@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FFAR2_HUMAN: (2016-01-09 )
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
Atome Classification :
(20 SA)
------------------------------.........10........20........30........40-........50........60--........70........80........90..--......100.......110...-....120-.........130.......140.....---..150.......160.....-..170.......180.......190.......200......-----.---------------------------------------210----.---------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------.--...----------...220-.......230......-.240.......------------250-.--..---.----------.....260.......270.......280.......290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------MLP
D
W
K
S
S
L
I
L
M
A
Y
I
I
I
F
LTGL
P
A
N
L
L
A
L
R
A
F
V
G
R
IRQPQP-A
P
V
H
I
L
L
L
S
L
T
L
A
D
L
L
L
L
L
L
--
L
P
F
K
I
I
E
A
ASN
F
R
W
Y
L
P
K
V
V
C
A
L
T
SFG
F
Y
S
S
I
--
Y
C
S
T
W
L
L
A
GI
S
I
E
R
YLGV
A
F
P
V
-
Q
Y
KLS---RR
P
L
Y
G
V
I
A
A
L
V
A
W
V
M
SFG
H
C
T
I
V
I
I
V
---
Q
YLN
T
T
E
Q
VRSGN
E
I
T
C
YEN-FTDNQ
L
D
V
V
L
P
V
R
L
E
L
C
L
V
L
F
F
I
P
M
A
V
T
I
F
C
Y
W
R
F
V
W
I
M
LS-----Q---------------------------------------P------
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
A
Q
R
----------
R
R
R
A
V
G
-
L
A
V
V
T
L
L
N
F
L
V
CFGPY-
N
V
S
H
L
V
G
Y
HQR------------K---
S
--
P
W
---
W
----------
R
S
I
A
V
V
F
S
S
LNAS
L
D
P
L
L
F
Y
F
S
S
S
V
V
R
R
A
F
G
R
G
L
Q
V
L
R
NQ
G
S
S
L
LGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
21
HHSearch
90.66
21%
-145
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-497]
---------------------------------
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
--
L
R
-
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
--
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
---
A
N
V
S
E
A
-----
D
D
R
Y
I
C
D
R
F
-
Y
P
N
D
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
-----
S
---------------------------------------
G
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGS
K
--
G
H
Q
----------
K
R
K
A
L
K
-
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
-
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
---
V
--
H
K
---
W
----------
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-------------------------------
43
Fugue
90.24
18%
-115
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
--
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
--
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-------
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----
A
---------------------------------------
A
------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
TT
Q
K
A
----------
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
F
T
H
Q
------------
G
---
S
--
D
F
GPI
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------
2
PsiBlast_PDB
89.49
20%
-150
- C4 -
4XNV
15
P2RY1_HUMAN
A:
[57-382]
-------------------------------------------
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
---
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
--
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
--
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
--
V
A
I
S
P
I
L
---
F
Y
S
G
T
--
G
V
R
K
N
K
T
I
T
C
Y
D
T
-
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
-----
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVC----
P
------
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
V
G
K
DQ
F
E
E
V
EE
P
L
R
R
K
S
I
Y
-
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
-
H
V
M
K
T
M
N
L
R
A
R
L
DF---------
Q
---
T
--
P
A
---
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
-----------------------------------------------
23
HHSearch
89.28
21%
-126
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
--
L
Q
-
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
-
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
--
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
---
W
Q
F
I
V
G
V
--
R
T
V
E
D
G
E
C
Y
I
Q
-
F
F
S
N
-----
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
-----
R
---------------------------------------
I
------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
P
S
R
----------
E
K
K
V
T
R
-
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
-
N
V
M
V
L
I
N
T
F
C
A
------------
P
CI-
P
--
N
T
---
V
----------
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------
3
PsiBlast_PDB
88.93
20%
-147
- C4 -
4XNW
2
RUBR_CLOPA
A:
[57-382]
-------------------------------------------
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
---
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
--
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
--
V
A
I
S
P
I
L
---
F
Y
S
G
T
--
G
V
R
K
N
K
T
I
T
C
Y
D
T
-
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
-----
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVC
P
------
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
V
G
K
DQ
F
E
E
V
EE
P
L
R
R
K
S
I
Y
-
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
-
H
V
M
K
T
M
N
L
R
A
R
L
DF---------
Q
---
T
--
P
A
---
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
-----------------------------------------------
32
HHSearch
88.29
23%
-143
* C4 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
--
L
Q
-
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
--
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
---
F
N
T
T
-------
G
D
P
T
V
C
S
I
S
-
N
P
D
--------
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
-----
R
---------------------------------------
R
------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
--
P
L
R
----------
E
K
K
A
T
Q
-
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
-
F
L
T
H
V
L
N
T
H
C
Q
------------
T
CHV
S
--
P
E
---
L
----------
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------------
25
HHSearch
87.96
20%
-130
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
--
L
Q
-
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V-
V
P
F
G
A
A
H
-
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H--
W
Y
R
A
T
H
-----
Q
E
A
I
N
C
Y
A
E
-
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
-----
Q
---------------------------------------
L
------
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
--
C
L
K
----------
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
Q
D
------------
N
LI-
R
--
K
E
---
V
----------
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------
11
PsiBlast_PDB
86.87
21%
-122
- C4 -
1F88
7
OPSD_BOVIN
A:
[35-346]
----------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
--
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
--
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
AAA-------------------------------------------------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
FG
P
I
---
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
------
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------
14
PsiBlast_PDB
86.03
21%
-145
- C4 -
3PXO
5
OPSD_BOVIN
A:
[35-326]
----------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
--
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
--
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
---------------------------------------
E
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
F
G
P
I
---
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------
19
PsiBlast_PDB
85.52
21%
-120
- C4 -
3OAX
17
OPSD_BOVIN
A:
[38-347]
----------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
--
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
--
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
AAAQQ
Q
---------------------------------------
E
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
FG
P
I
---
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------
12
PsiBlast_PDB
85.34
21%
-144
- C4 -
3DQB
7
GNAT1_BOVIN (first)
A:
[35-326]
----------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
--
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
--
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
---------------------------------------
E
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
F
G
P
I
---
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------
15
PsiBlast_PDB
85.27
21%
-146
- C4 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[35-326]
----------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
--
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
--
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
---------------------------------------
E
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
FG
P
I
---
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------
13
PsiBlast_PDB
85.02
21%
-146
- C4 -
3PQR
10
OPSD_BOVIN
A:
[35-326]
----------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
--
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
--
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
---------------------------------------
E
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
FG
P
I
---
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------
9
PsiBlast_PDB
84.97
21%
-146
- C4 -
3CAP
7
OPSD_BOVIN
A:
[35-326]
----------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
--
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
--
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
---------------------------------------
E
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
FG
P
I
---
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------
26
HHSearch
84.05
20%
-127
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-335]
----------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
--
L
Q
-
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
-
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
--
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
-
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
---
W
G
A
Y
T
L
E
----
G
V
L
C
N
C
S
F
D
-
Y
I
S
R
D
S
-
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
-----
H
---------------------------------------
E
------
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
A
N
A
----------
E
M
R
L
A
K
-
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
-
A
V
V
A
L
L
A
Q
F
G
P
------------
L
EWV
T
--
P
Y
---
A
----------
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
--------------
42
Fugue
83.91
18%
-118
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFSNKTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
--
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-------
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----
A
---------------------------------------
A
AQQQES
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
Q
K
A
----------
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
F
T
H
Q
------------
G
---
S
--
D
F
GPI
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
----
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------
16
PsiBlast_PDB
83.90
21%
-148
- C4 -
4PXF
8
OPSD_BOVIN
A:
[35-326]
----------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
--
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
--
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
---------------------------------------
E
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
F
G
P
I
---
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------
10
PsiBlast_PDB
83.57
21%
-120
- C- -
3C9L
13
OPSD_BOVIN
A:
[35-332]
----------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
--
Y
V
T
V
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
--
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
AAAQQ
Q
---------------------------------------
E
------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
Q
K
----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
---
D
FG
P
I
---
F
----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---
D
D
E
---------------------------
24
HHSearch
82.13
19%
-132
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
--
L
H
-
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
-
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
--
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
---
N
H
---------
R
R
E
D
K
C
E
T
D
-
F
Y
D
V
T
-----
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
-----
H
---------------------------------------
C
------
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
--
M
N
R
----------
E
R
K
A
A
K
-
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
-
F
I
F
F
M
V
I
A
F
C
K
------------
N
CC-
N
--
E
H
---
L
----------
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------------
41
Fugue
80.16
19%
-102
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------SFKCA
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
---
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
--
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
L
---
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
--------
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
-
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
-----
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
-------------------------
P
------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
D
P
D
----------
N
G
V
N
P
G
-
T
D
F
K
D
I
V
C
P
L
C
G
V
G
K
D
-
Q
F
E
E
V
E
E
P
L
R
R
------------
K
---
S
--
I
Y
---
L
------------
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
-
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R