@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EDNRA_HUMAN: (2016-01-09 )
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
Atome Classification :
(20 SA)
.........10........20........30........40...-.....50........60........70........80........90........100.......110......---.120.......130.......140-.......150.......160.......170.......180.......190....---...200.......210.......---------------220...-.-.....230-.......--..240.......250...---....260.......270...--....280--.....--.------------------------------------..290-------------------------------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------------------------------------------------------------------------------------------------------...-...300.......310.......320-.......330...-....340.......350.......360.......370.......380.......390.......400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
T
L
C
L
R
A
S
F
W
L
A
L
V
G
C
VISD
N
P
E
R
YSTNLSNHVDDFTTFRG
T
E
-
L
S
F
L
V
TTHQP
T
N
L
V
LPSNGSMHNYCPQQ
T
K
I
T
S
A
F
K
Y
I
N
T
V
I
S
C
T
I
F
I
V
GMVG
N
A
T
L
L
R
I
I
YQ
N
K
CMRNG
P
N
A
L
---
I
A
S
L
ALG
D
L
I
Y
V
V
I
DL
P
I
N
V
F
K
L
L
-AGRWPFDHN
D
F
G
V
F
L
C
K
L
F
P
F
L
Q
KSSV
G
I
T
V
L
N
L
C
AL
S
V
D
R
Y
R
A
V
ASWSRVQGI---G
I
P
L
V
T
A
I
E
I
V
S
I
W
I
L
S
F
I
L
A
I
P
---------------
E
--AI
G
-
F
-
V
M
V
P
F
E
---YRGEQ
H
K
--
T
C
M
L
N
A
T
S
K
F
M
E
F
Y
Q
D
V
K
---
D
W
W
L
F
G
F
Y
F
C
M
P
L
V
C
T
A
I
F
Y
--
T
L
M
T
C
E
---
M
L
NRR--N------------------------------------G
S
L
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
E
-
H
L
K
Q
R
R
E
V
A
K
T
V
F
C
L
V
V
I
F
A
L
C
W
F
P
L
-
H
L
S
R
I
L
K
K
T
V
Y
N
E
-
M
D
K
N
R
C
E
L
L
S
F
L
L
L
M
D
Y
IG
I
N
L
A
T
M
N
SC
I
N
P
I
A
L
Y
F
V
S
K
K
F
K
N
C
F
Q
S
C
L
C
C
C
C
YQSKS
L
M
TSVPMNG
T
S
I
Q
W
KNHDQNNHNTDRSSHKDSMN
22
HHSearch
83.94
22%
-106
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
---
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
-----
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
---------------
A
--
I
L
F
-
W
-
Q
F
I
V
G
V
----
R
T
V
E
D
G
--
E
C
Y
I
Q
F
F
S
------
N
A
A
V
---
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
--
W
H
I
S
R
A
---
S
K
S
R
I
--
N
------------------------------------
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
P
-
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
-
N
V
M
V
L
I
N
T
F
C
A
P
C
-
I
P
----------
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
------------------------------------------
21
HHSearch
83.74
23%
-112
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[42-499]
--------------------------------------------------------------------------
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
---
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
-----
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
---------------
D
--
F
I
F
-
A
-
N
V
S
E
-------
A
D
D
R
Y
--
I
C
D
R
F
Y
P
N
D
---
L
W
V
V
V
F
---
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
--
C
I
I
I
S
K
---
L
S
H
S
G
--
S
------------------------------------
N
I
F
E
M
-------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA
Y
G
S
-
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
-
Y
I
G
I
S
I
D
S
F
I
L
L
E
-
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
--------------------------------
3
PsiBlast_PDB
81.79
25%
-120
- C1 -
4RWA
2
C562_ECOLX (first)
A:
[104-404]
--------------------------------------------------------------
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
---
I
F
N
L
A
L
A
D
A
L
-
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
-----
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
---------------
I
--
M
V
M
-
A
-
V
T
R
P
-------
R
D
G
A
V
--
V
C
M
L
Q
F
P
S
P
S
W
-
Y
W
D
T
V
T
---
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
--------------------------------------------------
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
-
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
-
H
I
F
V
I
----
V
W
T
L
-
V
D
I
D
R
R
D
P
L
V
V
A
A
L
--
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------------------
4
PsiBlast_PDB
79.65
25%
-119
- C1 -
4RWD
7
C562_ECOLX (first)
A:
[104-404]
--------------------------------------------------------------
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
---
I
F
N
L
A
L
A
D
A
L
-
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
-----
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
---------------
I
--
M
V
M
-
A
-
V
T
R
P
-------
R
D
G
A
V
--
V
C
M
L
Q
F
P
S
P
S
W
-
Y
W
D
T
V
T
---
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
---
S
V
R
L
L
--
S
------------------------------------
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
-
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
-
H
I
F
V
I
----
V
W
T
L
-
V
D
I
D
R
R
D
P
L
V
V
A
A
L
--
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------------------
26
HHSearch
79.09
21%
-107
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
---
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
-----
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
---------------
I
--
L
G
--
W
-
N
H
----------
R
R
E
D
--
K
C
E
T
D
F
Y
D
V
------
T
W
F
---
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
--
A
K
I
Y
K
A
---
V
R
Q
H
C
--
N
------------------------------------
I
F
E
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
L
-
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
-
F
I
F
F
M
V
I
A
F
C
K
N
C
-
C
N
----------
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-----------------------------------------
25
HHSearch
78.35
21%
-108
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
------------------------------------------------------------------------------
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
---
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
-----
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
---------------
P
--
I
Q
M
H
W
-
Y
R
A
T
H
-------
Q
E
A
I
--
N
C
Y
A
E
E
T
C
C
D
-
F
F
T
N
Q
A
Y
---
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
--
S
R
V
F
Q
E
---
A
K
R
Q
L
--
N
------------------------------------
I
F
E
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
K
-
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
Q
D
N
L
-
I
----------
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------
1
PsiBlast_PDB
76.51
27%
-124
- C1 -
5C1M
7
?
A:
[29-296]
--------------------------------------------------------------------------------------------
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
---
I
F
N
L
A
L
A
D
A
L
-
A
T
S
T
L
P
F
Q
S
V
N
Y
L
-
M
G
T
W
P
F
-----
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
---------------
V
--
M
F
-----
M
A
T
T
K
---
Y
R
-
Q
G
S
I
--
D
C
T
L
T
F
-
S
H
P
T
W
Y
W
E
N
L
L
---
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
--
G
L
M
I
L
R
---
L
K
S
V
R
ML
S
------------------------------------
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
-
K
D
R
N
L
R
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
-
H
I
Y
V
I
I
K
A
L
I
--
T
-
I
P
E
T
T
F
Q
T
V
S
W
-----
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
-----------------------------------------------
43
Fugue
76.50
19%
-99
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------------------------------
M
N
G
T
E
G
P
N
---
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
---
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
-----
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
---------------
P
--
L
V
G
-
W
S
R
Y
I
P
E
G
---
M
Q
C
------
S
C
G
I
D
Y
Y
T
P
H
E
E
T
--
N
N
E
---
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
--
C
Y
G
Q
L
V
---
F
T
V
K
E
--
A
------------------------------------
A
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
-
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
F
T
H
Q
G
S
----------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
----------------------
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
32
HHSearch
75.99
21%
-117
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
---
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
-----
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
---------------
L
--
L
F
G
-
F
-
N
T
T
G
---------
D
P
T
--
V
C
S
I
S
N
P
---------
D
F
---
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
--
A
R
I
Y
V
V
---
L
K
Q
R
R
--
R
------------------------------------
K
N
I
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWD
A
Y
G
-
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
-
F
L
T
H
V
L
N
T
H
C
Q
T
C
-
H
V
---------
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-----------------------------------------
42
Fugue
75.72
21%
-117
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------------------------------------------------
S
F
K
C
A
L
-
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
-
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
---
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
-----
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
K
K
N
A
I
C
I
S
V
L
-
V
W
L
I
V
V
V
A
I
S
P
--------------------
I
-
L
-
F
Y
S
G
T
G
---
V
R
K
N
K
T
I
--
T
C
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
---
M
C
T
T
V
A
M
-
F
C
V
P
L
V
L
I
L
G
C
Y
--
G
L
I
V
R
A
---
L
I
Y
K
M
--
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLC
G
V
G
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
-
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------------------------
6
PsiBlast_PDB
74.16
25%
-123
- C1 -
4N6H
22
OPRD_HUMAN
A:
[129-407]
------------------------------------------------------------------------------------
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
---
I
F
N
L
A
L
A
D
A
L
-
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
-----
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
---------------
I
--
M
V
M
-
A
-
V
T
R
P
-------
R
D
G
A
V
--
V
C
M
L
Q
F
P
S
P
S
W
-
Y
W
D
T
V
T
---
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
---
S
V
R
L
L
--
S
------------------------------------
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
-
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
-
H
I
F
V
I
----
V
W
T
L
-
V
D
I
D
R
R
D
P
L
V
V
A
A
L
--
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
--------------------------------------
41
Fugue
73.98
19%
-82
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
---
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
-----
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
---------------
P
--
L
V
G
-
W
-
S
R
Y
I
P
E
-----
G
M
Q
C
---
S
C
G
I
D
Y
Y
T
P
H
E
E
T
--
N
N
E
---
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
--
C
Y
G
Q
L
V
---
F
T
V
K
E
--
A
------------------------------------
A
A
Q
Q
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
-
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
----------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
---------------
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-
13
PsiBlast_PDB
73.69
23%
-126
- C1 -
4LDE
3
A:
[187-462]
-------------------------------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
---
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
-----
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
---------------------------
F
L
P
I
Q
MHW
Y
R
A
T
H
Q
E
--
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
--
V
P
L
V
I
M
V
F
V
Y
--
S
R
V
F
Q
E
---
A
K
R
Q
L
--
Q
---------------------------------------
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
-
H
-----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
Q
D
N
L
-
I
R
K
------
E
V
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
P
L
-
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------
14
PsiBlast_PDB
73.28
23%
-128
- C1 -
4LDL
3
ADRB2_HUMAN
A:
[187-462]
-------------------------------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
---
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
-----
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
---------------------------
F
L
P
I
Q
M
HW
Y
R
A
T
H
Q
E
--
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
--
V
P
L
V
I
M
V
F
V
Y
--
S
R
V
F
Q
E
---
A
K
R
Q
L
--
Q
---------------------------------------
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
-
H
-----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
Q
D
N
L
-
I
R
K
------
E
V
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
P
L
-
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------
7
PsiBlast_PDB
73.20
24%
-123
- C1 -
4BWB
1
NTR1_RAT
A:
[19-327]
--------------------------------------------------------------------------------
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
-----
Q
S
L
Q
S
R
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
L
Y
N
F
I
-
W
V
H
H
P
W
A
F
G
D
A
G
---
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
GLQNLSGDGT
H
--
P
G
G
-
L
-
V
C
T
P
I
V
---
D
T
A
T
L
R
V
--
V
I
Q
L
N
---
T
F
M
S
-----------------
F
L
F
P
M
L
V
A
S
I
L
N
--
T
V
A
A
R
R
L
T
V
M
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
-
H
V
R
R
L
M
--
F
V
Y
I
S
-
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
C
---------------------------------------
12
PsiBlast_PDB
73.08
23%
-111
- C1 -
3ZEV
6
NTR1_RAT
A:
[19-325]
--------------------------------------------------------------------------------
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
-
W
V
H
H
P
W
A
F
G
D
A
G
---
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
---------------
M
--
L
F
T
-
M
-
G
L
Q
N
L
S
---
G
D
G
T
H
P
G
G
L
V
C
T
P
I
V
D
T
A
T
L
K
V
V
I
Q
V
N
---
T
F
M
S
F
L
F
----
P
M
L
V
A
S
I
L
N
--
T
V
I
A
N
K
L
T
V
M
V
H
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
-
H
V
R
R
L
M
F
C
Y
I
S
D
E
---
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
-----------------------------------------
15
PsiBlast_PDB
72.93
23%
-125
- C1 -
4LDO
3
A:
[187-462]
-------------------------------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
---
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
-----
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
---------------------------
F
L
P
I
Q
M
HW
Y
R
A
T
H
Q
E
--
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
--
V
P
L
V
I
M
V
F
V
Y
--
S
R
V
F
Q
E
---
A
K
R
Q
L
--
Q
---------------------------------------
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
-
H
-----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
Q
D
N
L
-
I
R
K
------
E
V
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
P
L
-
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------
17
PsiBlast_PDB
72.92
23%
-130
- C1 -
4QKX
2
ADRB2_HUMAN
A:
[187-462]
-------------------------------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
---
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
C
I
L
-
T
K
T
W
T
F
-----
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
---------------------------
F
L
P
I
Q
M
HW
Y
R
A
T
H
Q
E
--
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
--
V
P
L
V
I
M
V
F
V
Y
--
S
R
V
F
Q
E
---
A
K
R
Q
L
--
Q
---------------------------------------
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
-
H
-----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
Q
D
N
L
-
I
R
K
------
E
V
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
P
L
-
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------
10
PsiBlast_PDB
72.61
24%
-111
- C1 -
4BUO
10
NTR1_RAT
A:
[18-320]
--------------------------------------------------------------------------------
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
-
W
V
H
H
P
W
A
F
G
D
A
G
---
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
---------------
M
--
L
F
T
-
M
-
G
L
Q
N
L
S
---
G
D
G
T
H
P
G
GL
V
C
T
P
I
V
D
T
A
T
L
K
V
V
I
Q
V
N
---
T
F
M
S
F
L
F
----
P
M
L
V
A
S
I
L
N
--
T
V
I
A
N
K
L
T
V
M
V
H
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
R
-
V
Q
A
L
R
R
G
V
L
-
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
-
H
V
R
R
L
M
F
C
Y
I
S
D
E
---
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
-------------------------------------------
5
PsiBlast_PDB
72.30
24%
-128
- C1 -
4BV0
1
NTR1_RAT
A:
[19-326]
--------------------------------------------------------------------------------
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
K
-------
S
R
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
V
Y
N
F
I
-
W
V
H
H
P
W
A
F
G
D
A
G
---
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
R
H
P
-----
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
---------------
M
L
F
T
V
G
-
L
-
Q
N
L
S
G
D
---
G
T
H
P
G
G
L
--
V
C
T
P
I
V
D
T
A
T
L
K
V
V
I
Q
L
N
---
T
F
M
S
F
L
F
----
P
M
L
V
A
S
I
L
N
--
T
V
I
A
R
R
L
T
V
M
V
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
M
V
I
A
F
V
V
C
W
L
P
Y
-
H
V
R
R
L
M
--
F
V
Y
I
S
-
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
----------------------------------------