@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FZD1_HUMAN: (2016-01-09 )
MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
Atome Classification :
(24 SA)
-----------------------.........10........20........30........40......-----..50..-----......60........70........80........90........100.......110.......120.......130..----.....140.....----------------..150.....-..160.-----......170.---....---------------------.--.180.....--.----...190.......-200.......210.......220----..-.-..-..--..230.......240....-...250.......260.......270.......-------------------280.......290.......300.......310.......320.......330.......340.....-..--350.......360.......370..--....--.380.......390.......400--........-----------.410.......-------420.....---..430--.......440.......450.......460.......470.......480------.........490.....--------..500.......510.......520-.......----.530.....--------------------------..540.......550.......560......------------.570-.......580.......590....------...600...---....610.......620.......630.......640.....----------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------MAEEEAPKKSRAAGGGA
S
W
E
L
C
A
G
A
L
S
A
R
L
A
EEGSGDAGGRRRPPV
D
-----
P
R
R
L
A
R
-----
Q
L
L
L
L
L
W
L
L
E
A
P
L
L
L
G
V
R
AQAAGQGPGQGPGPGQQPPPP
P
Q
Q
QQSGQQYNGERGISVPDHGYCQPISIPLCTDIAYNQT
I
M
----
P
N
LLGHTNQEDAG----------------
L
E
V
H
Q
F
Y
P
L
V
-
K
V
Q
CSA-----
E
L
K
F
F
L
C
S
MY---
A
P
V
C
---------------------
T
--
V
L
--
E
QAL
P
--
P
----
C
R
S
L
C
E
R
A
R
Q
G
C
E
-
A
L
M
N
KFGFQWPDTLKCEKFPV------HG-A-G
E
-
L
C--VGQNTSDKGTPT
P
S
L
L
P
E
F
-WTSNPQHGGGGHRGGFPGGAGASERGKFSCPRA-------------------LKVPSY
L
N
Y
H
F
LGEKDCGAPCEP
T
K
V
Y
G
L
M
Y
F
G
P
E
E
L
R
F
S
R
T
W
I
G
I
W
S
V
L
C
C
A
S
T
L
F
T
V
L
T
Y
L
V
D
M
R
R-FS--YPER
P
I
I
F
LS
G
C
Y
T
A
V
A
V
A
Y
I
A
G
F
L
--LEDR--VVCNDKFAED
G
A
R
T
V
AQGTKKE----G
C
T
I
L
F
M
M
-----------
L
Y
F
F
S
M
A
S
S
I
W
-------
W
V
I
L
S
L
T
W
---
F
L
A
A
G
--
M
K
W
G
H
E
A
IEANS
Q
Y
F
H
L
A
AWAVPA
I
K
T
I
T
I
L
A
LGQVD
G
D
V
L
S
G
V
C
F
VG--------LN
N
V
D
A
L
R
G
F
V
L
A
P
L
F
V
--------
Y
L
F
I
G
T
S
F
L
L
A
G
F
V
S
L
F
R
I
R
T
I
M
K--HDGT
K
T
E
----
K
L
E
K
L
M
V
R
I
--------------------------
G
V
F
S
V
L
Y
TV
P
A
T
I
V
I
A
C
Y
F
Y
E
Q
A
F
R
D
Q
W
E
R
S
------------
W
V
A
Q
-
S
C
K
SYAIPCPHLQAGGGAPPHPPM------SP
D
F
T
V
F
M
I
---
K
Y
L
M
T
L
I
V
G
ITS
G
F
W
I
WSGK
T
L
N
S
W
R
K
F
Y
T
R
LTNSKQGETTV----------------------------------------------------
51
Fugue
80.39
26%
-99
- C6 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
D
L
E
D
N
W
----------------
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
-----
Q
V
K
D
A
L
T
K
M
R
---
A
A
A
L
---------------------
D
--
A
Q
--
K
---
A
--
T
----
P
P
K
L
E
D
K
S
P
D
S
P
E
-
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
------
A
N
-
E
-
G
K
-
V
K
--
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
-
Y
L
S
------------------------
G
Q
C
E
V
P
-------------------
L
V
R
T
D
N
P
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
------
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
--
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
DG
A
R
R
E
--
I
V
C
R
----
A
D
G
T
M
R
L
G
E
P
T
S
N
E
TL--
S
C
V
I
I
F
V
I
-----------
V
Y
Y
A
L
M
A
G
V
V
W
-------
F
V
V
L
T
Y
A
W
---
H
T
S
-
F
--
K
A
L
G
T
T
Y
Q
P
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
--------
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
--------
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
GL
L
S
E
K
A
A
S
----
K
I
N
E
T
M
L
R
L
--------------------------
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
------------
F
R
D
Y
V
L
C
Q
A
--------------
N
C
E
I
K
N
------
R
P
S
L
L
V
E
K
I
---
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
----------------------------------------------------------------
1
PsiBlast_PDB
77.70
30%
-134
- C6 -
4JKV
10
C562_ECOLX (first)
A:
[133-470]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
I
Q
C
Q
N
P
------
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
-
S
N
R-
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
----
A
D
G
T
M
R
L
G
E
P
T
S
N
E
TL--
S
C
V
I
I
F
V
I
-----------
V
Y
Y
A
L
M
A
G
V
V
W
-------
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
--
T
T
--
Y
Q
P
--
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
--------
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
--------
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
--
N
--
H
P
G
L
L
S
E
KAA
S
K
I
N
E
T
M
L
R
L
--------------------------
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
------------
F
------
R
D
Y
V
L
C
Q
A
N
-------------CEIK
N
-
R
P
S
L
L
V
E
K
I
---
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
----------------------------------------------------------------
2
PsiBlast_PDB
77.37
30%
-133
- C6 -
4N4W
6
SMO_HUMAN
A:
[133-473]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
I
Q
C
Q
N
P
------
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
-
S
N
R-
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
----
A
D
G
T
M
R
L
G
E
P
T
S
N
E
TL--
S
C
V
I
I
F
V
I
-----------
V
Y
Y
A
L
M
A
G
V
V
W
-------
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
--
T
T
--
Y
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
--------
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
--------
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
--
N
--
H
P
G
L
L
S
E
S---
K
I
N
E
T
M
L
R
L
--------------------------
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
------------
F
------
R
D
Y
V
L
C
Q
A
--------------DCEIK
N
R
P
S
L
L
V
E
K
I
---
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
L
T
-------------------------------------------------------------
56
Fugue
72.96
18%
-80
- C1 -
4TUU
-
PK3CA_HUMAN
A:
[5-944]
N
R
E
E
K
I
L
N
R
E
I
G
F
A
I
GMP
V
C
E
F
D
M
V
K
D
P
E
V
Q
D
F
R
R
N
----
I
L
N
V
C
K
E
A
V
D
L
R
D
L
N
S
P
H
S
R
A
M
Y
V
Y
P
P
N
V
E
SSPEL
P
K
H
I
Y
N
K
LDKG
Q
I
I
V
V
I
W
V
I
V
S
P
N
N
D
K
Q
K
Y
T
L
K
I
N
H
D
C
V
---
P
E
Q
V
I
A
E
A
I
R
K
K
T
R
S
M
L
Y
Q
G
K
Y
I
L
K
V
C
G
C
D
E
Y
F
L
E
K
Y
P
L
S
Q
Y
K
Y
I
R
S
C
I
M
L
G
R
M
P
N
L
M
L
M
A
K
E
S
L
Y
S
Q
LPM
D
C
F
T
M
P
SYSRKS
L
W
V
I
N
S
A
L
R
I
-
K
I
L
C
A
T
YVNVN
D
K
I
Y
V
R
T
G
I
Y
HGG
E
P
L
C
D
N
V
N
T
Q
RVPCS
N
P
R
W
N
E
W
L
N
Y
D
--
I
Y
--
I
P
D
L
P
--
R
A
A
R
L
C
L
S
I
C
S
V
K
E
E
H
C
P
L
A
W
G
N
I
N
L
F
D
Y
T
D
T
L
V
S
G
K
M
A
L
N
L
W
P
V
P
H
G
-
L
-
E
D
-
L
L
NP
I
G
V
T
G
S
N
P
N
K
E
T
P
C
L
E
L
E
F
D
W
F
S
S
V
V
K
--------
F
P
D
M
S
V
I
E
E
H
A
N
W
S
V
S
R
E
A
G
F
S
YSHAGLSNRLARDNE
L
R
E
N
D
K
E
Q
L
K
A
I
S
T
R
D
P
L
S
E
-
I
T
E
Q
E
K
D
F
L
W
S
H
R
H
Y
C
V
T
I
P
E
I
L
P
K
L
L
L
S
V
K
W
N
S
R
D
E
V
A
Q
M
Y
C
L
V
K
D
-
W
P
PI
K
P
E
Q
A
M
E
L
L
D
C
N
Y
P
D
P
M
V
R
G
F
A
V
R
C
--
L
E
K
Y
--
L
--
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
Y
E
QYLD
N
L
L
V
R
F
L
L
K
K
A
L
T
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
NKTV
S
Q
R
F
G
L
L
L
E
S
Y
---
C
R
A
C
G
M
Y
L
K
H
L
N
R
Q
V
E
A
M
E
K
L
I
N
L
T
D
I
L
K
Q
E
K
K
D
E
T
Q
K
V
Q
M
K
F
L
V
E
Q
M
R
R
P
D
F
M
D
A
L
Q
GFLSP
L
N
P
A
H
Q
L
G
N
L
R
L
E
E
C
R
I
M
SSAKRPL
W
L
N
W
E
N
P
D
I
M
S
E
L
L
F
Q
N
N
E
I
I
F
K
N
--
G
D
D
L
R
Q
D
----
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
GLDLRMLP
Y
G
C
L
S
IGDC
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
G
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
KG
E
I
Y
D
A
A
I
D
L
F
T
R
-
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
------
K
D
D
G
Q
L
F
H
I
DFG
H
F
L
D
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
S
T
K
T
R
E
F
E
R
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
GSGMPELQSFDDIA
Y
I
R
K
T
L
ALDKT
E
Q
E
A
L
E
Y
F
M
K
Q
M
N
DA
52
Fugue
65.30
52%
-107
* C4 *
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------------------------------------------------------------------------------------------------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
----
P
N
Q
F
N
H
D
T
Q
D
E
A
G
----------------
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
-----
D
L
K
F
F
L
C
S
M
Y
---
T
P
I
C
---------------------
L
ED
Y
K
---
K
P
L
P
--
P
----
C
R
S
V
C
E
R
A
K
A
G
C
A
-
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
------
Q
G
-
N
-
P
D
T
L
C
--
M
D
Y
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.98
52%
-107
- C4 -
1IJY
-
FZD8_MOUSE
A:
[8-126]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
----
P
N
Q
F
N
H
D
T
Q
D
E
A
G
----------------
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
-----
D
L
K
F
F
L
C
S
M
Y
---
T
P
I
C
L--------------------
E
--
D
Y
--
K
K
P
L
P
--
P
----
C
R
S
V
C
E
R
A
K
A
G
C
A
-
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
------
Q
G
-
N
-
P
D
T
L
C
--
M
D
Y
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
64.76
52%
-102
- C4 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------------------------------------------------------------------------------------------------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
----
P
N
Q
F
N
H
D
T
Q
D
E
A
G
----------------
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
-----
D
L
K
F
F
L
C
S
M
Y
---
T
P
I
C
---------------------
L
E-
D
Y
--
K
K
P
L
P
--
P
----
C
R
S
V
C
E
R
A
K
A
G
C
A
-
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
------
Q
G
N
P
-
D
T
-
L
C
--
M
D
Y
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.39
52%
-99
- C4 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-------------------------------------------------------------------------------------------------------------------------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
----
P
N
Q
F
N
H
D
T
Q
D
E
A
G
----------------
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
-----
D
L
K
F
F
L
C
S
M
Y
---
T
P
I
C
---------------------
L
--
E
D
Y-
K
K
P
L
P
--
P
----
C
R
S
V
C
E
R
A
K
A
G
C
A
-
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
------
Q
G
-
N
P
D
T
-
L
C
--
M
D
Y
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.79
55%
-107
- C4 -
4F0A
2
FZD8_MOUSE
A:
[8-123]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
N
Y
T
Y
M
----
P
N
Q
F
N
H
D
T
Q
D
E
A
G
----------------
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
-----
D
L
K
F
F
L
C
S
M
Y
---
T
P
I
C
L--------------------
E
--
D
Y
--
K
K
P
L
P
--
P
----
C
R
S
V
C
E
R
A
K
A
G
C
A
-
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
------
Q
G
-
N
-
P
D
T
L
C
--
M
D
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
62.51
42%
-107
- C4 -
1IJX
1
SFRP3_MOUSE
A:
[3-124]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
A
C
E
P
V
R
I
P
L
C
K
S
L
P
W
E
M
T
K
M
----
P
N
H
L
H
H
S
T
Q
A
N
A
I
----------------
L
A
M
E
Q
F
E
G
L
L
-
G
T
H
C
S
P
-----
D
L
L
F
F
L
C
A
M
Y
---
A
P
I
C
---------------------
T
--
I
D
FQ
H
E
P
I
K
--
P
----
C
K
S
V
C
E
R
A
R
Q
G
C
E
-
P
I
L
I
K
Y
R
H
S
W
P
E
S
L
A
C
D
E
L
P
V
------
Y
D
---
R
G
-
V
C
--
I
S
P
E
A
I
V
T
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.60
32%
-133
- C6 -
4QIN
1
C562_ECOLX (first)
A:
[27-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
I
Q
C
Q
N
P
------
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
-
S
N
R-
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
----
A
D
G
T
M
R
L
G
E
P
T
S
N
E
TL--
S
C
V
I
I
F
V
I
-----------
V
Y
Y
A
L
M
A
G
V
V
W
-------
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
--
T
T
--
Y
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
--------
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
--------
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
--
D
L
E
D
N
W
E
----
T
L
N
D
N
L
K
V
I
--------------------------
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
------------
E
D
K
S
-
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
------
K
L
A
N
E
G
K
V
K
---
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
----------------------------------------------------
20
PsiBlast_CBE
61.22
45%
-107
- C4 -
5CL1
2
?
D:
[16-120]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
61.01
40%
-98
- C4 -
5BPB
1
FZD4_HUMAN
D:
[7-134]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
G
D
E
E
V
P
L
P
H
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
60.96
46%
-107
- C4 -
1IJX
1
SFRP3_MOUSE
A:
[5-119]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
E
P
V
R
I
P
L
C
K
S
L
P
W
E
M
T
K
M
----
P
N
H
L
H
H
S
T
Q
A
N
A
I
----------------
L
A
M
E
Q
F
E
G
L
L
-
G
T
H
C
S
P
-----
D
L
L
F
F
L
C
A
M
Y
---
A
P
I
C
---------------------
T
--
I
D
--
F
Q
H
E
P
IK
P
----
C
K
S
V
C
E
R
A
R
Q
G
C
E
-
P
I
L
I
K
Y
R
H
S
W
P
E
S
L
A
C
D
E
L
P
V
------
Y
D
-
R
-
G
--
V
C
--
I
S
P
E
A
I
V
T
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
60.89
40%
-99
- C4 -
5BPQ
1
FZD4_HUMAN
D:
[7-124]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.82
45%
-107
- C4 -
5CL1
2
?
C:
[16-120]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
60.48
45%
-114
- C4 -
5CM4
2
?
B:
[6-110]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.11
45%
-109
- C4 -
5CM4
2
?
A:
[6-110]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
60.06
40%
-103
- C4 -
5BPQ
1
FZD4_HUMAN
A:
[7-124]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.49
40%
-105
- C4 -
5BPB
1
FZD4_HUMAN
A:
[7-124]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.11
40%
-105
- C4 -
5BQE
3
FZD4_HUMAN
C:
[7-126]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
-
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
-
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
58.54
40%
-98
- C4 -
5BPQ
1
FZD4_HUMAN
B:
[7-124]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
58.28
40%
-97
- C4 -
5BPQ
1
FZD4_HUMAN
C:
[7-124]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.78
40%
-92
- C4 -
5BQC
3
FZD4_HUMAN
B:
[7-128]
----------------------------------------------------------------------------------------------------------------------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
----
P
N
L
V
G
H
E
L
Q
T
D
A
E
----------------
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
-----
Q
L
Q
F
F
L
C
S
V
Y
---
V
P
M
C
---------------------
T
E-
K
I
--
N
I
P
I
G
--
P
----
C
G
G
M
C
L
S
V
K
R
R
C
E
-
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
------
Q
N
-
D
-
H
N
-
H
M
--
C
M
E
G
P
G
D
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------