@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FZD2_HUMAN: (2016-01-09 )
MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80.........90........100--.--.-.--.....110.......120.......130.......140...-.-...150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270-.......280.......290.......--300.--......310.......320...--....330.......340.......350---.......360.......370.......380.......390.......400.......410.......420.......430.......440....--...450.----......460.......470.......480.......490..----.....500.......510.......520.......530.......540.......550.......560...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
P
R
S
A
L
P
R
L
L
L
P
L
L
LLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQT
I
M
P
N
LLGHTNQEDAG
L
E
V
H
Q
F
Y
P
L
V
-
K
V
Q
CSP
E
L
R
F
F
L
C
S
M
Y
A
P
V
C
-
T
--
V
--
L
-
E
--QAI
P
P
C
R
S
I
C
E
R
A
R
Q
G
C
E
A
L
M
N
KFGFQ
W
P
E
R
L
R
CEHFPRHG-A-E
Q
I
C
VGQNHSEDGA
P
A
L
L
TTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHC
P
R
V
LKVPSY
L
S
Y
K
FLGERDCAAPCEPARPDG
S
M
F
FSQEE
T
R
F
A
R
L
W
I
L
T
W
S
V
L
C
C
A
S
T
F
F
T
V
T
T
Y
L
V
D
M
Q
R
-FRYPER
P
I
I
F
LS
G
C
Y
T
M
V
S
V
A
Y
I
A
G
F
V
--
L
Q
E
R
--
V
V
C
NERFSEDG
Y
R
T
V
V
QGTKKE--G
C
T
I
L
F
M
M
L
Y
F
F
S
M
A
S
S
I
W
W
V
I
L
S
L
T
W
---
F
L
A
A
G
M
K
W
G
H
E
A
IEANS
Q
Y
F
H
L
A
AWAVPA
V
K
T
I
T
I
L
A
MGQI
D
G
D
L
L
S
G
V
C
F
VGLNSL
D
P
L
R
G
F
V
L
A
P
L
F
V
Y
L
F
I
G
T
S
F
L
L
A
G
F
V
S
L
F
R
I
R
T
I
M
K--HDGT
K
T
E
----
K
L
E
R
L
M
V
R
I
G
V
F
S
V
L
Y
TV
P
A
T
I
V
I
A
C
Y
F
Y
E
Q
A
F
R
E
H
W
E
R
S
W
----
V
S
Q
H
C
K
SLAIPCPAHYTPRMSP
D
F
T
V
Y
M
I
K
Y
L
M
T
L
I
V
G
ITS
G
F
W
I
WSG
K
T
L
H
S
W
R
K
F
Y
T
R
L
TNSRHGETTV
42
Fugue
87.43
24%
-106
- C3 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
-------------------------------------------------------------
G
T
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
-
D
--
A
--
Q
-
K
-----
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
-
E
-
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
--------------------------
L
S
G
Q
C
E
V
P
L
V
R
T
D
N
P
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
------
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
DG
A
R
R
E
--
I
V
C
R
A
----
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
---
H
T
S
-
F
K
A
L
G
T
T
Y
Q
P
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
GL
L
S
E
K
A
A
S
----
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
----
R
D
Y
------
V
L
C
Q
A
N
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
------------
2
PsiBlast_PDB
81.40
30%
-137
- C3 -
4N4W
6
SMO_HUMAN
A:
[141-473]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
A
----
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
--
Y
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
--
N
--
H
P
G
L
L
S
E
S---
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
----------
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
L
T
---------
1
PsiBlast_PDB
78.66
30%
-138
- C3 -
4JKV
10
C562_ECOLX (first)
A:
[141-470]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
A
----
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
--
Y
Q
P
--
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
--
N
--
H
P
G
L
L
S
E
KAA
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
----------
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
------------
3
PsiBlast_PDB
66.84
57%
-111
- C5 -
4F0A
2
FZD8_MOUSE
A:
[8-115]
--------------------------------------
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
N
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
--
D
--
Y
-
K
--
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
-
N
-
P
D
T
L
C
M
D
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
66.73
52%
-116
- C5 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-----------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
ED
Y
--
K
----
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
-
D
T
L
C
M
D
Y
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
66.44
51%
-112
* C5 *
1IJY
-
FZD8_MOUSE
A:
[5-126]
-----------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
E-
D
--
Y
-
K
--
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
-
D
T
L
C
M
D
Y
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
66.12
50%
-109
- C5 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
-----------------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
--
E
--
D
Y
K
--
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
-
N
P
D
T
L
C
M
D
Y
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.55
51%
-116
- C5 -
1IJY
-
FZD8_MOUSE
A:
[8-126]
--------------------------------------
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
L
E
--
D
--
Y
-
K
--
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
-
N
P
D
T
L
C
M
D
Y
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
64.46
46%
-118
- C5 -
5CL1
2
?
D:
[16-120]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
64.06
44%
-111
- C5 -
1IJX
1
SFRP3_MOUSE
A:
[3-123]
------------------------------------
A
A
C
E
P
V
R
I
P
L
C
K
S
L
P
W
E
M
T
K
M
P
N
H
L
H
H
S
T
Q
A
N
A
I
L
A
M
E
Q
F
E
G
L
L
-
G
T
H
C
S
P
D
L
L
F
F
L
C
A
M
Y
A
P
I
C
-
T
--
I
--
D
-
F
QH
E
P
I
K
P
C
K
S
V
C
E
R
A
R
Q
G
C
E
P
I
L
I
K
Y
R
H
S
W
P
E
S
L
A
C
D
E
L
P
V
Y
D
---
R
G
V
C
I
S
P
E
A
I
V
T
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.58
49%
-116
- C5 -
1IJX
1
SFRP3_MOUSE
A:
[5-110]
--------------------------------------
C
E
P
V
R
I
P
L
C
K
S
L
P
W
E
M
T
K
M
P
N
H
L
H
H
S
T
Q
A
N
A
I
L
A
M
E
Q
F
E
G
L
L
-
G
T
H
C
S
P
D
L
L
F
F
L
C
A
M
Y
A
P
I
C
-
T
--
I
DF
Q
-
H
--
E
P
I
K
P
C
K
S
V
C
E
R
A
R
Q
G
C
E
P
I
L
I
K
Y
R
H
S
W
P
E
S
L
A
C
D
E
L
P
V
Y
D
-
R
-
G
V
C
I
S
P
E
A
I
V
T
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
63.50
46%
-118
- C5 -
5CL1
2
?
C:
[16-120]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.34
32%
-137
- C3 -
4QIN
1
C562_ECOLX (first)
A:
[35-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
A
----
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
A
L
G
T
T
--
Y
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
--
D
L
E
D
N
W
E
----
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
----
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
18
PsiBlast_CBE
62.14
39%
-108
- C5 -
5BPQ
1
FZD4_HUMAN
D:
[7-124]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
61.84
46%
-123
- C5 -
5CM4
2
?
B:
[6-110]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
G
P
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_CBE
61.35
39%
-111
- C5 -
5BPQ
1
FZD4_HUMAN
B:
[7-124]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
61.03
39%
-105
- C5 -
5BPB
1
FZD4_HUMAN
D:
[7-134]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
G
P
G
D
E
E
V
P
L
P
H
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.81
39%
-113
- C5 -
5BPQ
1
FZD4_HUMAN
A:
[7-124]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
60.75
32%
-143
- C3 -
4O9R
1
C562_ECOLX (first)
A:
[35-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
A
----
D
G
T
M
R
L
G
E
P
T
S
N
E
TL
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
------------
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
--
D
L
E
D
N
W
E
----
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
----
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
9
PsiBlast_PDB
60.70
39%
-115
- C5 -
5BPB
1
FZD4_HUMAN
A:
[7-124]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.00
39%
-117
- C5 -
5BQE
3
FZD4_HUMAN
C:
[7-126]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
-
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
-
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
G
P
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
59.99
39%
-105
- C5 -
5BQC
3
FZD4_HUMAN
B:
[7-128]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
G
P
G
D
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_CBE
59.64
39%
-105
- C5 -
5BPQ
1
FZD4_HUMAN
C:
[7-124]
--------------------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
E-
K
--
I
-
N
--
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
-
D
-
H
N
H
M
C
M
E
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------