@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CML1_HUMAN: (2016-01-09 )
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
Atome Classification :
(20 SA)
--.........10........20........30........40........50........60--.--.-.-..-.-..70-....-....80........90--........100.......110.......120.......130.......140.......150-.........160.......170.......180.-.---.-.-.-...190.......200.......210.......220.......230..------.....--------------------240------...-------------------------------------------.-----------------------------------------------.--------..------.--------.-----250------------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------------------------------------------------------------------------.....---.--------.260---.........270.....---..280--.-....------...-------290-------......-..300.......310-........320....-...330.......340.......350.......360.......370.----------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MRMEDEDYNTSISYGDE
Y
P
D
Y
L
D
S
I
V
V
LEDLS
P
L
E
A
R
V
T
R
I
F
L
V
V
V
Y
S
I
V
C
F
L
G
I
LGN
G
L
V
--
I
--
I
-
I
-
A
T
-
F
-
K
M
K
K
-
T
V
N
M
-
V
W
F
L
N
L
A
V
A
D
F
L
F
N
V
F
--
L
P
I
H
I
T
Y
A
A
M
D
Y
H
W
V
F
G
T
A
M
C
K
I
S
N
F
L
L
I
H
N
M
F
T
S
V
F
L
L
T
IISSD
R
C
I
S
V
L
L
P
V
WSQNH---
R
S
V
R
L
A
Y
M
A
C
M
V
I
W
V
L
A
F
F
LSSP
S
L
V
F
R
DTA-N-L---
H
-
G
-
K
-
I
S
C
FNNFSLSTPGSSSWPTHSQMDPVGYS
R
H
M
V
V
T
V
T
R
F
L
C
G
F
L
V
P
V
L
------
I
I
T
A
C
--------------------
Y
--------
L
T
I
-------------------------------------------
V
-----------------------------------------------
C
--------
K
L
------
Q
--------
R
-----
N
R-------------------------------------------------------------------------------------------------------------------------------------------------------------------L--------------------------------------------------------------------------------------------------------------------------------------------------------------------AKTKK---
P
--------
F
K
-----
I
I
V
T
I
I
I
T
F
F
L
C
WCPY
H
---
T
L
N
L
---
L
-
E
L
HH------TAM-------PG--------
S
V
F
SL
G
-
L
P
L
A
T
A
L
A
I
A
N
S
C
M
--
N
P
I
L
Y
V
FMGQ
D
F
K
K
F
-
K
V
A
L
F
S
R
L
V
N
A
L
SEDTGHSSYPSHRS
F
T
K
M
SSMNERTSMN
E
R
ETGML----------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
89.99
29%
-151
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[41-495]
----------------------------------
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
--
I
--
L
-
V
-
M
G
-
Y
Q
K
K
L
R
-
S
M
T
D
-
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
-
E
-
A
---
D
-
D
-
R
-
Y
I
C
D
R
F
Y
P
N
D
L
------------------
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
------
V
I
L
S
C
--------------------
Y
--------
C
I
I
-------------------------------------------
I
-----------------------------------------------
S
--------
K
L
------
S
--------
H
-----
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
---
A
--------
L
K
-----
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
---
I
G
I
S
---
I
-
D
S
F
I
------
L
L
E
I
I
K
Q
G
C
E
F
E
--------
N
T
V
H
K
W
-
I
S
I
T
E
A
L
A
F
F
H
C
C
L
--
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
86.26
24%
-169
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[52-382]
-------------------------------------------
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
--
I
--
W
-
M
-
F
V
-
F
-
H
M
K
P
-
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
-
V
-
R
---
K
-
N
-
K
T
I
T
C
Y
D
-------------
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
---
V
P
L
V
------
L
I
L
G
C
--------------------
Y
--------
G
L
I
-------------------------------------------
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPL----
C
--------
G
V
------
G
--------
K
-----
D
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
V
E
E
---
P
--------
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
-
D
F
Q
T
------
P
A
M
-------
C
A
F
N
D
-----
R
V
Y
A
T
--
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
--
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
--------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.83
24%
-169
- C2 -
4XNW
2
RUBR_CLOPA
A:
[52-382]
-------------------------------------------
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
--
I
--
W
-
M
-
F
V
-
F
-
H
M
K
P
-
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
-
V
-
R
---
K
-
N
-
K
T
I
T
C
Y
D
-------------
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
---
V
P
L
V
------
L
I
L
G
C
--------------------
Y
--------
G
L
I
-------------------------------------------
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPL
C
--------
G
V
------
G
--------
K
-----
D
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
V
E
E
---
P
--------
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
-
D
F
Q
T
------
P
A
M
-------
C
A
F
N
D
-----
R
V
Y
A
T
--
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
--
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
--------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
83.78
26%
-137
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------
S
F
K
C
A
L
T
---------------------
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
--
I
--
W
-
M
-
F
V
-
F
-
H
M
K
P
W
S
G
I
S
-
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
-
K
---
N
-
K
-
T
-
I
T
C
Y
D
T
--
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
G
Y
I
Y
N
PEDGDPDNGVNPGTD
F
--------
K
D
I
-------------------------------------------
V
-----------------------------------------------
C
PLCGVGKD
Q
F
------
E
--------
E
-----
V
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
R
R
K
---
S
--------
I
Y
-----
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
---
V
M
K
T
---
M
-
N
L
R
A
------
R
L
D
-------
F
Q
TPAM
C
A
F
N
D
R
V
Y
A
T
-
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
--
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
83.77
27%
-152
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
-------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
--
M
--
V
-
S
-
I
K
V
N
-
R
H
L
Q
-
T
V
N
N
-
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
-
V
-
G
VRT
V
-
E
-
D
-
G
E
C
Y
I
Q
F
F
S
---------------------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
------
I
M
T
V
L
--------------------
Y
--------
W
H
I
-------------------------------------------
S
-----------------------------------------------
R
--------
A
S
------
K
--------
S
-----
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
---
V
--------
T
R
-----
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
---
V
M
V
L
---
I
-
N
T
F
C
------
A
P
C
------------------
I
P
N
T
V
-
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
--
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.15
31%
-153
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[123-400]
------------------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
--
M
F
G
I
-
V
-
R
Y
-
T
-
K
M
K
T
-
A
T
N
--
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
-
R
---
D
-
G
-
A
-
V
V
C
M
L
Q
F
P
-----
S
P
S
W
Y
W
D
T
-----------
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
------
I
I
T
V
C
--------------------
Y
G
L
M
LL-----------------------------------------------------------------------------------------------------------
G
------
S
--------
K
-----
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
L
R
R
---
I
--------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
---
I
F
V
I
---
V
W
T
L
V
D
------
I
D
R
-------
R
D
--------
P
L
V
V
A
A
-
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-
F
R
Q
L
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.43
30%
-162
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[121-401]
----------------------------------
P
L
G
L
K
V
T
---
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
--
I
-
L
-
R
H
-
T
-
K
M
K
T
-
A
T
N
--
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
--
L
P
F
Q
G
T
D
I
L
L
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
G
S
A
Q
-
V
-
E
---
D
-
E
-
E
-
I
E
C
L
--
V
E
I
P
T
P
Q
D
Y
W
G
P
--------------
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
------
V
I
S
V
C
--------------------
Y
--------
S
L
M
-------------------------------------------
I
-----------------------------------------------
R
--------
R
L
------
R
GVRLLSGS
R
-----
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
L
R
R
---
I
--------
T
R
-----
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
---
V
F
-
V
---
L
-
A
Q
G
L
------
G
V
Q
-------
P
S
--------
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
--
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
-
F
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.37
30%
-163
- C2 -
5C1M
7
?
A:
[15-294]
---------------------------------------
V
T
A
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
--
M
Y
-
V
-
I
-
V
R
-
Y
-
T
K
M
K
-
T
A
T
N
-
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
V
N
Y
L
M
G
-
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
A
T
T
K
-
Y
-
R
---
Q
-
G
-
S
-
I
D
C
T
L
T
F
S
---------------
H
P
T
W
Y
W
E
N
L
-
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
------
I
I
T
V
C
--------------------
Y
--------
G
L
M
-------------------------------------------
I
-----------------------------------------------
L
--------
R
L
------
K
--------
S
-----
V
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
S
K
---
E
K
D
R
N
L
R
R
I
T
R
-----
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
---
I
Y
V
I
---
I
-
K
A
L
I
------
T
I
P
-------
E
T
--------
T
F
Q
T
V
S
-
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.34
31%
-151
- C2 -
4RWA
1
C562_ECOLX (first)
B:
[123-400]
------------------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
--
M
F
G
I
-
V
-
R
Y
-
T
-
K
M
K
T
-
A
T
N
--
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
-
R
---
D
-
G
-
A
-
V
V
C
M
L
Q
F
P
-----
S
P
S
W
Y
W
D
T
-----------
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
------
I
I
T
V
C
--------------------
Y
G
L
M
L
L
R----------------------------------------------------------------------------------------------------------
G
------
S
--------
K
-----
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
L
R
R
---
I
--------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
---
I
F
V
I
---
V
W
T
L
V
D
------
I
D
R
-------
R
D
--------
P
L
V
V
A
A
-
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-
F
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
81.97
24%
-149
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
--
L
--
Y
-
A
-
V
R
-
S
E
R
K
L
H
-
T
V
G
N
-
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
H
----------R
R
-
E
-
D
K
C
E
T
D
F
Y
D
---------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
------
L
M
L
W
F
--------------------
Y
--------
A
K
I
-------------------------------------------
Y
-----------------------------------------------
K
--------
A
V
------
R
--------
Q
-----
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
---
A
--------
A
K
-----
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
---
I
F
F
M
---
V
-
I
A
F
C
------
K
N
C
-------
C
-----------
N
E
H
L
-
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
--
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.79
31%
-153
- C2 -
4N6H
23
C562_ECOLX (first)
A:
[126-403]
------------------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
--
M
F
G
I
-
V
-
R
Y
-
T
-
K
M
K
T
-
A
T
N
--
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
-
R
---
D
-
G
-
A
-
V
V
C
M
L
Q
F
P
-----
S
P
S
W
Y
W
D
T
-----------
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
------
I
I
T
V
C
--------------------
Y
G
L
M
L
L
R
L
R
S
V
R
-------------------------------------------
L
-----------------------------------------------
L
--------
S
G
------
S
--------
K
-----
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
L
R
R
---
I
--------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
---
I
F
V
I
---
V
W
T
L
V
D
------
I
D
R
-------
R
D
--------
P
L
V
V
A
A
-
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-
F
R
Q
L
C
R
K
P
C
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.95
31%
-149
- C2 -
4RWD
6
C562_ECOLX (first)
B:
[123-400]
------------------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
--
M
FG
I
-
V
-
R
Y
-
T
-
K
M
K
T
-
A
T
N
--
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
-
R
---
D
-
G
-
A
-
V
V
C
M
L
Q
F
P
-----
S
P
S
W
Y
W
D
T
-----------
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
------
I
I
T
V
C
--------------------
Y
GLMLLRLR
S
V
R
-------------------------------------------
L
-----------------------------------------------
L
--------
S
G
------
S
--------
K
-----
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
L
R
R
---
I
--------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
---
I
F
V
I
---
V
W
T
L
V
D
------
I
D
R
-------
R
D
--------
P
L
V
V
A
A
-
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-
F
R
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.94
31%
-149
- C2 -
4RWD
7
C562_ECOLX (first)
A:
[123-400]
------------------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
--
M
F
G
I
-
V
-
R
Y
-
T
-
K
M
K
T
-
A
T
N
--
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
-
P
-
R
---
D
-
G
-
A
-
V
V
C
M
L
Q
F
P
-----
S
P
S
W
Y
W
D
T
-----------
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
------
I
I
T
V
C
--------------------
Y
G
L
M
L
L
R
L
R
S
V
R
-------------------------------------------
L
-----------------------------------------------
L
--------
S
G
------
S
--------
K
-----
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
L
R
R
---
I
--------
T
R
-----
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
---
I
F
V
I
---
V
W
T
L
V
D
------
I
D
R
-------
R
D
--------
P
L
V
V
A
A
-
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-
F
R
Q
L
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
78.94
23%
-159
- C2 -
4MBS
8
CCR5_HUMAN (first)
A:
[38-366]
-----------------------------------------------
L
Y
S
L
V
F
I
F
G
F
V
G
N
M
L
V
--
I
--
L
-
I
L
I
N
-
Y
-
K
R
L
K
-
S
M
T
D
-
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
T
--
V
P
F
W
A
H
Y
A
A
A
--
Q
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
---
R
T
V
T
F
G
V
V
T
S
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
I
F
T
R
S
Q
-
K
-
E
---
G
-
L
-
H
-
Y
T
C
S
S
H
F
P
Y
S
Q
--
Y
Q
F
W
K
N
F
Q
T
L
K
I
V
-------------
I
L
G
L
V
L
P
L
L
------
V
M
V
I
C
--------------------
Y
--------
S
G
I
L
K
T
L
L
R
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDW
V
-----------------------------------------------
C
--------
P
L
CGVGKD
Q
--------
F
-----
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
K
K
R
H
R
D
--------
V
R
-----
L
I
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
N
---
I
V
L
L
---
L
-
N
T
F
Q
EFFGLN
N
C
S
-------
S
S
--------
N
R
L
D
Q
A
-
M
Q
V
T
E
T
L
G
M
T
H
C
C
I
--
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
-
L
L
V
F
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
78.17
25%
-161
* C2 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
--
C
--
M
-
A
-
V
L
-
K
E
R
A
L
Q
-
T
T
T
N
-
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
-------
G
-
D
-
P
-
T
V
C
S
I
S
N
------------------------
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
------
V
T
V
L
V
--------------------
Y
--------
A
R
I
-------------------------------------------
Y
-----------------------------------------------
V
--------
V
L
------
K
--------
Q
-----
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
---
A
--------
T
Q
-----
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
---
L
T
H
V
---
L
-
N
T
H
C
------
Q
T
C
-----------------
H
V
S
P
E
L
-
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
--
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
77.08
23%
-122
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
P
C
F
R
E
E
N
A
N
F
------------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
--
I
--
L
V
M
-
G
Y
-
Q
-
K
K
L
R
-
S
M
T
D
-
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
A
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
-
E
-
A
---
D
-
D
-
R
-
Y
I
C
D
R
F
Y
P
N
------------------
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
------
V
I
L
S
C
--------------------
Y
--------
C
I
I
-------------------------------------------
I
-----------------------------------------------
S
--------
K
L
------
S
--------
H
-----
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
---
M
--------
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
---
T
I
G
I
--------------------------
G
--------
H
L
L
T
K
S
-
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GR
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
-
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
31
HHSearch
75.54
23%
-145
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-472]
------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
--
C
--
W
-
A
-
V
W
L
N
-
S
N
L
Q
-
N
V
T
N
-
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
-
Q
-------
S
-
Q
G
C
G
E
G
Q
V
A
C
L
F
-----------
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
------
L
M
L
G
V
--------------------
Y
--------
L
R
I
-------------------------------------------
F
-----------------------------------------------
L
--------
A
A
------
R
--------
R
-----
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
---
A
--------
A
K
-----
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
---
I
I
N
C
---
F
-
T
F
F
C
------
P
D
C
--------
S
--------
H
A
P
L
W
L
-
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
--
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
75.43
21%
-147
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
--
I
--
T
-
A
-
I
A
-
K
F
E
R
L
Q
-
T
V
T
N
-
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V-
V
P
F
G
A
A
H
I
-
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
-
A
-
T
H--
Q
-
E
-
A
-
I
N
C
Y
A
E
E
T
C
C
D
F
-----------
F
-----
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
------
I
M
V
F
V
--------------------
Y
--------
S
R
V
-------------------------------------------
F
-----------------------------------------------
Q
--------
E
A
------
K
--------
R
-----
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
---
A
--------
L
K
-----
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
---
I
V
N
I
---
V
-
H
V
I
Q
------
D
N
L
------------------
I
R
K
E
V
-
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
--
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
72.82
19%
-114
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
--
L
--
Y
-
V
-
T
V
Q
H
-
K
K
L
R
-
T
P
L
N
-
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
-
P
---
E
-
G
M
Q
-
C
S
C
G
I
D
Y
---------
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
------
F
I
I
P
L
I
------
V
I
F
F
C
--------------------
Y
--------
G
Q
L
-------------------------------------------
V
-----------------------------------------------
F
--------
T
V
------
K
--------
E
AAASA
T
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
---
V
--------
T
R
-----
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
---
G
V
A
F
---
Y
-
I
F
T
H
------
Q
G
S
-------
D
F
--------
G
P
I
F
M
T
-
I
P
A
F
F
A
K
T
S
A
V
--
Y
--
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
-
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
72.66
24%
-147
- C2 -
2Z73
5
OPSD_TODPA
A:
[32-332]
---------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
--
I
--
Y
-
L
-
F
T
-
K
T
K
S
L
Q
-
T
P
A
N
-
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
-
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
-
T
L
E
---
G
-
V
-
L
-
C
N
C
S
F
D
Y
I
S
R
D
S
-----------------
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
------
I
I
F
F
C
--------------------
Y
--------
F
N
I
-------------------------------------------
V
-----------------------------------------------
M
--------
S
V
------
S
--------
N
-----
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
---
L
--------
A
K
-----
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
---
V
V
A
L
---
L
-
A
Q
F
G
------
P
L
E
-----------------
W
V
T
P
Y
A
-
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
--
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------