@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CRFR1_HUMAN: (2016-01-09 )
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
Atome Classification :
(21 SA)
-------.........10....-....20........30........40--........50----------........60........70........80........90........100.......110.......120...---....130.......140.......150----.......160.......170------........180.....--..190.......200.-----...-.-...210..-.....220...--....----230.......240---..-------.....-250.----......260-....----.----..-----------..270.......-280---......---.290..-------.-----.----...300..---..---.-..310-------.......320.....----------..330-......-.340.......350.......-360...-.-----.--------..-370.......380.......390.......400.......410.......420.......430.......440..--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MGGH
P
Q
L
R
L
V
K
A
L
L
L
-LGLNPVS
A
S
L
Q
D
Q
H
C
E
S
L
S
L
ASNISG--
L
Q
CNASV
D
L
I
----------
G
TCWPRSPAG
Q
L
V
V
RPCP
A
F
F
Y
G
V
R
YNTTN
N
G
Y
R
E
C
LANG
S
W
A
A
RV
N
Y
S
E
C
Q
E
I
L
N
E
E
K
KS
K
V
H
Y
H
V
A
V
I
I
N
Y
L
---
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
RLRPGCTHWG----DQADG
A
L
E
VGAPWSGA
P
F
Q
-------
V
R
R
S
I
R
C
L
R
N
I
I
H
W
N
L
--
I
S
A
F
I
LRN
A
T
W
F
V
V
-
Q
-----
L
TM-S-PEVHQSNV-
G
W
C
R
L
V
T
A
A
YN--
Y
F
H
V
----
T
N
F
F
W
M
FGEG
C
Y
L
---
H
T
-------
A
I
V
L
T
-YS
T
D
----
R
L
R
K
W
M
F
---
I
C
I
G----W----GV-----------
P
F
P
I
I
V
A
W
A
I
G
K
-
L
Y
Y---DNE
K
C
W---FGKRPG-------V-----Y----
T
D
Y
IYQG
P
---
M
I
---
L
-
V
L
L
I
N
-------
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
----------RASTT-
S
E
T
I
Q
Y
-
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
F
-
F
VNPGE-
D
-----
E
--------
V
S
-
R
V
V
F
I
Y
F
N
S
F
L
E
S
F
Q
G
F
F
V
S
V
F
Y
C
F
L
N
S
E
V
R
S
A
I
R
K
R
W
H
R
W
Q
D
K
H
S
I
R
A
R
V
A
R
A
MSIPTSP
T
R
V
S
F
H
S
I
K
Q
STAV--
53
Fugue
76.89
42%
-97
- C2 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
-H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
-
V
A
F
V
L
F
L
R
A
R
S
I
R
C
L
R
N
I
I
H
A
N
L
I
A
A
--
F
I
L
R
N
A
T
W
F
V
----------
V
Q
L
T
M
S
P
E
V
H
Q
S
N
V
G
W
C
R
L
V
T
A
A
Y
N
Y
F
H
V
T
N
F
F
W
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
IGI
G
H
L
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
I
G
R
N
S
N
G
VIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
S
A
L
I
N
M
--
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
-
S
-----
L
R
M
-
L
-
Q
Q
K
R
W
D
E
A
-
A
V
N
L
A
K
S
R
W
Y
N
QT
P
N
R
A
----
K
R
V
I
A
T
F
R
T
G
T
W
-------------------
D
A
Y
D
----
R
L
R
A
W
M
F
---
I
C
I
G
----
W
----
G
V
-----------
P
F
P
I
I
V
A
W
A
I
G
K
-
L
Y
Y
---
D
N
E
K
C
W
---
A
G
K
R
P
G
-------
V
-----
Y
----
T
D
Y
I
Y
Q
G
P
---
M
A
---
L
-
V
L
L
I
N
-------
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
----------
R
A
S
T
T
-
S
E
T
I
Q
A
-
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
-
F
V
N
----------
E
--------
V
S
-
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
-------------------------------------------------
21
PsiBlast_CBE
70.31
95%
-134
- C2 -
4K5Y
2
CRFR1_HUMAN
C:
[279-422]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
R
L
R
A
W
M
F
---
I
C
I
G
----
W
----
G
V
-----------
P
F
P
I
I
V
A
W
A
I
G
K
-
L
Y
Y
---
D
N
E
K
C
W
---
A
G
K
R
P
G
-------
V
-----
Y
----
T
D
Y
I
Y
Q
G
P
---
M
A
---
L
-
V
L
L
I
N
-------
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
----------
R
A
S
T
T
-
S
E
T
I
Q
A
-
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
-
F
V
N
P
G
E
-
D
-----
E
--------
V
S
-
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
--------------------------------------------------
2
PsiBlast_PDB
58.22
100%
-40
- C4 -
3EHS
-
MALE_ECOLI
A:
[375-459]
-------------------------------
S
L
Q
D
Q
H
C
E
S
L
S
L
A
S
N
I
S
G
--
L
Q
C
N
A
S
V
D
L
I
----------
G
T
C
W
P
R
S
P
A
G
Q
L
V
V
R
P
C
P
A
F
F
Y
G
V
R
Y
N
T
T
N
N
G
Y
R
E
C
L
A
N
G
S
W
A
A
R
V
N
Y
S
E
C
Q
E
I
L
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.65
33%
-137
- C2 -
4L6R
1
GLR_HUMAN
A:
[152-393]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
H
C
T
R
N
A
I
H
A
N
L
--
F
A
S
F
V
L
K
A
S
S
V
L
V
I
-
D
G
L
L
R
T--------
L
S
D
G
A
V
-
A
G
C
R
V
A
A
V
F
M
Q
--
Y
G
I
V
----
A
N
Y
C
W
L
L
V
E
G
L
Y
L
---
H
N
-------
L
L
G
L
A
-
T
L
P
E
----
R
S
F
F
S
L
Y
---
L
G
I
G
----
W
----
G
A
-----------
P
M
L
F
V
V
P
W
A
V
V
K
-
C
L
F
---
E
N
V
Q
C
W
---
T
S
N
D
N
M
-------
G
-----
F
----
W
-
W
I
L
R
F
P
---
V
F
---
L
-
A
I
L
I
N
-------
F
F
I
F
V
R
I
V
Q
L
L
V
A
K
L
----------
R
A
R
Q
M
-
H
H
T
D
Y
K
-
F
R
L
A
K
S
T
L
T
L
I
P
L
L
G
V
H
E
V
V
F
A
F
V
T
D
E
H
-
A
-----
Q
--------
G
T
L
R
S
A
K
L
F
F
D
L
F
L
S
S
F
Q
G
L
L
V
A
V
L
Y
C
F
L
N
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
-------------------------
58
Fugue
55.04
21%
-115
* C3 *
4U6D
22
?
A:
[28-409]
--------
E
G
F
P
F
I
L
P
K
E
K
-----
P
N
R
P
L
S
A
A
M
Q
R
N
Y
D
N
Y
M
A
---------------------------------
P
R
P
E
N
N
E
L
Y
T
Q
----
F
K
Y
T
E
L
K
G
F
D
Y
N
G
H
-----
D
G
T
I
S
R
R
-------------
D
P
S
K
V
I
Y
E
N
G
--------------------
K
Y
Y
V
W
Y
T
Y
R
N
-----------------------
T
P
T
P
P
Q
-------
G
A
K
N
S
N
D
T
I
P
S
A
D
W
D
L
A
E
I
W
Y
A
T
S
K
D
G
F
T
W
E
E
-
Q
-----
G
V
A
-
V
-
P
R
P
P
K
P
N
V
-
G
W
-
R
S
V
T
T
-
T
D
--
I
L
K
W
----
K
G
K
F
Y
L
Y
Y
Q
G
F
M
E
---
A
S
GTRGD
D
C
P
V
A
V
S
-
Y
A
D
S
----
P
D
G
P
W
T
P
HTE
V
V
I
P
----
N
----
G
K
KGEWDQYSIHD
P
Y
P
I
V
Y
K
D
K
I
-
Y
-
L
Y
Y
---
K
S
D
F
D
G
DP
N
L
V
R
M
Q
G
-------
L
-----
A
----
I
A
D
N
P
L
G
P
---
F
K
KSP
L
-
N
P
V
I
N
SG
H
E
T
T
L
F
P
F
K
E
G
M
A
A
L
V
---
I
----------
R
D
G
T
E
-
H
N
T
V
Q
Y
A
E
D
G
V
N
F
N
I
A
S
I
V
E
F
M
P
N
A
A
G
P
-
Y
V
A
D
A
F
-
T
-----
N
TKYGRG--
I
S
-
W
G
I
S
H
F
T
N
A
T
T
W
D
Q
N
H
A
V
L
A
R
F
D
C
D
L
S
L
D
V
D
D
P
H
M
K
R
L
G
T
Y
F
-----
K
P
E
F
Y
Y
Q
M
G
L
----------
S
K
K
Q
R
E
R
I
--
62
Fugue
52.72
15%
-90
- C3 -
4C8H
-
CTF4_YEAST
A:
[25-476]
FRYMPFS
P
A
G
T
P
F
G
F
T
D
R
R
Y
L
T
M
N
E
V
G
Y
V
S
T
V
K
N
S
E
Q
Y
S
I
T
V
S
F
F
D
V
G
R
--
F
R
E
Y
H
F
E
D
L
F
GYD
L
C
F
L
N
EK
G
T
L
F
G
Q
S
K
T
G
Q
I
Q
Y
R
P
H
D
S
I
---------------------------
H
S
N
W
T
K
I
I
P
L
Q
A
G
E
R
I
T
S
V
A
A
T
P
V
R
-----------
V
I
V
G
T
S
L
G
Y
F
R
S
F
N
Q
F
G
V
P
F
A
----
V
E
K
T
S
P
I
V
A
L
T
A
Q
N
Y
R
V
F
S
-------
V
H
Y
S
--------
Q
F
H
G
--
L
S
Y
S
L
S
E
L
K
R
Y
Y
K
R
-
E
-----
C
P
L
-
P
M
S
L
P
N
I
N
S
D
M
K
--
K
D
A
N
L
D
Y
Y
--
N
F
N
P
MGIK
S
L
F
F
S
S
Y
G
D
P
C
I
F
G
SD
N
T
-------
L
L
L
L
S
K
W
R
S
P
----
E
E
S
K
W
L
P
---
I
L
D
S
N
M
E
I
W
K
M
S
G
G
K
-----------
E
T
T
D
I
H
V
W
P
L
-
A
-
L
A
Y
---
D
T
L
N
C
I
---
L
V
K
G
K
H
-------
I
-----
W
----
P
E
F
P
L
P
L
P
S
E
M
E
I
---
R
M
P
V
F
V
K
-------
S
K
L
L
E
E
N
K
A
I
L
N
K
E
I
----------
Q
I
P
V
S
M
A
A
E
E
E
Y
-
L
R
S
K
V
L
S
E
L
L
T
D
T
L
E
N
D
---------
G
E
M
Y
-----
G
--------
N
E
-
N
E
V
L
A
A
L
N
G
---
A
Y
D
K
A
L
L
R
L
F
A
S
A
C
S
D
Q
N
V
E
K
A
L
S
L
A
H
E
L
K
Q
D
R
A
L
T
A
A
V
K
I
S
E
R
A
E
L
P
S
L
V
K
K
I
N
N
I
R
E
A
R
Y
E
Q
Q
29
PsiBlast_CBE
51.31
64%
-19
- C4 -
3N93
2
B:
[412-476]
-----------------------------------------------------
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
K
I
N
Y
S
Q
C
E
P
I
L
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
51.20
15%
-121
- C2 -
2KS9
1
NK1R_HUMAN
A:
[36-324]
-------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
Y
T
V
---
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
----------------------------------------
R
M
R
T
V
T
N
Y
F
L
V
N
L
--
A
F
A
E
A
S
M
A
A
F
N
T
V
V
-
N
-----
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
-
F
Y
C
K
F
H
N
F
F
P
I
--
A
A
V
F
----
A
S
I
Y
S
M
T
A
V
A
F
D
R
---
Y
M
-------
A
I
I
H
P
-
L
Q
P
R
LS--
A
T
A
T
K
V
V
---
I
C
V
I
----
W
----
V
L
-----------
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
TMP
S
R
V
V
C
M
---
I
E
W
P
E
H
PNKIY
E
K
V
-----
Y
H
I
C
V
T
V
L
I
Y
F
L
P
---
L
L
---
V
-
I
G
Y
A
Y
-------
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S---------
S
D
R
Y
H
-
E
Q
V
S
A
K
-
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
-
H
I
F
F
L
L
-
P
-----
Y
I
NPDLYLK
K
F
-
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
--
3
PsiBlast_PDB
50.65
100%
-27
- C4 -
3EHT
1
MALE_ECOLI
A:
[375-454]
-------------------------------
S
L
Q
D
Q
H
C
E
S
L
S
L
A
S
N
I
S
G
--
L
Q
C
N
A
S
V
D
L
I
----------
G
T
C
W
P
R
S
P
A
G
Q
L
V
V
R
P
C
P
A
F
F
Y
G
V
R
Y
N
T
T
N
N
G
Y
R
E
C
L
A
N
G
S
W
A
A
R
V
N
Y
S
E
C
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
50.60
11%
-124
- C2 -
2Z73
5
OPSD_TODPA
A:
[35-334]
----------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
---
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
----------------------------------------
S
L
Q
T
P
A
N
M
F
I
I
N
L
--
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
-----
T
I
S
C
F
-
L
K
K
W
I
F
G
F
-
A
A
C
K
V
Y
G
F
I
G
G
--
I
F
G
F
----
M
S
I
M
T
M
A
M
I
S
I
D
R
---
Y
N
-------
V
I
G
R
P
-
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
---
I
I
F
V
----
W
----
L
W
-----------
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
---
F
D
Y
I
S
R
-------
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
---
I
L
---
I
-
I
F
F
C
Y
-------
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
-
A
G
A
N
A
E
-
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
-
A
V
V
A
L
L
-
A
Q
FGPL
E
--------
W
V
-
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-----------
26
PsiBlast_CBE
49.75
64%
-26
- C4 -
3N95
1
D:
[412-475]
-----------------------------------------------------
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
K
I
N
Y
S
Q
C
E
P
I
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
49.42
95%
-142
- C2 -
4K5Y
7
CRFR1_HUMAN (first)
B:
[279-423]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
R
L
R
A
W
M
F
---
I
C
I
G
----
W
----
G
V
-----------
P
F
P
I
I
V
A
W
A
I
G
K
-
L
Y
Y
---
D
N
E
K
C
W
---
A
G
K
R
---------------
Y
----
T
D
Y
I
Y
Q
G
P
---
M
A
---
L
-
V
L
L
I
N
-------
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
----------
R
A
S
T
T
-
S
E
T
I
Q
A
-
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
----------------------------
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
-------------------------------------------------
24
PsiBlast_CBE
49.15
64%
-22
- C4 -
3N96
1
CRFR2_HUMAN
C:
[412-474]
-----------------------------------------------------
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
K
I
N
Y
S
Q
C
E
P
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
49.00
64%
-19
- C4 -
3N95
1
CRFR2_HUMAN
C:
[412-474]
-----------------------------------------------------
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
K
I
N
Y
S
Q
C
E
P
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
48.84
64%
-16
- C4 -
3N93
-
CRFR2_HUMAN
A:
[412-473]
-----------------------------------------------------
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
K
I
N
Y
S
Q
C
E
P
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
48.54
64%
-22
- C4 -
3N96
1
CRFR2_HUMAN
B:
[412-473]
-----------------------------------------------------
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
K
I
N
Y
S
Q
C
E
P
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
48.51
64%
-22
- C4 -
3N96
1
D:
[412-475]
-----------------------------------------------------
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
K
I
N
Y
S
Q
C
E
P
I
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.30
64%
-20
- C4 -
3N95
-
CRFR2_HUMAN
A:
[412-472]
-----------------------------------------------------
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
K
I
N
Y
S
Q
C
E
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
47.86
64%
-25
- C4 -
3N96
1
CRFR2_HUMAN
A:
[412-475]
-----------------------------------------------------
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
K
I
N
Y
S
Q
C
E
P
I
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
47.41
95%
-133
- C2 -
4K5Y
4
CRFR1_HUMAN (first)
A:
[279-423]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
R
L
R
A
W
M
F
---
I
C
I
G
----
W
----
G
V
-----------
P
F
P
I
I
V
A
W
A
I
G
K
-
L
Y
Y
---
D
N
E
K
C
W
---
A
G
K
R
P
G
-------
V
-----
Y
----
T
D
Y
I
Y
Q
G
P
---
M
A
---
L
-
V
L
L
I
N
-------
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
----------
R
A
S
T
T
-
S
E
T
I
Q
A
-
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
-
F
V
N
----------
E
--------
V
S
-
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
-------------------------------------------------
6
PsiBlast_PDB
44.92
50%
-4
- C4 -
2JND
1
CRFR2_MOUSE
A:
[30-108]
------------------------------------
Y
C
H
R
T
T
I
G
-
N
F
S
G
P
Y
T
Y
C
N
T
T
L
D
Q
I
----------
G
T
C
W
P
Q
S
A
P
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
I
K
Y
N
T
T
R
N
A
Y
R
E
C
L
E
N
G
T
W
A
S
R
V
N
Y
S
H
C
E
P
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------