@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FZD3_HUMAN: (2016-01-09 )
MAMTWIVFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHRSRDGRYTPCSYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIEEDGTSA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........-70.........80........-90.--.-.--....-..100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....-..230........240.......250.....--..260-........270.......280.......290.......300.......310.......320-........330.......-340.......350.......360.......370.......380.......390.......400...--.------...410.......420.......430.......440.......450.......460.......470-.........480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660....--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
M
T
W
I
V
F
S
L
W
P
L
T
V
F
M
G
HIGGHSLFSCE
P
I
T
L
R
M
C
QDLPYNTT
F
M
P
N
L
L
N
H
Y
D
Q
Q
T
A
A
LAMEPFHPMV-N-LDCSRD
F
R
P
F
L
C
A
L
Y
A
P
I
C
-
M
-E--Y-G--RV
T
L
-
P
C
R
R
L
C
Q
R
A
Y
S
E
C
S
K
L
M
E
M
FGVPWPEDMECSRFPDCDEPYP
R
L
V
D
L
NLAGEPTEGA
P
V
A
V
QRDYGFWCPRELKIDPDLG
Y
S
F
L
H
VRDCSPPCPN
M
Y
F
R
R
E
E
L
S
F
A
R
Y
F
I
G
L
I
S
I
I
C
L
S
A
T
L
F
T
F
L
T
F
L
I
D
-
V
T
R-FRYPERP
I
I
F
Y
A
V
C
Y
M
M
V
S
L
I
F
F
I
G
F
L
--
L
EDR--VACNASIPAQ
Y
K
A
S
T
VTQGSH
N
K
A
C
T
M
L
F
M
I
L
Y
F
F
T
MAG
S
V
W
W
V
I
L
T
I
T
W
F
L
A
AVPKW
G
S
--
E
A
I
E
K
K
A
L
L
F
HASAWGI
P
-
G
T
L
T
I
I
L
L
A
M
NKIEGDNI
S
G
V
C
F
V
G
L
Y
D
V
D
A
L
R
Y
F
V
L
A
P
L
C
L
Y
V
V
V
G
V
S
L
L
L
A
G
I
ISL
N
R
V
R
I
E
I
P--L------EKE
N
Q
D
K
L
V
K
F
M
I
R
I
G
V
F
S
I
L
Y
L
V
P
L
L
V
V
I
G
C
Y
F
Y
E
Q
A
Y
R
GI
W
E
T
T
W
I
Q
E
R
C
R
EYHIPCP
Y
Q
VT---QMSR
P
D
L
I
L
F
L
M
K
Y
L
M
A
L
I
VGIP
S
V
F
W
VGS
K
K
T
C
F
E
W
A
S
F
FHG
R
R
K
K
E
I
V
N
E
S
R
Q
V
LQE
P
D
F
A
Q
S
L
LRDPNT
P
I
I
RKSRGTSTQGTSTHASS
T
Q
L
A
M
VDDQRSKA
G
S
I
H
S
K
V
S
S
Y
HGSLHRSRDGRYTPCSYR
G
M
E
E
RLPHG
S
M
S
R
L
TDHSRHSSSHRL
N
E
Q
S
R
H
S
S
I
R
DLSNNP
M
T
H
I
THGTS
M
N
R
V
I
EEDGTSA--
1
PsiBlast_PDB
84.03
27%
-157
- C5 -
4JKV
10
C562_ECOLX (first)
A:
[130-465]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
-
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
---
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
-
T
S
F
K
A
L
G
T
TY
Q
P
--
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
-
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
GL
L
------
S
E
K
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
-----
R
D
Y
-
V
L
C
Q
A
N
--CE-
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
83.44
22%
-121
- C5 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
--------------------------------------------------
G
T
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
-
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
-
D
-
A
--
Q
-
K
--
A
T
P
----
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
-
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
S
G
Q
C
E
V
P
L
V
R
T
D
N
P
K
S
W
Y
E
D
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
-
W
R
N
S
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
DG
A
R
R
E
--
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
---
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
S
F
K
-
A
L
G
T
--
T
Y
Q
P
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
-
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
GL
L
------
S
E
K
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
------
R
D
Y
V
L
C
Q
A
N
C
E
---
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.61
27%
-159
- C5 -
4N4W
6
SMO_HUMAN
A:
[130-465]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
-
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
---
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
-
T
S
F
K
A
L
G
T
TY
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
-
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
GL
L
------
S
E
---
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
-----
R
D
Y
-
V
L
C
Q
A
---DCE
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
73.34
18%
-96
* C4 *
4IWS
-
?
A:
[23-515]
-----
M
N
R
S
A
L
D
F
R
H
F
V
D
H
L
R
R
Q
G
-------------
D
L
V
D
V
H
T
E
V
D
A
N
L
E
I
G
A
I
T
R
R
V
Y
E
R
R
A
P
A
P
L
F
H
N
-
I
---
R
D
S
L
P
G
A
R
V
L
G
A
P
A
G
-
L
-
R
--
A
-
D
--
R
----------
A
R
A
H
---
S
R
L
A
L
H
F
G
L
P
E
H
S
G
-----------
P
R
D
I
V
A
M
L
R
A
A
M
R
A
E
P
I
A
P
R
R
L
E
R
G
---------------------------
P
V
Q
E
N
V
W
L
G
E
Q
V
D
L
T
R
F
P
V
P
L
L
H
E
Q
D
G
G
R
Y
F
G
T
Y
G
F
H
V
V
Q
-
T
P
------------------------------------------------------
D
G
S
W
D
S
W
S
V
G
R
L
M
L
V
D
R
N
T
L
A
G
P
T
----
I
P
T
Q
H
I
G
I
I
R
E
Q
W
R
R
----------
L
G
K
P
T
P
W
A
M
A
L
G
A
P
P
A
A
L
A
A
A
G
M
P
L
P
E
G
V
S
E
A
G
Y
V
G
A
L
V
G
E
P
V
E
V
V
R
T
Q
T
N
G
L
W
V
P
A
N
T
E
I
V
L
E
G
E
I
S
L
D
E
T
A
L
E
G
P
--
M
GEYHGY
S
F
P
I
G
K
P
Q
P
L
F
H
V
H
A
L
S
F
R
D
Q
P
I
L
P
I
C
V
A
G
T
P
P
E
E
N
H
T
I
W
G
T
M
I
S
A
Q
L
L
D
V
A
Q
N
A
G
L
P
------------------------------
V
D
M
V
W
C
S
Y
E
A
A
T
C
--
W
A
V
L
S
I
D
V
Q
R
L
A
A
L
G
T
D
A
A
A
F
A
A
-
R
V
A
E
T
V
F
G
S
H
A
G
H
L
V
P
K
L
I
L
V
G
N
D
I
D
V
T
E
I
D
Q
V
V
W
A
L
A
T
R
A
H
P
L
---------
H
D
H
F
A
F
P
Q
I
R
D
F
P
M
V
P
Y
L
D
A
E
D
K
A
R
---
G
S
G
G
R
L
V
I
N
C
L
Y
P
E
Q
F
A
G
Q
M
R
A
A
T
A
S
F
R
H
---------
A
Y
P
T
A
L
R
R
R
V
E
E
R
W
S
D
Y
GF
7
PsiBlast_PDB
64.94
41%
-107
- C6 -
1IJY
-
FZD8_MOUSE
A:
[6-117]
-------------------------
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
-
E
D-
Y
-
K
--
K
P
L
P
-
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
Y
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.39
28%
-149
- C5 -
4QIN
1
C562_ECOLX (first)
A:
[24-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
-
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
---
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
-
T
S
F
K
A
L
G
T
TY
Q
P
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
-
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
--
D
------
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
---
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
-----------------------------------------------------------
3
PsiBlast_PDB
64.25
41%
-102
- C6 -
4F0A
2
FZD8_MOUSE
A:
[8-117]
---------------------------
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
N
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
-
E
D-
Y
-
K
--
K
P
L
P
-
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
64.00
38%
-109
* C6 *
1IJY
-
FZD8_MOUSE
A:
[5-126]
------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
E
D
--
Y
-
K
--
K
P
L
P
-
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
Y
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
63.60
38%
-108
- C6 -
1IJY
-
FZD8_MOUSE
A:
[5-126]
------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
-
E
DY
K
----
K
P
L
P
-
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
Y
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
62.77
36%
-113
- C6 -
1IJX
1
SFRP3_MOUSE
A:
[3-121]
-------------------------
A
A
C
E
P
V
R
I
P
L
C
K
S
L
P
W
E
M
T
K
M
P
N
H
L
H
H
S
T
Q
A
N
A
I
L
A
M
E
Q
F
E
G
L
L
-
G
-
T
H
C
S
P
D
L
L
F
F
L
C
A
M
Y
A
P
I
C
-
T
-
I
--
D
-
F
QH
E
P
I
K
-
P
C
K
S
V
C
E
R
A
R
Q
G
C
E
P
I
L
I
K
Y
R
H
S
W
P
E
S
L
A
C
D
E
L
P
V
Y
D
--
R
G
V
C
I
S
P
E
A
I
V
T
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
62.69
37%
-107
- C6 -
1IJY
-
FZD8_MOUSE
A:
[5-125]
------------------------
E
L
A
C
Q
E
I
T
V
P
L
C
K
G
I
G
Y
E
Y
T
Y
M
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
V
H
Q
F
W
P
L
V
-
E
-
I
Q
C
S
P
D
L
K
F
F
L
C
S
M
Y
T
P
I
C
-
L
-
E
--
D
Y
K
--
K
P
L
P
-
P
C
R
S
V
C
E
R
A
K
A
G
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
M
R
C
D
R
L
P
E
Q
G
N
P
D
T
L
C
M
D
Y
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.94
28%
-152
- C5 -
4O9R
1
C562_ECOLX (first)
A:
[24-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
-
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
---
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
-
T
S
F
K
----------
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
-
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
--
D
------
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
---
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
V
T
I
P
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
-------------------------------------------------------
5
PsiBlast_PDB
61.77
28%
-155
- C5 -
4QIM
2
C562_ECOLX
A:
[24-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
G
C
G
I
Q
C
Q
N
P
L
F
T
E
A
E
H
Q
D
M
H
S
Y
I
A
A
F
G
A
V
T
G
L
C
T
L
F
T
L
A
T
F
V
A
D
W
R
N
S
-
N
R
Y
P
A
V
I
L
F
Y
V
N
A
C
F
F
V
G
S
I
G
W
L
A
Q
F
M
--
D
G
A
R
R
E
I
V
C
R
A
D
G
T
M
R
L
G
E
P
T
---
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
-
T
S
F
K
A
L
------
L
S
G
K
T
S
Y
F
H
L
L
T
W
S
L
P
-
F
V
L
T
V
A
I
L
A
V
A
Q
V
D
G
D
S
V
S
G
I
C
F
V
G
Y
K
N
Y
R
Y
R
A
G
F
V
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
A
--
D
------
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
---
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
S
K
I
N
E
T
M
L
R
L
G
I
F
G
F
L
A
F
G
F
V
L
I
T
F
S
C
H
F
Y
D
F
F
N
Q
A
E
W
E
R
S
F
R
D
Y
V
L
C
Q
A
N
V
T
I
G
L
P
T
K
Q
P
I
P
D
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
R
L
T
---------------------------------------------
19
PsiBlast_CBE
61.46
40%
-106
- C6 -
5BPQ
1
FZD4_HUMAN
D:
[7-111]
---------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
-
E
--
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.33
40%
-113
- C6 -
5BQC
2
FZD4_HUMAN
B:
[7-111]
---------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
-
E
--
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.28
40%
-107
- C6 -
5BPB
1
FZD4_HUMAN
A:
[7-111]
---------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
-
E
--
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.25
40%
-109
- C6 -
5CM4
2
?
A:
[6-110]
---------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
-
E
--
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
60.18
40%
-107
- C6 -
5CM4
2
?
B:
[6-110]
---------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
-
E
--
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.05
39%
-108
- C6 -
1IJX
1
SFRP3_MOUSE
A:
[4-110]
--------------------------
A
C
E
P
V
R
I
P
L
C
K
S
L
P
W
E
M
T
K
M
P
N
H
L
H
H
S
T
Q
A
N
A
I
L
A
M
E
Q
F
E
G
L
L
-
G
-
T
H
C
S
P
D
L
L
F
F
L
C
A
M
Y
A
P
I
C
T
I
-
D
--
F
-
Q
--
H
E
P
I
K
P
C
K
S
V
C
E
R
A
R
Q
G
C
E
P
I
L
I
K
Y
R
H
S
W
P
E
S
L
A
C
D
E
L
P
V
Y
D
R
G
V
C
I
S
P
E
A
I
V
T
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
59.88
40%
-107
- C6 -
5BPB
2
FZD4_HUMAN
B:
[7-111]
---------------------------
C
D
P
I
R
I
S
M
C
Q
N
L
G
Y
N
V
T
K
M
P
N
L
V
G
H
E
L
Q
T
D
A
E
L
Q
L
T
T
F
T
P
L
I
-
Q
-
Y
G
C
S
S
Q
L
Q
F
F
L
C
S
V
Y
V
P
M
C
-
T
-
E
--
K
-
I
--
N
I
P
I
G
P
C
G
G
M
C
L
S
V
K
R
R
C
E
P
V
L
K
E
F
G
F
A
W
P
E
S
L
N
C
S
K
F
P
P
Q
N
D
H
N
H
M
C
M
E
G
P
G
D
E
L
E
V
L
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------