@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FPR2_HUMAN: (2016-01-09 )
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
Atome Classification :
(20 SA)
-----------.........10.--.......20........30........40........-50..-.-....--..60.....-....70.....-.--..80........90........100.......110.......120.......130....---...140.......150.......160.-......--170.-...-.----------...180----.......190----------..------.....200.......-210.......220--------------------------.-.----...----------------------------....230--.-------..--------------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------------------------------------...----.-----.240----.....----...250----.......260.......270--.-------------...-----....280.......290.......300.......310.......320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------METNFSTPL
N
E
Y
--
E
E
VSYESAG
Y
T
V
L
R
I
L
P
L
V
V
L
G
V
T
F
V
L
G
V
LGN
G
L
V
I
W
-V-AG-F-
R
M
T
R
--
T
V
T
-
T
I
C
Y
L
-
N
L
A
LADF
S
F
T
A
-
T
--
L
P
F
L
I
V
S
M
AMGEKW
P
F
G
W
F
L
C
K
L
I
H
I
V
V
D
I
N
L
F
G
S
V
F
L
I
G
F
I
A
L
D
R
C
I
C
V
LHPVWAQN
H
---
R
T
V
S
L
A
M
K
V
I
V
G
P
W
I
L
A
L
V
L
T
L
P
V
F
L
F
-
L
T
T
V
T
I--P-NG-D
T
Y
-
C
----------
T
F
N
FAS----WGG
T
P
E
E
R
L
K
----------
V
A
------
I
T
M
L
T
A
R
G
I
I
R
F
V
I
G-FSL
P
M
S
I
V
A
I
C
----------------------------
Y
-
G
----
L
I
A
----------------------------
A
K
I
H
K----K-------GM--------------------------------------------------------------------------------------------------------------------------------------------------------------------I--------------------------------------------KSS----R-----
P
L
R
-----
V
L
T
A
V
----
V
A
S
F
F
I
----
C
W
F
P
F
Q
L
V
A
L
L
G
T
V
W
L
K
E
M
---
L
-------------
F
YG-----K
Y
K
I
I
D
I
L
VNP
T
S
S
L
A
F
F
N
S
C
L
N
P
M
L
Y
V
FV
G
Q
D
F
R
E
R
L
I
H
SL
P
T
S
L
E
R
A
L
SEDSAPTNDTAANSASPPAETELQAM
28
HHSearch
83.20
31%
-162
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-497]
------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
-
V
-
M
G
-
Y
Q
K
K
L
R
--
S
M
T
-
D
K
Y
R
L
-
H
L
S
V
A
D
L
L
F
V
I
-
T
--
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
V
S
E
---
A
-
D
D
-
R
Y
I
-
C
----------
D
R
F
Y
P
N
----
D
L
----------------------------
W
V
V
V
F
Q
F
Q
H
I
M
V
G
-
L
I
L
P
G
I
V
I
L
S
C
----------------------------
Y
-
C
----
I
I
I
----------------------------
S
K
L
S
H
----
S
-------
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
--------------------------------------------
Q
K
R
----
K
-----
A
L
K
-----
T
T
V
I
L
----
I
L
A
F
F
A
----
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
---
I
K
------------
Q
G
C
E
----
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------------------
15
PsiBlast_PDB
80.12
24%
-175
- C3 -
4MBS
8
CCR5_HUMAN (first)
A:
[33-366]
--------------------------------------
R
L
L
P
-
P
L
Y
S
L
V
F
I
F
G
F
V
G
N
M
L
V
I
L
-
I
L
I
N
-
Y
-
K
R
L
K
--
S
M
T
-
D
I
Y
L
L
-
N
L
A
I
S
D
L
F
F
L
L
-
T
--
V
P
F
W
--
A
H
Y
A
A
A
Q
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
---
R
T
V
T
F
G
V
V
T
S
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
I
F
---
T
R
S
Q
--
K
-
E
G
-
L
H
Y
T
C
----------
S
S
H
F
----------
P
Y
S
Q
Y
Q
----------
F
W
------
K
N
F
Q
T
L
K
I
V
I
---
L
G
-
L
V
L
P
L
L
V
M
V
I
C
----------------------------
Y
S
G
----
I
L
K
----------------------------
T
L
L
R
M
----
K
K
Y
T
C
TVC
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
V
E
E
EK
K
R
H
----
R
-----
D
V
R
-----
L
I
F
T
I
----
M
I
V
Y
F
L
----
F
W
A
P
Y
N
I
V
L
L
L
N
T
--
F
Q
E
------------------
F
F
G
LNN
C
S
S
S
N
R
L
D
Q
A
M
Q
V
T
E
T
L
G
M
T
H
C
C
I
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
F
Q
---------------------------------
1
PsiBlast_PDB
77.59
32%
-170
- C3 -
5C1M
7
?
A:
[21-294]
------------------------------------------
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
-
V
I
V
R
-
Y
-
T
K
M
K
--
T
A
T
-
N
I
Y
I
F
-
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
F
Q
S
V
N
Y
L
M
G
T
-
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
-
M
F
-
M
A
T
T
K
Y
--
R
-
Q
G
-
S
I
D
-
C
----------
T
L
T
F
S
H
----
P
T
W
Y
W
E
N
L
L
K
----------
I
C
------
V
----------
F
I
F
A
-
F
I
M
P
V
L
I
I
T
V
C
----------------------------
Y
-
G
----
L
M
I
----------------------------
L
R
L
K
S
----
V
-------
R
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------------------------------------------
S
G
S
K
E
K
D
R
-----
N
L
R
-----
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
----
C
W
T
P
I
H
I
Y
V
I
-----
I
K
A
L
---
I
-------------
T
I
P
-----
E
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
--------------------------------------
26
HHSearch
77.01
24%
-163
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
-
S
-
I
K
V
N
-
R
H
L
Q
--
T
V
N
-
N
Y
F
L
F
-
S
L
A
C
A
D
L
I
I
G
V
F
S
--
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
G
VR
T
-
V
E
-
D
G
E
-
C
----------
Y
I
Q
F
F
S
-----------------------------------
N
A
A
V
T
F
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
----------------------------
Y
-
W
----
H
I
S
----------------------------
R
A
S
K
S
----
R
-------
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP--
S
--------------------------------------------
R
E
K
----
K
-----
V
T
R
-----
T
I
L
A
I
----
L
L
A
F
I
I
----
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
--------------------------
P
---
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------
29
HHSearch
76.44
23%
-155
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
-
A
-
V
R
-
S
E
R
K
L
H
--
T
V
G
-
N
L
Y
I
V
-
S
L
S
V
A
D
L
I
V
G
A
V
V
--
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-
N
H
--------
R
R
-
E
D
K
-
C
----------
E
T
D
F
Y
D
----
V
-------------------------------
T
W
F
K
V
M
T
A
I
I
N
-
F
Y
L
P
T
L
L
M
L
W
F
----------------------------
Y
-
A
----
K
I
Y
----------------------------
K
A
V
R
Q
----
H
-------
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
--------------------------------------------
R
E
R
----
K
-----
A
A
K
-----
Q
L
G
F
I
----
M
A
A
F
I
L
----
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
C
------------------
N
-----------
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------
5
PsiBlast_PDB
76.25
29%
-157
- C3 -
4N6H
23
C562_ECOLX (first)
A:
[117-403]
------------------------------
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
-
V
R
-
Y
-
T
K
M
K
--
T
A
T
-
N
I
Y
I
F
-
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
F
Q
S
A
K
Y
L
M
-
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
---
A
V
T
R
--
P
R
D
G
-
A
V
V
-
C
----------
M
L
Q
F
P
S
P
S
W
Y
W
D
------------------------------
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
----------------------------
Y
-
G
L
M
L
L
R
L
R
----------------------------
S
V
R
L
L
----
S
-------
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------
E
K
D
----
R
-----
S
L
R
-----
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
F
V
I
V
W
T
L
----
V
---
D
-------------
I
D
R
-----
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
-----------------------------
36
HHSearch
76.24
23%
-160
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-336]
------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
-
L
-
F
T
-
K
T
K
S
L
Q
--
T
P
A
-
N
M
F
I
I
-
N
L
A
F
S
D
F
T
F
S
L
-
V
N
G
F
P
L
M
T
I
S
C
-
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
--
E
-
G
V
-
L
C
N
-
C
----------
S
F
D
Y
I
S
----
R
D
S
---------------------------
T
T
R
S
N
I
L
C
M
F
I
L
G
-
F
F
G
P
I
L
I
I
F
F
C
----------------------------
Y
-
F
----
N
I
V
----------------------------
M
S
V
S
N
----
H
-------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------
N
--------------------------------------------
A
E
M
----
R
-----
L
A
K
-----
I
S
I
V
I
----
V
S
Q
F
L
L
----
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
----------------------------
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
------
12
PsiBlast_PDB
76.06
29%
-176
- C3 -
4XT1
14
US28_HCMVA
A:
[45-318]
------------------------------------------
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
-
T
-
I
T
-
W
-
R
R
R
I
--
Q
C
S
G
D
V
Y
F
I
-
N
L
A
A
A
D
L
L
F
V
C
-
T
--
L
P
L
W
M
--
Q
Y
L
L
D
-----
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
----
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
V
-
V
T
--------
K
K
-
D
N
Q
-
C
----------
M
------------
T
D
Y
D
Y
L
E
----------
V
S
------
Y
P
I
I
L
N
---
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
----------------------------
Y
-
Y
----
R
I
S
----------------------------
R
I
V
A
V
----
S
-------
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------------------------------------
H
K
G
----
R
-----
I
V
R
-----
V
L
I
A
V
----
V
L
V
F
I
I
----
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
K
W
---
I
S
S
S
C
E
--------
F
E
R
-----
S
L
K
R
A
L
I
L
---
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
F
R
------------------------------
4
PsiBlast_PDB
75.97
28%
-149
- C3 -
4RWD
7
C562_ECOLX (first)
A:
[98-400]
--------------
Q
L
K
T
T
R
N
A
Y
IQ
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
-
V
R
-
Y
-
T
K
M
K
--
T
A
T
-
N
I
Y
I
F
-
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
F
Q
S
A
K
Y
L
M
-
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
---
A
V
T
R
--
P
R
D
G
-
A
V
V
-
C
----------
M
L
Q
F
P
S
P
S
W
Y
W
D
------------------------------
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
----------------------------
Y
-
G
L
M
L
L
R
L
R
----------------------------
S
V
R
L
L
----
S
-------
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------
E
K
D
----
R
-----
S
L
R
-----
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
F
V
I
V
W
T
L
----
V
---
D
-------------
I
D
R
-----
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------------------
3
PsiBlast_PDB
75.54
28%
-155
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[98-400]
--------------
Q
L
K
T
T
R
N
A
Y
IQ
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
-
V
R
-
Y
-
T
K
M
K
--
T
A
T
-
N
I
Y
I
F
-
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
F
Q
S
A
K
Y
L
M
-
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
---
A
V
T
R
--
P
R
D
G
-
A
V
V
-
C
----------
M
L
Q
F
P
S
P
S
W
Y
W
D
------------------------------
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
----------------------------
Y
-
G
L
M
LL------------------------------------------------
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------
E
K
D
----
R
-----
S
L
R
-----
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
----
C
W
A
P
I
H
I
F
V
I
V
W
T
L
----
V
---
D
-------------
I
D
R
-----
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------------------
13
PsiBlast_PDB
74.36
29%
-173
- C3 -
4XT3
2
US28_HCMVA
A:
[45-316]
------------------------------------------
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
-
T
-
I
T
-
W
-
R
R
R
I
--
Q
C
S
G
D
V
Y
F
I
-
N
L
A
A
A
D
L
L
F
V
C
-
T
--
L
P
L
W
M
--
Q
Y
L
L
D
H
---
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
----
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
V
-
V
T
--------
K
K
-
D
N
Q
-
C
----------
M
------------
T
D
Y
D
Y
L
E
----------
V
S
------
Y
P
I
I
L
N
---
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
----------------------------
Y
-
Y
----
R
I
S
----------------------------
R
I
V
A
V
----
S
-------
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------------------------------------
H
K
G
----
R
-----
I
V
R
-----
V
L
I
A
V
----
V
L
V
F
I
I
----
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
K
W
---
I
S
S
S
C
E
--------
F
E
R
-----
S
L
K
R
A
L
I
L
---
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
--------------------------------
45
Fugue
73.66
25%
-147
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------
S
F
K
C
A
L
T
K
----------
T
G
F
-
Q
F
Y
Y
L
P
A
V
Y
I
L
V
-
F
I
I
G
F
L
G
N
S
V
A
I
W
-
M
-
F
V
-
F
-
H
M
K
P
W-
S
G
I
-
S
V
Y
M
F
-
N
L
A
L
A
D
F
L
Y
V
L
-
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
--
K
-
N
K
-
T
I
T
-
C
YDTTSDEY
L
R
S
Y
F
I
Y
S
----
M
C
T
T
V
A
M
F
C
V
----------
P
L
------
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
-
Y
K
M
K
K
Y
T
C
T
V
C
G
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPL
C
-
G
----
V
G
K
----------------------------
D
Q
F
E
E
----
V
-------
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--------------------------------------------
L
R
R
----
K
-----
S
I
Y
-----
L
V
I
I
V
----
L
T
V
F
A
V
----
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
QTP
A
-------------
M
C
A
-----
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------
35
HHSearch
73.28
21%
-157
- C3 -
3EML
13
ENLYS_BPT4
A:
[22-472]
---------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-
A
-
V
W
-
L
N
S
N
L
Q
--
N
V
T
-
N
Y
F
V
V
-
S
L
A
A
A
D
I
A
V
G
V
L
A
--
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
G
Q
-------
S
Q
G
-
C
----------
G
E
G
Q
V
A
----
C
L
------
F
E
----------
D
V
------
V
-
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
----------------------------
Y
-
L
----
R
I
F
----------------------------
L
A
A
R
R
----
Q
-------
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
--------------------------------------------
K
E
V
----
H
-----
A
A
K
-----
S
L
A
I
I
----
V
G
L
F
A
L
----
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
--------------------------
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------------
18
PsiBlast_PDB
73.12
23%
-171
- C3 -
4XNW
2
RUBR_CLOPA
A:
[53-382]
----------------------------------------
L
P
A
V
Y
I
-
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
-
M
-
F
V
-
F
-
H
M
K
P
--
W
S
G
-
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
--
K
-
N
K
-
T
I
T
-
C
--------------------
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
-
Y
K
M
K
K
Y
T
C
T
V
C
------------------------------
G
----
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPL
C
G
V
G
K
----
D
-------
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------------------------------
E
V
E
----
E
-----
P
L
R
R
K
S
I
Y
L
V
I
I
V
----
L
T
V
F
A
V
----
S
Y
I
P
F
H
V
---
M
K
T
M
N
L
R
A
R
---
L
DFQTPAM
C
A
F
N
D
R
V
Y
A
-----
T
Y
Q
V
-------
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------
37
HHSearch
72.92
23%
-167
* C3 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
-
A
-
V
L
-
K
E
R
A
L
Q
--
T
T
T
-
N
Y
L
V
V
-
S
L
A
V
A
D
L
L
V
A
T
L
V
--
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
T
G
------
D
-
P
T
V
-
C
----------
S
I
S
N
P
--------------------------------------
D
F
V
I
Y
S
S
V
V
S
-
F
Y
L
P
F
G
V
T
V
L
V
----------------------------
Y
-
A
----
R
I
Y
----------------------------
V
V
L
K
Q
----
R
-------
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
--------------------------------------------
R
E
K
----
K
-----
A
T
Q
-----
M
V
A
I
V
----
L
G
A
F
I
V
----
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
H
----------------------------
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------
7
PsiBlast_PDB
72.64
29%
-164
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[137-401]
--------------------------------------------------
V
G
G
L
L
G
N
C
L
V
M
Y
-
V
-
I
--
L
-
R
H
T
K
MK
T
A
T
-
N
I
Y
I
F
-
N
L
A
L
A
D
T
L
V
L
L
-
T
--
L
P
F
Q
G
T
D
I
L
L
G
-
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
--
M
G
S
A
Q
V
--
E
-
D
E
-
E
I
E
-
C
----------
L
V
E
I
P
--------
T
P
Q
D
Y
W
G
----------
P
V
------
F
------
A
I
C
I
F
L
F
S
-
F
I
V
P
V
L
V
I
S
V
C
----------------------------
Y
-
S
----
L
M
I
----------------------------
R
R
L
R
G
VRLL
S
-------
G
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------------------------------------
E
K
D
----
R
-----
N
L
R
-----
R
I
T
R
L
----
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
Q
P
--------------------------
S
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-------------------------------------
46
Fugue
72.40
18%
-129
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
--
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
-
T
V
Q
H
-
K
K
L
R
--
T
P
L
-
N
Y
I
L
L
-
N
L
A
V
A
D
L
F
M
V
F
-
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
-
I
--
P
-
E
G
M
Q
C
S
-
C
----------
G
I
D
Y
Y
T
----
P
H
E
E
T
N
N
E
S
F
----------
V
I
------
Y
M
F
V
V
H
----------
F
I
I
P
L
I
V
I
F
F
C
----------------------------
Y
-
G
----
Q
L
V
----------------------------
F
T
V
K
E
----
A
-------
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------
A
T
T
----
Q
K
A
E
K
E
V
T
R
-----
M
V
I
I
M
----
V
I
A
F
L
I
----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-----------------------
H
Q
-----
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
-----
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------
27
HHSearch
72.34
21%
-156
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-
A
-
I
A
-
K
F
E
R
L
Q
--
T
V
T
-
N
Y
F
I
T
-
S
L
A
C
A
D
L
V
M
G
L
A
V
--
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
--
Q
--
E
-
A
I
N
-
C
----------
Y
A
E
E
T
C
----
C
D
--------------------------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
----------------------------
Y
-
S
----
R
V
F
----------------------------
Q
E
A
K
R
----
Q
-------
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
--------------------------------------------
K
E
H
----
K
-----
A
L
K
-----
T
L
G
I
I
----
M
G
T
F
T
L
----
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
-----------------------------
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------
17
PsiBlast_PDB
71.54
23%
-173
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[53-382]
----------------------------------------
L
P
A
V
Y
I
-
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
-
M
-
F
V
-
F
-
H
M
K
P
--
W
S
G
-
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
--
K
-
N
K
-
T
I
T
-
C
--------------------
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
MF
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
-
Y
K
M
K
K
Y
T
C
T
V
C
------------------------------
G
----
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPL----
C
G
V
G
K
----
D
-------
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------------------------------
E
V
E
----
E
-----
P
L
R
R
K
S
I
Y
L
V
I
I
V
----
L
T
V
F
A
V
----
S
Y
I
P
F
H
V
---
M
K
T
M
N
L
R
A
R
---
L
DFQTPAM
C
A
F
N
D
R
V
Y
A
-----
T
Y
Q
V
-------
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------
30
HHSearch
71.30
32%
-139
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
-------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
-
V
-
I
L
-
Y
S
R
V
G
R
--
S
V
T
-
D
V
Y
L
L
-
N
L
A
L
A
D
L
L
F
A
L
-
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
A
Y
H
P
--
N
-
N
S
-
S
P
V
-
C
----------
Y
E
V
L
G
N
----
D
T
--------------------------
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
-
F
I
V
P
L
F
V
M
L
F
C
----------------------------
Y
-
G
----
F
T
L
----------------------------
R
T
L
F
K
----
A
-------
H
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------------------------------------
Q
K
H
----
R
-----
A
M
R
-----
V
I
F
A
V
----
V
L
I
F
L
L
----
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
T
Q
V
---
I
QE-----------
S
C
E
-----
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
------------------------------