@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FFAR4_HUMAN: (2016-01-09 )
MSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
Atome Classification :
(20 SA)
.........10........20........30.....---...40........50........60......-.-.-70.........80.......-.-90.........100..-......110.......120.......130.......140.....--..---150.......160.....-...170....-.-...180.......190.......200........210----.------......220.......230...-------....240------------------.........-------------250--.-------------------------.----.-----------------------.-------------------.---------------.-----------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------.-----------------------------------------------------------------260----------------.------.------------.------------.------------.....270..---.....280...---....290....-...300.......------310.---------......320.......330-...----....--340.........350..---.....360.......370.....----------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
P
E
C
A
RAAGD
A
P
L
R
S
L
E
Q
ANRTRFPFFSDVKGD
H
R
---
L
V
L
A
A
V
E
T
T
V
L
V
L
I
F
A
V
S
L
L
G
N
V
C
A
L
V
L
V
A
R
-
R
-R-R-RG
A
T
A
C
L
V
L
N
L
F
C
A
D
L
L
F
-
I
-
S
-
A
I
P
L
V
L
A
V
R
W-
T
E
A
-
W
L
L
G
P
V
A
C
H
L
L
F
Y
V
M
TLSG
S
V
T
I
L
T
L
A
A
V
S
L
E
R
M
V
C
I
V
H
L
Q
R
GV--RG---P
G
R
R
A
R
A
V
L
L
A
L
-
I
W
G
Y
S
-
A
V
A
A
-
L
P
L
C
V
-
F
-
F
R
V
V
P
Q
RLPGADQ
E
I
S
I
C
T
L
I
WPT-IPG
E
I
S
W
D
V
S
F
V
----
T
------
L
N
F
LVPGL
V
I
V
I
S
Y
S
K
I
L
Q
T
S
E
-------
H
L
L
D
A
--------------------
R
A
VV
T
H
S
E
I
-------------
T
K---A-------------------------S----R-----------------------
K
-------------------
R
---------------
L
-----------------------------------------------------------------------------------------------------------------------------------
T
---------------------------------------------------------
V
-----------------------------------------------------------------
S
------------------
L
------
A
------------Y------------S------------ES
H
Q
I
R
V
S
Q
Q
---
D
F
R
L
F
R
T
L
F
L
L
---
M
V
S
F
F
I
M
W
S
P
I
-
I
I
T
I
L
L
I
L
I
Q
N
F
K
------
Q
D
L
V
---------
I
W
P
S
L
F
F
W
V
V
A
F
T
F
A
N
SA
L
-
N
P
I
----
L
Y
N
M
--
T
--
L
C
R
N
E
W
K
K
I
F
C
C
F
W
---FPEKG
A
I
LTDTSVKRN
D
L
SIISG----------------------------------------------------------------------------------
21
HHSearch
92.93
20%
-140
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[43-499]
----------------------------------
N
A
---
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
-
Q
-
K
K
L
-
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
-
V
-
I
-
T
L
P
F
W
A
V
D
A
V
--
A
N
-
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
--
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
-
V
W
I
P
A
-
L
L
L
T
-
I
P
D
F
I
-
F
-
A
N
V
S
E
A
------
D
D
R
Y
I
C
D
R
F
Y
P
N
-
D
L
W
V
V
V
F
Q
F
Q
H
I
----
M
------
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
-------
H
S
G
S
N
--------------------
I
F
E
M
L
R
I
D
E
-------------
G
L
---
R
-------------------------
L
----
K
-----------------------
I
-------------------
Y
---------------
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
---------------------------------------------------------
T
-----------------------------------------------------------------
F
------------------
R
------
T
------------
G
------------
T
------------
W
D
A
Y
G
S
K
G
H
Q
---
K
R
K
A
L
K
T
T
V
I
L
---
I
L
A
F
F
A
C
W
L
P
Y
-
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
---------
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
-
N
P
I
----
L
Y
A
F
--
L
GA
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
---
P
L
E
V
L
F
Q
--------------------------------------------------------------------------------------------------
25
HHSearch
92.15
18%
-156
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
----------------------------------------
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
-
F
-
E
R
L
-
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
-
G
-
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
--
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
-
V
W
I
V
S
-
G
L
T
S
-
F
L
P
I
Q
-
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
-----
T
N
Q
A
Y
A
I
A
S
S
----
I
------
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-------
R
Q
L
N
I
--------------------
F
E
M
L
R
I
D
E
G
-------------
L
R
---
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
----
A
-----------------------
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
---------------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
---------------------------------------------------------
Y
N
--------------------------------------------------------
Q
-----------------------------------------------------------------
T
------------------
P
------
N
R
A
K
R
V
I
T
T
F
R
--
T
------------
G
------------
T
W
D
A
Y
K
F
C
L
K
---
E
H
K
A
L
K
T
L
G
I
I
---
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
Q
D
N
----------
L
---------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
-
N
P
L
----
I
Y
C
R
--
S
P
-
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.86
23%
-141
- C3 -
1F88
7
OPSD_BOVIN
A:
[39-346]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
----
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
MN
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
P
-------
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
----------------------------------------------------------------------------------
13
PsiBlast_PDB
89.40
23%
-160
- C3 -
3PXO
5
OPSD_BOVIN
A:
[39-326]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
Q
Q
Q
E
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
MN
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
--------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
89.15
23%
-158
- C3 -
3DQB
6
GNAT1_BOVIN (first)
A:
[39-326]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
Q
Q
Q
E
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
MN
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
--------------------------------------------------------------------------------------------------------
23
HHSearch
88.60
17%
-160
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
-
N
-
R
H
L
-
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
-
G
-
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
--
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
-
A
W
V
L
S
-
F
I
L
W
-
A
P
A
I
L
-
F
-
W
Q
F
I
V
G
V
R
---
T
V
E
D
G
E
C
Y
I
Q
F
F
S
----
N
A
A
V
T
F
G
T
A
----
I
------
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
-------
S
R
I
N
I
--------------------
F
E
M
L
R
I
D
E
G
-------------
L
R
---
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKS----
P
----
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
-------------------
A
---------------
E
-----------------------------------------------------------------------------------------------------------------------------------
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
--------------------------------------------------
Y
N
-----------------
Q
------
T
------------
P
N
R
A
K
R
V
I
T
T
F
R
T
G
------------
T
W
D
A
Y
P
P
P
S
R
---
E
K
K
V
T
R
T
I
L
A
I
---
L
L
A
F
I
I
T
W
A
P
Y
-
N
V
M
V
L
I
N
T
F
C
A
P
C
-------------------
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
-
N
P
A
----
C
Y
A
L
--
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
88.23
23%
-164
- C3 -
2I36
2
OPSD_BOVIN
A:
[39-326]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
Q
Q
Q
E
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
MN
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
--------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.18
21%
-174
- C3 -
3SN6
1
R:
[188-478]
------------------------------------------------
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
-
R
-
L
-
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-
A
-
V
V
P
F
G
A
A
H
I
L
-
T
K
T
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
--
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
-
V
W
I
V
S
-
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
---
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
------
A
Y
A
I
A
S
S
----
I
------
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-------
R
Q
L
Q
K
-----------------------
I
D
K
S
E
G
-------------
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLK
E
H
K
A
L
K
T
L
G
I
I
---
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
----------
Q
D
N
L
---------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
-
N
P
L
----
I
Y
--------
C
R
S
P
D
F
R
I
A
F
Q
E
L
---
L
C
-------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
88.07
23%
-171
- C- -
3C9L
13
OPSD_BOVIN
A:
[39-332]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
Q
Q
Q
E
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
M
N
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
----
D
D
E
-------------------------------------------------------------------------------------------------
45
Fugue
88.03
18%
-148
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---
P
C
F
R
E
-------------------------
E
N
A
---
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
-
Q
-
K
-
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
-
V
-
I
-
T
L
P
F
W
A
V
D
A
V
-
A
-
N
-
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
--
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
-
V
W
I
P
A
-
L
L
L
T
-
I
P
D
F
I
-
F
-
A
N
V
S
E
------
A
D
D
R
Y
I
C
D
R
F
Y
P
N
-
D
L
W
V
V
V
F
Q
F
Q
H
I
----
M
------
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
HSGSN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GI
G
H
L
L
T
K
S
P
S
-------------
L
N
---
A
-------------------------
A
----
K
-----------------------
S
-------------------
E
---------------
L
-----------------------------------------------------------------------------------------------------------------------------------
D
---------------------------------------------------------
K
-----------------------------------------------------------------
A
------------------
I
GRNTNG
V
------------
I
------------
T
------------
K
D
E
A
E
K
L
F
N
Q
---
D
V
D
A
A
V
R
G
I
L
R
NAK
L
K
P
V
Y
D
S
L
D
A
V
-
R
R
A
A
L
I
N
M
V
F
Q
M
G
------
E
T
G
V
---------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
-
V
N
L
A
K
S
R
W
Y
N
Q
--
T
----
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
7
PsiBlast_PDB
87.83
23%
-147
- C- -
3C9M
1
OPSD_BOVIN
A:
[39-327]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
Q
Q
Q
E
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
C
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
MN
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
P
-------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.81
23%
-155
- C3 -
3PQR
10
OPSD_BOVIN
A:
[39-326]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
Q
Q
Q
E
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
MN
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
--------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.54
23%
-161
- C3 -
3CAP
5
OPSD_BOVIN
A:
[39-326]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
Q
Q
Q
E
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
MN
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
--------------------------------------------------------------------------------------------------------
43
Fugue
87.43
19%
-152
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-
S
F
K
C
A
L
T
K
----------------------
T
G
F
Q
F
---
Y
Y
L
P
A
V
----
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
-
H
M
K
-
P
-
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
-
L
-
T
L
P
A
L
I
F
Y
Y
F
-
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
-
P
K
S
L
--
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
-
V
W
L
I
V
-
V
V
A
I
-
S
P
I
L
F
-
Y
-
S
G
T
G
V
R
K
----
N
K
T
I
T
C
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
----
V
------
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
-------
Y
K
M
K
K
--------------------
Y
T
C
T
V
C
G
Y
I
Y
N
PEDGDPDNGVN
P
G
---
T
-------------------------
D
----
F
-----------------------
K
-------------------
D
---------------
I
-----------------------------------------------------------------------------------------------------------------------------------
V
---------------------------------------------------------
C
-----------------------------------------------------------------
P
------------------
L
------
C
------------
G
------------
V
------------
G
K
D
Q
F
E
E
V
E
E
---
P
L
R
R
K
S
I
Y
L
V
I
---
I
V
L
T
V
F
A
V
S
Y
I
-
P
F
H
V
M
K
T
M
N
L
R
A
R
------
L
D
F
Q
TPAM
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
-
N
P
I
----
L
Y
F
L
--
A
---------------------------
G
D
T
F
R
R
R
------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.42
25%
-164
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[97-391]
-----------------
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
-
Y
-
T
-
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
-
S
-
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
T
---
P
---
A
K
A
K
L
I
N
I
C
I
W
V
L
A
-
S
G
V
G
-
V
P
I
M
V
-
M
-
A
V
T
R
P
R
D
--
G
A
----
V
V
C
M
L
Q
F
P
S
-
P
----
S
W
Y
W
D
T
V
----
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
----------------------------------------
G
S
K
E
-------------
K
D
---
R
-------------------------
S
----
L
-----------------------
R
-------------------
R
---------------
I
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
L
V
V
---
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
------
R
D
P
L
---------
V
V
A
A
L
H
L
-
C
I
A
L
G
Y
A
N
S
S
L
-
N
P
V
----
L
Y
A
F
--
L
--
D
E
N
F
K
R
C
F
R
Q
L
C
--------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
87.07
23%
-162
- C3 -
4PXF
8
OPSD_BOVIN
A:
[39-326]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
Q
Q
Q
E
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
MN
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
--------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
87.00
23%
-158
- C3 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[39-326]
----------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
---
T
L
Y
V
T
V
Q
H
-
K
-
K
-
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
--
R
F
----
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
Y
T
--
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
------
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
----------
E
A
--------------------
A
A
Q
Q
Q
E
S
A
T
-------------
T
Q
---
K
-------------------------
A
----
E
-----------------------
K
-------------------
E
---------------
V
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
I
M
---
V
I
A
F
L
I
C
W
L
P
Y
-
A
G
V
A
F
Y
I
----
F
T
------
H
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
MN
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
--------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.96
25%
-161
- C3 -
4RWD
7
C562_ECOLX (first)
A:
[97-391]
-----------------
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
-
Y
-
T
-
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
-
S
-
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
T
---
P
---
A
K
A
K
L
I
N
I
C
I
W
V
L
A
-
S
G
V
G
-
V
P
I
M
V
-
M
-
A
V
T
R
P
R
D
--
G
A
----
V
V
C
M
L
Q
F
P
S
-
P
----
S
W
Y
W
D
T
V
----
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
-------
S
V
------------------------
R
L
L
S
G
S
K
E
-------------
K
D
---
R
-------------------------
S
----
L
-----------------------
R
-------------------
R
---------------
I
-----------------------------------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
L
V
V
---
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
------
R
D
P
L
---------
V
V
A
A
L
H
L
-
C
I
A
L
G
Y
A
N
S
S
L
-
N
P
V
----
L
Y
A
F
--
L
--
D
E
N
F
K
R
C
F
R
Q
L
C
--------------------------------------------------------------------------------------------------------------
26
HHSearch
86.88
16%
-157
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
--------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
-
E
-
R
K
L
-
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
-
G
-
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
-
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
--
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
-
A
W
F
L
S
-
F
L
W
V
-
I
P
I
L
G
-
W
-
N
H
----------
R
R
E
D
K
C
E
T
D
F
Y
D
-
V
---
T
W
F
K
V
M
T
A
----
I
------
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
-------
Q
H
C
N
I
--------------------
F
E
M
L
R
I
D
E
G
-------------
L
R
---
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLT------
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
G------------
R
-------------------
N
---------------
T
-----------------------------------------------------------------------------------------------------------------------------------
N
---------------------------------------------------------
G
VIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------
T
------------
P
------------
N
R
A
K
R
V
I
T
T
F
R
TG
T
W
D
A
Y
L
H
M
N
R
---
E
R
K
A
A
K
Q
L
G
F
I
---
M
A
A
F
I
L
C
W
I
P
Y
-
F
I
F
F
M
V
I
A
F
C
K
N
C
-------------------
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
-
N
P
L
----
I
Y
P
L
--
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------------------------------------------------------------------------
32
HHSearch
86.52
19%
-163
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
-
E
-
R
A
L
-
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
-
A
-
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
-
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
--
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
-
V
W
V
L
A
-
F
A
V
S
-
C
P
L
L
F
-
G
-
F
N
T
T
--------
G
D
P
T
V
C
S
I
S
N
P
-------
D
F
V
I
Y
S
S
----
V
------
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
-------
Q
R
R
R
K
--------------------
N
I
F
E
M
L
R
I
D
-------------
E
G
LRL
K
-------------------------
I
Y
---
K
D
TEG
Y
Y
T
I
G
IGHL----------
L
-------------------
T
KSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K---------------------------------------------------------
R
W
D
E
A
A
V
N
L
A
------------------------------------------------
K
S
R
W
Y
-------------------------------------------------------------
N
------------------
Q
------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
------------
G
------------
T
W
D
A
Y
G
V
P
L
R
---
E
K
K
A
T
Q
M
V
A
I
V
---
L
G
A
F
I
V
C
W
L
P
F
-
F
L
T
H
V
L
N
T
H
C
Q
T
C
---------
H
---------
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
-
N
P
V
----
I
Y
T
T
--
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------------------------------------------------------------------------