@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FFAR1_HUMAN: (2016-01-09 )
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
Atome Classification :
(20 SA)
----------------------------.........10.....----...20.....---...30........40---........50......---.--.60........70........80........90..-......100.......110-.....---..120--........130.--....-.---.140..-.--....150......-.160.......170..--.---.---.----.----.180..-......190--.........200....---...210------...------------------------------------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------------------------------------------------------------------------....220.....--..230------------...-......240...---------....250----------.-----------.-----------.-----..------..-..260--.......270.--.-.....---280-..--......290.......300-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------MDLPPQL
S
F
G
L
Y
V
A
A
F
----
A
LGFP
L
N
V
L
A
---IRGAT
A
H
A
R
L
R
L
T
P
S
---
L
V
Y
A
LNLGCS
D
L
L
L
T
V---S--L
P
L
K
A
V
E
A
L
ASGAWPL
P
A
S
L
C
P
V
F
A
V
A
H
F
F
P
LYAG-
G
G
F
L
A
A
L
SAGRYLGAAFP
L
-
G
Y
Q
A
F
---
R
R
P
C
---YSW
G
V
C
A
A
I
W
A
L
--
V
L
C
H
-
L
---
G
L
V
FGL-E--APGGWLDHSNTSL-GINTPVNGS
P
V
C
L
E
AW--D---P---A----S----AG-P
A
R
-
F
S
L
S
L
L
L
----
F
F
L
P
L
A
I
T
A
F
C
Y
V
G
C
L
---
R
A
L
A
R-------SG
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
R
R
K
L
R
A
A
W
VA
G
--
G
A
L
--------------
L
T
L
-
L
L
CVGPY
N
A
S
N
V
---------
A
S
F
LY------------P-----------N-----------L-----GG------S
W
-
R
K
L
G
L
--I
T
G
A
W
S
V
V
L
N
P
--
L
-
V
T
G
YL---GR--GP--G
L
K
T
V
C
A
ARTQGGKSQK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.73
98%
-148
- C5 -
4PHU
6
ENLYS_BPT4 (first)
A:
[14-224]
----------------------------
M
D
L
P
P
Q
L
S
F
G
L
Y
V
A
A
F
----
A
L
G
F
P
L
N
V
L
A
---
I
R
G
A
T
A
H
A
R
L
R
L
T
P
S
---
A
V
Y
A
L
N
L
G
C
S
D
L
L
L
T
V
---
S
--
L
P
L
K
A
V
E
A
L
A
S
G
A
W
P
L
P
A
S
L
C
P
V
F
A
V
A
H
F
A
P
L
Y
A
G
-
G
G
F
L
A
A
L
S
A
A
R
Y
L
G
A
A
F
P
------------
P
C
---
Y
S
W
G
V
C
A
A
I
W
A
L
--
V
L
C
H
-
L
---
G
L
V
F
G
L
-
E
--
A
P
G
G
W
L
D
H
S
N
T
S
L
-
G
I
N
T
P
V
N
G
S
P
V
C
L
E
A
W
--
D
---
P
---
A
----
S
----
A
G
-
P
A
R
-
F
S
L
S
L
L
L
----
F
F
L
P
L
A
I
T
A
F
C
F
V
G
C
L
---
R
A
L
A
R
-------
G
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
--
K
I
Y
--------------
K
D
T
-
E
G
Y
Y
T
I
G
I
G
H
L
L
---------
T
K
S
P
S
------------
L
-----------
N
-----------
A
-----
A
K
------
S
E
-
L
D
K
A
I
--
G
R
N
T
N
G
V
I
T
K
D
--
E
-
A
E
K
L
F
---
N
Q
--
D
V
--
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
75.48
21%
-110
- C5 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-498]
-------------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
----
L
T
G
I
V
G
N
G
L
V
---
I
L
V
M
G
Y
Q
K
K
L
R
-
S
M
T
---
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
---
T
--
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
-
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-
N
S
Q
R
P
---
R
K
L
L
---
A
E
K
V
V
Y
V
G
V
W
I
P
--
A
L
L
L
-
T
---
I
P
D
F
I
F
-
A
--
N
V
S
---------------
E
A
D
D
R
Y
I
C
D
R
F
Y
--
P
---
N
---
D
----
L
W
---
V
V
-
V
F
Q
-
F
Q
H
I
M
V
G
----
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
---
S
K
L
S
H
-------
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGS
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
Q
K
R
K
A
L
K
T
T
V
--
I
L
I
--------------
L
A
F
-
F
A
C
W
L
P
Y
Y
I
G
I
S
---------
I
D
S
F
I
------------
L
L
EI
I
K
Q
G
C
E
F
E
N
-----------
T
-----
V
H
------
K
W
-
I
S
I
T
E
--
A
L
A
F
F
H
C
C
L
N
P
--
I
-
L
Y
A
F
L
---
G
A
--
K
F
KT
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
75.24
17%
-105
- C5 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
---------------------------------
V
L
W
A
A
A
Y
T
V
I
V
----
V
T
S
V
V
G
N
V
V
V
---
M
W
I
I
L
A
H
K
R
M
R
-
T
V
T
---
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F--
N
--
T
V
V
N
F
T
Y
-
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
-
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-
Q
P
R
L
-----
S
A
T
---
A
T
K
V
V
I
C
V
I
W
V
L
--
A
L
L
L
-
A
---
F
P
Q
G
Y
Y
-
S
--
T
T
E
---------------
T
M
P
S
R
V
V
C
M
I
E
W
--
P
---
E
---
H
----
P
NKIY
E
K
-
V
Y
H
-
I
C
V
T
V
L
I
----
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
---
I
T
L
W
A
-------
S
E
I
PGDSSDRYH
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
A
K
R
K
V
V
K
M
M
I
--
V
V
V
--------------
C
T
F
-
A
I
C
W
L
P
F
H
I
F
F
L
---------
L
P
Y
I
N
------------
P
-----------
D
-----------
L
YLKKF
I
Q
------
Q
V
-
Y
L
A
I
M
--
W
L
A
M
S
S
T
M
Y
N
P
--
I
-
I
Y
C
C
L
---
N
D
--
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
72.76
17%
-113
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
----
L
A
I
V
F
G
N
V
L
V
---
I
T
A
I
A
K
F
E
R
L
Q
-
T
V
T
---
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A--
V
--
V
P
F
G
A
A
H
-
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
--
S
G
L
T
-
S
---
F
L
P
I
Q
M
-
H
--
W
Y
----
R
A
T
H
Q
E
A
----
I
N
C
Y
A
E
E
T
C
C
D
F
F
--
T
-----------------
N
Q
-
A
Y
A
-
I
A
S
S
I
V
S
----
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
---
Q
E
A
K
R
-------
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
K
E
H
K
A
L
K
T
L
G
--
I
I
M
--------------
G
T
F
-
T
L
C
W
L
P
F
F
I
V
N
I
---------
V
H
V
I
Q
------------
D
-----------
N
L----------
I
-----
R
K
------
E
V
-
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
F
N
P
--
L
-
I
Y
C
-
R
---
S
P
--
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Fugue
70.52
18%
-101
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRSPFEAPQ
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
---
L
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
---
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
---
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
---
G
E
N
H
---
A
I
M
G
V
A
F
T
W
V
M
A
--
L
A
C
A
-
A
---
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
----
Q
C
S
C
-
G
I
D
Y
Y
T
P
H
E
E
--------------------------
T
N
-
N
E
S
-
F
V
I
Y
M
F
V
VH--
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
FTV
K
E
A
A
A
-------
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
--
I
M
V
--------------
I
A
F
-
L
I
C
W
L
P
Y
A
G
V
A
F
---------
Y
I
F
T
H
------------
Q
-----------
G
-----------
S
-----
D
F
------
G
P
-
I
F
M
T
I
--
P
A
F
F
A
K
T
S
A
V
Y
--
N
-
P
V
I
Y
I
---
M
M
--
N
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Fugue
70.49
19%
-108
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFSNKTGVVRSPFEAPQ
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
---
L
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
---
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
---
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
---
G
---------
E
N
H
A
I
M
G
V
A
--
F
T
W
V
-
M
---
A
L
A
C
A
A
-
P
--
P
L
V
G
W
S
R
Y
I
P
E
G
M
-
Q
C
--------
S
C
G
I
D
Y
YT
P
---
H
---
E
----
E
----
T
N
-
N
E
S
-
F
V
I
Y
M
F
V
VH--
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
AAAQQQE
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
--
I
M
V
--------------
I
A
F
-
L
I
C
W
L
P
Y
A
G
V
A
F
---------
Y
I
F
T
H
------------
Q
-----------
G
SD---------
F
-----
G
P
------
I
F
-
M
T
I
P
A
--
F
F
A
K
T
S
A
V
Y
N
P
--
V
-
I
Y
I
M
M
N
K
Q
F
R
--
N
C
--
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
69.16
18%
-123
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------
Y
A
L
S
Y
C
A
L
I
----
L
A
I
V
F
G
N
G
L
V
---
C
M
A
V
L
K
E
R
A
L
Q
-
T
T
T
---
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L--
V
--
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
-
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-
H
Y
Q
H
G
T
G
Q
S
S
C
R
---
R
V
A
L
M
I
T
A
V
W
V
L
--
A
F
A
V
-
S
---
C
P
L
L
F
G
-
F
--
N
T
-----------------
T
G
D
P
T
V
C
S
I
S
N
--
P
--------------------
D
F
V
-
I
Y
S
S
V
V
S
----
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
---
V
V
L
K
Q
-------
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGV
P
L
R
E
K
K
A
T
Q
M
V
A
--
I
V
L
--------------
G
A
F
-
I
V
C
W
L
P
F
F
L
T
H
V
---------
L
N
T
H
C
------------
Q
-----------
T
CH---------
V
-----
S
P
------
E
L
-
Y
S
A
T
T
--
W
L
G
Y
V
N
S
A
L
N
P
--
V
-
I
Y
T
T
F
---
N
I
--
E
F
R
K
A
F
L
K
I
L
S
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
67.20
27%
-100
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[39-322]
--------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
----
L
L
S
L
L
G
N
S
L
V
---
M
L
V
I
L
Y
S
R
V
G
R
-
S
V
T
---
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
---
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
-
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
-
R
T
L
T
----
Q
K
R
H
---
L
V
K
F
V
C
L
G
C
W
G
L
--
S
M
N
L
-
S
---
L
P
F
F
L
F
-
R
--
Q
A
Y
--------------
H
P
N
N
S
S
P
V
C
Y
E
V
L
--
G
---
N
---
D
----
T
AKW-
R
M
-
V
L
R
-
I
L
P
H
T
F
G
----
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
---
R
T
L
F
K
-------
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
Q
K
H
R
A
M
R
V
I
F
--
A
V
V
--------------
L
I
F
-
L
L
C
W
L
P
Y
N
L
V
L
L
---------
A
D
T
L
M
------------
R
-----------
T
QVIQE
S
C
E
R
R
N
N
-----
I
G
------
R
A
-
L
D
A
T
E
--
I
L
G
F
L
H
S
C
L
N
P
--
I
-
I
Y
A
F
I
---
G
Q
--
N
F
RH
G
F
L
K
I
L
A
M
H
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Fugue
67.13
18%
-128
- C5 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------SFKC
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
----
I
L
V
F
I
I
G
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
---
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
-
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
L
---
K
K
K
N
----
A
I
C
I
S
V
L
V
W
L
I
--
V
V
V
A
-
I
---
S
P
I
L
F
Y
----------------
S
-
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
--
S
---
D
EY
L
R
----
S
----
Y
F
-
I
Y
S
-
M
C
T
T
V
A
M
----
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
---
R
A
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
M
K
K
Y
T
C
T
V
C
G
--
Y
I
Y
N
PEDGDPDNGVNPG
T
D
F
-
K
D
I
V
C
P
L
C
G
V
G
K
---------
D
Q
F
E
E
------------
V
-----------
E
-----------
E
-----
P
L
------
R
R
-
K
S
I
Y
L
--
V
I
I
V
L
T
V
F
A
V
S
--
Y
-
I
P
F
H
V
---
M
K
--
T
M
--
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR----------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
66.81
18%
-118
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
---------------------------------
M
P
L
V
V
V
L
S
T
I
C
----
L
V
T
V
G
L
N
L
L
V
---
L
Y
A
V
R
S
E
R
K
L
H
-
T
V
G
---
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V--
V
--
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
-
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-
R
Y
L
K
Y
---
R
T
K
T
---
R
A
S
A
T
I
L
G
A
W
F
L
--
S
F
L
W
-
V
---
I
P
I
L
G
W
-
N
--
H
-------------------
R
R
E
D
K
C
E
T
D
F
--
Y
---
D
---
V
----
T
-------
W
F
K
-
V
M
T
A
I
I
N
----
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
---
K
A
V
R
Q
-------
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
R
E
R
K
A
A
K
Q
L
G
--
F
I
M
--------------
A
A
F
-
I
L
C
W
I
P
Y
F
I
F
F
M
---------
V
I
A
F
C
------------
K
-----------
N
C----------
C
-----
N
E
------
H
L
-
H
M
F
T
I
--
W
L
G
Y
I
N
S
T
L
N
P
--
L
-
I
Y
P
L
C
---
N
E
--
N
F
K
K
T
F
K
R
I
L
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.54
27%
-110
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[43-311]
----------------------------------------
I
I
A
Y
----
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
---
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
---
T
--
L
P
I
W
A
A
S
K
V
--
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
-
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
-
R
T
L
T
Q
---
K
R
H
L
---
V
K
F
-
V
C
L
G
C
W
-------------
G
L
S
M
N
L
-
S
--
L
P
F
F
L
F
R
Q
A
-------
Y
H
P
N
N
S
S
P
V
C
Y
E
V
L
--
G
---
N
---
D
----
T
----
A
--
K
W
R
-
M
V
L
R
I
L
P
HTFG
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
---
R
T
L
F
K
-------
A
H
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
H
R
A
M
R
V
I
F
--
A
V
V
--------------
L
I
F
-
L
L
C
W
L
P
Y
N
L
V
L
L
---------
A
D
T
L
M
RTQVIQE
S
C
E
R
R
N
-----------
N
-----------
I
-----
G
R
------
A
L
-
D
A
T
E
---
I
L
G
F
L
H
S
C
L
N
P
--
I
-
I
Y
A
F
I
---
G
Q
--
N
F
--
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
66.32
17%
-107
* C5 *
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
----------------------------------
F
I
V
L
V
A
G
S
L
S
----
L
V
T
I
I
G
N
I
L
V
---
M
V
S
I
K
V
N
R
H
L
Q
-
T
V
N
---
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F--
S
--
M
N
L
Y
T
L
Y
-
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
-
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
Y
P
V
K
---
R
T
T
K
---
M
A
G
M
M
I
A
A
A
W
V
L
--
S
F
I
L
-
W
---
A
P
A
I
L
F
-
W
--
Q
F
I
-----
V
--
G
-----
V
R
T
V
E
D
G
E
C
Y
I
Q
F
--
F
---
S
---
N
----------
A
-
A
V
T
-
F
G
T
A
I
A
A
----
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
---
R
A
S
K
S
-------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYP--
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
R
E
K
K
V
T
R
T
I
L
--
A
I
L
--------------
L
A
F
-
I
I
T
W
A
P
Y
N
V
M
V
L
---------
I
N
T
F
C
------------
A
P----------
C
-----------
I
-----
P
N
------
T
V
-
W
T
I
G
Y
--
W
L
C
Y
I
N
S
T
I
N
P
--
A
-
C
Y
A
L
C
---
N
A
--
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
65.41
17%
-101
- C5 -
3EML
13
ENLYS_BPT4
A:
[22-472]
---------------------------------
S
V
Y
I
T
V
E
L
A
I
A
----
V
L
A
I
L
G
N
V
L
V
---
C
W
A
V
W
L
N
S
N
L
Q
-
N
V
T
---
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L--
A
--
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
---
R
A
K
G
I
I
A
I
C
W
V
L
--
S
F
A
I
-
G
---
L
T
P
M
L
G
-
W
--
N
N
C
G
Q
----------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
---
V
---
P
---------
M
N
-
Y
M
V
-
Y
F
N
F
F
A
C
----
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
L
A
A
R
R
-------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
-
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
K
E
V
H
A
A
K
S
L
A
--
I
I
V
--------------
G
L
F
-
A
L
C
W
L
P
L
H
I
I
N
C
---------
F
T
F
F
C
------------
P
DCS--------
H
-----------
A
-----
P
L
------
W
L
-
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
--
F
-
I
Y
A
Y
R
---
I
R
--
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
65.29
17%
-102
- C5 -
1U19
14
OPSD_BOVIN
A:
[41-328]
---------------------------------
S
M
L
A
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
---
L
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
---
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G--
G
--
F
T
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
----
G
E
N
---
H
A
I
M
G
V
A
F
T
W
V
M
--
A
L
A
C
-
A
---
A
P
P
L
V
G
-
W
--
S
R
Y
--------------
I
P
E
G
M
Q
C
S
C
G
I
D
Y
--
Y
---
T
---
P
HEET
N
----
N
E
-
S
F
V
-
I
Y
M
F
V
V
H
----
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
-------
A
A
A
QQQESA
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
--
I
M
V
--------------
I
A
F
-
L
I
C
W
L
P
Y
A
G
V
A
F
---------
Y
I
F
T
H
------------
Q
GS---------
D
-----------
F
-----
G
P
------
I
F
-
M
T
I
P
A
--
F
F
A
K
T
S
A
V
Y
N
P
--
V
-
I
Y
I
M
M
---
N
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Fugue
64.95
19%
-97
- C5 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------------------P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
----
L
T
G
I
V
G
N
G
L
V
---
I
L
V
M
G
Y
Q
K
K
L
R
-
S
M
T
---
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
---
T
--
L
P
F
W
A
V
D
A
V
A
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
-
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-
N
S
Q
R
P
---
R
K
L
L
---
A
E
K
V
V
Y
V
G
V
W
I
P
--
A
L
L
L
---------
T
I
-
P
--
D
F
I
F
A
N
V
S
E
A
----------
D
D
R
Y
I
C
D
R
F
Y
--
P
---
N
---
D
----
L
----
W
V
-
V
V
F
-
Q
F
Q
H
I
M
V
G---
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
---
S
K
L
S
H
-------
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
-----
G
L
R
--------------
L
K
I
-
Y
K
D
T
E
G
Y
Y
T
I
G
I
---------
G
H
L
L
T
------------
K
-----------
S
----------------------------
P
S
L
N
A
--
A
K
S
E
L
D
K
A
I
G
R
--
N
-
T
N
G
V
I
---
T
K
--
D
E
--
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
70
HHSearch
64.36
16%
-106
- C5 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
----
I
I
G
C
G
G
N
G
I
V
---
I
Y
L
F
T
K
T
K
S
L
Q
-
T
P
A
---
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
---
V
N
G
F
P
L
M
T
I
S
-
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
-
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
-
A
A
S
K
K
---
M
S
H
R
---
R
A
F
I
M
I
I
F
V
W
L
W
--
S
V
L
W
-
A
---
I
G
P
I
F
G
-
W
--
G
A
Y
--------------
T
L
E
G
V
L
C
N
C
S
F
D
Y
--
I
---
S
---
R
----
D
S
T
--
T
R
-
S
N
I
-
L
C
M
F
I
L
G
----
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
---
M
S
V
S
N
-------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
E
M
R
L
A
K
I
S
I
--
V
I
V
--------------
S
Q
F
-
L
L
S
W
S
P
Y
A
V
V
A
L
---------
L
A
Q
F
G
------------
P
LE---------
W
-----------
V
-----
T
P
------
Y
A
-
A
Q
L
P
V
--
M
F
A
K
A
S
A
I
H
N
P
--
M
-
I
Y
S
V
S
---
H
P
--
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Fugue
63.66
13%
-103
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
----
V
L
A
I
V
F
G
N
V
L
---
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
---
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
---
A
--
V
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
---
P
I
Q
M
H
W
-----------
Y
R
A
T
H
Q
-
E
A
I
N
C
Y
A
E
E
T
C
C
------
D
---
F
---
F
----
T
----
N
Q
-
A
Y
A
-
I
A
S
S
I
V
S
----
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
---
Q
E
A
K
R
-------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
I
F
E
M
L
R
I
D
E
--
G
L
R
--------------
L
K
I
-
Y
K
D
T
E
G
Y
Y
T
I
G
I
---------
G
H
L
L
T
------------
K
-----------
S
-----------
P
-----
S
L
------
N
A
-
A
K
S
E
L
--
D
K
A
I
G
R
N
T
N
G
V
IT
K
-
D
E
A
E
K
---
L
F
--
N
Q
--
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL----------------------------
83
Fugue
61.27
20%
-118
- C3 -
4RGL
1
?
A:
[8-335]
----------------------------
Y
Q
P
P
Y
T
I
T
P
A
I
V
N
L
V
A
----
E
I
G
E
I
I
G
R
Y
--------
T
V
L
A
E
Q
N
L
T
P
R
---
L
R
R
E
N
R
I
R
T
I
Q
A
S
L
A
I
E
NN
T
--
L
T
L
E
Q
V
T
A
V
I
D
G
K
R
V
L
G
H
P
R
-
E
I
Q
E
V
R
N
A
F
A
T
Y
E
A
M
E
D
W
D
A
S
V
-
E
G
D
L
L
A
A
H
E
L
L
M
R
G
L
V
D
---
E
T
G
R
---
Y
R
S
G
G
V
G
I
F
R
G
E
--
Q
L
V
H
M
A
P
PA
D
R
V
P
K
L
M
A
--
D
L
L
D
W
L
E
N
T
N
------
E
H
P
L
V
A
S
C
I
F
H
Y
E
F
--
E
F
I
H
P
---
F
----
A
----
D
G
-
N
G
R
M
G
R
L
W
Q
T
L
----
I
L
R
N
W
K
-
P
L
L
A
Y
L
P
V
E
---
T
V
I
R
D
-------
R
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
R
V
L
A
V
A
D
S
Q
A
DA
T
P
F
--------------
V
E
F
M
L
G
A
L
R
D
A
V
R
E
A
V
S
T
D
HQVT
D
Q
V
A
A
L
I
------------
R
-----------
A
-----------
I
-----
G
G
G
E
L
S
S
N
D
L
M
Q
A
L
G
L
SH
R
P
T
F
R
N
N
Y
L
N
P
--
A
M
E
D
E
W
I
---
E
R
TQ
P
D
--
S
P
R
S
P
T
Q
R
Y
R
L
T
G
K
G
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
60.74
22%
-139
- C5 -
4XT1
15
US28_HCMVA
A:
[43-255]
----------------------------------
V
T
L
F
L
Y
G
V
V
F
----
L
F
G
S
I
G
N
F
L
V
---
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
----
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
---
T
--
L
P
L
W
M
Q
Y
L
L
D
-------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
-
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
-
M
-
R
Y
R
P
V
---
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
--
P
--
H
-
F
---
M
V
V
--------------------------
T
K
K
D
N
Q
C
M
T
D
Y
--
D
---
Y
---
L
----
E
----
V
S
Y
P
I
I
-
L
N
V
E
L
M
L
G
A
--
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
---
R
I
V
A
V
-------
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
H
K
G
R
I
V
R
V
L
I
--
A
V
V
--------------
L
V
F
-
I
I
F
W
L
P
Y
H
L
T
L
F
---------
V
D
T
L
K
------------
L
-----------
L
-----------
K
-----
W
I
------
S
S
-
S
C
E
F
E
--
R
S
L
K
R
A
L
I
L
T
E
--
S
-
L
A
F
C
H
---
C
C
--
L
N
--
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.99
25%
-132
- C5 -
4EA3
3
C562_ECOLX (first)
A:
[130-316]
-------------------------------------
G
L
Y
L
A
V
C
----
V
G
G
L
L
G
N
C
L
V
---
M
Y
V
I
L
R
H
T
K
M
K
-
T
A
T
---
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
---
T
--
L
P
F
Q
G
T
D
I
L
L
-
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
-
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
-----------
T
S
S
---
K
A
Q
A
V
N
V
A
I
W
A
L
--
A
-
S
V
-
V
---
G
V
P
V
A
I
-
M
--
G
S
A
Q
V
E
D
E
E
I
E
C
L
V
E
I
P
T
P
-------
Q
D
Y
W
--
G
---
P
---
V
----
F
----
A
------
I
C
I
F
L
F
S
----
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
---
R
R
L
R
G
-------
V
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
R
E
K
D
R
N
L
R
R
--
I
T
R
--------------
L
V
L
-
V
V
V
A
V
F
V
G
C
W
T
P
---------
V
Q
V
F
V
------------
L
-----------
A
-----------
Q
-----
G
L
------
G
V
-
Q
P
S
S
E
--
T
A
V
A
I
L
R
F
C
T
A
--
L
-
G
Y
V
N
S
---
C
L
--
N
P
--
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------