHRAVPAASYGRIYAGGGTGSLSQPASRYSSREQLDLLLRRQLSRERLEEAPAPVLRPLSRPGSQECMDAAPGRLEPKDRGSTLPRRQPPRDYPGAMAGRFGSRDALDLGAPREWLSTLPPPRRTRDLDPQPPPLPLSPQRQLSRDPLLPSRPLDSLSRSSNSREQLDQVPSRHPSREALGPLPQLLRAREDSVSGPSHGPSTEQLDILSSILASFNSSALSSVQSSSTPLGPHTTATPSATASVLGPSTPRSATSHSISELSPDSEVPRSEGHS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360...-...-.-370.......380.......390.......400.......410.......420.......430.......440.......450.......460.---.---.....470.......480.......490.....-.-.500........510.......520.......530.......540.......----550.......560.........570....--...580..-....----.590-...--.----...600.......610.......620..-...--.--.--630.......640.......650...----....660....--...670.......---680--.---.......690..----.----...----.700.--------.....-.710-..-......-----720.......730--...---....740.......750.......760.........770.......780..-----.-----.----.----..790------......---.----.----.----800..----.--.--.--..-810....-...820.......830...---.------.---------.-----.840.......850.......860.......870.......880.....-..--890-.--........---900....-----..------.----..----910.......920..-----.....930....---.------.------.-------940.......950.......960......-.970.......980.......990..-.-....1000.-.....1010......---..1020.......-1030--..----.......1040......1050......1060..-....1070.......-.1080......1090......1100........---1110........1120..--....--1130......1140....-.---.1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520.......1530-.......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680--.-.......1690......1700......1710........1720......1730......1740......-1750......1760......1770......1780.......1790......1800.....--.1810......1820......1830.--.....1840......1850......1860......1870......1880......1890.......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780......2790......2800......2810......2820......2830......2840......2850......2860......2870......2880......2890......2900......2910......2920......2930......2940......2950......2960......2970......2980......2990......3000......3010......3020......3030......3040......3050......3060......3070......3080......3090......3100......3110......3120......3130......3140......3150......3160......3170......3180......3190......3200......3210......3220......3230......3240......3250......3260......3270......3280......3290......3300......3310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMARRPPWRGLGGR
S
T
P
I
L
L
L
L
L
L
S
LFPL
S
Q
E
ELGGGGHQGWDPGLAATTGPRAHIGG
G
A
L
A
LCPESSGVREDGGPGLGVRE
P
I
F
V
G
LRGR
R
Q
SARNSRGPPEQP
N
E
EL
G
I
E
HGVQPLGSRERETGQGPG
S
V
L
Y
WRPEVSSCGRTGPLQRGSLSP
G
A
LSSGVPGSGNSSPLP
S
D
F
L
I
RHHGPKPVSSQRNAGTGSRKRV
G
T
A
R
C
C
G
E
LWATGSKGQGERATTSGAERTAPRRNCLPGASGSGPELDSAPRTARTAPASGSAPRESRTAPEP
A
P
K
R
M
R
SRG
L
F
R
C
RFLPQRPGPRPPGLPARPE
A
R
KVT
S
A
N
R
A
R
F
R
R
A
ANRHPQFPQYN
Y
Q
TLVPENEAA
G
T
A
V
L
R
V
V
AQDPDAG
E
A
G
R
L
V
Y
S
L
A
-
A
L
M-N-SRS
L
E
L
F
S
IDPQS
G
L
I
R
T
A
A
AL
D
R
E
S
M
E
R
H
Y
L
R
V
T
AQDHGSPR
L
S
A
T
T
M
V
A
V
T
V
ADRNDHS
P
V
F
E
Q
A
Q
Y
R
E
T
L
R
E
N
V
E
EGY
P
I
L
Q
L
R
ATDGDAP---P---NA
N
L
R
Y
R
FVGPP
A
A
R
AA
A
A
A
A
F
E
IDPRS
G
L
IST-S-GR-V
D
R
E
H
M
E
S
Y
E
L
V
V
EASDQGQEPGPR
S
A
T
V
R
V
H
I
T
V
LDENDNAPQ
F
S
E
K
R
----
Y
V
A
Q
V
R
EDVRP--
H
T
V
V
L
R
V
T
ATDRDKDA--N
G
L
V
H
Y
N
I
-ISGN----SRG
H
-
F
A
I
--D----SLTG
E
I
Q
V
V
A
PLDFEAE
R
E
Y
A
L
R
I
R
AQD-AGR--P--P--LSNNTG
L
A
S
I
Q
V
V
DINDHI
P
I
F
VST
P
----
F
Q
V
S
V
LENAPL--G
H
S
V
I
H
I
Q
A
VDAD---HG---E---N
A
R
L
E
Y
S
L
TGVA----P----DT
P
----
F
V
I
NS--------AT
G
W
V
-
S
V-S-GP-L
D
R
E
S
V
-----
E
H
Y
F
F
G
V
E
ARDHG--SPP---LSAS
A
S
V
T
V
T
V
L
DVNDNRPEF
T
M
K
E
--
Y
H
L
R
LNEDAAVG
T
S
V
V
S
V
T
A
VDRD-----A-----N----
S
----
A
I
S
--------
Y
Q
I
TGG---N----T----R----
N
R
F
A
I
----S--T--Q--G
G
-
V
G
L
V
T
L
A
-LPLDYKQ
E
R
Y
F
K
L
V
L
TASD---R------A---------L-----H
D
H
C
Y
V
H
I
N
ITDANTHRP
V
F
QSA
H
Y
S
V
S
VNEDRPMG
S
T
I
V
V
I
SASDDDV-GE--N---
A
--
R
I
T
Y
L
LED---N--L
P
Q
F
-----
R
I
------D----AD----S
G
A
I
T
L
QAPLDYED
Q
-----
V
T
Y
T
L
A
I
T
ARDN---G------I------P-------QKAD
T
T
Y
V
E
V
M
V
NDVNDNA
P
Q
F
V
A
S
H
Y
T
G
-
L
VSEDAPPF
T
S
V
L
Q
I
SATDRDAHAN
G
-
R
-
V
Q
Y
T
FQNGE-DGDG
D
F
--
T
I
EPTS
G
---
I
V
R
-
T
V
R
R
L
D
R
E
A
-
V
-----
S
V
----
Y
E
L
T
A
Y
A
VDRGVPPLRTP
V
S
I
Q
V
M
V
Q
DVNDNAP-VF
P
A
E
--
E
F
E
V
R
V
KE-NS
I
V
G
S
V
V
A
Q
I
T
AVDPDEGPN
A
-
H
-
I
M
Y
Q
IVEG---N--I
P
E
L
F
Q
M
DIFSG
E
L
T
--
A
L
I
D--LD
Y
E
A
R
Q
E
Y
V
I
V
V
QATSA-P---
L
V
S
R
A
T
V
H
V
R
L
V
DQNDNSPVL
N
N
F
Q
I
L
F
N
N
YVSNRSDTFPSGIIGRIPAYDPDVSD
H
L
F
Y
S
FERG
N
E
L
Q
L
L
V
V
NQTSG
E
L
R
L
S
RKLDNNR
P
L
V
A
S
M
L
V
T
V
TD
G
L
H
S
V
T
A
Q
C
V
L
R
V
V
I
I
T
E
E
L
L
A
N
S
L
T
V
R
L
E
N
M
W
Q
E
R
F
L
S
P
L
L
G
R
F
L
E
G
V
A
A
V
LATPAE
D
V
F
I
F
NIQNDTDVG
G
T
V
L
N
V
S
F
S
ALAPRGAGAGAAGPWF
S
S
E
E
L
Q
E
Q
L
Y
V
R
R
A
A
L
A
A
R
S
L
L
D
VLPFDDNV
C
L
R
E
P
C
E
N
Y
M
K
C
V
S
V
L
RFDSSAP
F
L
A
S
A
S
T
L
F
RPIQPIAGLRCRCPPGFTG
D
F
C
E
T
E
L
D
L
CYSNPCRNGGACARREG
G
Y
T
C
V
C
RPRFTGEDCELDTEAGRCVPGVCRNGGTCTDAPNGG
F
R
C
QCPAGGAFEGPR
C
E
V
AARSF-PP
S
S
F
V
M
F
R
G
L
R
--
Q
R
F
H
L
T
L
S
L
S
F
A
T
VQQS
G
L
L
F
YNGRLNEKH
D
F
L
A
L
E
L
VAG
Q
V
R
L
T
Y
STGESN
T
V
V
SPTVPGGLSDG
Q
W
H
T
V
H
L
R
Y
YNKPRTDALGGAQGPSKD
K
V
A
V
L
S
VDDC
D
V
A
V
A
L
Q
FGAEIGNYSCAAAGVQTSSKKSLDLTG
P
L
LLGGVPNLPE----N-FPV
S
H
K
D
F
I
G
C
M
R
D
LHIDG
R
R
V
D
M
A
A
F
V--ANNGTMAG
C
Q
A
K
L
H
FCDSGPCKNSGF
C
S
E
RWGSFSCDCP-VGFGGK
D
C
Q
L
T
MAHPHHFRGN
G
T
L
S
W
NFGSD
M
-
A
V
SV
P
W
Y
L
G
L
A
F
RTRATQ
G
V
L
M
Q
V
QAG--PH
S
T
L
L
C
Q
LDRG
L
L
S
V
T
V
TRGSGR
A
S
--
H
L
L
L
D
Q
V
TVSDG
R
W
H
D
L
R
L
E
L
QEEPGGRRG
H
H
V
L
M
V
SL
D
F
S
L
F
Q
D
T
M
A
VGSELQG
L
-
K
V
K
Q
L
HVGGLPPGS
A
E
EA
P
Q
G
L
V
G
C
I
Q
G
V
WLGSTPSGSPALLPPSHRVNAEPG
C
V
V
TNACASGPCPP
H
A
D
C
R
D
L
W
Q
T
FS
C
T
CQPGYYGP
G
C
V
D
A
C
LLNPCQNQGSCRHLPGAPHG
Y
T
CDCVG
G
Y
F
G
H
H
C
E
H
R
M
D
QQCPRGWWGSPTCGPCNCDVHKGFDPNCNKTNG
Q
C
H
C
K
EFHYRPRGSDSCLPCDCYPVGSTSRSCAPHSGQCPCRPGALGRQCNSCDS
P
F
A
E
V
T
A
S
G
C
R
V
L
Y
D
A
C
P
K
S
L
RSGVWWPQTKF
G
V
L
A
TVPCPR
G
A
L
G
A
A
V
R
L
C
D
E
A
QGWLEPDLFNCT
S
P
A
F
R
E
L
S
L
L
L
DGLEL
N
K
T
A
L
D
T
M
E
A
K
K
L
A
Q
R
L
R
E
VTGHTDHY
F
S
Q
D
V
R
V
T
A
R
L
L
A
H
L
L
A
F
E
S
HQQGFGLTATQDAHFNEN
L
L
WAGSALLAPETG
D
L
W
A
A
L
GQRAPGGSP
G
S
A
G
L
V
R
H
L
E
E
Y
A
A
T
L
ARN
M
E
L
T
Y
LNPMGLVTP
N
I
M
L
S
I
DRMEHPSSPRGARRY
P
R
Y
HSNLFRGQDAWDPHT
H
V
L
LPSQSPRPSPSEVLPTSSSIENSTTSSVVPPPAPPEPEPG
I
S
I
I
I
L
L
V
Y
R
T
L
GGLL
P
A
Q
F
Q
A
E
RRGARLPQNPVMNSP
V
V
S
V
A
V
F
HG
R
N
F
L
R
G
I
L
ESPI
S
L
E
F
R
L
LQTANRS
K
A
I
C
V
QWDPPGL
A
E
QHGVWTAR
D
C
E
L
V
HRNGS
H
A
R
C
R
CSRTG
T
F
G
V
L
MDA
S
P
R
E
R
L
E
G
D
L
E
L
L
A
V
F
T
H
V
V
V
A
V
S
V
A
A
L
V
L
T
A
A
I
L
L
S
L
R
S
L
K
S
N
V
R
G
I
H
A
N
V
A
A
A
L
G
V
A
E
L
L
F
L
L
GIHRTH
N
Q
L
V
C
T
A
V
A
I
L
L
H
Y
F
F
L
S
T
F
A
W
L
F
V
QG
L
H
L
Y
R
M
QVEPRNV
D
R
G
A
M
R
F
Y
H
A
LGW
G
V
P
A
V
L
L
G
L
AVGLDPEGYGNP
D
F
C
W
I
S
VHEP
L
I
W
SFAG
P
V
V
L
V
I
V
MNG
T
M
F
L
L
A
ARTSCSTG
Q
R
E
A
KKT
S
A
L
T
L
R
S
S
F
L
L
L
L
L
V
S
A
S
W
L
F
G
L
L
A
VN
H
S
I
L
A
F
H
Y
L
H
A
G
L
C
G
L
Q
G
L
A
V
L
L
L
F
C
VLNADAR
A
A
W
M
P
A
C
LGRKAAPEEARPAPGLGPGAYNNT
A
L
FEES
G
L
I
R
I
T
LGA
S
T
V
S
S
V
S
S
ARSGRTQD
Q
D
S
Q
R
G
R
S
Y
L
RDN
V
L
V
RHGSAADHTDHSLQAHAGPTDL
D
V
A
M
F
HRDAGADSDSDSDLSL
E
E
ERSLSIPSSESEDNGRTRG
R
F
Q
R
P
L
C
R
A
A
Q
SERLLTHPKDVDG
N
D
L
L
S
YWPALGECEAAP
C
A
L
Q
TWGSERRLGLDTSKDAANNNQPDPALTSGDE
T
S
L
G
R
A
Q
R
Q
R
K
G
I
L
K
NRLQYPLVPQTRGAPE
L
S
W
C
R
AATLGHRAVPAASY
G
R
I
Y
AGGGTGSLS
Q
P
A
S
R
YS
S
R
E
Q
L
D
L
L
L
R
R
Q
L
S
R
E
R
L
E
EAPA
P
V
L
RPLSRP
G
S
Q
E
C
M
DAAPGRLEPKDRGSTLPRRQPPRDYP
G
A
M
AGRFGSRDALDLGA
P
R
E
W
L
S
TLPPPRRTRDLDPQPPPLPLS
P
Q
R
QLSRDPLLPSRP
L
D
S
L
SRSSN
S
R
E
Q
L
D
Q
VPSRHPS
R
E
AL
G
P
L
P
Q
L
L
R
A
REDSVSGPSHGPS
T
E
Q
L
D
I
L
S
S
I
L
A
S
F
N
S
S
A
L
S
S
V
QSSSTPLGPHTTATPSATASVLGPSTPRSATSH
S
I
SELSPDSEVPRSEGHS
130
HHSearch
92.37
29%
-45
- C9 -
3Q2W
26
CADH2_MOUSE
A:
[4-542]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
P
P
I
N
L
P
E
N
S
R
---
G
P
F
P
Q
E
L
V
R
I
R
S
D
R
D
K
--
N
L
S
L
R
Y
S
V
-
T
G
P
G
ADQP
P
T
G
I
-
F
I
I
--
N
----
P
I
S
G
Q
L
S
V
T
K
P
L
D
R
E
L
I
A
R
F
H
L
R
A
H
A
V
D
-
I
N
G
--
N
--
Q
--
V
E
N
-
P
I
D
I
V
I
N
V
I
D
M
N
D
N
R
P
E
F
L
H
Q
V
----
W
N
G
S
V
P
E
G
S
K
P
--
G
T
Y
V
M
T
V
T
A
I
D
A
D
---
D
P
NA-
L
---
N
G
M
L
R
Y
R
I
L
S
Q
A
PSTP
S
----
P
N
M
----
F
T
I
N
N
--------
E
T
G
D
I
I
T
V
-
A
-
A
G
-
L
D
R
E
K
V
-----
Q
Q
Y
T
L
I
I
Q
A
T
D
M
E
--
G
N
P
TY
G
L
S
N
T
A
T
A
V
I
T
V
T
D
V
N
D
N
P
P
E
F
T
A
M
T
--
F
Y
G
E
V
P
E
N
R
-
V
D
V
I
V
A
N
L
T
V
T
D
K
D
-----
Q
-----
P
----
H
TPAW
N
A
A
--------
Y
R
I
S
G
G
---
D
----
P
----
T
----
G
R
F
A
I
L
T
DP
N
--
S
--
N
--
D
---
G
L
V
T
V
V
-
K
P
I
D
F
E
T
N
R
M
F
V
L
T
V
A
A
E
N
---
Q
------
V
P
L
A
KGIQHP
P
-----
Q
S
T
A
T
V
S
V
T
V
I
D
V
N
E
N
-
P
Y
F
A
P
N
P
K
I
I
R
Q
E
E
G
L
H
A
G
T
M
L
T
T
L
T
A
Q
D
P
D
R
-
Y
M
--
Q
---
Q
--
N
I
R
Y
T
K
L
S
---
D
P-
A
N
W
L
-----
K
I
------
D
----
P
V
----
N
G
Q
I
T
T
I
A
V
L
D
R
E
S
P
NVKN-
N
I
Y
N
A
T
F
L
A
S
D
N
---
G
------
I
------
P
-------
P
M
S
G
T
G
T
L
Q
I
Y
L
L
D
I
N
D
N
A
P
Q
V
L
P
Q
E
A
---
E
T
C
E
T
P
E
P
N
S
--
I
N
I
T
A
L
D
Y
D
I
D
P
N
A
-
G
P
F
A
F
D
L
P
L
S
P
V
T
I
K
R
N
W
--
T
I
N
R
L
N
G
---
D
F
A
Q
L
N
L
K
I
K
F
-
E
-
A
-----
G
I
----
Y
E
V
P
I
I
I
T
D
S
G
N
P
P
K
S
N
I
S
I
L
R
V
K
V
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
86.58
29%
-47
- C9 -
1L3W
26
CADHF_XENLA
A:
[7-543]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
----
I
K
V
S
E
N
E
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
N
K
D
R
------------
F
N
K
V
Y
Y
S
I
T
G
Q
G
ADNP
P
----
Q
G
V
----
F
R
I
E
W
--------
E
T
G
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
E
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
E
N
--
G
S
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
--
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
-----
D
NIDSL
N
----
G
----
V
L
S
--------
Y
S
I
L
K
Q
---
D
----
P
EEPI
P
----
N
L
F
T
I
----
N
--
R
--
E
--
T
---
G
V
I
S
L
I
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
---
L
------
E
GA
G
------
L
-----
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
-
P
G
TP
A
---
W
--
Q
A
V
Y
K
I
R
V
N--
E
--
G
G
F
F
-----
N
I
------
T
T
D
PE
S
N
----
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
-----
K
Q
Y
V
L
Q
I
T
V
E
N
A
---
E
------
P
FS
V
---
P
-------
L
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
I
Q
-
K
-
L
S
Y
F
I
G
N
D
---
P
A
R
W
L
--
T
V
N
K
D
N
G
---
I
V
T
-
G
N
G
N
L
D
R
E
S
-
E
YVKN-
N
T
----
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
-
V
P
S
P
R
--
V
F
T
M
--
C
D
-
Q
-
N
P
E
P
Q
V
--
L
T
I
S
D
A
D
I
P
P
N
--
T
-
Y
P
Y
K
V
S
L
S
HGS
D
--
L
T
W
K
A
E
L
D
S
K
-
G
T
S
M
--
L
L
S
P
--
T
Q
Q
L
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
---
N
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
85.98
26%
-57
- C9 -
3Q2W
26
CADH2_MOUSE
A:
[4-542]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----
P
P
I
N
L
P
E
N
S
R
---
G
P
F
P
Q
E
L
V
R
I
R
S
D
---
R
D
---
K
---
N
L
S
L
R
Y
S
V
T
G
P
G
ADQP
P
----
T
G
I
----
F
I
I
N
P
--------
I
S
G
Q
L
-
S
V
-
T
-
K
P
-
L
D
R
E
L
I
-----
A
R
F
H
L
R
A
H
A
V
D
I
N
--
G
N
Q
---
V
E
N
P
I
D
I
V
I
N
V
I
D
M
N
D
N
R
P
E
F
L
H
Q
V
--
W
N
G
S
V
P
E
G
S
K
P
G
T
Y
V
M
T
V
T
A
I
D
A
D
-----
D
PNAL-
N
----
G
----
M
L
R
--------
Y
R
I
L
S
Q
---
A
PSTP
S
----
P
----
N
M
F
T
I
----
N
--
N
--
E
--
T
G
-
D
-
I
I
T
V
A
-
A
G
L
D
R
E
K
V
Q
Q
Y
T
L
I
I
Q
A
T
D
---
M
------
E
GNPTY
G
---
L
-----
S
N
T
A
T
A
V
I
T
V
T
D
V
N
D
N
P
P
E
F
T
A
M
T
F
Y
G
E
V
P
E
N
R
-
V
D
V
I
V
A
N
L
T
V
T
D
K
D
Q
-
P
H
--
T
PA-
W
--
N
A
A
Y
R
I
S
G
---
G
DP
T
G
R
F
-----
A
I
L
T
DP--
N
----
S
N
----
D
G
L
V
T
V
V
K
P
I
D
F
E
T
N
-----
R
M
F
V
L
T
V
A
A
E
N
Q
---
V
------
P
L
A
KGIQ
H
-------
P
P
Q
S
T
A
T
V
S
V
T
V
I
D
V
N
E
N
-
P
Y
F
A
P
N
P
K
I
I
-
R
Q
E
E
G
L
H
A
G
T
M
L
T
T
L
T
A
Q
D
P
D
R
Y
M
Q
Q
-
N
-
I
R
Y
T
K
L
S
D
---
P
A
N
W
L
--
K
I
D
P
V
N
G
---
Q
I
T
-
T
I
A
V
L
D
R
E
S
-
P
NVKN-
N
I
----
Y
N
A
T
F
L
A
S
D
N
G
I
P
P
M
S
G
T
G
T
L
Q
I
Y
L
L
D
I
N
D
N
A
P
-
Q
V
L
P
Q
--
E
A
--
E
T
C
E
-
T
P
E
P
N
--
S
I
N
I
T
A
L
D
Y
D
I
D
P
N
A
-
G
P
F
A
F
D
L
P
L
S
---
P
V
T
I
K
R
N
W
T
I
N
R
L
N
G
D
F
A
Q
-
L
N
L
K
--
I
K
F
-
E
A
G
I
Y
E
V
P
I
I
I
T
D
S
-
G
NP
P
K
S
N
I
S
I
L
R
V
K
V
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Fugue
84.88
24%
-28
- C9 -
1L3W
26
CADHF_XENLA
A:
[7-546]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
V
S
E
N
E
R
G
P
F
P
K
R
L
V
Q
I
---
K
S
N
K
D
R
F
N
K
V
Y
Y
S
I
T
G
Q
G
A
-
D
-
N
P
P
Q
G
V
F
R
I
E
W
E
T
G
W
M
L
V
T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
E
N
G
S
P
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
N
IDS
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
P
E
E
P
I
P
N
L
-
F
T
I
N
R
E
T
G
V
I
S
L
-
I
-
G
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
L
E
--
G
A
G
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
N
-
E
I
--
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
--
T
P
A
W
Q
A
V
Y
K
I
R
V
N
----
E
G
G
F
-
F
N
I
--
T
T
D
PE
S
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
K
Q
Y
V
L
Q
I
T
V
E
N
-
A
E
P
FS
V
--
P
--
L
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
A
-
P
F
F
V
P
A
V
----
S
R
V
D
V
S
E
D
L
S
R
--
G
E
K
I
I
S
L
V
A
Q
D
P
D
---
K
Q
---
Q
---
I
Q
K
L
S
Y
F
I
G
N
-
D
----
P
----
A
R
W
----
L
T
V
N
K
--------
D
N
G
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
S
E
YVKN-
N
T
Y
T
V
I
M
L
V
T
D
D
G
--
V
S
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
--
F
T
M
C
D
Q
N
P
---
E
P
Q
V
L
T
I
S
D
A
D
I
P
-----
P
-----
N
----
T
----
Y
-
P
--------
Y
K
V
S
L
S
---
H
----
G
----
S
----
D
L
T
W
K
----
A
--
E
--
L
--
D
S
-
K
G
T
S
M
L
L
-
S
P
T
Q
Q
L
K
K
G
D
Y
S
I
Y
V
L
L
S
D
---
A
QNN---
P
---------
Q
-----
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
83.35
25%
-32
- C9 -
1L3W
26
CADHF_XENLA
A:
[7-543]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
I
P
P
I
K
V
S
E
N
E
R
G
P
F
P
K
R
L
V
Q
I
K
S
N
K
D
R
---
F
N
K
V
Y
Y
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I
T
-
G
Q
G
A
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-
N
P
P
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W
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L
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T
R
P
L
D
R
E
E
Y
D
K
Y
V
L
S
S
H
A
V
S
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N
G
S
P
V
E
E
P
M
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I
T
I
N
V
I
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N
D
N
R
P
K
F
T
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G
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V
R
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G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
D
N
IDS
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
P
E
-
E
P
I
P
N
L
F
T
I
N
R
E
T
G
V
I
S
L
-
I
G
T
G
-
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
L
E
G
A
--
G
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
----
Y
T
A
L
V
P
E
N
E
-
I
--
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
TP
A
W
Q
A
V
Y
K
I
-
R
V
N
-----
E
G
G
F
-
F
N
I
--
T
T
D
PE
S
N
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
K
Q
Y
V
L
Q
I
T
V
E
N
-
A
E
P
--
F
--
S
V
P
L
P
T
S
T
A
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V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
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P
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----
S
R
V
D
V
S
E
D
L
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R
--
G
E
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I
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L
V
A
Q
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P
D
---
K
Q
---
Q
---
I
Q
K
L
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Y
F
I
G
N
D
-----
P
----
A
R
W
----
L
T
V
N
K
--------
D
N
G
I
V
-
T
G
-
N
-
G
N
-
L
D
R
E
S
E
YVKN-
N
T
Y
T
V
I
M
L
V
T
D
D
G
--
V
S
V
---
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
--
F
T
M
--
C
D
Q
-
N
P
E
P
Q
V
L
T
I
--
S
D
A
D
-----
I
P----
P
----
N
----
T
Y
P
--------
Y
K
V
S
L
S
HGS
D
----
L
----
T
----
W
K
A
E
L
----
D
--
S
--
K
--
G
----
T
S
M
L
L
-
S
P
T
Q
Q
L
K
K
G
D
Y
S
I
Y
V
L
L
S
D
---
A
------
Q
N--------
N
-----
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
83.28
25%
-48
- C9 -
1Q55
15
?
A:
[156-691]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWVI
P
P
I
K
V
S
E
N
E
R
G
PF
P
K
R
L
V
Q
I
K
S
N
K
D
---------
R
---
F
N
K
V
Y
Y
S
I
T
G
Q
G
----
A
DNPP
Q
G
V
----
F
R
I
E
W
--------
E
T
G
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
E
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
E
N
--
G
S
P
---
V
E
E
P
M
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I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
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D
V
--
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
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M
A
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S
A
T
D
E
D
-----
D
NIDSL
N
----
G
----
V
L
S
--------
Y
S
I
L
K
Q
---
D
PEEP
I
----
P
----
N
L
F
T
I
----
N
--
R
--
E
--
T
---
G
V
I
S
L
I
G
T
G
L
D
R
E
K
F
P
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Y
T
L
T
V
Q
A
T
D
---
L
------
E
GA
G
------
L
-----
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
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K
T
Y
T
A
L
V
P
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N
E
-
I
G
F
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R
L
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V
T
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L
D
M
-
P
G
TP
A
---
W
--
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A
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Y
K
I
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V
---
N
E-
G
G
F
F
-----
N
I
------
T
T
D
PE
S
N
----
Q
G
I
L
T
T
A
K
G
L
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F
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L
R
-----
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Y
V
L
Q
I
T
V
E
N
A
---
E
------
P
FS
V
---
P
-------
L
P
T
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T
A
T
V
T
V
T
V
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D
V
N
E
-
A
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P
A
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R
V
-
D
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D
L
S
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L
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A
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D
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D
K
Q
Q
I
Q
-
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L
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Y
F
I
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N
D
---
P
A
R
W
L
--
T
V
N
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D
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G
---
I
V
T
-
G
N
G
N
L
D
R
E
S
-
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YVKN-
N
T
----
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
-
V
P
S
P
R
--
V
F
T
--
M
C
D
-
Q
N
P
E
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---
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
P
-
Y
K
V
S
L
S
H
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---
S
D-
L
T
W
K
A
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L
D
S
-
K
G
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M
--
L
L
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P
--
T
Q
Q
L
K
K
G
D
Y
S
I
Y
V
L
L
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D
A
Q
N
---
N
P
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
81.82
24%
-41
* C9 *
1Q55
15
?
A:
[156-691]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWVI
P
P
I
K
V
S
E
N
E
R
G
PF
P
K
R
L
V
Q
I
K
S
N
K
D
---
R
--
F
N
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Y
Y
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-
T
G
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G
ADNP
P
Q
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I
--
E
----
W
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T
G
W
M
L
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T
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P
L
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D
K
Y
V
L
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S
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S
-
E
N
G
--
S
--
P
--
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E
-
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P
M
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T
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N
V
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K
F
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D
V
----
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R
G
S
V
R
E
G
V
Q
P
--
G
T
Q
V
M
A
V
S
A
T
D
E
D
---
D
N
IDS
L
---
N
G
V
L
S
Y
S
I
L
K
Q
D
PEEP
I
----
P
N
L
----
F
T
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N
R
--------
E
T
G
V
I
-
S
L
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I
G
T
G
-
L
D
R
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K
F
-----
P
E
Y
T
L
T
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Q
A
T
D
L
E
--
G
A
G
---
L
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
--
Y
T
A
L
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P
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N
E
-
I
G
F
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V
Q
R
L
S
V
T
D
L
D
-----
M
-----
P
GTPA
W
----
Q
A
V
--------
Y
K
I
R
V
N
--------
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----
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----
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F
N
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----
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--
T
--
D
PE
S
N
-
Q
G
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L
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A
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K
G
L
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L
R
K
Q
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L
Q
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N
---
A
------
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V
P
L
---
P
-----
T
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T
A
T
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T
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T
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D
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N
E
-
A
P
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---
Q
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L
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F
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---
D
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A
R
W
L
-----
T
V
------
N
----
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D
----
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G
N
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S
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N
T
Y
T
V
I
M
L
V
T
D
D
---
G
------
V
------
S
-------
V
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
V
P
S
P
R
V
F
T
---
M
C
D
Q
N
P
E
P
---
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
---
Y
P
Y
K
V
S
L
S
H
-
G
S
D
L
T
W
K
A
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L
D
S
-
K
G
---
T
S
M
-
L
L
S
P
T
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Q
L
K
-
K
-----
G
D
----
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
--
Q
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
-
K
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
81.28
25%
-40
- C9 -
3Q2V
22
CADH1_MOUSE
A:
[6-536]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
C
P
E
N
E
K
-
G
E
F
P
K
N
L
V
Q
I
K
S
N
R
D
K
E
T
K
V
F
Y
S
I
T
-
G
Q
G
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A
D
K
P
P
V
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V
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R
E
T
G
W
L
K
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A
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A
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Y
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Y
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H
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G
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A
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M
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V
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F
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G
S
V
A
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G
A
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P
G
T
S
V
M
K
V
S
A
T
D
A
D
D
D
---
V
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N
A
A
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A
Y
T
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V
S
Q
D
P
E
-
L
P
H
K
N
M
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L
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A
A
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L
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--
G
L
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A
K
A
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I
T
V
K
D
I
N
D
N
A
P
V
F
N
P
S
T
----
Y
Q
G
Q
V
P
E
N
E
-
V
--
N
A
R
I
A
T
L
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T
D
D
D
A
P
N
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A
W
K
A
V
Y
T
V
-
V
N
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P
-----
D
Q
Q
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F
V
V
V
T
D
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T
N
D
G
I
L
K
T
A
K
G
L
D
F
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A
K
Q
Q
Y
I
L
H
V
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V
E
N
-
E
E
P
--
F
EG
S
--
L
V
P
S
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A
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T
V
D
V
V
D
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N
E
-
A
P
I
F
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P
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----
R
R
V
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V
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--
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T
A
R
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D
---
T
F
---
M
---
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Y
R
I
W
R
D
-----
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----
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N
W
----
L
E
I
N
P
--------
E
T
G
A
I
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F
T
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R
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A
E
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M
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S
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A
L
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T
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I
---
A
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L
L
L
V
L
L
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V
N
D
N
A
P
I
P
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N
--
M
Q
F
C
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Q
R
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P
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Q
P
---
H
I
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T
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L
D
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D
-----
L
-----
P
PN--
T
S---
P
F
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--------
A
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G
---
A
---------
S
----
V
N
W
T
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----
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D
A
A
Q
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L
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L
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Q
P
R
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D
----
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Y
K
I
H
L
K
L
A
D
---
N
------
Q
N--------
K
-----
D
Q
V
T
T
L
D
V
H
V
C
D
C
E
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.45
29%
-42
- C10 -
1Q55
14
?
A:
[157-594]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
P
P
----
I
K
V
S
E
N
E
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
---
N
---
K
D
---
R
---
F
N
K
V
Y
Y
S
I
T
G
Q
G
----
A
----
D
N
P
PQGV
F
R
I
E
W
--------
E
T
G
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
E
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
E
N
--
G
S
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
--
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNIDS
L
-----
N
----
G
----
V
L
S
--------
Y
S
I
L
K
Q
---
D
----
P
----
E
EPIP
N
L
F
T
I
----
N
--
R
--
E
--
T
G
-
V
-
I
S
L
I
G
-
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
LEG
A
------
G
---------
L
-----
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
---
A
W-
Q
A
V
Y
K
I
R
V
---
N
--
E
G
G
F
F
N
I
T
T
D
P
------
E
----
S
N
----
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
-----
K
Q
Y
V
L
Q
I
T
V
E
N
A
EPF
S
------
V
------
P
-------
L
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
I
Q
-
K
-
L
S
Y
F
I
--
G
N
-
D
P
A
R
W
L
--
T
V
N
K
D
N
G
---
I
V
T
-
G
N
G
N
L
D
R
E
S
-
E
-----
Y
V
KNN
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
-
V
P
S
P
R
--
V
F
T
M
C
D
Q
N
-
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
P
Y
K
V
-
S
-
L
S
H
G
S
D
L
T
---
W
--
K
A
E
L
D
S
K
G
T
S
M
L
L
S
P
--
T
Q
Q
L
--
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
-
Q
---
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.36
29%
-42
- C10 -
1L3W
25
CADHF_XENLA
A:
[8-445]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
P
P
----
I
K
V
S
E
N
E
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
---
N
---
K
D
---
R
---
F
N
K
V
Y
Y
S
I
T
G
Q
G
----
A
----
D
N
P
PQGV
F
R
I
E
W
--------
E
T
G
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
E
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
E
N
--
G
S
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
--
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNIDS
L
-----
N
----
G
----
V
L
S
--------
Y
S
I
L
K
Q
---
D
----
P
----
E
EPIP
N
L
F
T
I
----
N
--
R
--
E
--
T
G
-
V
-
I
S
L
I
G
-
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
LEG
A
------
G
---------
L
-----
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
---
A
W-
Q
A
V
Y
K
I
R
V
---
N
--
E
G
G
F
F
N
I
T
T
D
P
------
E
----
S
N
----
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
-----
K
Q
Y
V
L
Q
I
T
V
E
N
A
EPF
S
------
V
------
P
-------
L
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
I
Q
-
K
-
L
S
Y
F
I
--
G
N
-
D
P
A
R
W
L
--
T
V
N
K
D
N
G
---
I
V
T
-
G
N
G
N
L
D
R
E
S
-
E
-----
Y
V
KNN
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
-
V
P
S
P
R
--
V
F
T
M
C
D
Q
N
-
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
P
Y
K
V
-
S
-
L
S
H
G
S
D
L
T
---
W
--
K
A
E
L
D
S
K
G
T
S
M
L
L
S
P
--
T
Q
Q
L
--
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
-
Q
---
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.21
28%
-33
- C10 -
3Q2W
25
CADH2_MOUSE
A:
[2-475]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
P
P
----
I
N
L
P
E
N
S
R
G
P
F
--
P
Q
E
L
V
R
I
R
S
---
D
---
R
D
---
K
---
N
L
S
L
R
Y
S
V
T
G
P
G
----
A
----
D
Q
P
PTGI
F
I
I
N
P
--------
I
S
G
Q
L
-
S
V
-
T
-
K
P
-
L
D
R
E
L
I
-----
A
R
F
H
L
R
A
H
A
V
D
I
N
--
G
N
Q
---
V
E
N
P
I
D
I
V
I
N
V
I
D
M
N
D
N
R
P
E
F
L
H
Q
V
--
W
N
G
S
V
P
E
G
S
K
P
G
T
Y
V
M
T
V
T
A
I
D
A
D
-----
D
-----
P
----
N
----
A
L
N
G
M
L
R
Y
R
I
L
S
Q
A
P
S
T
---
P
----
S
----
P
----
N
M
F
T
I
----
N
--
N
--
E
--
T
G
--
D
I
I
T
V
A
-
A
G
L
D
R
E
K
V
Q
Q
Y
T
L
I
I
Q
A
T
D
---
M
EGNPTY
G
---------
L
-----
S
N
T
A
T
A
V
I
T
V
T
D
V
N
D
N
P
P
E
F
T
A
M
T
F
Y
G
E
V
P
E
N
R
-
V
D
V
I
V
A
N
L
T
V
T
D
K
D
Q
-
P
H
--
T
---
P
AW
N
A
A
Y
R
I
S
G
---
G
--
D
P
T
G
-----
R
F
A
I
L
T
DP
N
----
S
N
----
D
G
L
V
T
V
V
K
P
I
D
F
E
T
N
-----
R
M
F
V
L
T
V
A
A
-
E
N
---
Q
------
V
------
P
L
A
KGIQH
P
P
Q
S
T
A
T
V
S
V
T
V
I
D
V
N
E
N
-
P
Y
F
A
P
N
P
K
I
I
-
R
Q
E
E
G
L
H
A
G
T
M
L
T
T
L
T
A
Q
D
P
D
R
Y
M
Q
Q
-
N
-
I
R
Y
T
--
K
L
S
-
D
P
A
N
W
L
--
K
I
D
P
V
N
G
---
Q
I
T
-
T
I
A
V
L
D
R
E
S
-
P
-----
N
V
KNN
I
Y
N
A
T
F
L
A
S
D
N
G
I
P
P
M
S
G
T
G
T
L
Q
I
Y
L
L
D
I
N
D
N
A
P
Q
V
L
P
Q
E
--
A
E
T
C
E
T
P
E
P
N
S
I
------
N
I
T
A
L
D
Y
D
I
D
P
N
A
-
G
-
P
F
A
F
D
L
P
L
---
S
--
P
V
T
I
K
R
N
W
T
I
N
R
L
N
G
--
D
F
A
Q
--
L
N
L
K
I
K
F
E
A
G
I
Y
E
V
P
I
I
I
-
T
---
D
S
G
N
P
P
K
S
N
I
S
I
L
R
V
K
V
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.17
29%
-42
- C10 -
1Q5C
14
?
A:
[157-594]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
P
P
----
I
K
V
S
E
N
E
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
---
N
---
K
D
---
R
---
F
N
K
V
Y
Y
S
I
T
G
Q
G
----
A
----
D
N
P
PQGV
F
R
I
E
W
--------
E
T
G
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
E
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
E
N
--
G
S
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
--
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNIDS
L
-----
N
----
G
----
V
L
S
--------
Y
S
I
L
K
Q
---
D
----
P
----
E
EPIP
N
L
F
T
I
----
N
--
R
--
E
--
T
G
-
V
-
I
S
L
I
G
-
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
LEG
A
------
G
---------
L
-----
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
---
A
W-
Q
A
V
Y
K
I
R
V
---
N
--
E
G
G
F
F
N
I
T
T
D
P
------
E
----
S
N
----
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
-----
K
Q
Y
V
L
Q
I
T
V
E
N
A
EPF
S
------
V
------
P
-------
L
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
I
Q
-
K
-
L
S
Y
F
I
--
G
N
-
D
P
A
R
W
L
--
T
V
N
K
D
N
G
---
I
V
T
-
G
N
G
N
L
D
R
E
S
-
E
-----
Y
V
KNN
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
-
V
P
S
P
R
--
V
F
T
M
C
D
Q
N
-
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
P
Y
K
V
-
S
-
L
S
H
G
S
D
L
T
---
W
--
K
A
E
L
D
S
K
G
T
S
M
L
L
S
P
--
T
Q
Q
L
--
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
-
Q
---
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
79.38
26%
-44
- C9 -
3Q2V
22
CADH1_MOUSE
A:
[7-536]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
C
P
E
N
E
K
---
G
E
F
P
K
N
L
V
Q
I
K
S
N
R
D
K
--
E
T
K
V
F
Y
S
I
-
T
G
Q
G
ADKP
P
V
G
V
-
F
I
I
--
E
----
R
E
T
G
W
L
K
V
T
Q
P
L
D
R
E
A
I
A
K
Y
I
L
Y
S
H
A
V
S
-
S
N
G
--
E
--
A
--
V
E
D
-
P
M
E
I
V
I
T
V
T
D
Q
N
D
N
R
P
E
F
T
Q
E
V
----
F
E
G
S
V
A
E
G
A
V
P
--
G
T
S
V
M
K
V
S
A
T
D
A
D
---
D
D
---
V
NTY
N
A
A
I
A
Y
T
I
V
S
Q
D
PELP
H
----
K
N
M
----
F
T
V
N
R
--------
D
T
G
V
I
-
S
V
L
T
-
S
G
-
L
D
R
E
S
Y
-----
P
T
Y
T
L
V
V
Q
A
A
D
L
Q
--
G
E
G
---
L
S
T
T
A
K
A
V
I
T
V
K
D
I
N
D
N
A
P
V
F
N
P
S
T
--
Y
Q
G
Q
V
P
E
N
E
-
V
N
A
R
I
A
T
L
K
V
T
D
D
D
-----
A
-----
P
NTPA
W
----
K
A
V
--------
Y
T
V
V
N
D
---
P
---------
D
----
Q
Q
F
V
V
----
V
T
D
P
--
T
--
T
N
-
D
G
I
L
K
T
A
-
K
G
L
D
F
E
A
K
Q
Q
Y
I
L
H
V
R
V
E
N
---
E
------
E
PFEGS
L
---
V
-----
P
S
T
A
T
V
T
V
D
V
V
D
V
N
E
-
A
P
I
F
M
P
A
E
R
R
V
E
V
P
E
D
F
G
V
G
Q
E
I
T
S
Y
T
A
R
E
P
D
T
-
F
M
--
D
---
Q
--
K
I
T
Y
R
I
W
R
---
D
T-
A
N
W
L
-----
E
I
------
N
----
P
E
----
T
G
A
I
F
T
R
A
E
M
D
R
E
D
A
EHVKN
S
T
Y
V
A
L
I
I
A
T
D
D
---
G
------
S
------
P
-------
I
A
T
G
T
G
T
L
L
L
V
L
L
D
V
N
D
N
A
P
I
P
E
P
R
N
M
Q
F
--
C
Q
R
N
P
-
Q
---
P
H
I
I
T
I
L
D
P
D
L
P
P
N
T
S
P
-
F
T
A
E
L
T
H
G
A
---
S
V
N
W
--
T
I
E
Y
N
D
A
AQE
S
L
I
-
L
-
Q
P
R
K
D
----------
E
----
Y
K
I
H
L
K
L
A
D
N
Q
N
K
--
D
Q
V
T
T
L
D
V
H
V
C
D
C
E
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.25
29%
-42
- C10 -
1Q5B
14
?
A:
[157-594]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
P
P
----
I
K
V
S
E
N
E
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
---
N
---
K
D
---
R
---
F
N
K
V
Y
Y
S
I
T
G
Q
G
----
A
----
D
N
P
PQGV
F
R
I
E
W
--------
E
T
G
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
E
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
E
N
--
G
S
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
--
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNIDS
L
-----
N
----
G
----
V
L
S
--------
Y
S
I
L
K
Q
---
D
----
P
----
E
EPIP
N
L
F
T
I
----
N
--
R
--
E
--
T
G
-
V
-
I
S
L
I
G
-
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
LEG
A
------
G
---------
L
-----
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
---
A
W-
Q
A
V
Y
K
I
R
V
---
N
--
E
G
G
F
F
N
I
T
T
D
P
------
E
----
S
N
----
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
-----
K
Q
Y
V
L
Q
I
T
V
E
N
A
EPF
S
------
V
------
P
-------
L
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
I
Q
-
K
-
L
S
Y
F
I
--
G
N
-
D
P
A
R
W
L
--
T
V
N
K
D
N
G
---
I
V
T
-
G
N
G
N
L
D
R
E
S
-
E
-----
Y
V
KNN
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
-
V
P
S
P
R
--
V
F
T
M
C
D
Q
N
-
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
P
Y
K
V
-
S
-
L
S
H
G
S
D
L
T
---
W
--
K
A
E
L
D
S
K
G
T
S
M
L
L
S
P
--
T
Q
Q
L
--
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
-
Q
---
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.25
29%
-42
- C10 -
1Q5A
14
?
A:
[157-594]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
P
P
----
I
K
V
S
E
N
E
R
G
P
F
--
P
K
R
L
V
Q
I
K
S
---
N
---
K
D
---
R
---
F
N
K
V
Y
Y
S
I
T
G
Q
G
----
A
----
D
N
P
PQGV
F
R
I
E
W
--------
E
T
G
W
M
-
L
V
-
T
-
R
P
-
L
D
R
E
E
Y
-----
D
K
Y
V
L
S
S
H
A
V
S
E
N
--
G
S
P
---
V
E
E
P
M
E
I
T
I
N
V
I
D
Q
N
D
N
R
P
K
F
T
Q
D
V
--
F
R
G
S
V
R
E
G
V
Q
P
G
T
Q
V
M
A
V
S
A
T
D
E
D
DNIDS
L
-----
N
----
G
----
V
L
S
--------
Y
S
I
L
K
Q
---
D
----
P
----
E
EPIP
N
L
F
T
I
----
N
--
R
--
E
--
T
G
-
V
-
I
S
L
I
G
-
T
G
L
D
R
E
K
F
P
E
Y
T
L
T
V
Q
A
T
D
LEG
A
------
G
---------
L
-----
S
V
E
G
K
A
I
I
Q
I
T
D
A
N
D
N
A
P
I
F
D
P
K
T
Y
T
A
L
V
P
E
N
E
-
I
G
F
E
V
Q
R
L
S
V
T
D
L
D
M
P
G
T
--
P
---
A
W-
Q
A
V
Y
K
I
R
V
---
N
--
E
G
G
F
F
N
I
T
T
D
P
------
E
----
S
N
----
Q
G
I
L
T
T
A
K
G
L
D
F
E
L
R
-----
K
Q
Y
V
L
Q
I
T
V
E
N
A
EPF
S
------
V
------
P
-------
L
P
T
S
T
A
T
V
T
V
T
V
E
D
V
N
E
-
A
P
F
F
V
P
A
V
S
R
V
-
D
V
S
E
D
L
S
R
G
E
K
I
I
S
L
V
A
Q
D
P
D
K
Q
Q
I
Q
-
K
-
L
S
Y
F
I
--
G
N
-
D
P
A
R
W
L
--
T
V
N
K
D
N
G
---
I
V
T
-
G
N
G
N
L
D
R
E
S
-
E
-----
Y
V
KNN
T
Y
T
V
I
M
L
V
T
D
D
G
V
S
V
G
T
G
T
G
T
L
I
L
H
V
L
D
V
N
D
N
G
P
-
V
P
S
P
R
--
V
F
T
M
C
D
Q
N
-
P
E
P
Q
V
L
T
I
S
D
A
D
I
P
P
N
T
Y
P
Y
K
V
-
S
-
L
S
H
G
S
D
L
T
---
W
--
K
A
E
L
D
S
K
G
T
S
M
L
L
S
P
--
T
Q
Q
L
--
K
K
G
D
Y
S
I
Y
V
L
L
S
D
A
Q
N
N
P
-
Q
---
L
T
V
V
N
A
T
V
C
S
C
E
G
K
A
I
K
C
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.17
25%
-30
- C10 -
3Q2V
21
CADH1_MOUSE
A:
[24-524]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
S
N
---
R
D
---
K
---
E
T
K
V
F
Y
S
I
T
G
Q
G
----
A
----
D
K
P
PVGV
F
I
I
E
R
--------
E
T
G
W
L
-
K
V
-
T
-
Q
P
-
L
D
R
E
A
I
-----
A
K
Y
I
L
Y
S
H
A
V
S
S
N
--
G
E
A
---
V
E
D
P
M
E
I
V
I
T
V
T
D
Q
N
D
N
R
P
E
F
T
Q
E
V
--
F
E
G
S
V
A
E
G
A
V
P
G
T
S
V
M
K
V
S
A
T
D
A
D
DDVNT
Y
-----
N
----
A
----
A
I
A
--------
Y
T
I
V
S
Q
---
D
----
P
ELPH
K
----
N
M
F
T
V
----
N
--
R
--
D
--
T
G
-
V
-
I
S
V
L
T
-
S
G
L
D
R
E
S
Y
P
T
Y
T
L
V
V
Q
A
A
D
LQG
E
------
G
---------
L
-----
S
T
T
A
K
A
V
I
T
V
K
D
I
N
D
N
A
P
V
F
N
P
S
T
Y
Q
G
Q
V
P
E
N
E
-
V
N
A
R
I
A
T
L
K
V
T
D
D
D
A
-
P
N
--
T
PAW
K
--
A
V
Y
T
V
V
N
D
---
P
--
D
Q
Q
F
-----
V
V
------
V
----
T
D
PTTN
D
G
I
L
K
T
A
K
G
L
D
F
E
A
K
-----
Q
Q
Y
I
L
H
V
R
V
E
N
E
---
E
PFEGS
L
V
------
P
-------
S
T
A
T
V
T
V
D
V
V
D
V
N
E
----
A
P
I
F
M
P
A
E
R
R
V
-
E
V
P
E
D
F
G
V
G
Q
E
I
T
S
Y
T
A
R
E
P
D
T
F
M
D
Q
-
K
-
I
--
T
Y
R
I
W
R
-
D
T
A
N
W
L
--
E
I
N
P
E
T
G
---
A
I
F
-
T
R
A
E
M
D
R
E
D
-
A
EHVKN
S
T
----
Y
V
A
L
I
I
A
T
D
D
G
S
P
I
A
T
G
T
G
T
L
L
L
V
L
L
D
V
N
D
N
A
P
-
I
P
E
P
R
N
M
Q
F
C
Q
R
N
P
Q
-
P
H
I
-------
I
T
I
L
D
P
D
L
P
P
N
T
------------------------
S
P
F
T
A
E
L
T
HG
A
S
V
N
W
T
I
E
Y
N
D
A
A
Q
E
S
L
I
L
Q
P
R
K
D
--------
E
Y
K
I
H
L
K
L
A
D
N
Q
N
K
D
Q
V
T
T
L
D
V
H
V
C
D
C
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
74.26
26%
-38
- C8 -
3UBH
6
A:
[7-418]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
V
R
P
T
K
R
I
E
F
T
E
A
D
---
G
D
---
T
---
E
G
K
S
V
F
Q
L
E
K
E
T
----
D
----
K
E
T
----
F
K
I
R
D
DNPW
V
T
V
E
T
N
G
A
V
-
R
V
-
K
-
K
K
-
W
D
Y
E
E
L
GPE--
K
T
I
D
F
W
V
I
I
T
N
----
H
N
A
G
I
K
Y
T
D
N
Q
R
V
I
I
L
V
K
D
V
N
D
E
P
P
Y
F
I
N
R
P
LP
M
Q
A
V
V
Q
L
N
A
P
P
N
T
P
V
F
T
L
Q
A
R
D
P
D
-----
T
-----
D
----
H
----
N
I
H
--------
Y
F
I
V
R
D
---
R
----
T
----
G
----
G
R
F
E
V
----
D
--
E
--
R
--
S
---
G
V
V
R
T
R
-
G
T
D
L
F
Q
L
D
M
E
Y
V
L
Y
V
K
A
E
D
---
Q
------
N
---------
G
KVRRF
Q
S
T
P
E
E
R
L
S
I
V
G
-
G
K
R
A
P
Q
F
Y
M
P
S
Y
E
A
E
I
P
E
N
Q
K
K
D
S
D
I
I
S
I
K
A
K
S
F
A
------
D
---
R
--
E
I
R
Y
T
L
K
A
QGQ
G
--
A
G
T
F
-----
N
I
------
G
----
P
T
----
S
G
I
V
K
L
A
K
E
L
D
F
E
D
L
RQP--
H
V
Y
S
L
I
V
T
A
T
E
D
---
S
-------------
G
-------
G
F
S
T
S
V
D
L
T
I
R
V
T
D
V
N
D
N
A
P
K
F
E
L
P
D
Y
Q
A
H
N
V
D
E
D
I
P
L
G
T
S
I
L
R
V
K
A
M
D
S
D
S
G
S
N
A
-
E
-
I
E
Y
L
V
S
D
------
D
H
F
--
A
V
D
S
-
N
G
---
I
I
V
-
N
N
K
Q
L
D
A
D
N
N
N
-----
A
Y
----
Y
E
F
I
V
T
A
K
D
K
G
E
P
P
K
S
G
V
A
T
V
R
V
Y
T
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
HHSearch
69.52
21%
-87
- C- -
2WJS
5
A:
[207-561]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
-
D
G
E
G
Y
A
L
V
S
R
P
I
RW
Y
P
N
I
S
T
V
M
F
K
F
R
T
F
S
S
S
A
L
L
M
Y
L
A
T
R
-
D
L
K
D
F
M
S
V
E
L
S
D
G
H
V
K
V
S
Y
D
L
G
S
G
M
T
S
V
V
--
S
N
Q
N
H
N
D
G
K
W
K
A
F
T
L
S
R
I
Q
----------------
K
Q
A
N
I
S
I
V
D
I
D
S
N
Q
E
E
N
-------
V
A
T
S
S
S
G
--
N
N
F
G
L
D
L
K
A
D
D
K
I
Y
F
G
G
L
P
T
L
R
N
----
L
R
P
E
V
N
V
K
K
Y
S
G
C
L
K
D
I
E
I
S
R
T
P
Y
N
I
L
S
S
P
--
D
Y
V
G
V
T
K
G
C
S
L
E
N
---------------------------------------
V
Y
T
V
S
F
P
K
P
G
F
V
E
L
A
A
V
----
S
I
D
V
G
T
E
I
N
L
S
F
S
T
R
N
E
S
G
I
I
L
L
G
S
-----
Q
A
Y
Y
A
I
F
L
N
K
G
R
L
E
V
H
L
S
S
----
M
R
K
I
V
I
K
P
E
P
N
R
F
H
D
G
R
E
H
S
V
H
V
E
R
T
R
--------
G
I
F
T
V
Q
I
D
E
D
R
R
H
M
Q
N
L
T
E
--
E
Q
P
I
-
E
V
K
K
L
F
V
G
G
A
P
P
-----
N
I
P
A
F
Q
G
C
V
W
N
L
V
I
N
S
I
P
M
D
F
A
Q
P
I
--
A
F
K
N
A
D
I
G
R
C
T
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
67.37
23%
-60
- C7 -
3ASI
2
A:
[9-377]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
K
T
K
S
S
Y
V
A
L
A
T
L
Q
--
A
Y
T
S
M
H
L
F
F
Q
F
K
T
T
S
L
D
G
L
I
L
Y
N
S
G
--
D
G
N
D
F
I
V
V
E
L
V
K
G
Y
L
H
Y
V
F
D
L
G
N
G
A
N
L
I
K
G
S
S
N
K
P
L
N
D
N
Q
W
H
N
V
M
I
S
R
D
T
S
---------------
N
L
H
T
V
K
I
D
T
K
I
T
T
Q
I
------------------
T
A
G
A
R
N
L
D
L
K
S
D
L
Y
I
G
G
V
A
K
E
T
Y
K
S
LP
K
-
L
V
H
A
K
E
G
F
Q
G
C
L
A
S
V
D
L
N
G
R
L
P
D
L
I
S
D
A
LF
C
N
G
Q
I
E
R
G
C
E
G
P
S
T
T
C
Q
E
D
S
C
S
N
Q
G
V
C
L
Q
Q
W
D
G
F
S
C
D
C
S
M
T
S
F
S
G
P
L
C
N
D
P
G
T
T
Y
I
F
S
K
G
G
G
Q
I
T
Y
K
W
P
P
N
D
R
P
S
T
R
A
D
R
L
A
I
G
F
S
T
V
Q
K
E
A
V
L
V
R
V
D
S
S
SG
L
G
D
Y
L
E
L
H
I
H
Q
G
K
I
G
V
K
F
N
V
G
T
D
D
I
A
---
I
E
E
S
N
A
I
I
N
D
G
K
Y
H
V
V
R
F
T
R
S
G
--------
G
N
A
T
L
Q
V
D
S
W
P
V
I
E
R
Y
P
A
G
R
Q
L
T
I
F
N
S
Q
A
T
I
I
I
G
G
K
E
Q
------
G
Q
P
F
Q
G
Q
L
S
G
L
Y
Y
N
G
L
K
V
L
N
M
A
A
E
N
D
A
N
I
A
I
V
G
N
V
R
L
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.20
34%
-19
- C9 -
2A62
6
CADH8_MOUSE
A:
[16-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
E
P
I
L
V
G
R
L
H
T
D
L
D
P
G
S
--
K
K
I
K
Y
--
I
-
L
S
G
D
----
G
A
G
T
I
F
Q
I
--
N
----
D
I
T
G
D
I
H
A
I
K
R
L
D
R
E
E
K
A
E
Y
T
L
T
A
Q
A
V
D
F
E
T
N
--
K
--
P
--
L
E
P
P
S
E
F
I
-
I
K
V
Q
D
I
N
D
N
A
P
E
F
L
N
G
P
----
Y
H
A
T
V
P
E
M
S
I
L
--
G
T
S
V
T
N
V
T
A
T
D
A
D
DPV
Y
G
---
N
---
S
A
K
L
V
Y
S
I
L
E
G
Q
----
P
------
Y
----
F
S
I
E
P
--------
E
T
A
I
I
-
K
T
-
A
-
L
P
N
M
D
R
E
A
K
-----
E
E
Y
L
V
V
I
Q
A
K
D
M
G
GH
S
G
G
---
L
S
G
T
T
T
L
T
V
T
L
T
D
V
N
D
N
P
P
K
F
A
Q
S
L
--
Y
H
F
S
V
P
E
D
V
V
L
G
T
A
I
G
R
V
K
A
N
D
Q
D
IG---
E
-----
N
----
A
----
Q
S
S
--------
Y
D
I
I
----------
G
----
T
----
A
L
F
E
I
----
T
--
S
D
A
Q
--
A
Q
-
D
G
V
I
R
L
R
-
K
P
L
D
F
E
T
K
K
S
Y
T
L
K
V
E
A
A
N
---
I
------
H
---------
I
-----
D
P
R
F
S
S
R
G
P
F
K
D
T
A
T
V
K
I
V
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------