@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CRFR2_HUMAN: (2016-01-09 )
MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
Atome Classification :
(23 SA)
------------------.........10........20........30........40........50........60........70........80...-------------------.....90.....-...100.......110.......120.......130.......140.......150.......160....-...------170-.-....-------------...180---.........190..-.....200.......210.-------------------------------------------------------------------------------------------------------------------------------------------------------......------220--.........230.......240.....-.------.---250.---......260-----.------.---------.--------..----....270.......280.......290..-.----------.----.-------------------------------------------------------------------------------------------------------------------------------------------------------..300.......310.......320....-...330.-----.--------------.....340--.........350.......360.......370.......380.......390.------......400.......410--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------M
D
A
A
L
L
H
S
L
L
EANC
S
L
A
L
A
E
E
L
L
LDGWGPPLDPEG
P
Y
S
Y
C
N
T
T
L
D
Q
IGTCWPRSAA
G
A
L
VERP
C
P
E
Y
FNGVKYN
T
T
R
N
A
Y
R
E
C
L
-------------------ENGTWASKI
N
Y
S
-QCEPILDDKQR
K
Y
D
L
H
Y
R
I
A
L
V
V
N
Y
L
G
H
C
V
S
V
A
A
L
V
A
A
F
L
L
F
L
A
L
R
S
I
R
C
L
R
N
V
I
H
W
N
L
I
T
T
F
I
L
R
N
V
M
W
-
F
L
L
------
Q
L
--
V
-
D
H
E
V-------------HESN-----
E
V
W
C
R
C
I
T
T
I
F
N
Y
F
-
V
V
T
N
F
F
W
M
F
VEG
C
Y
L
H
T
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
TY
S
T
------
E
----
R
L
R
K
C
L
F
L
F
I
G
W
CI
P
F
P
I
I
V
A
W
A
I
G
K
L
-
Y
------
Y
---ENE
Q
---
C
WFGKEP-------
G
------
D
---------
L
--------
V
D
----
Y
I
YQGP
I
I
L
V
L
L
I
N
F
V
F
L
F
N
I
V
R
I
L
M
T
K
L
-R----------A----S-------------------------------------------------------------------------------------------------------------------------------------------------------TT
S
E
T
I
Q
Y
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
F
-
F
VNPGE
D
-----
D
--------------
L
S
Q
I
M
F
----
I
Y
F
N
S
F
L
Q
S
F
Q
G
F
F
V
S
V
F
Y
C
FFNG
E
V
R
S
A
V
R
K
R
W
H
R
W
QDHHSLRV
P
M
A
R
AMSI------PTSP
T
R
I
S
F
H
S
I
K
Q
T
AAV---
65
Fugue
90.85
72%
-179
- C3 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
C
L
R
N
I
I
H
A
N
L
I
A
A
F
I
L
R
N
A
T
W
-
F
V
V
------
Q
L
--
T
M
S
P
E
V
-------------
H
Q
S
N
-----
V
G
W
C
R
L
V
T
A
A
Y
N
Y
F
-
H
V
T
N
F
F
W
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
T
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
S
V
A
K
S
E
L
D
K
A
I
GRNSNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
S
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
FT
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
SRWYNQT
P
N
R
A
K
R
V
I
A
T
F
R
T
GTW
D
A
Y
D
----
R
L
R
A
W
M
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
L
-
Y
------
Y
---
D
N
E
K
---
C
W
A
G
K
R
P
-------
G
------
V
---------
Y
--------
T
D
----
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
-
R
----------
A
----
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
-
F
V
N
---------
E
--------------
V
S
R
V
V
F
----
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
S
--------------------------------------------------------
21
PsiBlast_CBE
61.50
79%
-133
- C3 -
4K5Y
2
CRFR1_HUMAN
C:
[279-422]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
R
L
R
A
W
M
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
L
-
Y
------
Y
---
D
N
E
K
---
C
W
A
G
K
R
P
-------
G
------
V
---------
Y
--------
T
D
----
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
-
R
----------
A
----
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
-
F
V
N
P
G
E
D
-----
E
--------------
V
S
R
V
V
F
----
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
V
S
V
F
A
C
F
L
N
---------------------------------------------------------
2
PsiBlast_PDB
61.43
100%
-76
- C4 -
3N93
-
CRFR2_HUMAN
A:
[375-473]
--------------------
A
A
L
L
H
S
L
L
E
A
N
C
S
L
A
L
A
E
E
L
L
L
D
G
W
G
P
P
L
D
P
E
G
P
Y
S
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
K
I
N
Y
S
-
Q
C
E
P
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.20
100%
-80
- C4 -
3N96
1
CRFR2_HUMAN
A:
[375-475]
--------------------
A
A
L
L
H
S
L
L
E
A
N
C
S
L
A
L
A
E
E
L
L
L
D
G
W
G
P
P
L
D
P
E
G
P
Y
S
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
K
I
N
Y
S
-
Q
C
E
P
I
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
60.83
100%
-80
- C4 -
3N96
1
D:
[375-475]
--------------------
A
A
L
L
H
S
L
L
E
A
N
C
S
L
A
L
A
E
E
L
L
L
D
G
W
G
P
P
-----
P
Y
S
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
K
I
N
Y
S
-
Q
C
E
P
I
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.39
100%
-79
- C4 -
3N95
-
CRFR2_HUMAN
A:
[375-472]
--------------------
A
A
L
L
H
S
L
L
E
A
N
C
S
L
A
L
A
E
E
L
L
L
D
G
W
G
P
P
L
D
P
E
G
P
Y
S
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
K
I
N
Y
S
-
Q
C
E
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
59.75
100%
-73
- C4 -
3N96
1
CRFR2_HUMAN
C:
[375-474]
--------------------
A
A
L
L
H
S
L
L
E
A
N
C
S
L
A
L
A
E
E
L
L
L
D
G
W
G
P
P
-----
P
Y
S
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
K
I
N
Y
S
-
Q
C
E
P
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
59.66
100%
-77
- C4 -
3N96
1
CRFR2_HUMAN
B:
[375-473]
--------------------
A
A
L
L
H
S
L
L
E
A
N
C
S
L
A
L
A
E
E
L
L
L
D
G
W
G
P
P
L
D
P
E
G
P
Y
S
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
K
I
N
Y
S
-
Q
C
E
P
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
59.40
100%
-74
- C4 -
3N93
2
B:
[375-476]
--------------------
A
A
L
L
H
S
L
L
E
A
N
C
S
L
A
L
A
E
E
L
L
L
D
----------
P
Y
S
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
K
I
N
Y
S
-
Q
C
E
P
I
L
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
58.77
100%
-71
- C4 -
3N95
1
D:
[375-475]
--------------------
A
A
L
L
H
S
L
L
E
A
N
C
S
L
A
L
A
E
E
L
L
L
D
G
----------
Y
S
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
K
I
N
Y
S
-
Q
C
E
P
I
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
57.33
100%
-71
- C4 -
3N95
1
CRFR2_HUMAN
C:
[375-474]
--------------------
A
A
L
L
H
S
L
L
E
A
N
C
S
L
A
L
A
E
E
L
L
L
D
G
----------
Y
S
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
R
S
A
A
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
V
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
K
I
N
Y
S
-
Q
C
E
P
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
55.02
34%
-159
- C3 -
4L6R
1
GLR_HUMAN
A:
[152-393]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
H
C
T
R
N
A
I
H
A
N
L
F
A
S
F
V
L
K
A
S
S
V
-
L
V
I
D
G
L
L
R
T---------------------------LSDGA
V
A
G
C
R
V
A
A
V
F
M
Q
Y
G
-
I
V
A
N
Y
C
W
L
L
V
E
G
L
Y
L
H
N
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
A
T
L
P
------
E
----
R
S
F
F
S
L
Y
L
G
I
G
W
G
A
P
M
L
F
V
V
P
W
A
V
V
K
C
-
L
------
F
---
E
N
V
Q
---
C
W
T
S
N
D
N
-------
M
------
G
---------
F
--------
W
-----
W
I
L
R
F
P
V
F
L
A
I
L
I
N
F
F
I
F
V
R
I
V
Q
L
L
V
A
K
L
-
R
----------
A
----
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
H
H
T
D
Y
K
F
R
L
A
K
S
T
L
T
L
I
P
L
L
G
V
H
E
V
V
F
A
F
V
T
---
D
-----
E
--------------
H
A
Q
G
T
L
R
S
A
K
L
F
F
D
L
F
L
S
S
F
Q
G
L
L
V
A
V
L
Y
C
F
L
N
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
--------------------------------
49
HHSearch
54.40
11%
-140
* C3 *
2Z73
5
OPSD_TODPA
A:
[35-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
------
M
T
I
S
C
-
F
L
K
K
-------------
W
I
F
G
-----
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
-
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
P
M
A
A
------
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
---
G
---
V
L
C
N
---
C
S
F
D
Y
I
S
-------
R
------
D
S
T
T
R
S
N
I
L
C
M
--------
F
I
----
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
-
A
M
A
K
RLNAKE
L
R
----
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
-
A
V
V
A
L
L
A
-----
Q
FGPLE---------
W
V
T
P
Y
A
----
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
------
A
E
T
E
I
P
A
G
E
------------
72
Fugue
52.45
12%
-100
- C3 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
GTAD
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
YIQKYLSGQCEVP
L
V
R
T
DN
P
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
--
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
-
Q
F
M
------
D
G
--
A
-
R
R
E
I
VCRADGTMRLGEP
T
S
N
E
-----
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
G
T
T
Y
------
Q
----
P
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
-
V
------
D
---
G
D
S
V
SG
I
C
F
V
G
Y
K
N
-------
Y
------
R
---------
Y
--------
R
A
----
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
-
S
----------
N
----
H
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
L
L
S
E
K
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
-------
F
V
-----
L
--------------
I
T
F
S
C
H
----
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
------
W
T
K
A
T
L
L
I
W
R
R
T
W
C
-------
50
HHSearch
51.41
11%
-137
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[50-497]
--------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
L
-
P
F
W
------
A
V
--
D
-
A
V
A
N
-------------
W
Y
F
G
-----
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
-
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
A
T
N
S
------
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
-
V
------
S
E
A
D
D
R
Y
I
---
C
D
R
F
Y
P
N
-------
D
------
L
---------
W
V
V
V
F
Q
F
Q
H
I
M
----
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
-
E
----------
M
L
R
--
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
-
Y
I
G
I
S
I
D
-----
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
----
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------------------------------
57
HHSearch
50.42
13%
-132
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
------
N
F
T
Y
A
-
V
H
N
E
-------------
W
Y
Y
G
-----
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
-
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
I
H
P
L
Q
P
------
R
LS--
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
-
T
------
E
TMP
S
R
V
V
---
C
M
I
E
W
P
E
-------
H
PNKIY
E
K
---------
V
Y
H
I
C
V
---
T
V
----
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
----------
D
----
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
-
H
I
F
F
L
L
P
-----
Y
I
NPDLYLK------
K
F
I
Q
Q
V
----
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
------
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
---
53
HHSearch
49.35
9%
-134
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[27-457]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
------
Y
T
L
Y
T
-
V
I
G
Y
-------------
W
P
L
G
-----
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
-
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
P
L
T
Y
------
P
VKRT
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
-
F
I
V
GVRT
V
---
E
D
G
E
---
C
Y
I
Q
F
F
S
-------
N
------
A
---------
A
V
T
F
G
T
---
A
I
----
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
-
I
F
-
E
----------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD---
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
-
N
V
M
V
L
I
N
-----
T
F
CAP----------
C
I
P
N
T
V
----
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------
11
PsiBlast_PDB
48.25
61%
-23
- C4 -
3EHU
2
CRFR1_HUMAN (first)
A:
[395-455]
---------------------------------------------------------
C
N
A
S
V
D
L
I
G
T
C
W
P
R
S
P
A
G
Q
L
V
V
R
P
C
P
A
F
F
Y
G
V
R
Y
N
T
T
N
N
G
Y
R
E
C
L
-------------------
A
N
G
S
W
A
A
R
V
N
Y
S
-
E
C
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
47.73
10%
-130
- C3 -
1U19
14
OPSD_BOVIN
A:
[43-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
------
T
L
Y
T
S
-
L
H
G
Y
-------------
F
V
F
G
-----
P
T
G
C
N
L
E
G
F
F
A
T
L
G
-
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
C
K
P
M
S
N
------
F
R
F
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
---
C
G
I
D
Y
Y
T
PHEETN
N
E
------
S
---------
F
--------
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
----
T
V
K
E
A
A
-
A
----------
Q
QQ--
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
F
T
H
QG
S
--------------
D
F
G
P
I
F
----
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
------
E
T
S
Q
V
A
P
A
-------------
71
Fugue
47.22
11%
-116
- C2 -
2WE8
9
?
A:
[4-360]
---------------GVR
D
V
L
G
T
L
S
A
V
W
E
S
G
G
T
A
G
V
G
T
V
V
R
T
F
R
S
A
P
R
--
P
A
G
A
S
M
V
V
A
P
D
G
T
V
S
G
S
V
S
-----------------
G
G
C
V
E
G
A
V
Y
D
L
A
T
E
V
V
-------------------
A
T
G
T
----------------
P
V
L
Q
R
Y
G
V
G
G
I
L
D
V
F
V
E
P
V
S
Q
--
K
T
F
P
Q
L
G
A
I
R
D
D
I
E
A
Q
-----
R
P
V
A
V
A
T
V
I
T
H
P
D
A
Q
W
I
G
R
-
R
L
V
------
V
H
--
T
-
D
E
V
A
-------------
G
S
L
G
------------
S
S
R
A
D
A
A
-
V
T
D
D
A
R
G
L
L
A
A
G
--
R
S
E
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
G
P
D
G
------
Q
----
R
R
G
E
G
M
E
V
F
V
S
S
Y
A
P
R
P
R
M
L
V
F
G
A
I
D
-------------------------
F
A
-------
A
------
A
---------
V
--------
A
Q
----
Q
G
A
F
L
G
Y
R
V
T
V
C
D
A
R
P
V
F
A
T
T
A
R
-----
F
-
P
----------
T
----
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
V
V
V
D
W
P
H
R
Y
L
A
A
Q
A
E
A
G
A
I
D
A
R
T
V
V
C
V
-
L
T
H
D
P
K
F
-----
D
--------------
V
P
L
L
E
V
----
A
L
R
L
P
----------
D
I
A
Y
I
G
A
M
G
S
-
R
R
T
H
E
D
R
L
A
R
L
R
E
A
G
L
T
E
E
E
L
A
R
L
S
S
P
IGLDLG
G
R
T
P
E
E
T
A
V
S
I
A
A
E
I
I
A
K
R
WG
30
PsiBlast_CBE
46.75
61%
-16
- C4 -
3EHU
2
B:
[395-455]
---------------------------------------------------------
C
N
A
S
V
D
L
I
G
T
C
W
P
R
S
P
A
G
Q
L
V
V
R
P
C
P
A
F
F
Y
G
V
R
Y
N
T
T
N
N
G
Y
R
E
C
L
-------------------
A
N
G
S
W
A
A
R
V
N
Y
S
-
E
C
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
43.19
91%
-18
- C4 -
2JND
1
CRFR2_MOUSE
A:
[41-108]
----------------------------------------------------
G
P
Y
T
Y
C
N
T
T
L
D
Q
I
G
T
C
W
P
Q
S
A
P
G
A
L
V
E
R
P
C
P
E
Y
F
N
G
I
K
Y
N
T
T
R
N
A
Y
R
E
C
L
-------------------
E
N
G
T
W
A
S
R
V
N
Y
S
-
H
C
E
P
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
39.41
61%
5
- C4 -
3EHT
1
A:
[395-454]
---------------------------------------------------------
C
N
A
S
V
D
L
I
G
T
C
W
P
R
S
P
A
G
Q
L
V
V
R
P
C
P
A
F
F
Y
G
V
R
Y
N
T
T
N
N
G
Y
R
E
C
L
-------------------
A
N
G
S
W
A
A
R
V
N
Y
S
-
E
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------