@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EDNRB_HUMAN: (2016-01-09 )
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100........110.......120.......130..---.....140.......150.......160.--......170.......180.......190.......200.......210---.-......220-.......230......-.240.....-...250..--.....260....-...270....-------...280.----------........290.......300.-----..--------------------......310--------------------------------------------------------------------------------------------------------------------------------------------------------..-----------------...--------------------------------------..-----.--.320.......330.......340...-..-..350.-......360.......370.......380.......390.......400.......410.......420.......430.......440
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQP
P
P
S
L
C
G
R
A
L
V
A
L
V
L
A
C
G
L
S
R
I
WGEERGFPPDRATP
L
L
QTAEIMTPPTKTLWPKGS
N
A
S
L
A
R
SLAPAEVPKGDRTAGSPPRTISPPPCQG
P
I
E
I
K
E
T
F
K
-
Y
I
N
T
V
V
S
C
L
V
F
V
L
G
I
IG
N
S
T
L
L
R
I
I
YK
N
K
CMRN---GP
N
I
L
I
A
S
L
A
L
G
D
L
L
H
I
V
I
DI
P
I
N
V
Y
K
L
L
--AEDWP
F
G
A
E
M
C
K
L
V
P
F
I
Q
KAS
V
G
I
T
V
L
S
L
C
A
L
S
I
D
R
Y
R
A
V
ASWSRIKGI---G-VPK
W
T
A
V
E
I
-
V
L
I
W
V
V
S
V
V
L
A
V
P
E
AI-
G
F
D
-
I
I
T
M
D-YKG
S
Y
L
R
I
--
C
L
LHP
V
Q
K
T
A
F
M
-
Q
F
Y
K
T
A
K
D
W
W
-------
L
F
S
F
--
Y
----------
F
C
L
P
L
A
I
T
A
F
F
Y
T
L
M
T
C
E
M
--
L
-----
R
K
--------------------KSG
M
Q
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
-----------------
D
H
L
--------------------------------------
K
Q
-----
R
--
R
E
V
A
K
T
V
F
C
L
V
L
V
F
A
L
C
W
L
P
L
H
L
S
R
I
L
-
K
L
-
T
L
YNQN-DP
N
R
C
E
L
L
S
F
L
L
V
L
D
Y
IGI
N
M
A
S
L
N
S
C
I
N
P
I
A
L
Y
L
V
S
K
R
F
K
N
C
F
K
S
C
L
C
C
W
C
Q
S
F
E
E
K
Q
S
L
E
E
K
Q
S
C
L
KFKANDHGYDNFRSSNKYSSS
8
PsiBlast_PDB
88.70
27%
-140
- C4 -
4RWA
2
C562_ECOLX (first)
A:
[126-406]
---------------------------------------------------------------------------------------------------------
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
---
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
--
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
-
T
P
A
K
A
K
L
I
N
-
I
C
I
W
V
L
A
S
G
V
G
V
P
--
I
-
M
V
M
-
A
V
T
R
P
-
R
D
G
A
V
--
V
--
C
M
L
---
Q
F
P
S
P
S
-
W
Y
W
D
T
V
T
K
I
C
-------
V
F
L
F
--
A
----------
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
------------------------------------
G
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
-----------------
D
----------------------------------------
R
S
-----
L
--
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
-
V
D
I
D
R
R
-
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
-------
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
-
L
C
----------------------------------------
28
HHSearch
88.60
22%
-110
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
--------------------------------------------------------------------------------------------------
V
W
V
-
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
--
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
-
T
K
N
K
A
R
V
I
I
-
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-
R
A
T
H
Q
-----
E
A
I
N
--
C
Y
A
E
E
T
C
C
D
F
F
----
T
N
Q
A
Y
A
I
A
-------
S
S
I
V
--
S
----------
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
--
K
-----
R
Q
--------------------
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
-----------------
K
F
C
--------------------------------------
L
K
-----
E
--
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
-
H
V
-
I
Q
D
N
L
I
-----------
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------
48
Fugue
88.35
25%
-115
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
---------------
S
F
K
C
A
L
T
K
-----
T
G
F
-------------------------------------------------------------------
Q
F
Y
-
Y
L
P
A
V
Y
I
-
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
---
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
--
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
-
K
K
N
A
I
C
I
-
S
-
V
L
V
W
L
I
V
V
V
A
I
S
P
----------
I
L
F
-
Y
S
G
T
G
V
R
K
--
N
K
T
I
T
C
Y
D
T
T
S
D
-
E
Y
L
R
S
Y
F
I
Y
S
-------
M
C
T
T
V
A
M
----------
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
--
I
-----
Y
K
--------------------
M
K
K
Y
T
C
T
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
C
-----------------
G
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
EE
P
L
-----
R
--
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
-
N
L
-
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------------
3
PsiBlast_PDB
87.21
24%
-113
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-380]
--------------------------------------------------------------------------------------
S
F
K
C
A
---
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
---
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
--
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
--
Y
P
-
K
S
L
---
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
----------
I
L
F
-
Y
S
G
T
----------
G
V
R
K
N
K
T
I
-
T
C
Y
D
T
T
S
D
E
Y
-------
L
R
S
Y
--
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
--
I
-----
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDP
D
N
G
V
N
P
G
----------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
FKDIVCPLCGVGK----
D
Q
F
--------------------------------------
E
E
V
EE
P
L
R
--
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
-
N
L
R
A
R
L
D
F
Q
-
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------------
9
PsiBlast_PDB
85.91
27%
-135
- C4 -
4RWD
6
C562_ECOLX (first)
A:
[126-406]
---------------------------------------------------------------------------------------------------------
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
---
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
--
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
-
T
P
A
K
A
K
L
I
N
-
I
C
I
W
V
L
A
S
G
V
G
V
P
--
I
-
M
V
M
-
A
V
T
R
P
-
R
D
G
A
V
--
V
--
C
M
L
---
Q
F
P
S
P
S
-
W
Y
W
D
T
V
T
K
I
C
-------
V
F
L
F
--
A
----------
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
--
R
-----
S
V
--------------------
R
L
L
S
G
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
-----------------
D
----------------------------------------
R
S
-----
L
--
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
-
V
D
I
D
R
R
-
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
-------
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
-
L
C
----------------------------------------
4
PsiBlast_PDB
85.82
24%
-111
- C4 -
4XNW
2
RUBR_CLOPA
A:
[37-380]
-------------------------------------------------------------------------------------
S
S
F
K
C
A
---
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
---
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
--
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
--
Y
P
L
K
S
L
---
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
----------
I
L
F
-
Y
S
G
T
----------
G
V
R
K
N
K
T
I
-
T
C
Y
D
T
T
S
D
E
Y
-------
L
R
S
Y
--
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
--
I
-----
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDP
D
N
G
V
N
P
G
----------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
FKDIPDDWVCPLCGVGK
D
Q
F
--------------------------------------
E
E
V
EE
P
L
R
--
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
-
N
L
R
A
R
L
D
F
Q
-
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------------
7
PsiBlast_PDB
85.54
27%
-139
- C4 -
4N6H
22
OPRD_HUMAN
A:
[129-409]
---------------------------------------------------------------------------------------------------------
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
---
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
--
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
-
T
P
A
K
A
K
L
I
N
-
I
C
I
W
V
L
A
S
G
V
G
V
P
--
I
-
M
V
M
-
A
V
T
R
P
-
R
D
G
A
V
--
V
--
C
M
L
---
Q
F
P
S
P
S
-
W
Y
W
D
T
V
T
K
I
C
-------
V
F
L
F
--
A
----------
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
--
R
-----
S
V
--------------------
R
L
L
S
G
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
-----------------
D
----------------------------------------
R
S
-----
L
--
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
-
V
D
I
D
R
R
-
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
-------
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
-
L
C
R
K
P
C
G
-----------------------------------
25
HHSearch
85.32
22%
-113
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
----------------------------------------------------------------------------------------------------
V
-
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
---
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
--
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
-
T
T
K
M
A
G
M
M
I
-
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
Q
-
F
I
V
G
V
-
R
-
T
V
E
D
G
E
--
C
Y
I
Q
F
F
S
---------
N
A
A
V
T
F
G
-------
T
A
I
A
--
A
----------
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
--
K
-----
S
R
--------------------
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
-----------------
P
P
P
--------------------------------------
S
R
-----
E
--
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
-
N
T
-
F
C
A
P
C
I
--
P
---------
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
----------------------------------------
24
HHSearch
84.60
21%
-106
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[41-499]
---------------------------------------------------------------------------------------------
E
E
N
A
N
F
N
K
-
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
---
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
L
P
F
W
A
V
D
A
V
---
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
-
K
L
L
A
E
K
V
V
Y
-
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
-
F
A
N
-
V
S
E
A
-----
D
D
R
Y
I
--
C
D
R
F
Y
P
N
D
L
------
W
V
V
V
F
Q
F
Q
-------
H
I
M
V
--
G
----------
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
--
S
-----
H
S
--------------------
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA
Y
G
-----------------
S
K
G
--------------------------------------
H
Q
-----
K
--
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
-
D
S
-
F
I
L
L
E
I
-
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
------------------------------
35
HHSearch
84.34
21%
-120
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
---
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
-
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
-
S
C
R
R
V
A
L
M
I
-
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
N
-
T
T
G
-------
D
P
T
V
--
C
S
I
S
N
P
------------
D
F
V
I
Y
-------
S
S
V
V
--
S
----------
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
--
K
-----
Q
R
--------------------
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWD
A
Y
-----------------
G
V
P
--------------------------------------
L
R
-----
E
--
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
-
N
T
-
H
C
Q
T
C
H
-
V
---------
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------------------------------------
27
HHSearch
83.78
21%
-116
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
---
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
--
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
-
T
K
T
R
A
S
A
T
I
-
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
--
W
N
-
H
--------
R
R
E
D
K
--
C
E
T
D
F
Y
D
V
T
---------
W
F
K
V
M
-------
T
A
I
I
--
N
----------
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
--
R
-----
Q
H
--------------------
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
-----------------
L
H
M
--------------------------------------
N
R
-----
E
--
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
-
I
A
-
F
C
K
N
C
C
-
N
----------
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
---------------------------------------
47
Fugue
83.24
20%
-96
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
-------------------------------------------
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
--
P
F
E
A
P
------------------
Q
Y
Y
L
A
E
P
W
Q
F
S
-
M
L
A
A
Y
M
-
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
--
E
N
H
A
I
M
G
V
-
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
-
M
Q
C
S
C
G
I
D
--
Y
Y
T
P
H
E
E
T
N
---------
N
E
S
F
V
-------
I
Y
M
F
--
V
----------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
--
T
-----
V
K
--------------------
E
A
A
---
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
-----------------
T
T
Q
--------------------------------------
K
A
-----
E
--
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
--
A
G
V
A
-
F
Y
-
I
F
T
H
Q
G
-
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
-------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
--------------------
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
18
PsiBlast_PDB
82.94
23%
-123
- C4 -
3ZEV
6
NTR1_RAT
A:
[19-325]
----------------------------------------------------------------------------------------------------
K
-
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
WV
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
-
S
R
S
R
T
K
K
F
I
-
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
-
T
M
G
-
L
Q
N
L
S
-
G
D
G
T
H
P
G
G
--
L
V
C
T
P
I
V
D
T
A
T
L
-
K
V
V
I
Q
V
N
T
F
M
-------
S
F
L
F
----------------
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
--
T
V
M
V
HQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------
G
R
V
--------------------------------------
Q
A
-----
L
--
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
---
M
-
F
C
Y
I
S
D
-
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
---------------------------------------
1
PsiBlast_PDB
82.93
27%
-135
- C4 -
4EA3
3
C562_ECOLX (first)
A:
[135-405]
---------------------------------------------------------------------------------------------------------------
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
---
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
-
V
L
L
T
L
P
F
Q
G
T
D
I
L
--
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
-----------
T
S
S
K
A
Q
A
V
N
-
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
-
M
G
S
-
A
Q
V
E
D
-
E
E
I
E
------
C
L
V
E
-----------
I
P
T
P
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
--
S
----------
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
----
M
--
I
-----
R
R
--------------------
L
R
G
V
R
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
-----------------
S
R
E
--------------------------------------
K
D
-----
R
N
L
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
-
Q
G
-
L
G
V
Q
P
S
-
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
-------
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
--------------------------------------------
15
PsiBlast_PDB
82.39
23%
-125
- C4 -
4BUO
10
NTR1_RAT
A:
[18-320]
----------------------------------------------------------------------------------------------------
K
-
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
WV
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
-
S
R
S
R
T
K
K
F
I
-
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
-
T
M
G
-
L
Q
N
L
S
-
G
D
G
T
H
P
G
G
--
L
V
C
T
P
I
V
D
T
A
T
L
-
K
V
V
I
Q
V
N
T
F
M
-------
S
F
L
F
----------------
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
M
-----
V
H
--------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------P----------------
G
R
V
--------------------------------------
Q
A
-----
L
--
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
---
M
-
F
C
Y
I
S
D
-
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
-----------------------------------------
19
PsiBlast_PDB
81.93
26%
-130
- C4 -
4QKX
2
ADRB2_HUMAN
A:
[187-462]
----------------------------------------------------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
C
I
L
--
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
-
T
K
N
K
A
R
V
I
I
-
L
M
V
W
I
V
S
G
L
T
S
-------
F
L
-
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
---------
I
V
S
F
--
Y
------------
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
--
K
-----
R
Q
--------------------
L
Q
--
K
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----------------
E
H
--------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
-
H
V
-
I
---
Q
D
-
N
L
I
R
K
E
V
---
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
P
L
-
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------
31
HHSearch
80.93
21%
-112
* C4 *
3EML
13
ENLYS_BPT4
A:
[22-472]
------------------------------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
-
T
G
T
R
A
K
G
I
I
-
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
-
N
C
G
Q
-------
S
Q
G
--
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
M
N
Y
M
V
Y
F
-------
N
F
F
A
--
C
----------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
--
R
-----
R
Q
--------------------
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
-
Y
R
-----------------
S
T
L
--------------------------------------
Q
K
-----
E
--
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
-
T
F
-
F
C
P
D
C
S
-
H
--------
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------
12
PsiBlast_PDB
80.76
26%
-127
- C4 -
4LDE
3
A:
[187-462]
----------------------------------------------------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
--
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
-
T
K
N
K
A
R
V
I
I
-
L
M
V
W
I
V
S
G
L
T
S
-------
F
L
-
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
---------
I
V
S
F
--
Y
------------
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
--
K
-----
R
Q
--------------------
L
Q
--
K
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----------------
E
H
--------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
-
H
V
-
I
---
Q
D
-
N
L
I
R
K
E
V
---
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
P
L
-
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------
10
PsiBlast_PDB
80.74
23%
-126
- C4 -
4BWB
1
NTR1_RAT
A:
[19-327]
----------------------------------------------------------------------------------------------------
K
-
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
-----
Q
S
L
Q
S
R
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
L
Y
N
F
I
WV
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
-
S
R
S
R
T
K
K
F
I
-
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
-
T
M
G
-
L
Q
N
L
S
-
G
D
G
T
H
P
G
G
--
L
V
C
T
P
I
V
D
T
A
T
L
-
R
V
V
I
Q
L
N
T
F
M
-------
S
F
L
F
----------------
P
M
L
V
A
S
I
L
N
T
V
A
A
R
R
L
--
T
V
M
V-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
-----------------
G
R
V
--------------------------------------
Q
A
-----
L
--
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
---
M
-
F
V
Y
I
S
D
-
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
C
-------------------------------------
13
PsiBlast_PDB
80.22
26%
-130
- C4 -
4LDL
3
ADRB2_HUMAN
A:
[187-462]
----------------------------------------------------------------------------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
--
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
-
T
K
N
K
A
R
V
I
I
-
L
M
V
W
I
V
S
G
L
T
S
-------
F
L
-
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
---------
I
V
S
F
--
Y
------------
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
--
K
-----
R
Q
--------------------
L
Q
--
K
F
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-----------------
E
H
--------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
-
H
V
-
I
---
Q
D
-
N
L
I
R
K
E
V
---
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
P
L
-
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------